Spectrum Pharmaceuticals (SPPI) 10-Q 14 Nov 16 2016 Q3 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	9 Months Ended
	Sep. 30, 2016	Oct. 31, 2016
Document And Entity Information [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Sep. 30, 2016
Document Fiscal Year Focus	2,016
Document Fiscal Period Focus	Q3
Trading Symbol	SPPI
Entity Registrant Name	SPECTRUM PHARMACEUTICALS INC
Entity Central Index Key	831,547
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		80,557,934

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 171,605	$ 139,741
Marketable securities	247	245
Accounts receivable, net of allowance for doubtful accounts of $15 and $120, respectively	42,466	30,384
Other receivables	7,091	12,572
Inventories	7,303	4,176
Prepaid expenses and other assets	2,702	3,507
Total current assets	231,414	190,625
Property and equipment, net of accumulated depreciation	538	918
Intangible assets, net of accumulated amortization and impairment charges	171,460	190,335
Goodwill	18,017	17,960
Other assets	28,015	19,211
Total assets	449,444	419,049
Current liabilities:
Accounts payable and other accrued liabilities	49,977	56,539
Accrued payroll and benefits	7,741	8,188
Deferred revenue	4,458	6,130
Drug development liability	156	259
Acquisition-related contingent obligations	0	5,227
Total current liabilities	62,332	76,343
Drug development liability, less current portion	14,004	14,427
Deferred revenue, less current portion	741	383
Acquisition-related contingent obligations, less current portion	1,915	1,439
Deferred tax liability	6,739	6,779
Other long-term liabilities	8,772	7,444
Convertible senior notes	104,144	99,377
Total liabilities	198,647	206,192
Commitments and contingencies
Stockholders’ equity:
Preferred stock	0	0
Common stock, $0.001 par value; 175,000,000 shares authorized; 80,566,699 and 68,228,935 shares issued and outstanding at September 30, 2016 and December 31, 2015, respectively	80	68
Additional paid-in capital	638,006	552,108
Accumulated other comprehensive loss	(2,090)	(5,319)
Accumulated deficit	(385,199)	(334,123)
Total stockholders’ equity	250,797	212,857
Total liabilities and stockholders’ equity	449,444	419,049
Series B junior participating preferred stock [Member]
Stockholders’ equity:
Preferred stock	0	0
Series E Convertible Voting Preferred Stock [Member]
Stockholders’ equity:
Preferred stock	$ 0	$ 123

Condensed Consolidated Balance3

Condensed Consolidated Balance Sheets (Parenthetical) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Allowance for doubtful accounts receivable	$ 15	$ 120
Preferred stock, par value ($ per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	5,000,000	5,000,000
Common stock, par value ($ per share)	$ 0.001	$ 0.001
Common stock, shares authorized	175,000,000	175,000,000
Common stock, shares issued	80,566,699	68,228,935
Common stock, shares outstanding	80,566,699	68,228,935
Series B junior participating preferred stock [Member]
Preferred stock, par value ($ per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	1,500,000	1,500,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Series E Convertible Voting Preferred Stock [Member]
Preferred stock, par value ($ per share)	$ 0.001	$ 0.001
Preferred stock, stated value ($ per share)	$ 10,000	$ 10,000
Preferred stock, shares authorized	2,000	2,000
Preferred stock, shares issued	0	20
Preferred stock, shares outstanding	0	20
Convertible preferred shares	40,000	40,000

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues:
Product sales, net	$ 30,272	$ 28,457	$ 96,401	$ 102,014
License fees and service revenue	3,121	170	14,807	10,212
Total revenues	33,393	28,627	111,208	112,226
Operating costs and expenses:
Cost of product sales (excludes amortization and impairment charges of intangible assets)	7,503	8,447	18,715	21,508
Cost of service revenue	2,221	0	5,716	0
Selling, general and administrative	19,465	19,411	69,047	65,297
Research and development	13,293	9,924	43,037	35,333
Amortization and impairment charges of intangible assets	6,907	6,919	19,052	27,857
Total operating costs and expenses	49,389	44,701	155,567	149,995
Loss from operations	(15,996)	(16,074)	(44,359)	(37,769)
Other (expense) income:
Interest expense, net	(2,373)	(2,274)	(7,087)	(6,760)
Change in fair value of contingent consideration related to acquisitions	78	81	(1,249)	(565)
Other income (expense), net	372	(535)	990	(1,501)
Total other expenses	(1,923)	(2,728)	(7,346)	(8,826)
Loss before income taxes	(17,919)	(18,802)	(51,705)	(46,595)
Benefit (provision) for income taxes	464	78	635	(37)
Net loss	$ (17,455)	$ (18,724)	$ (51,070)	$ (46,632)
Net loss per share:
Basic and diluted ($ per share)	$ (0.22)	$ (0.28)	$ (0.73)	$ (0.71)
Weighted average shares outstanding:
Basic and diluted (shares)	79,303,380	65,855,727	70,437,885	65,457,060

Condensed Consolidated Stateme5

Condensed Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Statement of Comprehensive Income [Abstract]
Net loss	$ (17,455)	$ (18,724)	$ (51,070)	$ (46,632)
Other comprehensive income (loss), net of income tax:
Unrealized gain (loss) on available-for-sale securities	465	(3,934)	2,975	(949)
Foreign currency translation adjustments	96	387	254	(1,913)
Other comprehensive income (loss)	561	(3,547)	3,229	(2,862)
Total comprehensive loss	$ (16,894)	$ (22,271)	$ (47,841)	$ (49,494)

Condensed Consolidated Stateme6

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015
Cash Flows From Operating Activities:
Net loss	$ (51,070)	$ (46,632)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Depreciation and amortization	19,493	21,235
Stock-based compensation	9,754	8,490
Accretion of debt discount, recorded to interest expense on 2018 Convertible Notes (Note 14)	4,246	3,895
Amortization of deferred financing costs, recorded to interest expense on 2018 Convertible Notes (Note 14)	521	493
Bad debt (recovery) expense	(15)	11
Impairment of intangible assets (Note 3(f))	0	7,160
Unrealized foreign currency exchange loss (gain)	(155)	435
Research and development expense recognized for the value of stock issued in connection with milestone achievement (Note 16(b)(xii))	2,419	0
Change in fair value of contingent consideration related to the EVOMELA and Talon acquisitions (Note 9)	1,249	565
Changes in operating assets and liabilities:
Accounts receivable, net	(12,040)	22,537
Other receivables	5,571	(8,008)
Inventories	(6,768)	2,127
Prepaid expenses	804	(133)
Deferred tax assets	0	(147)
Other assets	(2,095)	(1,398)
Accounts payable and other accrued obligations	(6,595)	(5,638)
Accrued payroll and benefits	(451)	(1,286)
Drug development liability	(526)	(1,385)
Acquisition related contingent obligations	(1,300)	0
Deferred revenue	(1,417)	359
Deferred tax liability	(40)	89
Other long-term liabilities	1,321	874
Net cash (used in) provided by operating activities	(37,094)	3,643
Cash Flows From Investing Activities:
Proceeds from sale of available-for-sale securities	0	3,061
Redemption of mutual funds	(1)	0
Purchases of property and equipment	(61)	(212)
Net cash (used in) provided by investing activities	(62)	2,849
Cash Flows From Financing Activities:
Proceeds from exercise of stock options	190	1,482
Proceeds from sale of stock under employee stock purchase plan	383	335
Purchase and retirement of restricted stock to satisfy employees' tax liability at vesting	(829)	(629)
Payment of contingent consideration related to EVOMELA acquisition (Note 9(b))	(4,700)	0
Proceeds from common shares sold under an at-the-market-issuance sales agreement (Note 18)	73,869	0
Dividends paid upon conversion of Series E Convertible Voting Preferred Stock (Note 18)	(6)	0
Net cash provided by financing activities	68,907	1,188
Effect of exchange rates on cash and equivalents	113	(1,095)
Net increase in cash and cash equivalents	31,864	6,585
Cash and cash equivalents—beginning of period	139,741	129,942
Cash and cash equivalents—end of period	171,605	136,527
Supplemental disclosure of cash flow information:
Cash paid for income taxes	11	332
Cash paid for interest	$ 1,650	$ 1,650

Description of Business, Basis

Description of Business, Basis of Presentation, and Operating Segment	9 Months Ended
	Sep. 30, 2016
Accounting Policies [Abstract]
Description of Business, Basis of Presentation, and Operating Segment	DESCRIPTION OF BUSINESS, BASIS OF PRESENTATION, AND OPERATING SEGMENT (a) Description of Business Spectrum Pharmaceuticals, Inc. (“Spectrum”, the “Company”, “we”, “our”, or “us”) is a biotechnology company, with a primary strategy comprised of acquiring, developing, and commercializing a broad and diverse pipeline of late-stage clinical and commercial products. We have an in-house clinical development organization with regulatory and data management capabilities, and a commercial infrastructure and field sales force for our marketed products. Currently, we market six approved oncology/hematology products that target different types of non-Hodgkin's lymphoma ("NHL"), advanced metastatic colorectal cancer, acute lymphoblastic leukemia ("ALL"), and multiple myeloma ("MM"). We also have three drugs in late-stage development: • ROLONTIS (formerly referred to as SPI-2012) for chemotherapy-induced neutropenia in patients with breast cancer. • QAPZOLA (formerly referred to as APAZIQUONE) for immediate intravesical instillation in post-transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer. • POZIOTINIB, a novel pan-HER inhibitor used in the treatment of patients with breast cancer. (b) Basis of Presentation Interim Financial Statements The interim financial data as of September 30, 2016 and 2015 is unaudited, and is not necessarily indicative of our operating results for a full year. In the opinion of our management, the interim data includes normal and recurring adjustments necessary for a fair presentation of our financial results for the three and nine months ended September 30, 2016 and 2015 . Certain information and footnote disclosures normally included in annual financial statements prepared in accordance with generally accepted accounting principles in the United States of America (“GAAP”) have been condensed or omitted pursuant to U.S. Securities and Exchange Commission (“SEC”) rules and regulations relating to interim financial statements. The December 31, 2015 balances reported herein are derived from the audited Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2015 . The accompanying Condensed Consolidated Financial Statements should be read in conjunction with our audited Consolidated Financial Statements and Notes thereto included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2015 , filed with the SEC on March 14, 2016. Principles of Consolidation The accompanying Condensed Consolidated Financial Statements have been prepared in accordance with GAAP and with the rules and regulations of the SEC. These financial statements include the financial position, results of operations, and cash flows of Spectrum and its subsidiaries, all of which are wholly-owned (except for Spectrum Pharma Canada ("SPC"), as discussed below). All inter-company accounts and transactions among these legal entities have been eliminated in consolidation. Variable Interest Entity We own fifty -percent of SPC, a legal entity organized in Quebec, Canada in January 2008. Certain of our drug clinical studies are conducted through this “variable interest entity” (as defined under applicable GAAP) and we fund all of SPC’s operating costs. Since we carry the full risks and rewards of SPC, we meet the applicable GAAP criteria as being its “primary beneficiary.” Accordingly, SPC’s balance sheets and statements of operations are included in our Condensed Consolidated Financial Statements as if it were a wholly-owned subsidiary for all periods presented. (c) Operating Segment We operate in one reportable operating segment that is focused exclusively on developing and commercializing oncology and hematology drug products. For the three and nine months ended September 30, 2016 and 2015 , all of our revenue and related expenses were solely attributable to these activities. Substantially all of our assets (excluding our cash held in certain foreign bank accounts and our ZEVALIN distribution rights for the Ex-U.S. territory) are held in the U.S.

Use of Estimates and Summary of

Use of Estimates and Summary of Significant Accounting Policies	9 Months Ended
	Sep. 30, 2016
Accounting Policies [Abstract]
Use of Estimates and Summary of Significant Accounting Policies	USE OF ESTIMATES AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES The preparation of financial statements in conformity with GAAP requires our management to make informed estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, and expenses. However, actual values may materially differ, since estimates are inherently uncertain. On an on-going basis, our management evaluates its estimates and assumptions, including those related to (i) gross-to-net revenue adjustments; (ii) the timing of revenue recognition; (iii) the collectability of customer accounts; (iv) whether the cost of inventories can be recovered; (v) the fair value of goodwill and intangible assets; (vi) the realization of tax assets and estimates of tax liabilities; (vii) the likelihood of payment and value of contingent liabilities; (viii) the fair value of investments; (ix) the valuation of stock options and the periodic expense recognition of stock-based compensation; and (x) the potential outcome of ongoing or threatened litigation. The estimates and assumptions that most significantly impact the presented amounts within these accompanying Condensed Consolidated Financial Statements are further described below: (i) Revenue Recognition (a) Product Sales : We sell our products to wholesalers/distributors (i.e., our customers), except for our U.S. sales of ZEVALIN in which case the end-user (i.e. clinic or hospital) is our customer. Our wholesalers/distributors in turn sell our products directly to clinics, hospitals, and private oncology-based practices. Revenue from our product sales is recognized when title and risk of loss have transferred to our customer, and the following additional criteria are met: (1) appropriate evidence of a binding arrangement exists with our customer; (2) price is substantially fixed or determinable; (3) collection from our customer is reasonably assured; (4) our customer’s obligation to pay us is not contingent on resale of the product; (5) we do not have significant continued performance obligations to our customer; and (6) we have a reasonable basis to estimate returns. Our gross revenue is reduced by our gross-to-net (“GTN”) estimates each period, resulting in our reported “product sales, net” in the accompanying Condensed Consolidated Statements of Operations. We defer revenue recognition in full if these estimates are not reasonably determinable at the time of sale. These estimates are based upon information received from external sources (such as written and oral information obtained from our customers with respect to their period-end inventory levels, and their sales to end-users during the period), in combination with management’s informed judgments. Due to the inherent uncertainty of estimates, the actual amount we incur may be materially different than our GTN estimates, and require prospective revenue adjustments in periods after the initial sale was recorded. Our GTN estimates are comprised of the following categories: Product Returns Allowances : Our FUSILEV, MARQIBO, and BELEODAQ customers are permitted to return purchased product beginning at its expiration date, and within six months thereafter. Our EVOMELA customers are permitted to return purchased product beginning at six months prior to its expiration date, and within 12 months thereafter (as well as for overstock inventory, as determined by end-users). Returned product is generally not resold. Returns for expiry of ZEVALIN and FOLOTYN are not contractually, or customarily, allowed. We estimate expected returns based on our historical return rates. Government Chargebacks : Our products are subject to pricing limits under certain federal government programs (e.g., Medicare and the 340B Drug Pricing Program). Qualifying entities (i.e., end-users) purchase product from our customers at their qualifying discounted price. The chargeback amount we incur represents the difference between our contractual sales price to our customer, and the end-user’s applicable discounted purchase price under the government program. There may be significant lag time between our reported net product sales and our receipt of corresponding government chargeback claims from our customers. Prompt Pay Discounts : Discounts for prompt payment are estimated at the time of sale, based on our eligible customers’ prompt payment history and the contractual discount percentage. Commercial Rebates : Commercial rebates are based on (i) our estimates of end-user purchases through a group purchasing organization ("GPO"), (ii) the corresponding contractual rebate percentage tier we expect each GPO to achieve, and (iii) our estimates of the impact of any prospective rebate program changes made by us. Medicaid Rebates : Our products are subject to state government-managed Medicaid programs, whereby rebates are issued to participating state governments. These rebates arise when a patient treated with our product is covered under Medicaid, resulting in a discounted price for our product under the applicable Medicaid program. Our Medicaid rebate accrual calculations require us to project the magnitude of our sales, by state, that will be subject to these rebates. There is a significant time lag in us receiving rebate notices from each state (generally several months or longer after our sale is recognized). Our estimates are based on our historical claim levels by state, as supplemented by management’s judgment. Distribution, Data, and GPO Administrative Fees : Distribution, data, and GPO administrative fees are paid to authorized wholesalers/distributors of our products (except for U.S. sales of ZEVALIN) for various commercial services, including: contract administration, inventory management, delivery of end-user sales data, and product returns processing. These fees are based on a contractually-determined percentage of our applicable sales. (b) License Fees : Our out-license arrangements may include one or more of the following: (a) upfront license fees, (b) royalties from our licensees’ sales, and (c) milestone payments from our licensees’ sales or regulatory achievements. We recognize revenue from these categories based on the contractual terms that establish the legal rights and obligations between us and our licensees. (i) We first assess the number of “units of accounting” in the arrangement in accordance with multiple element arrangement guidance. We consider if the separate “deliverable” has standalone value to our licensee, and if standalone value does not exist for a deliverable, it is combined with other deliverables until the "bundle" has standalone value. The allocation of arrangement consideration and the recognition of revenue then is determined for those combined deliverables as a single unit of accounting (ii) Next, we measure and allocate arrangement consideration among the separate units of accounting. This measurement and allocation is based upon the fixed and discreet license fee payments and fixed royalties (as a percentage of our licensees’ net sales) that are part of the contractual terms within our arrangements. This fixed or determinable consideration is allocated to the units of accounting using the "relative selling price method". (iii) We evaluate certain customer payments as follows: (a) For upfront license fees, we consider whether the revenue is earned and realizable at the time of contract execution (i.e., when the license rights transfer to the customer). We give specific consideration to whether we have any on-going contractual service obligations to the licensee, including any requirements for us to provide on-going support services, and/or for us to supply drug products for the licensee’s future sales. As a result, we may either recognize all upfront license fees as revenue in the period of contract execution, or recognize these fees over the actual (or implied) contractual term of the out-license. (b) For royalties, when we have no on-going performance obligation, we recognize revenue in the period that our licensee has sales for which we are contractually entitled to a percentage-based royalty payment. (c) For our licensees’ sales or regulatory milestone achievements, revenue associated with substantive at-risk milestones is recognized when we have no on-going performance obligation and based upon the achievement of the milestones set forth in the respective agreements, as this is the point at which the additional consideration becomes fixed or determinable. (c) Service Revenue : We receive fees under certain arrangements for (a) sales and marketing services, (b) supply chain services (c) research and development services, and (d) clinical trial management services. Payment for these services may be triggered by (i) an established fixed-fee schedule, (ii) the completion of product delivery in our capacity as a procurement agent, (iii) the successful completion of a phase of development, (iv) favorable results from a clinical trial, and/or (v) regulatory approval events. We consider whether revenue associated with these service arrangements is “realizable and earned” each reporting period, based on our completed services or deliverables during the period, and the contractual terms of the arrangement (which typically includes fee schedules). For any/all milestone achievements in the reporting period that contractually result in fixed payments due to us, we apply the “milestone method” of revenue recognition. Accordingly, this revenue recognition occurs as each “substantive” milestone (as discussed below) is achieved by us, since (1) all contingencies associated with each milestone is resolved upon its achievement, (2) the milestone achievement relates solely to our past performance, and (3) no remaining milestone performance obligations exist in relation to our receipt of payment. In recognizing revenue under the milestone method, we first assess the number of “units of accounting” in the arrangement. We consider if the separate “deliverable” has standalone value to our licensee, and if standalone value does not exist for a deliverable, it is combined with other deliverables until the "bundle" has standalone value. The allocation of arrangement consideration and the recognition of revenue is determined for those combined deliverables as a single unit of accounting. This includes allocation of consideration associated with milestones achieved by our licensees. Next, we measure and allocate arrangement consideration among the separate units of accounting. This fixed or determinable consideration is allocated to the units of accounting using the "relative selling price method". Variable fees subsequently earned (other than substantive milestone payments) are allocated to the units of accounting on the same basis. We determine whether the milestone is substantive by considering (i) the extent of our effort to achieve the milestone and/or the enhancement of the value of the delivered item(s) as a result of milestone achievement, (ii) whether the milestone achievement relates solely to our past performance, and (iii) if the milestone payment is reasonable relative to all of the deliverables and payment terms (including other potential milestone consideration) within the arrangement. For service contracts without milestones, we recognize revenue when all of the following criteria are met: (i) persuasive evidence of an arrangement exists, (ii) services have been rendered, (iii) fees are fixed or determinable, and (iv) collectability is reasonably assured. (d) New Revenue Recognition Standard : The new revenue recognition standard, ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606) (“ASU 2014-09”), is effective for us beginning January 1, 2018. This new standard requires that our revenue is recognized in a manner that reasonably reflects the delivery of our goods or services to customers in return for expected consideration. To achieve this core principle, the guidance provides the following steps: (1) identify the contract(s) with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenue when (or as) the entity satisfies a performance obligation. We intend to apply the "cumulative effect transition method" of ASU 2014-09 for its implementation. We continue to evaluate the impact of this new standard on our current revenue recognition models for product sales, license fees, and service revenue (as described above), though we currently believe the most significant impact of this new standard relates to the timing of our license fee revenue. (ii) Cash and Equivalents Our cash and equivalents consist of bank deposits and highly liquid investments with maturities of three months or less from the purchase date. (iii) Marketable Securities Our marketable securities consist of our holdings in mutual funds and bank certificates of deposit. Since we classify these securities as “available-for-sale” under applicable GAAP, any unrealized gains or losses from their change in value is reflected in “unrealized gain (loss) on available-for-sale securities” on the accompanying Condensed Consolidated Statements of Comprehensive Loss. Realized gains and losses on available-for-sale securities are included in “other income (expense), net” on the accompanying Condensed Consolidated Statements of Operations. (iv) Accounts Receivable Our accounts receivables are derived from our product sales and license fees (our service revenue is recorded in "other receivables"), and do not bear interest. The allowance for doubtful accounts is management’s best estimate of the amount of probable credit losses in our existing accounts receivable. Account balances are charged off against the allowance after appropriate collection efforts are exhausted. (v) Inventories We value our inventory at the lower of (i) the actual cost of its purchase or manufacture, or (ii) its current market value. Inventory cost is determined on the first-in, first-out method. We regularly review our inventory quantities in process of manufacture and on hand. When appropriate, we record a provision for obsolete and excess inventory to derive its new cost basis, which takes into account our sales forecast by product and corresponding expiry dates. Direct and indirect manufacturing costs related to the production of inventory prior to U.S. Food and Drug Administration ("FDA") approval are expensed through “research and development,” rather than being capitalized to inventory cost. (vi) Property and Equipment Our property and equipment is stated at historical cost, and is depreciated on a straight-line basis over an estimated useful life that corresponds with its designated asset category. We evaluate the recoverability of “long-lived assets” (which includes property and equipment) whenever events or changes in circumstances in our business indicate that the asset’s carrying amount may not be recoverable through on-going operations. (vii) Goodwill and Intangible Assets Our goodwill represents the excess of our business acquisition cost over the estimated fair value of the net assets acquired in the corresponding transaction. Goodwill has an indefinite accounting life and is therefore not amortized. Instead, goodwill is evaluated for impairment on an annual basis (as of each October 1 st ), unless we identify impairment indicators that would require earlier testing. We evaluate the recoverability of indefinite-lived intangible assets at least annually, or whenever events or changes in our business indicate that an intangible asset’s (whether indefinite or definite-lived) carrying amount may not be recoverable. Such circumstances could include, but are not limited to the following: (a) a significant decrease in the market value of an asset; (b) a significant adverse change in the extent or manner in which an asset is used; or (c) an accumulation of costs significantly in excess of the amount originally expected for the acquisition of an asset. Intangible assets with finite useful lives are amortized over their estimated useful lives on a straight-line basis. We review these assets for potential impairment if/when facts or circumstances suggest that the carrying value of these assets may not be recoverable. (viii) Stock-Based Compensation Stock-based compensation expense for equity awards granted to our employees and members of our board of directors is recognized on a straight-line basis over each award's vesting period. Recognized compensation expense is net of an estimated forfeiture rate, representing the percentage of awards that are expected to be forfeited (by termination of employment or service) prior to vesting. We use the Black-Scholes option pricing model to determine the fair value of stock options (as of the date of grant) which carry service conditions for vesting. When applicable, we use the Monte Carlo valuation model to value equity awards (as of the date of grant) which carry combined market conditions and service conditions for vesting. The calculation of the fair value of stock options on the date of grant, and the recognition of stock-based compensation expense over the appropriate time period, requires uncertain assumptions, including (a) the pre-vesting forfeiture rate of the stock option, (b) the term of the stock option, (c) the stock price volatility over the term of the stock option, and (d) the risk-free interest rate over the term of the stock option. We estimate forfeiture rates based on our employees’ overall forfeiture history, which we believe will be representative of future results. We estimate the expected term of stock options granted based on our employees’ historical exercise patterns, which we believe will be representative of their future behavior. We estimate the volatility of our common stock on the date of grant based on historical volatility of our common stock for a look-back period that corresponds with the expected term. We estimate the risk-free interest rate based upon the U.S. Treasury yields in effect at award grant, for a period equaling the stock options’ expected term. (ix) Foreign Currency Translation We translate the assets and liabilities of our foreign subsidiaries that are stated in their functional currencies (i.e., local operating currencies), to U.S. dollars at the rates of exchange in effect at the reported balance sheet date. Revenues and expenses are translated using the monthly average exchange rates during the reported period. Unrealized gains and losses from the translation of our subsidiaries’ financial statements (that are initially denominated in the corresponding functional currency) are included as a separate component of “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. We record foreign currency transactions, when initially denominated in a currency other than the respective functional currency of our subsidiary, at the prevailing exchange rate on the date of the transaction. Resulting unrealized foreign exchange gains and losses from transactions with third parties are included in “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. All unrealized foreign exchange gains and losses associated with our intercompany loans are included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets, as these loans with our foreign subsidiaries are not expected to be settled in the "foreseeable future." For the period January 1, 2015 through March 31, 2015, unrealized foreign exchange gains and losses associated with our intercompany loans were included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets and in "other income (expense), net" in the Condensed Consolidated Statements of Operations. (x) Basic and Diluted Net (Loss) Income per Share We calculate basic and diluted net (loss) income per share using the weighted average number of common shares outstanding during the periods presented. In periods of a net loss, basic and diluted loss per share are the same. For the diluted earnings per share calculation, we adjust the weighted average number of common shares outstanding to include only dilutive stock options, warrants, and other common stock equivalents outstanding during the period. (xi) Income Taxes Deferred tax assets and liabilities are recorded based on the estimated future tax effects of temporary differences between the tax basis of assets and liabilities and amounts reported in the financial statements, as well as operating losses and tax credit carry forwards using enacted tax rates and laws that are expected to be in effect when the differences are expected to reverse. Realization of deferred tax assets is dependent upon future earnings, the timing and amount of which are uncertain. We have recorded a valuation allowance to reduce our deferred tax assets, because we believe that, based upon a weighting of positive and negative factors, it is more likely than not that these deferred tax assets will not be realized. If/when we determine that our deferred tax assets are realizable, an adjustment to the corresponding valuation allowance would increase our net income in the period that such determination was made. In the event that we are assessed interest and/or penalties from taxing authorities that have not been previously accrued, such amounts would be included in “benefit (provision) for income taxes” within the Condensed Consolidated Statements of Operations in the period the notice was received. (xii) Research and Development Costs Our research and development costs are expensed as incurred, or as certain milestone payments become due, generally triggered by clinical or regulatory events. (xiii) Fair Value Measurements We determine measurement-date fair value based on the proceeds that would be received through the sale of the asset, or that we would pay to settle or transfer the liability, in an orderly transaction between market participants. We utilize valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible. Fair value measurements are based on a three-tier hierarchy that prioritizes the inputs used in descending order to measure fair value. These tiers include the following: Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities that are publicly accessible at the measurement date. Level 2: Observable prices that are based on inputs not quoted on active markets, but that are corroborated by market data. These inputs may include quoted prices for similar assets or liabilities or quoted market prices in markets that are not active to the general public. Level 3: Unobservable inputs are used when little or no market data is available.

Balance Sheet Account Detail

Balance Sheet Account Detail	9 Months Ended
	Sep. 30, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Balance Sheet Account Detail	BALANCE SHEET ACCOUNT DETAIL The composition of selected financial statement captions that comprise the accompanying Condensed Consolidated Balance Sheets are summarized below: (a) Cash and Cash Equivalents and Marketable Securities As of September 30, 2016 and December 31, 2015 , our holdings included within “cash and cash equivalents” and “marketable securities” were at major financial institutions. Our investment policy requires that investments in marketable securities be in only highly-rated instruments, which are primarily U.S. treasury bills or U.S. treasury-backed securities, and limited investments in securities of any single issuer. We maintain cash balances in excess of federally insured limits with reputable financial institutions. To a limited degree, the Federal Deposit Insurance Corporation ("FDIC") and other third parties insure these investments. However, these investments are not insured against the possibility of a complete loss of earnings or principal and are inherently subject to the credit risk related to the continued credit worthiness of the underlying issuer and general credit market risks. We manage such risks on our portfolio by investing in highly liquid, highly rated instruments, and limit investing in long-term maturity instruments. The carrying amount of our equity securities, money market funds, bank certificates of deposits, and mutual funds approximates their fair value (utilizing Level 1 or Level 2 inputs – see Note 2(xiii) ) because of our ability to immediately convert these instruments into cash with minimal expected change in value. The following is a summary of our “cash and cash equivalents” and “marketable securities”: Marketable Securities Cost Gross Gross Estimated Cash and Cash Current Long September 30, 2016 Bank deposits $ 28,134 $ — $ — $ 28,134 $ 28,134 $ — $ — Money market funds 138,472 — — 138,472 138,472 — — Bank certificates of deposits 5,246 — — 5,246 4,999 247 — Total cash and cash equivalents and marketable securities $ 171,852 $ — $ — $ 171,852 $ 171,605 $ 247 $ — December 31, 2015 Bank deposits $ 59,625 $ — $ — $ 59,625 $ 59,625 $ — $ — Money market funds 80,116 — — 80,116 80,116 — — Bank certificates of deposits 245 — — 245 — 245 — Total cash and cash equivalents and marketable securities $ 139,986 $ — $ — $ 139,986 $ 139,741 $ 245 $ — As of September 30, 2016 , none of these securities had been in a continuous unrealized loss position longer than one year. (b) Property and Equipment, Net of Accumulated Depreciation “Property and equipment, net of accumulated depreciation” consist of the following: September 30, 2016 December 31, 2015 Computer hardware and software $ 3,823 $ 3,785 Laboratory equipment 622 608 Office furniture 354 355 Leasehold improvements 2,880 2,872 Property and equipment, at cost 7,679 7,620 (Less): Accumulated depreciation (7,141 ) (6,702 ) Property and equipment, net of accumulated depreciation $ 538 $ 918 Depreciation expense (included within “total operating costs and expenses” in the accompanying Condensed Consolidated Statements of Operations) for the nine months ended September 30, 2016 and 2015 , was $0.4 million and $0.5 million , respectively. In February 2016, the FASB issued ASU 2016-02 , which amends the FASB Accounting Standards Codification and creates Topic 842, “Leases.” The new topic supersedes Topic 840, “Leases,” and requires lease assets and lease liabilities (including for operating leases) to be presented on the balance sheet at its "gross amount" and requires additional disclosures regarding lease arrangements. The guidance is effective for us beginning January 1, 2019, and mandates a "modified retrospective" transition method. We are currently assessing the impact this guidance will have on our consolidated financial statements. We presently do not have any capital lease arrangements, though we have several operating lease agreements that primarily relate to our principal executive office in Henderson, Nevada, and our research and development facility in Irvine, California, in addition to several other administrative office leases. (c) Inventories “Inventories” consist of the following: September 30, 2016 December 31, 2015 Raw materials $ 2,632 $ 1,606 Work-in-process* 10,091 4,228 Finished goods 1,380 1,498 (Less:) Non-current portion of inventories included within "other assets" ** (6,800 ) (3,156 ) Inventories $ 7,303 $ 4,176 * In January 2016, we received $3.4 million of ZEVALIN antibody materials for its future manufacture (representing strategic long-term supply). ** The "non-current" portion of inventories is presented within "other assets" in the accompanying Condensed Consolidated Balance Sheet at September 30, 2016 and December 31, 2015, respectively. This value of $6.8 million at September 30, 2016 represents product that we expect to sell beyond September 30, 2017. (d) Prepaid expenses and other assets “Prepaid expenses and other assets” consist of the following: September 30, 2016 December 31, 2015 Prepaid operating expenses $ 2,702 $ 3,507 Current portion of debt issuance costs* — — Prepaid expenses and other assets $ 2,702 $ 3,507 * Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith the FASB-issued Accounting Standards Update 2015-03, Simplifying the Presentation of Debt Issuance Costs (“ASU 2015-03”). These amounts were $1.7 million and $2.2 million (including current and non-current portions) as of September 30, 2016 and December 31, 2015, respectively. (e) Other receivables “Other receivables” consist of the following: September 30, 2016 December 31, 2015 Income tax receivable $ 1,264 $ 1,301 Insurance receivable 350 7,100 Mundipharma promissory note — 2,215 CASI note - short term* 1,500 — Eagle receivable for services and support costs ( Note 13 ) 1,896 — Research and development expenses - reimbursements due 1,726 1,699 Other miscellaneous receivables 355 257 Other receivables $ 7,091 $ 12,572 * This full balance was prospectively reclassified beginning March 31, 2016 to "other receivables" (presented within current assets on the accompanying Condensed Consolidated Balance Sheets) from "other assets" (presented within non-current assets) due to this note's maturity date of March 17, 2017 (i.e., within 12 months of September 30, 2016 ) - see Note 10 . (f) Intangible Assets and Goodwill “Intangible assets, net of accumulated amortization and impairment charges” consist of the following: September 30, 2016 Historical Accumulated Foreign Impairment Net Amount Full Remaining MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 n/a n/a EVOMELA distribution rights (1) 7,700 (296 ) — — 7,404 156 150 BELEODAQ distribution rights 25,000 (4,219 ) — — 20,781 160 133 MARQIBO distribution rights 26,900 (11,783 ) — — 15,117 81 42 FOLOTYN distribution rights (2) 118,400 (37,767 ) — — 80,633 152 74 ZEVALIN distribution rights – U.S. 41,900 (33,214 ) — — 8,686 123 30 ZEVALIN distribution rights – Ex-U.S. 23,490 (14,159 ) (3,818 ) — 5,513 96 42 FUSILEV distribution rights (3) 16,778 (9,618 ) — (7,160 ) — 56 0 FOLOTYN out-license (4) 27,900 (11,151 ) — (1,023 ) 15,726 110 70 Total intangible assets $ 305,668 $ (122,207 ) $ (3,818 ) $ (8,183 ) $ 171,460 (1) The FDA approval of EVOMELA in March 2016 triggered a $6 million payment due to CyDex Pharmaceuticals, Inc. (a wholly-owned subsidiary of Ligand Pharmaceuticals Incorporated ("Ligand")). This event also resulted in a reclassification of our $7.7 million "EVOMELA IPR&D" to "EVOMELA distribution rights" due to our ability to begin its commercialization with this FDA approval. Amortization commenced on April 1, 2016, in accordance with our capitalization policy for intangible assets. (2) Beginning June 2016, we adjusted the amortization period of our FOLOTYN distribution rights to November 2022 from March 2025, representing the period through which we expect to have patent protection from generic competition (see Note 16(g) ). (3) On February 20, 2015, the U.S. District Court for the District of Nevada found the patent covering FUSILEV to be invalid, which was upheld on appeal. On April 24, 2015, Sandoz began to commercialize a generic version of FUSILEV. This represented a “triggering event” under applicable GAAP in evaluating the value of our FUSILEV distribution rights as of March 31, 2015, resulting in a $7.2 million impairment charge (non-cash) in the first quarter of 2015. We accelerated amortization expense recognition in 2015 for the then remaining net book value of FUSILEV distribution rights. (4) On May 29, 2013, we amended our FOLOTYN collaboration agreement with Mundipharma International Corporation Limited ("Mundipharma"). As a result of the amendment, Europe and Turkey were excluded from Mundipharma’s commercialization territory, and their royalty rates and milestone payments to us were modified. This constituted a change under which we originally valued the FOLOTYN out-license as part of business combination accounting, resulting in an impairment charge (non-cash) of $1.0 million in the second quarter of 2013. December 31, 2015 Historical Accumulated Foreign Impairment Net Amount MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 EVOMELA IPR&D 7,700 — — — 7,700 BELEODAQ distribution rights 25,000 (2,812 ) — — 22,188 MARQIBO distribution rights 26,900 (8,544 ) — — 18,356 FOLOTYN distribution rights 118,400 (29,474 ) — — 88,926 ZEVALIN distribution rights – U.S. 41,900 (30,608 ) — — 11,292 ZEVALIN distribution rights – Ex-U.S. 23,490 (12,632 ) (4,353 ) — 6,505 FUSILEV distribution rights 16,778 (9,618 ) — (7,160 ) — FOLOTYN out-license 27,900 (9,109 ) — (1,023 ) 17,768 Total intangible assets $ 305,668 $ (102,797 ) $ (4,353 ) $ (8,183 ) $ 190,335 Intangible asset amortization expense recognized during the nine months ended September 30, 2016 was $19.1 million , as compared to $27.9 million of amortization and impairment expense recognized in the prior year period (of which $7.2 million relates to the impairment of the FUSILEV distribution rights, and the remaining $20.7 million relates to scheduled amortization expense). Estimated intangible asset amortization expense for the remainder of 2016 and the five succeeding fiscal years and thereafter is as follows: Years Ending December 31, Remainder of 2016 $ 6,909 2017 27,635 2018 27,635 2019 25,029 2020 19,740 2021 18,266 2022 and thereafter 28,646 $ 153,860 “Goodwill” is comprised of the following: September 30, 2016 December 31, 2015 Acquisition of Talon (MARQIBO rights) $ 10,526 $ 10,526 Acquisition of ZEVALIN Ex-U.S. distribution rights 2,525 2,525 Acquisition of Allos (FOLOTYN rights) 5,346 5,346 Foreign currency exchange translation effects (380 ) (437 ) Goodwill $ 18,017 $ 17,960 (g) Other assets “Other assets” are comprised of the following: September 30, 2016 December 31, 2015 Equity securities and secured promissory note - CASI (see Note 10)* $ 9,146 $ 6,689 Supplies and deposits 181 185 2018 Convertible Notes issuance costs (excluding current portion)** — — Executive officer life insurance – cash surrender value 11,845 9,181 Inventories - non-current portion 6,800 3,156 Other miscellaneous assets 43 — Other assets $ 28,015 $ 19,211 * These equity securities were excluded from “marketable securities” (see Note 3(a) ) due to our intent to hold these securities for at least one year beyond September 30, 2016 , as discussed in Note 10 . The “unrealized gain on available-for-sale securities" within the Condensed Consolidated Statements of Comprehensive Loss, totaled $3.0 million , net of income tax, for the nine months ended September 30, 2016 . ** Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith ASU 2015-03. These amounts were $1.7 million and $2.2 million (including current and non-current portions) as of September 30, 2016 and December 31, 2015 , respectively. (h) Accounts payable and other accrued liabilities “Accounts payable and other accrued liabilities” are comprised of the following : September 30, 2016 December 31, 2015 Trade accounts payable and other accrued liabilities $ 27,180 $ 26,684 Accrued rebates 10,130 18,166 Accrued product royalty 5,286 4,908 Allowance for returns 2,237 1,394 Accrued data and distribution fees 2,996 1,830 Accrued GPO administrative fees 342 1,058 Accrued inventory management fee 323 498 Allowance for chargebacks 1,483 2,001 Accounts payable and other accrued liabilities $ 49,977 $ 56,539 Amounts presented within “accounts payable and other accrued liabilities” in the accompanying Condensed Consolidated Balance Sheets specifically for GTN estimates (see Note 2(i) ) are as follows: Rebates and Data and Returns Balance as of December 31, 2014 $ 45,822 $ 8,284 $ 1,135 Add: provisions 75,498 15,928 1,486 (Less): credits or actual allowances (101,153 ) (20,826 ) (1,227 ) Balance as of December 31, 2015 20,167 3,386 1,394 Add: provisions 67,390 10,235 1,558 (Less): credits or actual allowances (75,944 ) (9,960 ) (715 ) Balance as of September 30, 2016 $ 11,613 $ 3,661 $ 2,237 (i) Deferred revenue Deferred revenue (current and non-current) is comprised of the following: September 30, 2016 December 31, 2015 Mundipharma deferred revenue (see Note 11 ) $ 1,700 $ — EVOMELA deferred revenue* 3,094 — FUSILEV deferred revenue** — 6,083 Dr. Reddy's out-license (see Note 16(b)(iii) ) 405 430 Deferred revenue $ 5,199 $ 6,513 *We commercialized EVOMELA beginning in April 2016, and have deferred revenue recognition (see Note 2(i)(a) ) for any product shipped to our distributors, but not ordered and received by end-users as of September 30, 2016 . **In the third quarter of 2015, we deferred revenue recognition related to certain FUSILEV product shipments that did not meet our revenue recognition criteria (see Note 2(i)(a )), aggregating $9.9 million . Specifically, this deferral resulted from our inability to concurrently estimate future rebate values (with requisite precision) offered to our customers in order to compete with generic products. During the fourth quarter of 2015, we recognized $3.8 million for these third quarter shipments, and $6.1 million remained deferred as of December 31, 2015 . In the first quarter of 2016, this $6.1 million of deferred revenue was recognized in full. (j) Other long-term liabilities Other long-term liabilities are comprised of the following: September 30, 2016 December 31, 2015 Accrued executive deferred compensation $ 7,797 $ 6,458 Deferred rent (non-current portion) 193 248 Clinical study holdback costs, non-current 44 — Other tax liabilities 738 738 Other long-term liabilities $ 8,772 $ 7,444

Gross-to-Net Product Sales

Gross-to-Net Product Sales	9 Months Ended
	Sep. 30, 2016
Revenue, Net [Abstract]
Gross-to-Net Product Sales	GROSS-TO-NET PRODUCT SALES The below table presents a GTN product sales reconciliation for the accompanying Condensed Consolidated Statements of Operations: Three Months Ended Nine Months Ended 2016 2015 2016 2015 Gross product sales $ 61,513 $ 44,713 $ 175,963 $ 160,111 Commercial rebates and government chargebacks (26,167 ) (12,515 ) (67,389 ) (44,364 ) Data and distribution fees, GPO fees, and inventory management fees (4,234 ) (3,503 ) (10,235 ) (12,709 ) Prompt pay discounts (300 ) (15 ) (380 ) (16 ) Product returns allowance (540 ) (223 ) (1,558 ) (1,008 ) Net product sales $ 30,272 $ 28,457 $ 96,401 $ 102,014

Net Product Sales by Geographic

Net Product Sales by Geographic Region and Product Line, and Composition of License Fees and Service Revenue	9 Months Ended
	Sep. 30, 2016
Segment Reporting [Abstract]
Net Product Sales by Geographic Region and Product Line, and Composition of License Fees and Service Revenue	NET PRODUCT SALES BY GEOGRAPHIC REGION AND PRODUCT LINE, AND COMPOSITION OF LICENSE FEES AND SERVICE REVENUE The below table presents our net product sales by geography for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 United States $ 29,576 97.7 % $ 26,262 92.3 % $ 93,392 96.9 % $ 96,546 94.6 % International: Europe 696 2.3 % 709 2.5 % 3,009 3.1 % 1,806 1.8 % Asia Pacific* — — % 1,486 5.2 % — — % 3,662 3.6 % Total international 696 2.3 % 2,195 7.7 % 3,009 3.1 % 5,468 5.4 % Net product sales $ 30,272 100.0 % $ 28,457 100.0 % $ 96,401 100.0 % $ 102,014 100.0 % * See Note 11 for discussion of our November 2015 out-license for Asia Pacific territory to Mundipharma. The below table presents our net product sales by product line for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 FUSILEV $ 4,893 16.2 % $ 11,101 39.0 % $ 30,568 31.7 % $ 45,597 44.7 % FOLOTYN 11,315 37.4 % 8,722 30.6 % 35,577 36.9 % 30,261 29.7 % ZEVALIN 2,627 8.7 % 4,762 16.7 % 8,224 8.5 % 13,784 13.5 % MARQIBO 1,925 6.4 % 1,316 4.6 % 4,921 5.1 % 5,290 5.2 % BELEODAQ 3,635 12.0 % 2,556 9.0 % 10,326 10.7 % 7,082 6.9 % EVOMELA 5,877 19.4 % — — % 6,785 7.0 % — — % Net product sales $ 30,272 100.0 % $ 28,457 100.0 % $ 96,401 100.0 % $ 102,014 100.0 % The below table presents our license fee and service revenue by source for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 Out-license to Servier in Canada territory ( Note 12 ) $ — — % $ — — % $ 6,000 40.5 % $ — — % Co-promotion with Eagle ( Note 13 ) 2,406 77.1 % — — % 6,737 45.5 % — — % Out-license to Mundipharma in China and other ex-U.S. territories (Note 11 and 15) 703 22.5 % 158 92.9 % 2,013 13.6 % 493 4.8 % Out-license to CASI in China territory ( Note 10 ) — — % — — % — — % 9,682 94.8 % Other license fees and service revenues 12 0.4 % 12 7.1 % 57 0.4 % 37 0.4 % License fees and service revenues $ 3,121 100.0 % $ 170 100.0 % $ 14,807 100.0 % $ 10,212 100.0 %

Stock-Based Compensation

Stock-Based Compensation	9 Months Ended
	Sep. 30, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Stock-Based Compensation	STOCK-BASED COMPENSATION We classify our stock-based compensation expense (inclusive of our incentive stock plan, employee stock purchase plan, and 401(k) contribution matching program) in the accompanying Condensed Consolidated Statements of Operations, based on the department to which the recipient belongs. Stock-based compensation expense included within “Total operating costs and expenses” for the three and nine months ended September 30, 2016 and 2015 was as follows: Three Months Ended Nine Months Ended 2016 2015 2016 2015 Cost of product sales $ 30 $ 21 $ 84 $ 43 Research and development 470 474 1,461 1,326 Selling, general and administrative 2,650 2,005 8,209 7,121 Total stock-based compensation $ 3,150 $ 2,500 $ 9,754 $ 8,490

Net Loss Per Share

Net Loss Per Share	9 Months Ended
	Sep. 30, 2016
Earnings Per Share [Abstract]
Net Loss Per Share	NET LOSS PER SHARE Net loss per share was computed by dividing net loss by the weighted average number of common shares outstanding for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 Net loss $ (17,455 ) $ (18,724 ) $ (51,070 ) $ (46,632 ) Weighted average shares – basic and diluted 79,303,380 65,855,727 70,437,885 65,457,060 Net loss per share – basic and diluted $ (0.22 ) $ (0.28 ) $ (0.73 ) $ (0.71 ) The below outstanding securities were excluded from the above calculation of net loss per share because their impact would have been anti-dilutive due to net loss per share in the three and nine months ended September 30, 2016 and 2015 , as summarized below: Three Months Ended Nine Months Ended 2016 2015 2016 2015 2018 Convertible Notes 11,401,284 11,401,284 11,401,284 11,401,284 Common stock options 1,603,028 1,591,709 1,498,034 1,507,700 Restricted stock awards 2,609,533 1,457,232 2,609,533 1,457,232 Common stock warrants — 59,853 1,674 45,121 Preferred stock — 40,000 — 40,000 Total 15,613,845 14,550,078 15,510,525 14,451,337

Fair Value Measurements

Fair Value Measurements	9 Months Ended
	Sep. 30, 2016
Fair Value Disclosures [Abstract]
Fair Value Measurements	FAIR VALUE MEASUREMENTS The table below summarizes certain asset and liability fair values that are included within our accompanying Condensed Consolidated Balance Sheets, and their designations among three fair value measurement categories: September 30, 2016 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 5,246 $ — $ 5,246 Money market currency funds — 138,472 — 138,472 Equity securities 9,146 — — 9,146 Mutual funds — 45 — 45 Deferred compensation investments, including life insurance cash surrender value — 11,845 — 11,845 $ 9,146 $ 155,608 $ — $ 164,754 Liabilities: Deferred executive compensation liability $ — $ 7,797 $ — $ 7,797 Drug development liability ( Note 15 ) — — 14,160 14,160 Talon CVR ( Note 9(a) ) — — 1,853 1,853 Corixa Liability — — 62 62 $ — $ 7,797 $ 16,075 $ 23,872 December 31, 2015 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 245 $ — $ 245 Money market currency funds — 80,116 — 80,116 Equity securities 5,189 — — 5,189 Deferred compensation investments, including life insurance cash surrender value — 9,181 — 9,181 $ 5,189 $ 89,542 $ — $ 94,731 Liabilities: Deferred executive compensation liability $ — $ 6,458 $ — $ 6,458 Drug development liability — — 14,686 14,686 Ligand Contingent Consideration — — 5,227 5,227 Talon CVR — — 1,377 1,377 Corixa Liability — — 62 62 $ — $ 6,458 $ 21,352 $ 27,810 We did not have any transfers between Levels 1 and 2 for all periods presented. The following presents a roll forward of our liabilities for which we utilize Level 3 inputs in determining period-end value. These liabilities are included on our Condensed Consolidated Balance Sheets within “acquisition-related contingent obligations” and “drug development liability”. The basis of the various Level 3 valuation inputs are discussed in the Notes to these accompanying Condensed Consolidated Financial Statements. Our carrying amounts of financial instruments such as cash equivalents, accounts receivable, prepaid expenses, accounts payable, and accrued liabilities, excluding acquisition-related contingent obligations, approximate their related fair values due to their short-term nature. Fair Value Measurements of Balance at December 31, 2014 $ 23,127 Deferred drug development costs (1,099 ) Ligand Contingent Consideration fair value adjustment 326 Talon CVR fair value adjustment (1,002 ) Balance at December 31, 2015 21,352 Settlement of Ligand Contingent Consideration liability (see Note 9(b)) (6,000 ) Deferred drug development costs (see Note 15 ) (526 ) Ligand Contingent Consideration fair value adjustment prior to settlement (see Note 9(b) ) 773 Talon CVR fair value adjustment (see Note 9(a) ) 476 Balance at September 30, 2016* $ 16,075 * This amount is comprised of the current and non-current portions of “drug development liability” and of “acquisition-related contingent obligations” on our accompanying Condensed Consolidated Balance Sheets.

Business Combinations and Conti

Business Combinations and Contingent Consideration	9 Months Ended
	Sep. 30, 2016
Business Combinations [Abstract]
Business Combinations and Contingent Consideration	BUSINESS COMBINATIONS AND CONTINGENT CONSIDERATION (a) Acquisition of Talon Therapeutics, Inc. and Related Contingent Consideration Overview of Talon Acquisition On July 17, 2013 , we purchased all of the outstanding shares of common stock of Talon Therapeutics, Inc. (“Talon”). Through the acquisition of Talon, we gained worldwide rights to MARQIBO. The Talon purchase consideration comprised of (i) an aggregate upfront cash amount of $11.3 million , (ii) issuance of 3.0 million shares of our common stock, then equivalent to $26.3 million (based on a closing price of $8.77 per share on July 17, 2013), and (iii) the issuance of contingent value rights (“CVR”) initially valued at $6.5 million . The CVR was valued using a valuation model that probability-weights expected outcomes (ranging from 50% to 100% ) and discounts those amounts to their present value, using an appropriate discount rate (these represent unobservable inputs and are therefore classified as Level 3 inputs – see Note 2 (xiii) ). The CVR has a maximum payout of $195 million if all sales and regulatory approval milestones are achieved, as summarized below: • $5 million upon the achievement of net sales of MARQIBO in excess of $30 million in any calendar year • $10 million upon the achievement of net sales of MARQIBO in excess of $60 million in any calendar year • $25 million upon the achievement of net sales of MARQIBO in excess of $100 million in any calendar year • $50 million upon the achievement of net sales of MARQIBO in excess of $200 million in any calendar year • $100 million upon the achievement of net sales of MARQIBO in excess of $400 million in any calendar year • $5 million upon receipt of marketing authorization from the FDA regarding Menadione Topical Lotion Talon CVR Fair Value as of September 30, 2016 and December 31, 2015 The CVR fair value will continue to be evaluated on a quarterly basis. Current and future changes in its fair value results from the likelihood and timing of milestone achievement and/or the corresponding discount rate applied thereon. Adjustments to CVR fair value are recognized within “change in fair value of contingent consideration related to acquisitions” in the accompanying Condensed Consolidated Statements of Operations. Fair Value December 31, 2015 $ 1,377 Fair value adjustment for the nine months ended September 30, 2016 476 September 30, 2016 $ 1,853 (b) Acquisition of Rights to EVOMELA and Related Contingent Consideration Overview of Acquisition of Rights to EVOMELA In March 2013, we completed the acquisition of exclusive global development and commercialization rights to Captisol-enabled®, propylene glycol-free MELPHALAN (which we branded as “EVOMELA”) for use as a conditioning treatment prior to autologous stem cell transplant for patients with MM. We acquired these rights from CyDex Pharmaceuticals, Inc. a wholly-owned subsidiary of Ligand ("CyDex") for an initial license fee of $3 million , and assumed responsibility for EVOMELA's then-ongoing clinical and regulatory development program. Concurrent with the execution of this in-license agreement, we entered into an exclusive supply agreement with CyDex that requires that all of our purchases of the Captisol product (which is required to formulate EVOMELA) must be from CyDex, while CyDex must supply us with all of our future commercial needs of this raw material. We accounted for this transaction as a business combination, which required that assets acquired and liabilities assumed be recognized on the balance sheet at their fair values as of the transaction date. We are required to pay Ligand additional amounts up to an aggregate $60 million upon the achievement of annual net sales thresholds (exclusive of the $6 million milestone payment triggered in March 2016, as discussed below), however, we continue to not expect to achieve these sales thresholds based on our estimated market size for this product and our projected market share. We also must pay royalties of 20% on our net sales of EVOMELA in all territories. Our EVOMELA royalty obligation and sales-based milestones are jointly treated under GAAP as part of an "executory contract" that is connected with an at-market supply agreement for Captisol (requiring the continuing involvement of CyDex). As a result, this royalty obligation and sales-based milestones are treated as separate transactions apart from consideration for the EVOMELA rights. Our royalty expenses are reported through “cost of goods sold” on our Consolidated Statement of Operations in the period of our recognized revenue for the product sale. Consideration Transferred The acquisition-date fair value of the consideration transferred consisted of the following: Cash consideration $ 3,000 Ligand Contingent Consideration - FDA approval milestone 4,700 Total purchase consideration $ 7,700 Fair Value Estimate of Asset Acquired and Liability Assumed The total purchase consideration is allocated to the acquisition of the net tangible and intangible assets based on their estimated fair values as of the closing date. The allocation of the total purchase price to the net assets acquired is as follows: EVOMELA IPR&D $ 7,700 We estimated the fair value of the in-process research and development using the income approach. The income approach uses valuation techniques to convert future amounts to a single present amount (discounted). Our measurement is based on the value indicated by current market expectations about those future amounts. The fair value estimate took into account our estimates of future incremental earnings that may be achieved upon regulatory approval, promotion, and distribution associated with the rights, and included estimated cash flows of approximately 10 years and a discount rate of approximately 25% . The fair value of the contingent consideration liability assumed was determined using the probability of success and the discounted cash flow method of the income approach (representing unobservable inputs and are therefore represent Level 3 values - see Note 2(xiii) ). In March 2016, the FDA approved EVOMELA, triggering a $6 million milestone payment to Ligand (“Ligand Contingent Consideration”) that was paid in April 2016. "EVOMELA IPR&D" of $7.7 million was reclassified to "EVOMELA distribution rights" within "Intangible assets, net of accumulated amortization and impairment charges" in the accompanying Condensed Consolidated Balance Sheets as of September 30, 2016 (see Note 3(f) ). Amortization related to this intangible asset commenced on April 1, 2016. Ligand Contingent Consideration Fair Value as of September 30, 2016 and December 31, 2015 The fair value of the Ligand Contingent Consideration immediately prior to its payment was the full $6 million payment due upon milestone achievement. Accordingly, in the first quarter of 2016, we recorded a $0.8 million adjustment to the “change in fair value of contingent consideration related to acquisitions” in the accompanying Condensed Consolidated Statements of Operations. Fair Value of December 31, 2015 $ 5,227 Fair value adjustment for the three months ended March 31, 2016 773 Payment to Ligand in April 2016 for FDA approval milestone achievement $ (6,000 ) September 30, 2016 $ — (c) Allos Acquisition We acquired Allos Therapeutics, Inc. (“Allos”) on September 5, 2012, which was accounted for as a business combination. Our total cash consideration for this acquisition was $205.2 million , through which we acquired FOLOTYN distribution rights. We have no contingent consideration obligations as part of this transaction.

Out-License of Marqibo, Zevalin

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	9 Months Ended
	Sep. 30, 2016
Other Commitments [Abstract]
Out-License Of Zevalin, Folotyn, Beleodaq, and Marqibo In Canada Territory To Servier/Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	OUT-LICENSE OF MARQIBO, ZEVALIN, AND EVOMELA IN CHINA TERRITORY TO CASI Overview of CASI Out-License On September 17, 2014, we executed three product out-license agreements with a perpetual term (collectively, the “CASI Out-License”) with CASI Pharmaceuticals, Inc. (“CASI”), a publicly-traded biopharmaceutical company (NASDAQ: CASI) with a primary focus on the China market. Under the CASI Out-License, we granted CASI the exclusive rights to distribute two of our commercialized oncology drugs, ZEVALIN and MARQIBO, and our Phase 3 drug candidate, EVOMELA (“CASI Out-Licensed Products”) in greater China (which includes Taiwan, Hong Kong and Macau). In return, we received CASI equity for the rights related to ZEVALIN and EVOMELA and a secured promissory note for the rights related to MARQIBO. Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities. In February 2016 and July 2016, we acquired an additional 1.7 million and 1.1 million common shares of CASI at par value, respectively, resulting in our total holding of 8.2 million common shares as of September 30, 2016 . CASI will be responsible for the development and commercialization of these three drugs, including the submission of import drug registration applications to regulatory authorities and conducting any confirmatory clinical studies in greater China. We will provide CASI with future commercial supply of the CASI Out-Licensed Products under typical market terms. Proceeds Received in the Third Quarter of 2014 The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $9.1 million as of September 30, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of September 30, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets. In addition, CASI will be responsible for paying any royalties or milestones that we are obligated to pay to our third-party licensors resulting from the achievement of certain milestones and/or sales of CASI Out-Licensed Products, but only to the extent of the greater China portion of such royalties or milestones.

Out-License Of Zevalin In Certa

Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma	9 Months Ended
	Sep. 30, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma	OUT-LICENSE OF MARQIBO, ZEVALIN, AND EVOMELA IN CHINA TERRITORY TO CASI Overview of CASI Out-License On September 17, 2014, we executed three product out-license agreements with a perpetual term (collectively, the “CASI Out-License”) with CASI Pharmaceuticals, Inc. (“CASI”), a publicly-traded biopharmaceutical company (NASDAQ: CASI) with a primary focus on the China market. Under the CASI Out-License, we granted CASI the exclusive rights to distribute two of our commercialized oncology drugs, ZEVALIN and MARQIBO, and our Phase 3 drug candidate, EVOMELA (“CASI Out-Licensed Products”) in greater China (which includes Taiwan, Hong Kong and Macau). In return, we received CASI equity for the rights related to ZEVALIN and EVOMELA and a secured promissory note for the rights related to MARQIBO. Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities. In February 2016 and July 2016, we acquired an additional 1.7 million and 1.1 million common shares of CASI at par value, respectively, resulting in our total holding of 8.2 million common shares as of September 30, 2016 . CASI will be responsible for the development and commercialization of these three drugs, including the submission of import drug registration applications to regulatory authorities and conducting any confirmatory clinical studies in greater China. We will provide CASI with future commercial supply of the CASI Out-Licensed Products under typical market terms. Proceeds Received in the Third Quarter of 2014 The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $9.1 million as of September 30, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of September 30, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets. In addition, CASI will be responsible for paying any royalties or milestones that we are obligated to pay to our third-party licensors resulting from the achievement of certain milestones and/or sales of CASI Out-Licensed Products, but only to the extent of the greater China portion of such royalties or milestones.
Mundipharma [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma	OUT-LICENSE OF ZEVALIN IN CERTAIN EX-U.S. TERRITORIES TO MUNDIPHARMA On November 16, 2015, we entered into an out-license agreement with Mundipharma International Corporation Limited for their commercialization of ZEVALIN in Asia (excluding India and Greater China), Australia, New Zealand, Africa, the Middle East, and Latin America (including the Caribbean). In return, we received $18 million (comprised of $15 million received in December 2015 and $3 million received in January 2016). Of these proceeds, $15 million was recognized within "license fees and service revenue" in the fourth quarter of 2015, and $1.3 million of the $3 million payment was recognized in the same caption for the nine months ended September 30, 2016 . As of September 30, 2016 , $1.7 million remains deferred and is presented within "deferred revenue" (current and non-current) in the accompanying Condensed Consolidated Balance Sheets. We are also eligible to receive an additional $2 million upon Mundipharma's achievement of a specified sales milestone, that if/when achieved, will also be reported within "license fees and service revenue". As Mundipharma has sales of ZEVALIN kits in their territories, the remaining unrecognized portion of this $3 million payment will be reported by us within "license fees and service revenue" on an established per-unit basis. Mundipharma is required to reimburse us for our payment of royalties due to Bayer Pharma AG ("Bayer") from their ZEVALIN sales - see Note 16(b)(ii) . In connection with this out-license, on November 16, 2015, we concurrently sold to Mundipharma K.K., all common stock of Spectrum Pharmaceuticals GK (the legal entity through which we previously sold ZEVALIN in Japan) for $2.2 million (in the form of an unsecured note, which was paid in full in June 2016), representing its net asset value (excluding inventory) as of November 16, 2015.

Out-License Of Zevalin, Folotyn

Out-License Of Zevalin, Folotyn, Beleodaq, And Marqibo In Canada Territory To Servier	9 Months Ended
	Sep. 30, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin, Folotyn, Beleodaq, and Marqibo In Canada Territory To Servier/Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	OUT-LICENSE OF MARQIBO, ZEVALIN, AND EVOMELA IN CHINA TERRITORY TO CASI Overview of CASI Out-License On September 17, 2014, we executed three product out-license agreements with a perpetual term (collectively, the “CASI Out-License”) with CASI Pharmaceuticals, Inc. (“CASI”), a publicly-traded biopharmaceutical company (NASDAQ: CASI) with a primary focus on the China market. Under the CASI Out-License, we granted CASI the exclusive rights to distribute two of our commercialized oncology drugs, ZEVALIN and MARQIBO, and our Phase 3 drug candidate, EVOMELA (“CASI Out-Licensed Products”) in greater China (which includes Taiwan, Hong Kong and Macau). In return, we received CASI equity for the rights related to ZEVALIN and EVOMELA and a secured promissory note for the rights related to MARQIBO. Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities. In February 2016 and July 2016, we acquired an additional 1.7 million and 1.1 million common shares of CASI at par value, respectively, resulting in our total holding of 8.2 million common shares as of September 30, 2016 . CASI will be responsible for the development and commercialization of these three drugs, including the submission of import drug registration applications to regulatory authorities and conducting any confirmatory clinical studies in greater China. We will provide CASI with future commercial supply of the CASI Out-Licensed Products under typical market terms. Proceeds Received in the Third Quarter of 2014 The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $9.1 million as of September 30, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of September 30, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets. In addition, CASI will be responsible for paying any royalties or milestones that we are obligated to pay to our third-party licensors resulting from the achievement of certain milestones and/or sales of CASI Out-Licensed Products, but only to the extent of the greater China portion of such royalties or milestones.
Servier Canada [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin, Folotyn, Beleodaq, and Marqibo In Canada Territory To Servier/Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	OUT-LICENSE OF ZEVALIN, FOLOTYN, BELEODAQ, AND MARQIBO IN CANADA TERRITORY TO SERVIER On January 8, 2016, we entered into a strategic partnership with Servier Canada, Inc. ("Servier") for the out-licenses of ZEVALIN, FOLOTYN, BELEODAQ, and MARQIBO. We received $6 million in upfront payments in the first quarter of 2016 which was recognized within "license fees and service revenue" in the accompanying Condensed Consolidated Statement of Operations for the nine months ended September 30, 2016 . We will also receive development milestone payments if/when achieved, and a high single-digit royalty on their sales of these products.

Co-Promotion Arrangement With E

Co-Promotion Arrangement With Eagle Pharmaceuticals	9 Months Ended
	Sep. 30, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Co-Promotion Arrangement With Eagle Pharmaceuticals	CO-PROMOTION ARRANGEMENT WITH EAGLE PHARMACEUTICALS On November 4, 2015, we executed an agreement with Eagle Pharmaceuticals, Inc. ("Eagle") whereby designated members of our sales force will concurrently market up to six of Eagle's pharmaceutical products along with our products, in return for fixed monthly payments over the initial 18 month contract term through June 30, 2017, aggregating $12.8 million (the "Eagle Agreement"). We are also eligible to receive milestone payments of up to $5 million for sales made in 2016 that exceed certain thresholds, and up to $4 million for sales made in the first half 2017 that exceed certain thresholds. In addition, for performance above such sales levels in 2016, and in the first half of 2017, we are eligible to receive variable-based payments in the high single-digits on incremental sales of Eagle's products above these established threshold levels. The fixed payments received by us, as well as reimbursable costs for certain marketing activities that we coordinate with third parties on Eagle's behalf, are recognized within "license fees and service revenue" on our accompanying Consolidated Statement of Operations. This amount was $2.4 million and $6.7 million for the three and nine months ended September 30, 2016 , respectively. Any variable payments due to us will be recognized in the period earned and reported within the same revenue caption. An allocation of our sales personnel costs that are dedicated to Eagle sales activities are reported within "cost of service revenue" on our accompanying Consolidated Statement of Operations, as are reimbursable costs for Eagle marketing activities. These were an aggregate $2.2 million and $5.7 million for the three and nine months ended September 30, 2016 , respectively. Eagle may extend the initial term of this agreement by six months to December 31, 2017 at its sole election. Any extensions after December 31, 2017 require mutual consent and will be for six months per extension. The Eagle Agreement may be terminated by either party for uncured material breaches and certain other events following a change of control or insolvency of either party, and solely by Eagle for convenience with 60 days written notice, subject to an established termination fee, as calculated within the Eagle Agreement.

Convertible Senior Notes

Convertible Senior Notes	9 Months Ended
	Sep. 30, 2016
Debt Disclosure [Abstract]
Convertible Senior Notes	CONVERTIBLE SENIOR NOTES Overview On December 17, 2013, we entered into an agreement for the sale of $120 million aggregate principal amount of 2.75% Convertible Senior Notes due December 2018 (the “2018 Convertible Notes”). The 2018 Convertible Notes are convertible into shares of our common stock at a conversion rate of 95 shares per $1,000 principal amount of the 2018 Convertible Notes, equating to 11.4 million common shares if fully converted. The in-the-money conversion price is equivalent to $10.53 per common share. The conversion rate and conversion price is subject to adjustment under certain limited circumstances. The 2018 Convertible Notes bear interest at a rate of 2.75% per year, payable semiannually in arrears on June 15 and December 15 of each year. The 2018 Convertible Notes will mature and become payable on December 15, 2018, subject to earlier conversion into common stock at the holders’ option. The sale of the 2018 Convertible Notes closed on December 23, 2013 and our net proceeds were $115.4 million , after deducting banker and professional fees of $4.6 million . We used a portion of these net proceeds to simultaneously enter into “bought call” and “sold warrant” transactions with Royal Bank of Canada (collectively, the “Note Hedge”). We recorded the Note Hedge on a net cost basis of $13.1 million , as a reduction to “additional paid-in capital” in our accompanying Condensed Consolidated Balance Sheets. Under applicable GAAP, the Note Hedge transaction is not expected to be marked-to-market through earnings or comprehensive income in future reported periods. Conversion Hedge We entered into Note Hedge transactions to reduce the potential dilution to our stockholders and/or offset any cash payments that we are required to make in excess of the principal amount, upon conversion of the 2018 Convertible Notes (in the event that the market price of our common stock is greater than the conversion price). The strike price of the “bought call” is equal to the conversion price and conversion rate of the 2018 Convertible Notes, matching the 11.4 million common shares the 2018 Convertible Notes may be converted into. The strike price of our “sold warrant” is $14.03 per share of our common stock, and is also for 11.4 million common shares. Conversion Events On and after June 15, 2018, and until the close of business on the second scheduled trading day immediately preceding the maturity date, holders may convert all or a portion of their 2018 Convertible Notes. Prior to June 15, 2018, holders may convert all or a portion of their 2018 Convertible Notes only under any of the following circumstances: (1) during any fiscal quarter (and only during such fiscal quarter), if, for at least 20 trading days (whether or not consecutive) during the 30 consecutive trading day period ending on the last trading day of the immediately preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than or equal to 130% of the Notes' conversion price on such trading day; (2) during the five consecutive business day period immediately following any five consecutive trading day period in which, for each trading day of that measurement period, the trading price per $1,000 principal amount of 2018 Convertible Notes for such trading day was less than 98% of the product of (i) the last reported sale price of our common stock on such trading day and (ii) the Notes' conversion rate on such trading day; (3) upon the occurrence of certain corporate transactions; and (4) at any time prior to our stockholders’ approval to settle the 2018 Convertible Notes in our common shares and/or cash. As of September 30, 2016 , the 2018 Convertible Notes are not eligible to be converted into our common stock, as none of the above elements (1) through (4) were met. Our stockholders’ approval of "flexible settlement" occurred at our Annual Meeting of Stockholders on June 29, 2015. As a result, we may (at our election) settle any future conversions of the 2018 Convertible Notes by paying or delivering cash, shares of our common stock, or a combination of cash and shares of our common stock. However, if the holders of the Convertible Notes do not elect any conversion into our common stock, our December 2018 obligation to repay the principal amount of $120 million in cash, plus any accrued and unpaid interest, is unchanged. Carrying Value and Fair Value The carrying value of the 2018 Convertible Notes as of September 30, 2016 is summarized as follows: Principal amount $ 120,000 (Less): Unamortized debt discount (amortized through December 2018) (14,206 ) (Less): Debt issuance costs (see Note 3(d) ) (1,650 ) September 30, 2016 carrying value $ 104,144 As of September 30, 2016 and December 31, 2015 , the estimated aggregate fair value of the 2018 Notes is $106.5 million and $105.1 million , respectively. These fair value estimates are less than the principal amount of $120 million , largely since the conversion feature of the 2018 Notes was, and remains, out-of-the-money. These estimated fair values represent a Level 2 measurement (see Note 2(xiii) ), based upon the 2018 Convertible Notes' quoted bid price at each date in a thinly-traded market. Components of Interest Expense on 2018 Convertible Notes The following table sets forth the components of interest expense recognized in the accompanying Condensed Consolidated Statements of Operations for the 2018 Convertible Notes for the nine months ended September 30, 2016 : Contractual coupon interest expense $ 2,475 Amortization of debt issuance costs 521 Accretion of debt discount 4,246 Total $ 7,242 Effective interest rate 8.66 %

Mundipharma Agreement And Drug

Mundipharma Agreement And Drug Development Liability	9 Months Ended
	Sep. 30, 2016
Business Combinations [Abstract]
Mundipharma Agreement And Drug Development Liability	MUNDIPHARMA AGREEMENT AND DRUG DEVELOPMENT LIABILITY As the result of our acquisition of Allos Therapeutics, Inc. on September 5, 2012 (through which we obtained distribution rights for FOLOTYN), we assumed its obligations under an active strategic collaboration agreement with a third-party, Mundipharma (the “Mundipharma Collaboration Agreement”). Under the Mundipharma Collaboration Agreement, we retained full commercialization rights for FOLOTYN in the U.S. and Canada, with Mundipharma having exclusive rights to commercialize FOLOTYN in all other countries in the world (the “Mundipharma Territories”). On May 29, 2013, the Mundipharma Collaboration Agreement was amended and restated (the “Amended Mundipharma Collaboration Agreement”), in order to modify: (i) the scope of the licensed territory, (ii) milestone payments, (iii) royalty rates, and (iv) drug development obligations. In connection with the Amended Mundipharma Collaboration Agreement, we received a one-time $7 million payment from Mundipharma for certain research and development activities to be performed by us. As a result of the Amended Mundipharma Collaboration Agreement, (a) Europe and Turkey were excluded from Mundipharma’s commercialization territory, (b) we may receive regulatory milestone payments of up to $16 million , and commercial progress and sales-dependent milestone payments of up to $107 million , (c) we will receive tiered double-digit royalties based on net sales of FOLOTYN within Mundipharma’s licensed territories, and (d) we and Mundipharma will bear our own FOLOTYN development costs. On May 29, 2015 and effective as of May 1, 2015, we entered into an amendment to the Amended Mundipharma Collaboration Agreement (the “Amendment”). Pursuant to the Amendment, among other things, the parties revised the conditions to our exercise of the option to gain commercialization rights in Switzerland from Mundipharma, and also revised tiered double-digit royalties payable by Mundipharma on net sales in Switzerland. The fair value of this liability is included in the current and long-term portions of “drug development liability” within the accompanying Condensed Consolidated Balance Sheets, and it includes our assumptions about personnel needed to perform these research and development activities, third party costs for projected clinical trial enrollment, and patient treatment-related follow up through approximately 2031. The fair value of our “drug development liability” within our accompanying Condensed Consolidated Balance Sheets was estimated using the discounted income approach model. The unobservable inputs (i.e., Level 3 inputs - see Note 2(xiii) ) in this valuation model that have the most significant effect on these liabilities include (i) estimates of research and development personnel costs needed to perform the research and development services, (ii) estimates of expected cash outflows to third parties for services and supplies during the expected period of performance through 2031, and (iii) an appropriate discount rate for these expenditures. These inputs are reviewed by management on a quarterly basis for continued applicability. We assess this liability at each reporting date and record its adjustment through “research and development” expense in our accompanying Condensed Consolidated Statements of Operations. Drug Drug Total Drug Balance at December 31, 2015 $ 259 $ 14,427 $ 14,686 Transfer from long-term to current in 2016 423 (423 ) — (Less): Expenses incurred in 2016 (526 ) — (526 ) Balance at September 30, 2016 $ 156 $ 14,004 $ 14,160

Commitments and Contingencies

Commitments and Contingencies	9 Months Ended
	Sep. 30, 2016
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	COMMITMENTS AND CONTINGENCIES (a) Facility Leases We lease our principal executive office in Henderson, Nevada under a non-cancelable operating lease expiring April 30, 2019 . We also lease our research and development facility in Irvine, California under a non-cancelable operating lease expiring May 31, 2019 , in addition to several other administrative office leases. Each lease agreement contains scheduled rent increases which are accounted for on a straight-line basis. (b) In/Out Licensing Agreements and Co-Development Arrangements The in-license agreements for our commercialized and development-stage drug products provide us with territory-specific rights to their manufacture and distribution (including sub-licensing, or out-licensing, rights). We are generally responsible for all related clinical development costs, patent filings and maintenance costs, marketing costs, and liability insurance costs. We are also obligated to make specified milestone payments to our licensors upon the achievement of certain regulatory and sales milestones, and to pay royalties based on our net sales of all in-licensed products. We also enter into out-license agreements for territory-specific rights to our drug products which include one or more of: upfront license fees, royalties from our licensees’ sales, and/or milestone payments from our licensees’ sales or regulatory achievements. For certain development-stage drug products, we may enter into cost/effort-sharing arrangements with our licensees and licensors. Our most significant of these agreements, and the key financial terms and our accounting for each, are summarized below: (i) ZEVALIN U.S.: In-Licensing and Development in the U.S. In December 2008, we acquired rights to commercialize and develop ZEVALIN in the U.S. as the result of a transaction with Cell Therapeutics, Inc. (“CTI”) through our wholly-owned subsidiary, RIT Oncology LLC (“RIT”). We assumed certain agreements with various third parties related to ZEVALIN intellectual property for its manufacture, use, and sale in the U.S. In accordance with the terms of assumed contracts, we are required to meet specified payment obligations, including a milestone payment to Corixa Corporation of $5 million based on ZEVALIN sales in the U.S. (the “Corixa Liability”). This milestone has not yet been met, and $0.1 million for this potential milestone achievement is included within “acquisition-related contingent obligations” in our accompanying Condensed Consolidated Balance Sheet as of September 30, 2016 and December 31, 2015 , respectively. Our U.S. net sales-based royalties are in the low to mid-single digits to Genentech, Inc. and mid-teens to Biogen. (ii) ZEVALIN Ex-U.S.: In-License and Asset Purchase Agreement with Bayer Pharma In April 2012, through our wholly-owned subsidiary, Spectrum Pharmaceuticals Cayman, L.P., we completed the acquisition of licensing rights to market ZEVALIN outside of the U.S. from Bayer. ZEVALIN is currently approved in approximately 40 countries outside the U.S. for the treatment of B-cell non-Hodgkin lymphoma, including countries in Europe, Latin America, and Asia. In consideration for the rights granted under the agreement, concurrent with the closing, we paid Bayer a one-time fee of €19 million . Our ex-U.S. net sales-based royalty to Bayer ranges between the single digits to mid-teens. We amended the agreement in February 2016. Under the amendment, in the event that we elect to sublicense the rights in certain countries, our applicable royalty on net sales to Bayer would be adjusted to a tiered rate from the single-digits to 20% in such countries. Unless earlier terminated, the term of the agreement, as amended, continues until the expiration of the last-to-expire patent covering the sale of a licensed product in the relevant country, or 15 years from the date of first commercial sale of the licensed product in such country, whichever is longer. (iii) ZEVALIN Ex-U.S.: Out-License Agreement with Dr. Reddy’s Effective June 27, 2014, we executed an exclusive License Agreement with Dr. Reddy’s Laboratories Ltd. (“Dr. Reddy’s”), for the distribution rights of ZEVALIN within India. The agreement term is 15 years from the receipt of pending approval of ZEVALIN from the Drug Controller General of India. On December 17, 2014, upon the execution of a supply agreement, an upfront and non-refundable payment of $0.5 million was triggered and was paid to us in February 2015. The recognition of this upfront payment is reported on a straight-line basis within “license fee and service revenue” on the Condensed Consolidated Statements of Operations over a 10 year term through December 2024. Additionally, sales and regulatory milestones (aggregating $3 million ) will become payable to us when achieved by Dr. Reddy’s, as well as a 20% royalty on net sales of ZEVALIN in India. (iv) ZEVALIN Ex-U.S.: Out-License Agreement with Mundipharma On November 16, 2015, we entered into an out-license agreement with Mundipharma for their commercialization of ZEVALIN in Asia (excluding India and Greater China), Australia, New Zealand, Africa, the Middle East, and Latin America (including the Caribbean). In return, we received $18 million (comprised of $15 million received in December 2015 and $3 million received in January 2016). Of these proceeds, $15 million was recognized within "license fees and service revenue" in the fourth quarter of 2015, and $1.3 million of the $3 million payment was recognized in the same caption for the nine months ended September 30, 2016 . As of September 30, 2016 , $1.7 million remains deferred and is presented within "deferred revenue" (current and non-current) in the accompanying Condensed Consolidated Balance Sheets. As Mundipharma has sales of ZEVALIN kits in their territories, the remaining unrecognized portion of this $1.7 million value will be recognized by us in subsequent periods within "license fees and service revenue" on an established per-unit basis. Mundipharma is required to reimburse us for our payment of royalties due to Bayer from their net sales of ZEVALIN (see Note 16(b)(ii)). We are also eligible to receive an additional $2 million upon Mundipharma's achievement of a specified sales milestone, that if/when achieved, will also be reported within "license fees and service revenue". (v) FUSILEV: In-License Agreement with Merck & Cie AG In May 2006, we amended and restated a license agreement with Merck & Cie AG (“Merck”), which we assumed in connection with our March 2006 acquisition of the assets of Targent, Inc. Pursuant to the license agreement with Merck, we obtained the exclusive license to use regulatory filings related to FUSILEV and a non-exclusive license under certain patents and know-how to develop, manufacture, use, and sell FUSILEV in the field of oncology in North America in return for a royalty percentage (in the mid-single digits) of net sales. Merck is eligible to receive a $0.2 million payment from us upon the achievement of a FDA approval of an oral form of FUSILEV. This milestone has not yet been met, and no amounts have been accrued in our accompanying Condensed Consolidated Balance Sheets for its potential achievement. (vi) FOLOTYN: In-License Agreement with Sloan-Kettering Institute, SRI International and Southern Research Institute In December 2002, Allos entered into the FOLOTYN License Agreement with Sloan-Kettering Institute for Cancer Research, SRI International, and Southern Research Institute. As a result of Allos becoming our wholly owned subsidiary in September 2012, we are bound by the FOLOTYN License Agreement under which we obtained exclusive worldwide rights to a portfolio of patents and patent applications related to FOLOTYN and its uses. Under the terms of the FOLOTYN License Agreement, we are required to fund all development programs and will have sole responsibility for all commercialization activities. In addition, we pay graduated royalties to our licensors based on our (including sub licensees) worldwide annual net sales of FOLOTYN. Royalties are 8% of annual worldwide net sales up to $150 million ; 9% of annual worldwide net sales of $150 million through $300 million ; and 11% of annual worldwide net sales in excess of $300 million . (vii) EVOMELA: In-License Agreement with Cydex Pharmaceuticals, Inc. In March 2013, we completed the acquisition of exclusive global development and commercialization rights to EVOMELA from Ligand (see Note 9(b) ) and assumed responsibility for EVOMELA's ongoing clinical and regulatory development program. We filed a New Drug Application ("NDA") with the FDA in December 2015 for its use as a conditioning treatment prior to autologous stem cell transplant for patients with MM. On March 10, 2016, the FDA communicated its approval of the NDA for EVOMELA. In connection with this FDA approval, we made a $6 million milestone payment to Ligand on April 13, 2016. We are required to pay Ligand additional amounts of up to $60 million (exclusive of the $6 million milestone paid in April 2016), upon the achievement of specified net sales thresholds. We will also pay royalties of 20% on our net sales of licensed products in all territories. (viii) MARQIBO: Acquisition of Talon Therapeutics, Inc. and Related Contingent Consideration Agreement In July 2013, we completed the acquisition of Talon, through which we obtained exclusive global development and commercialization rights to MARQIBO (see Note 9(a) ). As part of this acquisition, we issued the former Talon stockholders a CVR that we have valued and presented on our accompanying Condensed Consolidated Balance Sheets as a $1.9 million and $1.4 million liability within “acquisition-related contingent obligations” as of September 30, 2016 and December 31, 2015 , respectively. The CVR has a maximum payout value of $195 million if all sales and regulatory approval milestones are achieved. (ix) QAPZOLA: License Agreements with Allergan, Inc. and NDDO Research Foundation In October 2008, we entered into an exclusive development and commercialization collaboration agreement with Allergan for QAPZOLA. Pursuant to the terms of the agreement, Allergan paid us an up-front non-refundable fee of $41.5 million at closing (which we have amortized through revenue within “license fees and service revenue” in full as of December 31, 2013). In October 2008, pursuant to a letter agreement with NDDO Research Foundation (“NDDO”), we agreed to pay NDDO the following in relation to QAPZOLA milestones: (a) upon FDA acceptance of the NDA, the issuance of 25,000 of our common shares (which occurred in March 2016, and the $0.1 million value of these shares is included in "research and development" expense for the nine months ended September 30, 2016 ) and (b) upon FDA approval of the drug (its target decision date is set for December 11, 2016), a one-time payment of $0.3 million . In January 2013, we entered into a second amendment to the license, development, supply and distribution agreement with Allergan to amend the agreement and reacquire the rights originally licensed to Allergan in the U.S., Europe, and other territories in exchange for a tiered single-digit royalty on certain products containing QAPZOLA, and relieved Allergan of its development and commercialization obligations. (x) QAPZOLA: Collaboration Agreement with Nippon Kayaku Co. LTD. In November 2009, we entered into a collaboration agreement with Nippon Kayaku Co., LTD. (“Nippon Kayaku”) for the development and commercialization of QAPZOLA in Asia, except North and South Korea (the “Nippon Kayaku Territory”). In addition, Nippon Kayaku received exclusive rights to QAPZOLA for the treatment of non-muscle invasive bladder cancer in Asia (other than North and South Korea), including Japan and China. Nippon Kayaku will conduct QAPZOLA clinical trials in the Nippon Kayaku Territory pursuant to a development plan. Further, Nippon Kayaku will be responsible for all expenses relating to the development and commercialization of QAPZOLA in the Nippon Kayaku Territory. Under the terms of this agreement, Nippon Kayaku paid us an upfront fee of $15 million (which we have amortized through revenue within “license fees and service revenue” in full as of December 31, 2013). Nippon Kayaku is also obligated to make additional payments to us based on the achievement of certain development, regulatory and commercialization milestones. Under the terms of the agreement, we are entitled to payment of $10 million and $126 million upon achievement of certain regulatory and commercialization milestones, respectively. Also, Nippon Kayaku has agreed to pay us royalties based on a percentage of net sales of the subject products in the defined territory in the mid-teen digits. (xi) BELEODAQ: In-License and Collaboration Agreement with Onxeo In February 2010, we entered into a licensing and collaboration agreement with TopoTarget A/S (now Onxeo DK) (“Onxeo”), as amended in October 2013, for the development and commercialization of BELEODAQ. The agreement provides that we have the exclusive right to manufacture, develop, and commercialize BELEODAQ in North America and India, with an option for China. Pursuant to the terms of this agreement, we paid Onxeo an upfront fee of $30 million in 2010. Under continuing terms, all development, including studies, will be conducted under a joint development plan, which we will fund 70% of such costs, and Onxeo will fund 30% . We have final decision-making authority for all developmental activities in North America and India (and China upon exercise of its option). Onxeo has final decision-making authority for all developmental activities in all other jurisdictions. In February 2014, upon FDA acceptance of our new drug application, we issued one million shares of our common stock, and made a $10 million milestone payment to Onxeo. The aggregate payout value of this first milestone at achievement was $17.8 million , and was recognized within “research and development” in the first quarter of 2014. In July 2014, we received approval from the FDA for BELEODAQ’s use for injection and treatment of relapsed or refractory peripheral T-cell lymphoma. As a result, we paid a second milestone payment to Onxeo of $25 million in November 2014, which we capitalized as an amortizable intangible asset. Other potential milestone payments due upon BELEODAQ regulatory achievements and sales thresholds (aggregating up to $278 million ) are not included within “total liabilities” in our accompanying Condensed Consolidated Balance Sheets. We will pay Onxeo future royalties in the mid-teen digits based on net sales of BELEODAQ. The agreement will continue until the expiration of the last royalty payment period in the last country in the defined territory with certain provisions surviving, unless earlier terminated in accordance with its terms. (xii) ROLONTIS: Co-Development and Commercialization Agreement with Hanmi Pharmaceutical Company In October 2014, we exercised our option under a License Option and Research Collaboration Agreement dated January 2012 (as amended) with Hanmi Pharmaceutical Company, Ltd. (“Hanmi”), for ROLONTIS, formerly known as “LAPS-GCSF" or "SPI-2012”, a drug based on Hanmi’s proprietary LAPSCOVERY™ technology for the treatment of chemotherapy induced neutropenia. Under the terms of this agreement, as amended, we have primary financial responsibility for the ROLONTIS development plan. We have worldwide rights for ROLONTIS, except for Korea, China, and Japan. In the first quarter of 2016, we accrued a milestone payment of $1.9 million (as quantified under GAAP) related to Hanmi, based on initial patient dosing in January 2016 as part of our Phase III study. On April 26, 2016, we (i) issued 318,750 of our common shares to Hanmi and (ii) remitted a $0.4 million payment to the Internal Revenue Service (IRS) on their behalf for related tax obligations. This aggregate $2.7 million value was recognized within "research and development" expense in accompanying Condensed Consolidated Statement of Operations for the nine months ended September 30, 2016 . We will also be responsible for milestones relating to regulatory approvals and sales thresholds (aggregating $238 million ), which are not included within "total liabilities" in our Condensed Consolidated Balance Sheets. We will pay Hanmi royalties in the mid-teen digits on our net sales of ROLONTIS. (xiii) POZIOTINIB: In-License Agreement with Hanmi In February 2015, we executed an in-license agreement with Hanmi Pharmaceutical Co., Ltd for POZIOTINIB, a pan-HER inhibitor in Phase 2 clinical trials, requiring our upfront payment for these rights. This drug has shown single agent activity in the treatment of various cancer types during Phase I studies, including breast, gastric, colorectal, and lung cancers. Under the terms of this agreement, we received the exclusive rights to commercialize POZIOTINIB globally, excluding Korea and China. Hanmi, and its development partners, will bear full responsibility for completion of on-going Phase 2 trials in Korea. We will bear full financial responsibility for all other clinical studies. We will pay Hanmi future regulatory and sales-dependent milestones payments (aggregating $358 million ), which are not included within “total liabilities” in our accompanying Condensed Consolidated Balance Sheets. We will pay Hanmi royalties in the low to mid-teen digits on our net sales of POZIOTINIB. (xiv) ZEVALIN, FOLOTYN, BELEODAQ, and MARQIBO: Out-License Agreement with Servier In January 2016, we entered into a strategic partnership with Servier for the out-licenses of ZEVALIN, FOLOTYN, BELEODAQ, and MARQIBO. We received an aggregate $6 million in upfront payments in the first quarter of 2016, which is recognized within "license fees and service revenue" in our accompanying Condensed Consolidated Statement of Operations for the nine months ended September 30, 2016 . We will also receive development milestone payments if/when achieved, and a high single-digit royalty on their sales of these products. (c) Service Agreements In connection with the research and development of our drug products, we have entered into contracts with numerous third party service providers, such as radio-pharmacies, distributors, clinical trial centers, clinical research organizations, data monitoring centers, and with drug formulation, development and testing laboratories. The financial terms of these agreements are varied and generally obligate us to pay in stages, depending on achievement of certain events specified in the agreements, such as contract execution, reservation of service or production capacity, actual performance of service, or the successful accrual and dosing of patients. At each period end, we accrue for all services received, with such accruals based on factors such as estimates of work performed, patient enrollment, completion of patient studies and other events. Should we decide to discontinue and/or slow-down the work on any project, the associated costs for those projects would be limited to the extent of the work completed. Generally, we are able to terminate these contracts due to the discontinuance of the related project(s) and thus avoid paying for the services that have not yet been rendered. (d) Supply Agreements We have entered into certain supply agreements, or have issued purchase orders, which require us to make minimum purchases from vendors for the manufacture of our products. These commitments do not exceed our planned commercial requirements, and the contracted prices do not exceed their fair market value. (e) Employment Agreement We have entered into an employment agreement with our Chief Executive Officer under which cash compensation and benefits would become payable in the event of termination by us for any reason other than cause, his resignation for good reason, or upon a change in control of our Company. (f) Deferred Compensation Plan The Spectrum Pharmaceuticals, Inc. Deferred Compensation Plan (the “DC Plan”) is administered by the Compensation Committee of our Board of Directors and is intended to comply with the requirements of Section 409A of the Internal Revenue Code of 1986, as amended. The DC Plan is maintained to provide deferred compensation benefits for a select group of our employees (the “DC Participants”). Under the DC Plan, we provide the DC Participants with the opportunity to make annual elections to defer up to a specified amount or percentage of their eligible cash compensation, and we have the option to make discretionary contributions. At September 30, 2016 and December 31, 2015 , the aggregate DC Plan deferrals by employees and our discretionary contributions totaled $7.8 million and $6.5 million , respectively, and are included within “other long-term liabilities” in the accompanying Condensed Consolidated Balance Sheets. (g) Litigation We are involved from time-to-time with various legal matters arising in the ordinary course of business. These claims and legal proceedings are of a nature we believe are normal and incidental to a pharmaceutical business, and may include product liability, intellectual property, employment matters, and other general claims. We make provisions for liabilities when it is both probable that a liability has been incurred and the amount of the loss can be reasonably estimated. Such provisions are assessed at least quarterly and adjusted to reflect the impact of any settlement negotiations, judicial and administrative rulings, advice of legal counsel, and other information and events pertaining to a particular case. Litigation is inherently unpredictable. Although the ultimate resolution of these various matters cannot be determined at this time, we do not believe that such matters, individually or in the aggregate, will have a material adverse effect on our consolidated results of operations, cash flows, or financial condition. FOLOTYN ANDA Litigation On June 19, 2014, we filed a lawsuit against five parties resulting from Paragraph IV certifications in connection with four separate ANDAs to manufacture a generic version of FOLOTYN: (1)Teva Pharmaceuticals USA, Inc. (“Teva”), (2) Sandoz Inc. (“Sandoz”), (3) Fresenius Kabi USA, LLC (“Fresenius”), (4) Dr. Reddy’s Laboratories, Ltd., and (5) Dr. Reddy’s Laboratories, Inc. (collectively “Dr. Reddy’s”). We reached confidential settlement agreements with each defendant. As a result of the settlements, Teva, Dr. Reddy’s, Sandoz and Fresenius will be permitted to market a generic version of FOLOTYN in the United States commencing on November 15, 2022 or earlier under certain circumstances. The litigation has been dismissed as of August 17, 2016. All costs pertaining to this matter (incurred and accrued) have been recognized within "selling, general and administrative" expenses on the accompanying Condensed Consolidated Statement of Operations for all periods presented. Stockholder Litigation Timothy Fik v. Rajesh C. Shrotriya, et al. (Filed April 11, 2013 in United States District Court, District of Nevada; Case Number 2:2013-cv-00624-JCM-CWH); Christopher J. Watkins v. Rajesh C. Shrotriya, et al. (Filed April 22, 2013 in United States District Court, District of Nevada; Case Number 2:2013-cv-00684-JCM-VCF); and Stefan Muenchhagen v. Rajesh C. Shrotriya, et al. (Filed May 28, 2013; Case Number 2:2013-cv-00942-APG-PAL). These consolidated federal derivative actions are brought by the respective purported stockholders on behalf of nominal plaintiff Spectrum against certain current and former directors and officers. The complaints generally allege breaches of fiduciary duty based on conduct relating to a March 12, 2013 press release concerning sales of Spectrum's product FUSILEV. The complaints seek compensatory damages, corporate governance reforms, restitution and disgorgement of defendants’ alleged profits, and costs and fees. These actions are stayed. Settlement discussions are ongoing, and accordingly, no agreement has yet been reached to resolve these derivative complaints. If a settlement were reached, we believe it would be reimbursable by our insurance carrier, and would be subject to preliminary and final court approval. Hardik Kakadia v. Rajesh C. Shrotriya, et al. (Filed April 23, 2013 in the Eighth Judicial District Court of the State of Nevada in and for Clark County; Case Number A-13-680643-B); and Joel Besner v. Rajesh C. Shrotriya, et al. (Filed May 31, 2013; Case Number A-13-682668-C) (collectively the “State Derivative Actions”). These consolidated state derivative actions are brought by the respective purported stockholders on behalf of nominal plaintiff Spectrum against certain current and former directors and officers and are substantially similar to the consolidated federal derivative actions. These actions are stayed. Settlement discussions are ongoing, and accordingly, no agreement has yet been reached to resolve these derivative complaints. If a settlement were reached, we believe it would be reimbursable by our insurance carrier, and would be subject to preliminary and final court approval. Olutayo Ayeni v. Spectrum Pharmaceuticals, Inc., et al. (Filed September 21, 2016 in the United States District Court, Central District of California; Case No. 2:16-cv-07074) and Glen Hartsock v. Spectrum Pharmaceuticals, Inc., et al. (Filed September 28, 2016 in the United States District Court, District Court of Nevada Case; No. 2:16-cv-02279-RFB-GWF). These putative class action lawsuits allege that we and certain of our executive officers made false or misleading statements and failed to disclose material facts about our business and the prospects of approval for our new drug application to the FDA for QAPZOLA in violation of Section 10(b) (and Rule 10b-5 promulgated thereunder) and 20(a) of the Exchange Act. The plaintiffs seek damages, interest, costs, attorneys’ fees, and other unspecified equitable relief. We believe that these claims are without merit, and intend to vigorously defend against these claims.

Income Taxes

Income Taxes	9 Months Ended
	Sep. 30, 2016
Income Tax Disclosure [Abstract]
Income Taxes	INCOME TAXES We apply an estimated annual effective tax rate (“ETR”) approach for calculating a tax provision for interim periods, as required under GAAP. We recorded a benefit for income taxes of $0.6 million and a provision for income taxes of $37 thousand for the nine months ended September 30, 2016 and 2015 , respectively. Our ETR differs from the U.S. federal statutory tax rate of 35% primarily as a result of nondeductible expenses, state income taxes, foreign income taxes, and the impact of a valuation allowance on our deferred tax assets. Our provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. A valuation allowance is established when it is more likely than not the future realization of all or some of the deferred tax assets will not be achieved. The evaluation of the need for a valuation allowance is performed on a jurisdiction by jurisdiction basis, and includes a review of all available positive and negative evidence. We recognize excess tax benefits associated with share-based compensation to stockholders’ equity only when realized. When assessing whether excess tax benefits relating to share-based compensation have been realized, we follow the with-and-without approach, excluding any indirect effects of the excess tax deductions. Under this approach, excess tax benefits related to share-based compensation are not deemed to be realized until after the utilization of all other tax benefits available to us. We recognize the impact of a tax position in our financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense. The intra period tax allocation rules require that we allocate the provision for income taxes between continuing operations and other categories of earnings, such as other comprehensive income. In periods which we have a year-to-date pretax loss from continuing operations and year-to-date pre-tax income in other categories of earnings, such as other comprehensive income, ASC 740-20-45-7 requires that we allocate the tax provision to other categories of earnings, and then record a related tax benefit in continuing operations. For the three months ended September 30, 2016 , we recognized a net loss from investments and currency transactions and recorded a tax expense of $0.3 million in "other comprehensive income (loss), net of income tax" on the accompanying Condensed Consolidated Statements of Comprehensive Loss. For the nine months ended September 30, 2016 , we recognized net income from investments and currency transactions and recorded a tax charge of $0.9 million in "other comprehensive income (loss), net of income tax" on the accompanying Condensed Consolidated Statements of Comprehensive Loss. As a result of the taxes allocated to year-to-date "other comprehensive income (loss), net of income tax", we recognized a benefit of $0.5 million and $0.6 million for the three and nine months ended September 30, 2016 , respectively, within "benefit (provision) for income taxes" on the Condensed Consolidated Statements of Operations.

Stockholders' Equity

Stockholders' Equity	9 Months Ended
	Sep. 30, 2016
Equity [Abstract]
Stockholders' Equity	STOCKHOLDERS' EQUITY Sale of Common Stock - December 2015 ATM Agreement On December 23, 2015, we entered into a collective at-market-issuance sales agreement with FBR Capital Markets & Co., MLV & Co. LLC, and H.C. Wainwright & Co., LLC. (“December 2015 ATM Agreement”), through which we are able to raise gross proceeds of up to $100 million from the sale of our common stock through these brokers under our shelf registration statement on Form S-3 (File No. 333-208760), declared effective by the SEC on February 3, 2016. Beginning in the second quarter of 2016 through September 30, 2016, we sold and issued shares of our common stock under this December 2015 ATM Agreement, as summarized in the following table: Description of Financing Transaction No. of Common Shares Issued Proceeds Received (Net of Broker Commissions and Fees ) Common shares issued pursuant to the December 2015 ATM Agreement between April 1, 2016 and September 30, 2016 (included within our issued and outstanding share count at September 30, 2016) 10,890,915 $ 73,869 Conversion of Series E Convertible Voting Preferred Stock In June 2016, our then 20 outstanding shares of Series E convertible voting preferred stock were converted (at the election of the preferred stockholders) into an aggregate of 40,000 common shares; a $6 thousand dividend in arrears was paid upon this conversion.

Description of Business, Basi25

Description of Business, Basis of Presentation, and Operating Segment (Policies)	9 Months Ended
	Sep. 30, 2016
Accounting Policies [Abstract]
Description of Business	(a) Description of Business Spectrum Pharmaceuticals, Inc. (“Spectrum”, the “Company”, “we”, “our”, or “us”) is a biotechnology company, with a primary strategy comprised of acquiring, developing, and commercializing a broad and diverse pipeline of late-stage clinical and commercial products. We have an in-house clinical development organization with regulatory and data management capabilities, and a commercial infrastructure and field sales force for our marketed products. Currently, we market six approved oncology/hematology products that target different types of non-Hodgkin's lymphoma ("NHL"), advanced metastatic colorectal cancer, acute lymphoblastic leukemia ("ALL"), and multiple myeloma ("MM"). We also have three drugs in late-stage development: • ROLONTIS (formerly referred to as SPI-2012) for chemotherapy-induced neutropenia in patients with breast cancer. • QAPZOLA (formerly referred to as APAZIQUONE) for immediate intravesical instillation in post-transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer. • POZIOTINIB, a novel pan-HER inhibitor used in the treatment of patients with breast cancer.
Basis of Presentation	(b) Basis of Presentation Interim Financial Statements The interim financial data as of September 30, 2016 and 2015 is unaudited, and is not necessarily indicative of our operating results for a full year. In the opinion of our management, the interim data includes normal and recurring adjustments necessary for a fair presentation of our financial results for the three and nine months ended September 30, 2016 and 2015 . Certain information and footnote disclosures normally included in annual financial statements prepared in accordance with generally accepted accounting principles in the United States of America (“GAAP”) have been condensed or omitted pursuant to U.S. Securities and Exchange Commission (“SEC”) rules and regulations relating to interim financial statements. The December 31, 2015 balances reported herein are derived from the audited Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2015 . The accompanying Condensed Consolidated Financial Statements should be read in conjunction with our audited Consolidated Financial Statements and Notes thereto included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2015 , filed with the SEC on March 14, 2016. Principles of Consolidation The accompanying Condensed Consolidated Financial Statements have been prepared in accordance with GAAP and with the rules and regulations of the SEC. These financial statements include the financial position, results of operations, and cash flows of Spectrum and its subsidiaries, all of which are wholly-owned (except for Spectrum Pharma Canada ("SPC"), as discussed below). All inter-company accounts and transactions among these legal entities have been eliminated in consolidation. Variable Interest Entity We own fifty -percent of SPC, a legal entity organized in Quebec, Canada in January 2008. Certain of our drug clinical studies are conducted through this “variable interest entity” (as defined under applicable GAAP) and we fund all of SPC’s operating costs. Since we carry the full risks and rewards of SPC, we meet the applicable GAAP criteria as being its “primary beneficiary.” Accordingly, SPC’s balance sheets and statements of operations are included in our Condensed Consolidated Financial Statements as if it were a wholly-owned subsidiary for all periods presented.
Operating Segment	(c) Operating Segment We operate in one reportable operating segment that is focused exclusively on developing and commercializing oncology and hematology drug products. For the three and nine months ended September 30, 2016 and 2015 , all of our revenue and related expenses were solely attributable to these activities. Substantially all of our assets (excluding our cash held in certain foreign bank accounts and our ZEVALIN distribution rights for the Ex-U.S. territory) are held in the U.S.
Revenue Recognition	(i) Revenue Recognition (a) Product Sales : We sell our products to wholesalers/distributors (i.e., our customers), except for our U.S. sales of ZEVALIN in which case the end-user (i.e. clinic or hospital) is our customer. Our wholesalers/distributors in turn sell our products directly to clinics, hospitals, and private oncology-based practices. Revenue from our product sales is recognized when title and risk of loss have transferred to our customer, and the following additional criteria are met: (1) appropriate evidence of a binding arrangement exists with our customer; (2) price is substantially fixed or determinable; (3) collection from our customer is reasonably assured; (4) our customer’s obligation to pay us is not contingent on resale of the product; (5) we do not have significant continued performance obligations to our customer; and (6) we have a reasonable basis to estimate returns. Our gross revenue is reduced by our gross-to-net (“GTN”) estimates each period, resulting in our reported “product sales, net” in the accompanying Condensed Consolidated Statements of Operations. We defer revenue recognition in full if these estimates are not reasonably determinable at the time of sale. These estimates are based upon information received from external sources (such as written and oral information obtained from our customers with respect to their period-end inventory levels, and their sales to end-users during the period), in combination with management’s informed judgments. Due to the inherent uncertainty of estimates, the actual amount we incur may be materially different than our GTN estimates, and require prospective revenue adjustments in periods after the initial sale was recorded. Our GTN estimates are comprised of the following categories: Product Returns Allowances : Our FUSILEV, MARQIBO, and BELEODAQ customers are permitted to return purchased product beginning at its expiration date, and within six months thereafter. Our EVOMELA customers are permitted to return purchased product beginning at six months prior to its expiration date, and within 12 months thereafter (as well as for overstock inventory, as determined by end-users). Returned product is generally not resold. Returns for expiry of ZEVALIN and FOLOTYN are not contractually, or customarily, allowed. We estimate expected returns based on our historical return rates. Government Chargebacks : Our products are subject to pricing limits under certain federal government programs (e.g., Medicare and the 340B Drug Pricing Program). Qualifying entities (i.e., end-users) purchase product from our customers at their qualifying discounted price. The chargeback amount we incur represents the difference between our contractual sales price to our customer, and the end-user’s applicable discounted purchase price under the government program. There may be significant lag time between our reported net product sales and our receipt of corresponding government chargeback claims from our customers. Prompt Pay Discounts : Discounts for prompt payment are estimated at the time of sale, based on our eligible customers’ prompt payment history and the contractual discount percentage. Commercial Rebates : Commercial rebates are based on (i) our estimates of end-user purchases through a group purchasing organization ("GPO"), (ii) the corresponding contractual rebate percentage tier we expect each GPO to achieve, and (iii) our estimates of the impact of any prospective rebate program changes made by us. Medicaid Rebates : Our products are subject to state government-managed Medicaid programs, whereby rebates are issued to participating state governments. These rebates arise when a patient treated with our product is covered under Medicaid, resulting in a discounted price for our product under the applicable Medicaid program. Our Medicaid rebate accrual calculations require us to project the magnitude of our sales, by state, that will be subject to these rebates. There is a significant time lag in us receiving rebate notices from each state (generally several months or longer after our sale is recognized). Our estimates are based on our historical claim levels by state, as supplemented by management’s judgment. Distribution, Data, and GPO Administrative Fees : Distribution, data, and GPO administrative fees are paid to authorized wholesalers/distributors of our products (except for U.S. sales of ZEVALIN) for various commercial services, including: contract administration, inventory management, delivery of end-user sales data, and product returns processing. These fees are based on a contractually-determined percentage of our applicable sales. (b) License Fees : Our out-license arrangements may include one or more of the following: (a) upfront license fees, (b) royalties from our licensees’ sales, and (c) milestone payments from our licensees’ sales or regulatory achievements. We recognize revenue from these categories based on the contractual terms that establish the legal rights and obligations between us and our licensees. (i) We first assess the number of “units of accounting” in the arrangement in accordance with multiple element arrangement guidance. We consider if the separate “deliverable” has standalone value to our licensee, and if standalone value does not exist for a deliverable, it is combined with other deliverables until the "bundle" has standalone value. The allocation of arrangement consideration and the recognition of revenue then is determined for those combined deliverables as a single unit of accounting (ii) Next, we measure and allocate arrangement consideration among the separate units of accounting. This measurement and allocation is based upon the fixed and discreet license fee payments and fixed royalties (as a percentage of our licensees’ net sales) that are part of the contractual terms within our arrangements. This fixed or determinable consideration is allocated to the units of accounting using the "relative selling price method". (iii) We evaluate certain customer payments as follows: (a) For upfront license fees, we consider whether the revenue is earned and realizable at the time of contract execution (i.e., when the license rights transfer to the customer). We give specific consideration to whether we have any on-going contractual service obligations to the licensee, including any requirements for us to provide on-going support services, and/or for us to supply drug products for the licensee’s future sales. As a result, we may either recognize all upfront license fees as revenue in the period of contract execution, or recognize these fees over the actual (or implied) contractual term of the out-license. (b) For royalties, when we have no on-going performance obligation, we recognize revenue in the period that our licensee has sales for which we are contractually entitled to a percentage-based royalty payment. (c) For our licensees’ sales or regulatory milestone achievements, revenue associated with substantive at-risk milestones is recognized when we have no on-going performance obligation and based upon the achievement of the milestones set forth in the respective agreements, as this is the point at which the additional consideration becomes fixed or determinable. (c) Service Revenue : We receive fees under certain arrangements for (a) sales and marketing services, (b) supply chain services (c) research and development services, and (d) clinical trial management services. Payment for these services may be triggered by (i) an established fixed-fee schedule, (ii) the completion of product delivery in our capacity as a procurement agent, (iii) the successful completion of a phase of development, (iv) favorable results from a clinical trial, and/or (v) regulatory approval events. We consider whether revenue associated with these service arrangements is “realizable and earned” each reporting period, based on our completed services or deliverables during the period, and the contractual terms of the arrangement (which typically includes fee schedules). For any/all milestone achievements in the reporting period that contractually result in fixed payments due to us, we apply the “milestone method” of revenue recognition. Accordingly, this revenue recognition occurs as each “substantive” milestone (as discussed below) is achieved by us, since (1) all contingencies associated with each milestone is resolved upon its achievement, (2) the milestone achievement relates solely to our past performance, and (3) no remaining milestone performance obligations exist in relation to our receipt of payment. In recognizing revenue under the milestone method, we first assess the number of “units of accounting” in the arrangement. We consider if the separate “deliverable” has standalone value to our licensee, and if standalone value does not exist for a deliverable, it is combined with other deliverables until the "bundle" has standalone value. The allocation of arrangement consideration and the recognition of revenue is determined for those combined deliverables as a single unit of accounting. This includes allocation of consideration associated with milestones achieved by our licensees. Next, we measure and allocate arrangement consideration among the separate units of accounting. This fixed or determinable consideration is allocated to the units of accounting using the "relative selling price method". Variable fees subsequently earned (other than substantive milestone payments) are allocated to the units of accounting on the same basis. We determine whether the milestone is substantive by considering (i) the extent of our effort to achieve the milestone and/or the enhancement of the value of the delivered item(s) as a result of milestone achievement, (ii) whether the milestone achievement relates solely to our past performance, and (iii) if the milestone payment is reasonable relative to all of the deliverables and payment terms (including other potential milestone consideration) within the arrangement. For service contracts without milestones, we recognize revenue when all of the following criteria are met: (i) persuasive evidence of an arrangement exists, (ii) services have been rendered, (iii) fees are fixed or determinable, and (iv) collectability is reasonably assured. (d) New Revenue Recognition Standard : The new revenue recognition standard, ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606) (“ASU 2014-09”), is effective for us beginning January 1, 2018. This new standard requires that our revenue is recognized in a manner that reasonably reflects the delivery of our goods or services to customers in return for expected consideration. To achieve this core principle, the guidance provides the following steps: (1) identify the contract(s) with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenue when (or as) the entity satisfies a performance obligation. We intend to apply the "cumulative effect transition method" of ASU 2014-09 for its implementation. We continue to evaluate the impact of this new standard on our current revenue recognition models for product sales, license fees, and service revenue (as described above), though we currently believe the most significant impact of this new standard relates to the timing of our license fee revenue.
Cash and Equivalents	ii) Cash and Equivalents Our cash and equivalents consist of bank deposits and highly liquid investments with maturities of three months or less from the purchase date.
Marketable Securities	iii) Marketable Securities Our marketable securities consist of our holdings in mutual funds and bank certificates of deposit. Since we classify these securities as “available-for-sale” under applicable GAAP, any unrealized gains or losses from their change in value is reflected in “unrealized gain (loss) on available-for-sale securities” on the accompanying Condensed Consolidated Statements of Comprehensive Loss. Realized gains and losses on available-for-sale securities are included in “other income (expense), net” on the accompanying Condensed Consolidated Statements of Operations.
Accounts Receivable	iv) Accounts Receivable Our accounts receivables are derived from our product sales and license fees (our service revenue is recorded in "other receivables"), and do not bear interest. The allowance for doubtful accounts is management’s best estimate of the amount of probable credit losses in our existing accounts receivable. Account balances are charged off against the allowance after appropriate collection efforts are exhausted.
Inventories	v) Inventories We value our inventory at the lower of (i) the actual cost of its purchase or manufacture, or (ii) its current market value. Inventory cost is determined on the first-in, first-out method. We regularly review our inventory quantities in process of manufacture and on hand. When appropriate, we record a provision for obsolete and excess inventory to derive its new cost basis, which takes into account our sales forecast by product and corresponding expiry dates. Direct and indirect manufacturing costs related to the production of inventory prior to U.S. Food and Drug Administration ("FDA") approval are expensed through “research and development,” rather than being capitalized to inventory cost.
Property and Equipment	vi) Property and Equipment Our property and equipment is stated at historical cost, and is depreciated on a straight-line basis over an estimated useful life that corresponds with its designated asset category. We evaluate the recoverability of “long-lived assets” (which includes property and equipment) whenever events or changes in circumstances in our business indicate that the asset’s carrying amount may not be recoverable through on-going operations.
Goodwill and Intangible Assets	vii) Goodwill and Intangible Assets Our goodwill represents the excess of our business acquisition cost over the estimated fair value of the net assets acquired in the corresponding transaction. Goodwill has an indefinite accounting life and is therefore not amortized. Instead, goodwill is evaluated for impairment on an annual basis (as of each October 1 st ), unless we identify impairment indicators that would require earlier testing. We evaluate the recoverability of indefinite-lived intangible assets at least annually, or whenever events or changes in our business indicate that an intangible asset’s (whether indefinite or definite-lived) carrying amount may not be recoverable. Such circumstances could include, but are not limited to the following: (a) a significant decrease in the market value of an asset; (b) a significant adverse change in the extent or manner in which an asset is used; or (c) an accumulation of costs significantly in excess of the amount originally expected for the acquisition of an asset. Intangible assets with finite useful lives are amortized over their estimated useful lives on a straight-line basis. We review these assets for potential impairment if/when facts or circumstances suggest that the carrying value of these assets may not be recoverable.
Stock-Based Compensation	viii) Stock-Based Compensation Stock-based compensation expense for equity awards granted to our employees and members of our board of directors is recognized on a straight-line basis over each award's vesting period. Recognized compensation expense is net of an estimated forfeiture rate, representing the percentage of awards that are expected to be forfeited (by termination of employment or service) prior to vesting. We use the Black-Scholes option pricing model to determine the fair value of stock options (as of the date of grant) which carry service conditions for vesting. When applicable, we use the Monte Carlo valuation model to value equity awards (as of the date of grant) which carry combined market conditions and service conditions for vesting. The calculation of the fair value of stock options on the date of grant, and the recognition of stock-based compensation expense over the appropriate time period, requires uncertain assumptions, including (a) the pre-vesting forfeiture rate of the stock option, (b) the term of the stock option, (c) the stock price volatility over the term of the stock option, and (d) the risk-free interest rate over the term of the stock option. We estimate forfeiture rates based on our employees’ overall forfeiture history, which we believe will be representative of future results. We estimate the expected term of stock options granted based on our employees’ historical exercise patterns, which we believe will be representative of their future behavior. We estimate the volatility of our common stock on the date of grant based on historical volatility of our common stock for a look-back period that corresponds with the expected term. We estimate the risk-free interest rate based upon the U.S. Treasury yields in effect at award grant, for a period equaling the stock options’ expected term.
Foreign Currency Transactions and Translation	ix) Foreign Currency Translation We translate the assets and liabilities of our foreign subsidiaries that are stated in their functional currencies (i.e., local operating currencies), to U.S. dollars at the rates of exchange in effect at the reported balance sheet date. Revenues and expenses are translated using the monthly average exchange rates during the reported period. Unrealized gains and losses from the translation of our subsidiaries’ financial statements (that are initially denominated in the corresponding functional currency) are included as a separate component of “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. We record foreign currency transactions, when initially denominated in a currency other than the respective functional currency of our subsidiary, at the prevailing exchange rate on the date of the transaction. Resulting unrealized foreign exchange gains and losses from transactions with third parties are included in “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. All unrealized foreign exchange gains and losses associated with our intercompany loans are included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets, as these loans with our foreign subsidiaries are not expected to be settled in the "foreseeable future." For the period January 1, 2015 through March 31, 2015, unrealized foreign exchange gains and losses associated with our intercompany loans were included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets and in "other income (expense), net" in the Condensed Consolidated Statements of Operations.
Basic and Diluted Net (Loss) Income per Share	x) Basic and Diluted Net (Loss) Income per Share We calculate basic and diluted net (loss) income per share using the weighted average number of common shares outstanding during the periods presented. In periods of a net loss, basic and diluted loss per share are the same. For the diluted earnings per share calculation, we adjust the weighted average number of common shares outstanding to include only dilutive stock options, warrants, and other common stock equivalents outstanding during the period.
Income Taxes	xi) Income Taxes Deferred tax assets and liabilities are recorded based on the estimated future tax effects of temporary differences between the tax basis of assets and liabilities and amounts reported in the financial statements, as well as operating losses and tax credit carry forwards using enacted tax rates and laws that are expected to be in effect when the differences are expected to reverse. Realization of deferred tax assets is dependent upon future earnings, the timing and amount of which are uncertain. We have recorded a valuation allowance to reduce our deferred tax assets, because we believe that, based upon a weighting of positive and negative factors, it is more likely than not that these deferred tax assets will not be realized. If/when we determine that our deferred tax assets are realizable, an adjustment to the corresponding valuation allowance would increase our net income in the period that such determination was made. In the event that we are assessed interest and/or penalties from taxing authorities that have not been previously accrued, such amounts would be included in “benefit (provision) for income taxes” within the Condensed Consolidated Statements of Operations in the period the notice was received.
Research and Development Costs	xii) Research and Development Costs Our research and development costs are expensed as incurred, or as certain milestone payments become due, generally triggered by clinical or regulatory events.
Fair Value Measurements	xiii) Fair Value Measurements We determine measurement-date fair value based on the proceeds that would be received through the sale of the asset, or that we would pay to settle or transfer the liability, in an orderly transaction between market participants. We utilize valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible. Fair value measurements are based on a three-tier hierarchy that prioritizes the inputs used in descending order to measure fair value. These tiers include the following: Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities that are publicly accessible at the measurement date. Level 2: Observable prices that are based on inputs not quoted on active markets, but that are corroborated by market data. These inputs may include quoted prices for similar assets or liabilities or quoted market prices in markets that are not active to the general public. Level 3: Unobservable inputs are used when little or no market data is available.

Balance Sheet Account Detail (T

Balance Sheet Account Detail (Tables)	9 Months Ended
	Sep. 30, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Cash And Cash Equivalent Marketable Securities Unrealized Gain Table	The following is a summary of our “cash and cash equivalents” and “marketable securities”: Marketable Securities Cost Gross Gross Estimated Cash and Cash Current Long September 30, 2016 Bank deposits $ 28,134 $ — $ — $ 28,134 $ 28,134 $ — $ — Money market funds 138,472 — — 138,472 138,472 — — Bank certificates of deposits 5,246 — — 5,246 4,999 247 — Total cash and cash equivalents and marketable securities $ 171,852 $ — $ — $ 171,852 $ 171,605 $ 247 $ — December 31, 2015 Bank deposits $ 59,625 $ — $ — $ 59,625 $ 59,625 $ — $ — Money market funds 80,116 — — 80,116 80,116 — — Bank certificates of deposits 245 — — 245 — 245 — Total cash and cash equivalents and marketable securities $ 139,986 $ — $ — $ 139,986 $ 139,741 $ 245 $ —
Schedule of Property and Equipment Net of Accumulated Depreciation	“Property and equipment, net of accumulated depreciation” consist of the following: September 30, 2016 December 31, 2015 Computer hardware and software $ 3,823 $ 3,785 Laboratory equipment 622 608 Office furniture 354 355 Leasehold improvements 2,880 2,872 Property and equipment, at cost 7,679 7,620 (Less): Accumulated depreciation (7,141 ) (6,702 ) Property and equipment, net of accumulated depreciation $ 538 $ 918
Components of Inventories	“Inventories” consist of the following: September 30, 2016 December 31, 2015 Raw materials $ 2,632 $ 1,606 Work-in-process* 10,091 4,228 Finished goods 1,380 1,498 (Less:) Non-current portion of inventories included within "other assets" ** (6,800 ) (3,156 ) Inventories $ 7,303 $ 4,176 * In January 2016, we received $3.4 million of ZEVALIN antibody materials for its future manufacture (representing strategic long-term supply). ** The "non-current" portion of inventories is presented within "other assets" in the accompanying Condensed Consolidated Balance Sheet at September 30, 2016 and December 31, 2015, respectively. This value of $6.8 million at September 30, 2016 represents product that we expect to sell beyond September 30, 2017.
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure	“Prepaid expenses and other assets” consist of the following: September 30, 2016 December 31, 2015 Prepaid operating expenses $ 2,702 $ 3,507 Current portion of debt issuance costs* — — Prepaid expenses and other assets $ 2,702 $ 3,507 * Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith the FASB-issued Accounting Standards Update 2015-03, Simplifying the Presentation of Debt Issuance Costs (“ASU 2015-03”). These amounts were $1.7 million and $2.2 million (including current and non-current portions) as of September 30, 2016 and December 31, 2015, respectively.
Schedule of Other Receivables	“Other receivables” consist of the following: September 30, 2016 December 31, 2015 Income tax receivable $ 1,264 $ 1,301 Insurance receivable 350 7,100 Mundipharma promissory note — 2,215 CASI note - short term* 1,500 — Eagle receivable for services and support costs ( Note 13 ) 1,896 — Research and development expenses - reimbursements due 1,726 1,699 Other miscellaneous receivables 355 257 Other receivables $ 7,091 $ 12,572 * This full balance was prospectively reclassified beginning March 31, 2016 to "other receivables" (presented within current assets on the accompanying Condensed Consolidated Balance Sheets) from "other assets" (presented within non-current assets) due to this note's maturity date of March 17, 2017 (i.e., within 12 months of September 30, 2016 ) - see Note 10 .
Components of Intangible Assets Net of Accumulated Amortization	“Intangible assets, net of accumulated amortization and impairment charges” consist of the following: September 30, 2016 Historical Accumulated Foreign Impairment Net Amount Full Remaining MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 n/a n/a EVOMELA distribution rights (1) 7,700 (296 ) — — 7,404 156 150 BELEODAQ distribution rights 25,000 (4,219 ) — — 20,781 160 133 MARQIBO distribution rights 26,900 (11,783 ) — — 15,117 81 42 FOLOTYN distribution rights (2) 118,400 (37,767 ) — — 80,633 152 74 ZEVALIN distribution rights – U.S. 41,900 (33,214 ) — — 8,686 123 30 ZEVALIN distribution rights – Ex-U.S. 23,490 (14,159 ) (3,818 ) — 5,513 96 42 FUSILEV distribution rights (3) 16,778 (9,618 ) — (7,160 ) — 56 0 FOLOTYN out-license (4) 27,900 (11,151 ) — (1,023 ) 15,726 110 70 Total intangible assets $ 305,668 $ (122,207 ) $ (3,818 ) $ (8,183 ) $ 171,460 (1) The FDA approval of EVOMELA in March 2016 triggered a $6 million payment due to CyDex Pharmaceuticals, Inc. (a wholly-owned subsidiary of Ligand Pharmaceuticals Incorporated ("Ligand")). This event also resulted in a reclassification of our $7.7 million "EVOMELA IPR&D" to "EVOMELA distribution rights" due to our ability to begin its commercialization with this FDA approval. Amortization commenced on April 1, 2016, in accordance with our capitalization policy for intangible assets. (2) Beginning June 2016, we adjusted the amortization period of our FOLOTYN distribution rights to November 2022 from March 2025, representing the period through which we expect to have patent protection from generic competition (see Note 16(g) ). (3) On February 20, 2015, the U.S. District Court for the District of Nevada found the patent covering FUSILEV to be invalid, which was upheld on appeal. On April 24, 2015, Sandoz began to commercialize a generic version of FUSILEV. This represented a “triggering event” under applicable GAAP in evaluating the value of our FUSILEV distribution rights as of March 31, 2015, resulting in a $7.2 million impairment charge (non-cash) in the first quarter of 2015. We accelerated amortization expense recognition in 2015 for the then remaining net book value of FUSILEV distribution rights. (4) On May 29, 2013, we amended our FOLOTYN collaboration agreement with Mundipharma International Corporation Limited ("Mundipharma"). As a result of the amendment, Europe and Turkey were excluded from Mundipharma’s commercialization territory, and their royalty rates and milestone payments to us were modified. This constituted a change under which we originally valued the FOLOTYN out-license as part of business combination accounting, resulting in an impairment charge (non-cash) of $1.0 million in the second quarter of 2013. December 31, 2015 Historical Accumulated Foreign Impairment Net Amount MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 EVOMELA IPR&D 7,700 — — — 7,700 BELEODAQ distribution rights 25,000 (2,812 ) — — 22,188 MARQIBO distribution rights 26,900 (8,544 ) — — 18,356 FOLOTYN distribution rights 118,400 (29,474 ) — — 88,926 ZEVALIN distribution rights – U.S. 41,900 (30,608 ) — — 11,292 ZEVALIN distribution rights – Ex-U.S. 23,490 (12,632 ) (4,353 ) — 6,505 FUSILEV distribution rights 16,778 (9,618 ) — (7,160 ) — FOLOTYN out-license 27,900 (9,109 ) — (1,023 ) 17,768 Total intangible assets $ 305,668 $ (102,797 ) $ (4,353 ) $ (8,183 ) $ 190,335
Estimated Intangible Asset Amortization Expense	Estimated intangible asset amortization expense for the remainder of 2016 and the five succeeding fiscal years and thereafter is as follows: Years Ending December 31, Remainder of 2016 $ 6,909 2017 27,635 2018 27,635 2019 25,029 2020 19,740 2021 18,266 2022 and thereafter 28,646 $ 153,860
Schedule of Goodwill	“Goodwill” is comprised of the following: September 30, 2016 December 31, 2015 Acquisition of Talon (MARQIBO rights) $ 10,526 $ 10,526 Acquisition of ZEVALIN Ex-U.S. distribution rights 2,525 2,525 Acquisition of Allos (FOLOTYN rights) 5,346 5,346 Foreign currency exchange translation effects (380 ) (437 ) Goodwill $ 18,017 $ 17,960
Summary of Other Assets	“Other assets” are comprised of the following: September 30, 2016 December 31, 2015 Equity securities and secured promissory note - CASI (see Note 10)* $ 9,146 $ 6,689 Supplies and deposits 181 185 2018 Convertible Notes issuance costs (excluding current portion)** — — Executive officer life insurance – cash surrender value 11,845 9,181 Inventories - non-current portion 6,800 3,156 Other miscellaneous assets 43 — Other assets $ 28,015 $ 19,211 * These equity securities were excluded from “marketable securities” (see Note 3(a) ) due to our intent to hold these securities for at least one year beyond September 30, 2016 , as discussed in Note 10 . The “unrealized gain on available-for-sale securities" within the Condensed Consolidated Statements of Comprehensive Loss, totaled $3.0 million , net of income tax, for the nine months ended September 30, 2016 . ** Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith ASU 2015-03. These amounts were $1.7 million and $2.2 million (including current and non-current portions) as of September 30, 2016 and December 31, 2015 , respectively.
Schedule of Accounts Payable and Other Accrued Liabilities	“Accounts payable and other accrued liabilities” are comprised of the following : September 30, 2016 December 31, 2015 Trade accounts payable and other accrued liabilities $ 27,180 $ 26,684 Accrued rebates 10,130 18,166 Accrued product royalty 5,286 4,908 Allowance for returns 2,237 1,394 Accrued data and distribution fees 2,996 1,830 Accrued GPO administrative fees 342 1,058 Accrued inventory management fee 323 498 Allowance for chargebacks 1,483 2,001 Accounts payable and other accrued liabilities $ 49,977 $ 56,539
Schedule of Amounts Presented in Accounts Payable and Other Accrued Liabilities	Amounts presented within “accounts payable and other accrued liabilities” in the accompanying Condensed Consolidated Balance Sheets specifically for GTN estimates (see Note 2(i) ) are as follows: Rebates and Data and Returns Balance as of December 31, 2014 $ 45,822 $ 8,284 $ 1,135 Add: provisions 75,498 15,928 1,486 (Less): credits or actual allowances (101,153 ) (20,826 ) (1,227 ) Balance as of December 31, 2015 20,167 3,386 1,394 Add: provisions 67,390 10,235 1,558 (Less): credits or actual allowances (75,944 ) (9,960 ) (715 ) Balance as of September 30, 2016 $ 11,613 $ 3,661 $ 2,237
Deferred Revenue, by Arrangement, Disclosure	Deferred revenue (current and non-current) is comprised of the following: September 30, 2016 December 31, 2015 Mundipharma deferred revenue (see Note 11 ) $ 1,700 $ — EVOMELA deferred revenue* 3,094 — FUSILEV deferred revenue** — 6,083 Dr. Reddy's out-license (see Note 16(b)(iii) ) 405 430 Deferred revenue $ 5,199 $ 6,513 *We commercialized EVOMELA beginning in April 2016, and have deferred revenue recognition (see Note 2(i)(a) ) for any product shipped to our distributors, but not ordered and received by end-users as of September 30, 2016 . **In the third quarter of 2015, we deferred revenue recognition related to certain FUSILEV product shipments that did not meet our revenue recognition criteria (see Note 2(i)(a )), aggregating $9.9 million . Specifically, this deferral resulted from our inability to concurrently estimate future rebate values (with requisite precision) offered to our customers in order to compete with generic products. During the fourth quarter of 2015, we recognized $3.8 million for these third quarter shipments, and $6.1 million remained deferred as of December 31, 2015 . In the first quarter of 2016, this $6.1 million of deferred revenue was recognized in full.
Summary of Other Long-Term Liabilities	Other long-term liabilities are comprised of the following: September 30, 2016 December 31, 2015 Accrued executive deferred compensation $ 7,797 $ 6,458 Deferred rent (non-current portion) 193 248 Clinical study holdback costs, non-current 44 — Other tax liabilities 738 738 Other long-term liabilities $ 8,772 $ 7,444

Gross-to-Net Product Sales (Tab

Gross-to-Net Product Sales (Tables)	9 Months Ended
	Sep. 30, 2016
Revenue, Net [Abstract]
Reconciliation of Gross to Net Product Sales	The below table presents a GTN product sales reconciliation for the accompanying Condensed Consolidated Statements of Operations: Three Months Ended Nine Months Ended 2016 2015 2016 2015 Gross product sales $ 61,513 $ 44,713 $ 175,963 $ 160,111 Commercial rebates and government chargebacks (26,167 ) (12,515 ) (67,389 ) (44,364 ) Data and distribution fees, GPO fees, and inventory management fees (4,234 ) (3,503 ) (10,235 ) (12,709 ) Prompt pay discounts (300 ) (15 ) (380 ) (16 ) Product returns allowance (540 ) (223 ) (1,558 ) (1,008 ) Net product sales $ 30,272 $ 28,457 $ 96,401 $ 102,014

Net Product Sales by Geograph28

Net Product Sales by Geographic Region and Product Line, and Composition of License Fees and Service Revenue (Tables)	9 Months Ended
	Sep. 30, 2016
Segment Reporting [Abstract]
Schedule of Product Sales, Net by Geography	The below table presents our net product sales by geography for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 United States $ 29,576 97.7 % $ 26,262 92.3 % $ 93,392 96.9 % $ 96,546 94.6 % International: Europe 696 2.3 % 709 2.5 % 3,009 3.1 % 1,806 1.8 % Asia Pacific* — — % 1,486 5.2 % — — % 3,662 3.6 % Total international 696 2.3 % 2,195 7.7 % 3,009 3.1 % 5,468 5.4 % Net product sales $ 30,272 100.0 % $ 28,457 100.0 % $ 96,401 100.0 % $ 102,014 100.0 % * See Note 11 for discussion of our November 2015 out-license for Asia Pacific territory to Mundipharma.
Schedule Of Net Sales By Product Line Table	The below table presents our net product sales by product line for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 FUSILEV $ 4,893 16.2 % $ 11,101 39.0 % $ 30,568 31.7 % $ 45,597 44.7 % FOLOTYN 11,315 37.4 % 8,722 30.6 % 35,577 36.9 % 30,261 29.7 % ZEVALIN 2,627 8.7 % 4,762 16.7 % 8,224 8.5 % 13,784 13.5 % MARQIBO 1,925 6.4 % 1,316 4.6 % 4,921 5.1 % 5,290 5.2 % BELEODAQ 3,635 12.0 % 2,556 9.0 % 10,326 10.7 % 7,082 6.9 % EVOMELA 5,877 19.4 % — — % 6,785 7.0 % — — % Net product sales $ 30,272 100.0 % $ 28,457 100.0 % $ 96,401 100.0 % $ 102,014 100.0 % The below table presents our license fee and service revenue by source for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 Out-license to Servier in Canada territory ( Note 12 ) $ — — % $ — — % $ 6,000 40.5 % $ — — % Co-promotion with Eagle ( Note 13 ) 2,406 77.1 % — — % 6,737 45.5 % — — % Out-license to Mundipharma in China and other ex-U.S. territories (Note 11 and 15) 703 22.5 % 158 92.9 % 2,013 13.6 % 493 4.8 % Out-license to CASI in China territory ( Note 10 ) — — % — — % — — % 9,682 94.8 % Other license fees and service revenues 12 0.4 % 12 7.1 % 57 0.4 % 37 0.4 % License fees and service revenues $ 3,121 100.0 % $ 170 100.0 % $ 14,807 100.0 % $ 10,212 100.0 %

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	9 Months Ended
	Sep. 30, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Summary of Stock-Based Compensation Expense	Stock-based compensation expense included within “Total operating costs and expenses” for the three and nine months ended September 30, 2016 and 2015 was as follows: Three Months Ended Nine Months Ended 2016 2015 2016 2015 Cost of product sales $ 30 $ 21 $ 84 $ 43 Research and development 470 474 1,461 1,326 Selling, general and administrative 2,650 2,005 8,209 7,121 Total stock-based compensation $ 3,150 $ 2,500 $ 9,754 $ 8,490

Net Loss Per Share (Tables)

Net Loss Per Share (Tables)	9 Months Ended
	Sep. 30, 2016
Earnings Per Share [Abstract]
Computation of Net Loss Per Share	Net loss per share was computed by dividing net loss by the weighted average number of common shares outstanding for the three and nine months ended September 30, 2016 and 2015 : Three Months Ended Nine Months Ended 2016 2015 2016 2015 Net loss $ (17,455 ) $ (18,724 ) $ (51,070 ) $ (46,632 ) Weighted average shares – basic and diluted 79,303,380 65,855,727 70,437,885 65,457,060 Net loss per share – basic and diluted $ (0.22 ) $ (0.28 ) $ (0.73 ) $ (0.71 )
Schedule of Securities Excluded from Calculation of Net Loss Per Share	The below outstanding securities were excluded from the above calculation of net loss per share because their impact would have been anti-dilutive due to net loss per share in the three and nine months ended September 30, 2016 and 2015 , as summarized below: Three Months Ended Nine Months Ended 2016 2015 2016 2015 2018 Convertible Notes 11,401,284 11,401,284 11,401,284 11,401,284 Common stock options 1,603,028 1,591,709 1,498,034 1,507,700 Restricted stock awards 2,609,533 1,457,232 2,609,533 1,457,232 Common stock warrants — 59,853 1,674 45,121 Preferred stock — 40,000 — 40,000 Total 15,613,845 14,550,078 15,510,525 14,451,337

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	9 Months Ended
	Sep. 30, 2016
Fair Value Disclosures [Abstract]
Summary of Asset and Liability Fair Values	The table below summarizes certain asset and liability fair values that are included within our accompanying Condensed Consolidated Balance Sheets, and their designations among three fair value measurement categories: September 30, 2016 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 5,246 $ — $ 5,246 Money market currency funds — 138,472 — 138,472 Equity securities 9,146 — — 9,146 Mutual funds — 45 — 45 Deferred compensation investments, including life insurance cash surrender value — 11,845 — 11,845 $ 9,146 $ 155,608 $ — $ 164,754 Liabilities: Deferred executive compensation liability $ — $ 7,797 $ — $ 7,797 Drug development liability ( Note 15 ) — — 14,160 14,160 Talon CVR ( Note 9(a) ) — — 1,853 1,853 Corixa Liability — — 62 62 $ — $ 7,797 $ 16,075 $ 23,872 December 31, 2015 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 245 $ — $ 245 Money market currency funds — 80,116 — 80,116 Equity securities 5,189 — — 5,189 Deferred compensation investments, including life insurance cash surrender value — 9,181 — 9,181 $ 5,189 $ 89,542 $ — $ 94,731 Liabilities: Deferred executive compensation liability $ — $ 6,458 $ — $ 6,458 Drug development liability — — 14,686 14,686 Ligand Contingent Consideration — — 5,227 5,227 Talon CVR — — 1,377 1,377 Corixa Liability — — 62 62 $ — $ 6,458 $ 21,352 $ 27,810
Fair Value Measurement Activity for Liabilities Utilize Level 3 Inputs	The following presents a roll forward of our liabilities for which we utilize Level 3 inputs in determining period-end value. These liabilities are included on our Condensed Consolidated Balance Sheets within “acquisition-related contingent obligations” and “drug development liability”. The basis of the various Level 3 valuation inputs are discussed in the Notes to these accompanying Condensed Consolidated Financial Statements. Our carrying amounts of financial instruments such as cash equivalents, accounts receivable, prepaid expenses, accounts payable, and accrued liabilities, excluding acquisition-related contingent obligations, approximate their related fair values due to their short-term nature. Fair Value Measurements of Balance at December 31, 2014 $ 23,127 Deferred drug development costs (1,099 ) Ligand Contingent Consideration fair value adjustment 326 Talon CVR fair value adjustment (1,002 ) Balance at December 31, 2015 21,352 Settlement of Ligand Contingent Consideration liability (see Note 9(b)) (6,000 ) Deferred drug development costs (see Note 15 ) (526 ) Ligand Contingent Consideration fair value adjustment prior to settlement (see Note 9(b) ) 773 Talon CVR fair value adjustment (see Note 9(a) ) 476 Balance at September 30, 2016* $ 16,075 * This amount is comprised of the current and non-current portions of “drug development liability” and of “acquisition-related contingent obligations” on our accompanying Condensed Consolidated Balance Sheets.

Business Combinations and Con32

Business Combinations and Contingent Consideration (Tables)	9 Months Ended
	Sep. 30, 2016
Talon Therapeutics, Inc. [Member]
Change in Fair Value of Contingent Consideration Related to Acquisitions	Fair Value December 31, 2015 $ 1,377 Fair value adjustment for the nine months ended September 30, 2016 476 September 30, 2016 $ 1,853
Acquisition-Date Fair Value of Consideration Transferred	The acquisition-date fair value of the consideration transferred consisted of the following: Cash consideration $ 3,000 Ligand Contingent Consideration - FDA approval milestone 4,700 Total purchase consideration $ 7,700
Melphalan license [Member]
Change in Fair Value of Contingent Consideration Related to Acquisitions	Fair Value of December 31, 2015 $ 5,227 Fair value adjustment for the three months ended March 31, 2016 773 Payment to Ligand in April 2016 for FDA approval milestone achievement $ (6,000 ) September 30, 2016 $ —
Summary of Allocation of Total Purchase Price to Net Assets Acquired	The allocation of the total purchase price to the net assets acquired is as follows: EVOMELA IPR&D $ 7,700

Out-License of Marqibo, Zeval33

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI (Tables)	9 Months Ended
	Sep. 30, 2016
Other Commitments [Abstract]
Schedule of Proceeds Received and Fair Value on CASI Out-License Execution Date	The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $9.1 million as of September 30, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of September 30, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets.

Convertible Senior Notes (Table

Convertible Senior Notes (Tables)	9 Months Ended
	Sep. 30, 2016
Debt Disclosure [Abstract]
Carrying Value of 2018 Convertible Notes	The carrying value of the 2018 Convertible Notes as of September 30, 2016 is summarized as follows: Principal amount $ 120,000 (Less): Unamortized debt discount (amortized through December 2018) (14,206 ) (Less): Debt issuance costs (see Note 3(d) ) (1,650 ) September 30, 2016 carrying value $ 104,144
Components of the Interest Expense Recognized	The following table sets forth the components of interest expense recognized in the accompanying Condensed Consolidated Statements of Operations for the 2018 Convertible Notes for the nine months ended September 30, 2016 : Contractual coupon interest expense $ 2,475 Amortization of debt issuance costs 521 Accretion of debt discount 4,246 Total $ 7,242 Effective interest rate 8.66 %

Mundipharma Agreement And Dru35

Mundipharma Agreement And Drug Development Liability (Tables)	9 Months Ended
	Sep. 30, 2016
Business Combinations [Abstract]
Schedule of Drug Development Liability Adjustments	Drug Drug Total Drug Balance at December 31, 2015 $ 259 $ 14,427 $ 14,686 Transfer from long-term to current in 2016 423 (423 ) — (Less): Expenses incurred in 2016 (526 ) — (526 ) Balance at September 30, 2016 $ 156 $ 14,004 $ 14,160

Stockholders' Equity (Tables)

Stockholders' Equity (Tables)	9 Months Ended
	Sep. 30, 2016
Equity [Abstract]
Stock Issued	Beginning in the second quarter of 2016 through September 30, 2016, we sold and issued shares of our common stock under this December 2015 ATM Agreement, as summarized in the following table: Description of Financing Transaction No. of Common Shares Issued Proceeds Received (Net of Broker Commissions and Fees ) Common shares issued pursuant to the December 2015 ATM Agreement between April 1, 2016 and September 30, 2016 (included within our issued and outstanding share count at September 30, 2016) 10,890,915 $ 73,869

Description of Business, Basi37

Description of Business, Basis of Presentation, and Operating Segment - Additional Information (Detail)	9 Months Ended
	Sep. 30, 2016Segmentproduct
Segment Reporting Information [Line Items]
Number of late stage development products	3
Number of reportable operating segment | Segment	1
Spectrum Pharma Canada [Member]
Segment Reporting Information [Line Items]
Ownership interest, percentage	50.00%
Cancer Drugs [Member]
Segment Reporting Information [Line Items]
Number of products for sale	6

Use of Estimates and Summary 38

Use of Estimates and Summary of Significant Accounting Policies - Additional Information (Detail)	9 Months Ended
	Sep. 30, 2016
Accounting Policies [Line Items]
Number of months customers are allowed to return products	6 months
Cash and equivalents maturities period	3 months
EVOMELA [Member]
Accounting Policies [Line Items]
Number of months customers are allowed to return products	12 months

Balance Sheet Account Detail -

Balance Sheet Account Detail - Summary of Cash and Cash Equivalents and Marketable Securities (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015	Sep. 30, 2015	Dec. 31, 2014
Schedule of Investments [Line Items]
Cash and cash equivalents, Marketable securities, Cost	$ 171,852	$ 139,986
Cash and cash equivalents, Marketable securities, Gross Unrealized Gains	0	0
Cash and cash equivalents, Marketable securities, Gross Unrealized Losses	0	0
Marketable security, Estimated fair Value	45
Cash and cash equivalents, Marketable securities, Estimated fair Value	171,852	139,986
Cash and cash equivalents	171,605	139,741	$ 136,527	$ 129,942
Marketable Security, Current	247	245
Bank Deposits [Member]
Schedule of Investments [Line Items]
Bank deposits, Cost	28,134	59,625
Bank deposits, Gross Unrealized Gains	0	0
Bank deposits, Gross Unrealized Losses	0	0
Bank deposits, Estimated fair Value	28,134	59,625
Cash and cash equivalents	28,134	59,625
Money market funds [Member]
Schedule of Investments [Line Items]
Marketable security, Amortized Cost	138,472	80,116
Marketable security, Gross Unrealized Gains	0	0
Marketable security, Gross Unrealized Losses	0	0
Marketable security, Estimated fair Value	138,472	80,116
Cash and cash equivalents	138,472	80,116
Bank CDs [Member]
Schedule of Investments [Line Items]
Marketable security, Amortized Cost	5,246	245
Marketable security, Gross Unrealized Gains	0	0
Marketable security, Gross Unrealized Losses	0	0
Marketable security, Estimated fair Value	5,246	245
Marketable Security, Current	$ 247	$ 245

Balance Sheet Account Detail 40

Balance Sheet Account Detail - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended		12 Months Ended
	Mar. 31, 2015	Sep. 30, 2016	Sep. 30, 2015	Dec. 31, 2015
Schedule Of Investments In Marketable Securities [Line Items]
Securities in continuous unrealized loss position, period		longer than one year.
Depreciation expense		$ 400	$ 500
Intangible asset amortization expense		19,100	20,700
Impairment of intangible assets		$ 8,183		$ 8,183
Other Intangible Assets [Member]
Schedule Of Investments In Marketable Securities [Line Items]
Intangible asset amortization expense			27,900
FUSILEV [Member]
Schedule Of Investments In Marketable Securities [Line Items]
Impairment of intangible assets	$ 7,200		$ 7,200

Balance Sheet Account Detail 41

Balance Sheet Account Detail - Schedule of Property and Equipment Net of Accumulated Depreciation (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	$ 7,679	$ 7,620
(Less): Accumulated depreciation	(7,141)	(6,702)
Property and equipment, net of accumulated depreciation	538	918
Computer hardware and software [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	3,823	3,785
Laboratory equipment [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	622	608
Office furniture [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	354	355
Leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	$ 2,880	$ 2,872

Balance Sheet Account Detail 42

Balance Sheet Account Detail - Components of Inventories (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Jan. 31, 2016	Dec. 31, 2015
Inventory [Line Items]
Raw materials	$ 2,632		$ 1,606
Work-in-process	10,091		4,228
Finished goods	1,380		1,498
(Less:) Non-current portion of inventories included within other assets	(6,800)		(3,156)
Inventories	$ 7,303		$ 4,176
ZEVALIN [Member]
Inventory [Line Items]
Work-in-process		$ 3,400

Balance Sheet Account Detail 43

Balance Sheet Account Detail - Prepaid Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Prepaid operating expenses	$ 2,702	$ 3,507
Current portion of debt issuance costs	0	0
Prepaid expenses and other assets	2,702	3,507
Long-term Debt [Member] | Accounting Standards Update 2015-03 [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt issuance costs	1,700	2,200
Other Assets [Member] | Accounting Standards Update 2015-03 [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt issuance costs	$ (1,700)	$ (2,200)

Balance Sheet Account Detail 44

Balance Sheet Account Detail - Schedule of Other Receivables (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Income tax receivable	$ 1,264	$ 1,301
Insurance receivable	350	7,100
Mundipharma promissory note	0	2,215
CASI note - short term	1,500	0
Eagle receivable for services and support costs (Note 13)	1,896	0
Research and development expenses - reimbursements due	1,726	1,699
Other miscellaneous receivables	355	257
Other receivables	$ 7,091	$ 12,572

Balance Sheet Account Detail 45

Balance Sheet Account Detail - Components of Intangible Assets Net of Accumulated Amortization (Detail) - USD ($) $ in Thousands	Mar. 10, 2016	Mar. 31, 2016	Mar. 31, 2015	Jun. 30, 2013	Sep. 30, 2016	Sep. 30, 2015	Dec. 31, 2015
Product Rights [Line Items]
Historical Cost					$ 305,668		$ 305,668
Accumulated Amortization					(122,207)		(102,797)
Foreign Currency Translation					(3,818)		(4,353)
Impairment					(8,183)		(8,183)
Net Amount					171,460		190,335
Ligand Pharmaceuticals Inc [Member]
Product Rights [Line Items]
Milestone payments	$ 6,000	$ 6,000
MARQIBO IPR&D (NHL indication) [Member]
Product Rights [Line Items]
Historical Cost					17,600		17,600
Accumulated Amortization					0		0
Foreign Currency Translation					0		0
Impairment					0		0
Net Amount					17,600		17,600
EVOMELA distribution rights [Member]
Product Rights [Line Items]
Historical Cost					7,700		7,700
Accumulated Amortization					(296)		0
Foreign Currency Translation					0		0
Impairment					0		0
Net Amount					$ 7,404		7,700
Full Amortization Period (months)					156 months
Remaining Amortization Period (months)					150 months
BELEODAQ distribution rights [Member]
Product Rights [Line Items]
Historical Cost					$ 25,000		25,000
Accumulated Amortization					(4,219)		(2,812)
Foreign Currency Translation					0		0
Impairment					0		0
Net Amount					$ 20,781		22,188
Full Amortization Period (months)					160 months
Remaining Amortization Period (months)					133 months
MARQIBO distribution rights [Member]
Product Rights [Line Items]
Historical Cost					$ 26,900		26,900
Accumulated Amortization					(11,783)		(8,544)
Foreign Currency Translation					0		0
Impairment					0		0
Net Amount					$ 15,117		18,356
Full Amortization Period (months)					81 months
Remaining Amortization Period (months)					42 months
FOLOTYN distribution rights [Member]
Product Rights [Line Items]
Historical Cost					$ 118,400		118,400
Accumulated Amortization					(37,767)		(29,474)
Foreign Currency Translation					0		0
Impairment				$ (1,000)	0		0
Net Amount					$ 80,633		88,926
Full Amortization Period (months)					152 months
Remaining Amortization Period (months)					74 months
ZEVALIN distribution rights [Member] | United States [Member]
Product Rights [Line Items]
Historical Cost					$ 41,900		41,900
Accumulated Amortization					(33,214)		(30,608)
Foreign Currency Translation					0		0
Impairment					0		0
Net Amount					$ 8,686		11,292
Full Amortization Period (months)					123 months
Remaining Amortization Period (months)					30 months
ZEVALIN distribution rights [Member] | Ex-U.S. [Member]
Product Rights [Line Items]
Historical Cost					$ 23,490		23,490
Accumulated Amortization					(14,159)		(12,632)
Foreign Currency Translation					(3,818)		(4,353)
Impairment					0		0
Net Amount					$ 5,513		6,505
Full Amortization Period (months)					96 months
Remaining Amortization Period (months)					42 months
FUSILEV distribution rights [Member]
Product Rights [Line Items]
Historical Cost					$ 16,778		16,778
Accumulated Amortization					(9,618)		(9,618)
Foreign Currency Translation					0		0
Impairment					(7,160)		(7,160)
Net Amount					$ 0		0
Full Amortization Period (months)					56 months
Remaining Amortization Period (months)					0 months
FOLOTYN out-License [Member]
Product Rights [Line Items]
Historical Cost					$ 27,900		27,900
Accumulated Amortization					(11,151)		(9,109)
Foreign Currency Translation					0		0
Impairment					(1,023)		(1,023)
Net Amount					$ 15,726		$ 17,768
Full Amortization Period (months)					110 months
Remaining Amortization Period (months)					70 months
FUSILEV [Member]
Product Rights [Line Items]
Impairment			$ (7,200)			$ (7,200)
EVOMELA [Member]
Product Rights [Line Items]
Historical Cost		$ 7,700

Balance Sheet Account Detail 46

Balance Sheet Account Detail - Estimated Intangible Asset Amortization Expense (Detail) $ in Thousands	Sep. 30, 2016USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Remainder of 2016	$ 6,909
2,017	27,635
2,018	27,635
2,019	25,029
2,020	19,740
2,021	18,266
2022 and thereafter	28,646
Intangible Assets, Net Total	$ 153,860

Balance Sheet Account Detail 47

Balance Sheet Account Detail - Schedule of Goodwill (Detail) - USD ($) $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2016	Dec. 31, 2015
Goodwill [Line Items]
Foreign currency exchange translation effects	$ (380)	$ (437)
Goodwill	18,017	17,960
ZEVALIN Ex-U.S. Distribution Rights [Member]
Goodwill [Line Items]
Acquisition	2,525	2,525
Allos Therapeutics, Inc. [Member]
Goodwill [Line Items]
Acquisition	5,346	5,346
Talon [Member]
Goodwill [Line Items]
Acquisition	$ 10,526	$ 10,526

Balance Sheet Account Detail 48

Balance Sheet Account Detail - Summary of Other Assets (Detail) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Dec. 31, 2015
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Equity securities - CASI (see Note 10)	$ 9,146	$ 6,689
Supplies and deposits	181	185
2018 Convertible Notes issuance costs (excluding current portion)	0	0
Executive officer life insurance – cash surrender value	11,845	9,181
Inventories - non-current portion	6,800	3,156
Other miscellaneous assets	43	0
Other assets	28,015	19,211
Gross unrealized losses	3,000
Accounting Standards Update 2015-03 [Member] | Long-term Debt [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt issuance costs	$ 1,700	$ 2,200

Balance Sheet Account Detail 49

Balance Sheet Account Detail - Schedule of Accounts Payable and Other Accrued Liabilities (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Trade accounts payable and other accrued liabilities	$ 27,180	$ 26,684
Accrued rebates	10,130	18,166
Accrued product royalty	5,286	4,908
Allowance for returns	2,237	1,394
Accrued data and distribution fees	2,996	1,830
Accrued GPO administrative fees	342	1,058
Accrued inventory management fee	323	498
Allowance for chargebacks	1,483	2,001
Accounts payable and other accrued liabilities	$ 49,977	$ 56,539

Balance Sheet Account Detail 50

Balance Sheet Account Detail - Schedule of Amounts Presented in Accounts Payable and Other Accrued Liabilities (Detail) - USD ($) $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2016	Dec. 31, 2015
Rebates and Chargebacks [Member]
Accounts Payable and Other Liabilities [Roll Forward]
Beginning balance	$ 20,167	$ 45,822
Add: provisions	67,390	75,498
(Less): credits or actual allowances	(75,944)	(101,153)
Ending balance	11,613	20,167
Data and Distribution, GPO Fees, and Inventory Management Fees [Member]
Accounts Payable and Other Liabilities [Roll Forward]
Beginning balance	3,386	8,284
Add: provisions	10,235	15,928
(Less): credits or actual allowances	(9,960)	(20,826)
Ending balance	3,661	3,386
Returns [Member]
Accounts Payable and Other Liabilities [Roll Forward]
Beginning balance	1,394	1,135
Add: provisions	1,558	1,486
(Less): credits or actual allowances	(715)	(1,227)
Ending balance	$ 2,237	$ 1,394

Balance Sheet Account Detail 51

Balance Sheet Account Detail - Deferred Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Dec. 31, 2015	Sep. 30, 2016	Sep. 30, 2015
Deferred Revenue Arrangement [Line Items]
Deferred revenue		$ 6,513	$ 5,199
Mundipharma [Member]
Deferred Revenue Arrangement [Line Items]
Deferred revenue		0	1,700
EVOMELA [Member]
Deferred Revenue Arrangement [Line Items]
Deferred revenue		0	3,094
FUSILEV [Member]
Deferred Revenue Arrangement [Line Items]
Deferred revenue		6,083	0	$ 9,900
Revenue recognized	$ 6,100	3,800
Dr. Reddy
Deferred Revenue Arrangement [Line Items]
Deferred revenue		$ 430	$ 405

Balance Sheet Account Detail 52

Balance Sheet Account Detail - Summary of Other Long-Term Liabilities (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accrued executive deferred compensation	$ 7,797	$ 6,458
Deferred rent (non-current portion)	193	248
Clinical study holdback costs, non-current	44	0
Other tax liabilities	738	738
Other long-term liabilities	$ 8,772	$ 7,444

Gross-to-Net Product Sales - Re

Gross-to-Net Product Sales - Reconciliation of Gross-to-Net Product Sales (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenue, Net [Abstract]
Gross product sales	$ 61,513	$ 44,713	$ 175,963	$ 160,111
Commercial rebates and government chargebacks	(26,167)	(12,515)	(67,389)	(44,364)
Data and distribution fees, GPO fees, and inventory management fees	(4,234)	(3,503)	(10,235)	(12,709)
Prompt pay discounts	(300)	(15)	(380)	(16)
Product returns allowance	(540)	(223)	(1,558)	(1,008)
Net product sales	$ 30,272	$ 28,457	$ 96,401	$ 102,014

Net Product Sales by Geograph54

Net Product Sales by Geographic Region and Product Line, and Composition of License Fees and Service Revenue - Schedule of Product Sales, Net by Geography (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Segment Reporting Information [Line Items]
Product sales, net	$ 30,272	$ 28,457	$ 96,401	$ 102,014
Percentage of product sales, net	100.00%	100.00%	100.00%	100.00%
United States [Member]
Segment Reporting Information [Line Items]
Product sales, net	$ 29,576	$ 26,262	$ 93,392	$ 96,546
Percentage of product sales, net	97.70%	92.30%	96.90%	94.60%
Total International [Member]
Segment Reporting Information [Line Items]
Product sales, net	$ 696	$ 2,195	$ 3,009	$ 5,468
Percentage of product sales, net	2.30%	7.70%	3.10%	5.40%
Total International [Member] | Europe (ZEVALIN only) [Member]
Segment Reporting Information [Line Items]
Product sales, net	$ 696	$ 709	$ 3,009	$ 1,806
Percentage of product sales, net	2.30%	2.50%	3.10%	1.80%
Total International [Member] | Asia Pacific (ZEVALIN only)[Member]
Segment Reporting Information [Line Items]
Product sales, net	$ 0	$ 1,486	$ 0	$ 3,662
Percentage of product sales, net	0.00%	5.20%	0.00%	3.60%

Net Product Sales by Geograph55

Net Product Sales by Geographic Region and Product Line, and Composition of License Fees and Service Revenue - Schedule of Product Sales, Net by Product Line (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Segment Reporting Information [Line Items]
Product sales, net	$ 30,272	$ 28,457	$ 96,401	$ 102,014
Percentage of product sales, net	100.00%	100.00%	100.00%	100.00%
FUSILEV [Member]
Segment Reporting Information [Line Items]
Product sales, net	$ 4,893	$ 11,101	$ 30,568	$ 45,597
FOLOTYN [Member]
Segment Reporting Information [Line Items]
Product sales, net	11,315	8,722	35,577	30,261
ZEVALIN [Member]
Segment Reporting Information [Line Items]
Product sales, net	2,627	4,762	8,224	13,784
MARQIBO [Member]
Segment Reporting Information [Line Items]
Product sales, net	1,925	1,316	4,921	5,290
BELEODAQ [Member]
Segment Reporting Information [Line Items]
Product sales, net	3,635	2,556	10,326	7,082
EVOMELA [Member]
Segment Reporting Information [Line Items]
Product sales, net	$ 5,877	$ 0	$ 6,785	$ 0
Sales [Member]
Segment Reporting Information [Line Items]
Percentage of product sales, net	100.00%	100.00%	100.00%	100.00%
Sales [Member] | FUSILEV [Member]
Segment Reporting Information [Line Items]
Percentage of product sales, net	16.20%	39.00%	31.70%	44.70%
Sales [Member] | FOLOTYN [Member]
Segment Reporting Information [Line Items]
Percentage of product sales, net	37.40%	30.60%	36.90%	29.70%
Sales [Member] | ZEVALIN [Member]
Segment Reporting Information [Line Items]
Percentage of product sales, net	8.70%	16.70%	8.50%	13.50%
Sales [Member] | MARQIBO [Member]
Segment Reporting Information [Line Items]
Percentage of product sales, net	6.40%	4.60%	5.10%	5.20%
Sales [Member] | BELEODAQ [Member]
Segment Reporting Information [Line Items]
Percentage of product sales, net	12.00%	9.00%	10.70%	6.90%
Sales [Member] | EVOMELA [Member]
Segment Reporting Information [Line Items]
Percentage of product sales, net	19.40%	0.00%	7.00%	0.00%

Net Product Sales by Geograph56

Net Product Sales by Geographic Region and Product Line, and Composition of License Fees and Service Revenue - By Product Line (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Concentration Risk [Line Items]
License fees and service revenue	$ 3,121	$ 170	$ 14,807	$ 10,212
License fees and service revenues	100.00%	100.00%	100.00%	100.00%
Sales Revenue, Services, Net [Member]
Concentration Risk [Line Items]
License fees and service revenues	100.00%	100.00%	100.00%	100.00%
Out-license to Servier in Canada territory [Member]
Concentration Risk [Line Items]
License fees and service revenue	$ 0	$ 0	$ 6,000	$ 0
Out-license to Servier in Canada territory [Member] | Sales Revenue, Services, Net [Member]
Concentration Risk [Line Items]
License fees and service revenues	0.00%	0.00%	40.50%	0.00%
Co-Promotion With Eagle [Member]
Concentration Risk [Line Items]
License fees and service revenue		$ 0	$ 6,737	$ 0
Co-Promotion With Eagle [Member] | Sales Revenue, Services, Net [Member]
Concentration Risk [Line Items]
License fees and service revenues	77.10%	0.00%	45.50%	0.00%
Out-license to Mundipharma in China and other ex-U.S. territories[Member]
Concentration Risk [Line Items]
License fees and service revenue	$ 703	$ 158	$ 2,013	$ 493
Out-license to Mundipharma in China and other ex-U.S. territories[Member] | Sales Revenue, Services, Net [Member]
Concentration Risk [Line Items]
License fees and service revenues	22.50%	92.90%	13.60%	4.80%
CASI Out-License [Member]
Concentration Risk [Line Items]
License fees and service revenue	$ 0	$ 0	$ 0	$ 9,682
CASI Out-License [Member] | Sales Revenue, Services, Net [Member]
Concentration Risk [Line Items]
License fees and service revenues	0.00%	0.00%	0.00%	94.80%
Other license fees and service revenue [Member]
Concentration Risk [Line Items]
License fees and service revenue	$ 12	$ 12	$ 57	$ 37
Other license fees and service revenue [Member] | Sales Revenue, Services, Net [Member]
Concentration Risk [Line Items]
License fees and service revenues	0.40%	7.10%	0.40%	0.40%

Stock-Based Compensation - Summ

Stock-Based Compensation - Summary of Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	$ 3,150	$ 2,500	$ 9,754	$ 8,490
Cost of Sales [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	30	21	84	43
Research and development [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	470	474	1,461	1,326
Selling, general and administrative [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	$ 2,650	$ 2,005	$ 8,209	$ 7,121

Net Loss Per Share - Computatio

Net Loss Per Share - Computation of Net Loss Per Share (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Earnings Per Share [Abstract]
Net loss	$ (17,455)	$ (18,724)	$ (51,070)	$ (46,632)
Weighted average shares - basic and diluted (shares)	79,303,380	65,855,727	70,437,885	65,457,060
Net loss per share - basic and diluted ($ per share)	$ (0.22)	$ (0.28)	$ (0.73)	$ (0.71)

Net Loss Per Share - Schedule o

Net Loss Per Share - Schedule of Securities Excluded from Calculation of Net Loss Per Share (Detail) - shares	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	15,613,845	14,550,078	15,510,525	14,451,337
Preferred stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	0	40,000	0	40,000
Common stock warrants [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	0	59,853	1,674	45,121
2018 Convertible Notes [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	11,401,284	11,401,284	11,401,284	11,401,284
Common stock options [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	1,603,028	1,591,709	1,498,034	1,507,700
Restricted stock awards [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	2,609,533	1,457,232	2,609,533	1,457,232

Fair Value Measurements - Summa

Fair Value Measurements - Summary of Asset and Liability Fair Values (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Assets:
Marketable securities, fair value	$ 45
Total Assets	164,754	$ 94,731
Liabilities:
Deferred executive compensation liability	7,797	6,458
Drug development liability (Note 15)	14,160
Drug development liability		14,686
Ligand Contingent Consideration		5,227
Talon CVR (Note 9(a))	1,853	1,377
Corixa Liability	62	62
Total Liabilities	23,872	27,810
Bank CDs [Member]
Assets:
Marketable securities, fair value	5,246	245
Money market currency funds [Member]
Assets:
Marketable securities, fair value	138,472	80,116
Equity securities [Member]
Assets:
Marketable securities, fair value	9,146	5,189
Deferred compensation investments, including life insurance cash surrender value [Member]
Assets:
Marketable securities, fair value	11,845	9,181
Level 1 [Member]
Assets:
Total Assets	9,146	5,189
Level 1 [Member] | Equity securities [Member]
Assets:
Marketable securities, fair value	9,146	5,189
Level 2 [Member]
Assets:
Marketable securities, fair value	45
Total Assets	155,608	89,542
Liabilities:
Deferred executive compensation liability	7,797	6,458
Total Liabilities	7,797	6,458
Level 2 [Member] | Bank CDs [Member]
Assets:
Marketable securities, fair value	5,246	245
Level 2 [Member] | Money market currency funds [Member]
Assets:
Marketable securities, fair value	138,472	80,116
Level 2 [Member] | Deferred compensation investments, including life insurance cash surrender value [Member]
Assets:
Marketable securities, fair value	11,845	9,181
Level 3 [Member]
Assets:
Total Assets	0	0
Liabilities:
Drug development liability (Note 15)	14,160
Drug development liability		14,686
Ligand Contingent Consideration		5,227
Talon CVR (Note 9(a))	1,853	1,377
Corixa Liability	62	62
Total Liabilities	$ 16,075	$ 21,352

Fair Value Measurements - Fair

Fair Value Measurements - Fair Value Measurement Activity for Liabilities Utilize Level 3 Inputs (Detail) - USD ($) $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2016	Dec. 31, 2015
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
December 31, 2015	$ 21,352	$ 23,127
Settlement of Ligand Contingent Consideration liability (see Note 9(b))	(6,000)
September 30, 2016	16,075	21,352
Deferred development costs [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Increase/decrease	(526)	(1,099)
Ligand Contingent Consideration [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Increase/decrease	773	326
Talon CVR [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Increase/decrease	$ 476	$ (1,002)

Business Combinations and Con62

Business Combinations and Contingent Consideration - Additional Information (Detail) - USD ($) $ / shares in Units, shares in Millions	Mar. 10, 2016	Jul. 17, 2013	Sep. 05, 2012	Mar. 31, 2016	Mar. 31, 2013	Mar. 31, 2016	Sep. 30, 2016	Sep. 30, 2015	Dec. 31, 2015
Business Acquisition [Line Items]
License fees received					$ 3,000,000
Ligand Contingent Consideration									$ 5,227,000
Historical Cost							$ 305,668,000		305,668,000
Acquisition related contingent obligations							(1,300,000)	$ 0
In-process research and development [Member]
Business Acquisition [Line Items]
Estimated cash flow period					10 years
Estimated cash flow discount rate					25.00%
Ligand Pharmaceuticals Inc [Member]
Business Acquisition [Line Items]
Milestone payments	$ 6,000,000			$ 6,000,000
Melphalan In Process Research and Development [Member]
Business Acquisition [Line Items]
Historical Cost							$ 7,700,000		$ 7,700,000
Minimum [Member]
Business Acquisition [Line Items]
Royalties payout percentage on our future net sales of licensed products							20.00%
Milestone Payments [Member]
Business Acquisition [Line Items]
Milestone payments		$ 5,000,000					$ 60,000,000
Milestone net sales achievement		30,000,000
Ligand Contingent Consideration				$ 6,000,000		$ 6,000,000
Milestone Payment One [Member]
Business Acquisition [Line Items]
Milestone payments		10,000,000
Milestone net sales achievement		60,000,000
Milestone Payment Two [Member]
Business Acquisition [Line Items]
Milestone payments		25,000,000
Milestone net sales achievement		100,000,000
Milestone Payment Three [Member]
Business Acquisition [Line Items]
Milestone payments		50,000,000
Milestone net sales achievement		200,000,000
Milestone Payment Four [Member]
Business Acquisition [Line Items]
Milestone payments		100,000,000
Milestone net sales achievement		400,000,000
Menadione Topical Lotion [Member]
Business Acquisition [Line Items]
Milestone payments		5,000,000
Talon Therapeutics, Inc. [Member]
Business Acquisition [Line Items]
Additional shares business acquisition date							Jul. 17, 2013
Cash consideration		$ 11,300,000
Shares issued in acquisition (shares)		3
Common stock value assigned		$ 26,300,000
Common stock value, per share ($ per share)		$ 8.77
Estimated fair value of acquisition		$ 6,500,000
Contingent value rights future cash payments		$ 195,000,000					$ 195,000,000
Talon Therapeutics, Inc. [Member] | Minimum [Member]
Business Acquisition [Line Items]
Contingent value rights expected rate		50.00%
Talon Therapeutics, Inc. [Member] | Maximum [Member]
Business Acquisition [Line Items]
Contingent value rights expected rate		100.00%
Ligand Pharmaceuticals Inc [Member]
Business Acquisition [Line Items]
Ligand Contingent Consideration							$ 6,000,000
Acquisition related contingent obligations						$ 800,000
Allos Therapeutics, Inc. [Member]
Business Acquisition [Line Items]
Cash consideration			$ 205,200,000

Business Combinations and Con63

Business Combinations and Contingent Consideration - Change in Fair Value of Contingent Consideration Related to Acquisitions (Detail) $ in Thousands	9 Months Ended
	Sep. 30, 2016USD ($)
Change in Fair Value of Contingent Consideration [Roll Forward]
December 31, 2015	$ 21,352
September 30, 2016	16,075
Contingent Consideration [Member]
Change in Fair Value of Contingent Consideration [Roll Forward]
Payment to Ligand in April 2016	(6,000)
Contingent Consideration [Member] | Talon Therapeutics, Inc. [Member]
Change in Fair Value of Contingent Consideration [Roll Forward]
December 31, 2015	1,377
Fair value adjustment for the nine months ended September 30, 2016	476
September 30, 2016	1,853
Contingent Consideration [Member] | Ligand Pharmaceuticals Inc [Member]
Change in Fair Value of Contingent Consideration [Roll Forward]
December 31, 2015	5,227
Fair value adjustment for the nine months ended September 30, 2016	773
September 30, 2016	$ 0

Business Combinations and Con64

Business Combinations and Contingent Consideration - Acquisition-Date Fair Value of Consideration Transferred (Detail) - Captisol-enabled, propylene glycol-free melphalan rights [Member] $ in Thousands	1 Months Ended
	Mar. 31, 2013USD ($)
Business Acquisition [Line Items]
Cash consideration	$ 3,000
Ligand Contingent Consideration	4,700
Total purchase consideration	$ 7,700

Business Combinations and Con65

Business Combinations and Contingent Consideration - Summary of Allocation of Total Purchase Price to Net Assets Acquired (Detail) - Captisol-enabled, propylene glycol-free melphalan rights [Member] - USD ($) $ in Thousands	Sep. 30, 2016	Mar. 31, 2013
Business Acquisition, Contingent Consideration [Line Items]
Total purchase consideration		$ 7,700
In-process research and development [Member]
Business Acquisition, Contingent Consideration [Line Items]
Total purchase consideration	$ 7,700

Out-License of Marqibo, Zeval66

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI - Additional Information (Detail) - CASI Out-License [Member] shares in Millions	Sep. 17, 2014productagreementshares	Jul. 31, 2016shares	Feb. 29, 2016shares	Sep. 30, 2016shares
Other Commitments [Line Items]
Number of agreements | agreement	3
Number of products | product	2
License agreement description				Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities.
Shares received (shares) | shares	5.4	1.1	1.7	8.2

Out-License of Marqibo, Zeval67

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI - Schedule of Proceeds Received and Fair Value on CASI Out-License Execution Date (Detail) - USD ($) $ / shares in Units, shares in Millions	Sep. 17, 2014	Jul. 31, 2016	Feb. 29, 2016	Sep. 30, 2016	Dec. 31, 2015
Other Commitments [Line Items]
Fair value				$ 9,146,000	$ 6,689,000
Secured Promissory Note Due March 17, 2016 [Member]
Other Commitments [Line Items]
Debt instrument face value	$ 1,500,000
CASI Out-License [Member]
Other Commitments [Line Items]
Total consideration received	$ 9,959,000
Shares received (shares)	5.4	1.1	1.7	8.2
Share price ($ per share)	$ 1.6
CASI Out-License [Member] | Secured Promissory Note Due March 17, 2016 [Member]
Other Commitments [Line Items]
Total consideration received	$ 1,310,000
Debt instrument coupon rate	0.50%
CASI Out-License [Member] | Common Stock [Member]
Other Commitments [Line Items]
Total consideration received	$ 8,649,000
Fair value				$ 9,100,000

Out-License Of Zevalin In Cer68

Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma (Details) - USD ($) $ in Thousands	Nov. 16, 2015	Dec. 31, 2015	Sep. 30, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue		$ 6,513	$ 5,199
Zevalin Rights [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential payment	$ 2,000
Zevalin Rights [Member] | Total Consideration [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	18,000
Milestone net sales achievement		$ 15,000
Zevalin Rights [Member] | Payment One [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	15,000
Zevalin Rights [Member] | Payment Two [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	3,000
Milestone net sales achievement			1,300
Deferred revenue			$ 1,700
Mundipharma [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Proceeds from sale of business	$ 2,200

Out-License Of Zevalin, Folot69

Out-License Of Zevalin, Folotyn, Beleodaq, And Marqibo In Canada Territory To Servier (Details) $ in Millions	3 Months Ended
	Mar. 31, 2016USD ($)
ZEVALIN, FOLOTYN, BELEODAQ, And MARQIBO [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	$ 6

Co-Promotion Arrangement With70

Co-Promotion Arrangement With Eagle Pharmaceuticals (Details) $ in Thousands	Nov. 04, 2015USD ($)product	Sep. 30, 2016USD ($)	Sep. 30, 2015USD ($)	Jun. 30, 2017USD ($)	Sep. 30, 2016USD ($)	Sep. 30, 2015USD ($)	Dec. 31, 2016USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
License fees and service revenue		$ 3,121	$ 170		$ 14,807	$ 10,212
Collaborative Arrangement, Co-promotion [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of products | product	6
Term of contract	18 months
Fixed payment	$ 12,800
Milestone net sales achievement					6,700
License fees and service revenue		2,400
Reimbursable expense		$ 2,200			$ 5,700
Extension term	6 months
Termination notice	60 days
Maximum [Member] | Scenario, Forecast [Member] | Collaborative Arrangement, Co-promotion [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone net sales achievement				$ 4,000			$ 5,000

Convertible Senior Notes - Addi

Convertible Senior Notes - Additional Information (Detail) - USD ($)	Dec. 17, 2013	Sep. 30, 2016	Dec. 31, 2015
Debt Disclosure [Line Items]
Additional paid-in capital		$ 638,006,000	$ 552,108,000
Common shares sold (shares)		$ 80,000	68,000
2.75% Convertible Senior Notes Due 2018 [Member]
Debt Disclosure [Line Items]
Interest rate	2.75%	2.75%
Sale of convertible notes, principal amount	$ 120,000,000
Conversion rate, shares (shares)		95
Conversion rate, price per share ($ per share)		$ 1,000
Money conversion price per share ($ per share)		$ 10.53
Convertible senior notes maturity date		Dec. 15, 2018
Net proceeds from convertible notes	115,400,000
Professional fee	$ 4,600,000
Additional paid-in capital		$ 13,100,000
Common shares converted value (shares)		$ 11,400,000
Strike price per share ($ per share)		$ 14.03
Common shares sold (shares)		$ 11,400,000
Threshold percentage of conversion price		130.00%
Convertible senior notes trading price		$ 1,000
Percentage of product of last reported sale price of common stock		98.00%
Convertible senior notes conversion description		Prior to June 15, 2018, holders may convert all or a portion of their 2018 Convertible Notes only under any of the following circumstances: (1) during any fiscal quarter (and only during such fiscal quarter), if, for at least 20 trading days (whether or not consecutive) during the 30 consecutive trading day period ending on the last trading day of the immediately preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than or equal to 130% of the Notes' conversion price on such trading day; (2) during the five consecutive business day period immediately following any five consecutive trading day period in which, for each trading day of that measurement period, the trading price per $1,000 principal amount of 2018 Convertible Notes for such trading day was less than 98% of the product of (i) the last reported sale price of our common stock on such trading day and (ii) the Notes' conversion rate on such trading day; (3) upon the occurrence of certain corporate transactions; and (4) at any time prior to our stockholders’ approval to settle the 2018 Convertible Notes in our common shares and/or cash.
2.75% Convertible Senior Notes Due 2018 [Member] | Minimum [Member]
Debt Disclosure [Line Items]
Debt convertible trading days		20 days
Debt convertible consecutive trading days		5 days
2.75% Convertible Senior Notes Due 2018 [Member] | Maximum [Member]
Debt Disclosure [Line Items]
Debt convertible consecutive trading days		30 days
2018 Convertible Notes [Member]
Debt Disclosure [Line Items]
Fair value		$ 106,500,000	$ 105,100,000

Convertible Senior Notes - Carr

Convertible Senior Notes - Carrying Value of 2018 Convertible Notes (Detail) - 2018 Convertible Notes [Member] $ in Thousands	Sep. 30, 2016USD ($)
Debt Instrument [Line Items]
Principal amount	$ 120,000
(Less): Unamortized debt discount (amortized through December 2018)	(14,206)
(Less): Debt issuance costs (see Note 3(d))	(1,650)
September 30, 2016 carrying value	$ 104,144

Convertible Senior Notes - Comp

Convertible Senior Notes - Components of the Interest Expense Recognized (Detail) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015
Debt Disclosure [Abstract]
Contractual coupon interest expense	$ 2,475
Amortization of debt issuance costs	521	$ 493
Accretion of debt discount	4,246	$ 3,895
Total	$ 7,242
Effective interest rate	8.66%

Mundipharma Agreement And Dru74

Mundipharma Agreement And Drug Development Liability - Additional Information (Detail) - USD ($) $ in Thousands	May 29, 2013	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Company determined development payment		$ 49,389	$ 44,701	$ 155,567	$ 149,995
Mundipharma [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Company determined development payment	$ 7,000
Maximum [Member] | Regulatory [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments				16,000
Maximum [Member] | Commercial progress and sales-dependent [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments				$ 107,000

Mundipharma Agreement And Dru75

Mundipharma Agreement And Drug Development Liability - Schedule of Drug Development Liability Adjustments (Detail) $ in Thousands	9 Months Ended
	Sep. 30, 2016USD ($)
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	$ 259
Balance at September 30, 2016	156
FOLOTYN [Member]
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	14,686
Transfer from long-term to current in 2016	0
(Less): Expenses incurred in 2016	(526)
Balance at September 30, 2016	14,160
FOLOTYN [Member] | Drug Development Liability Current [Member]
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	259
Transfer from long-term to current in 2016	423
(Less): Expenses incurred in 2016	(526)
Balance at September 30, 2016	156
FOLOTYN [Member] | Drug Development Liability Long Term [Member]
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	14,427
Transfer from long-term to current in 2016	(423)
(Less): Expenses incurred in 2016	0
Balance at September 30, 2016	$ 14,004

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) € in Millions

Apr. 26, 2016USD ($)shares

Apr. 13, 2016USD ($)

Mar. 10, 2016USD ($)

Nov. 16, 2015USD ($)

Jun. 27, 2014USD ($)

Jun. 19, 2014defendantANDA

Mar. 31, 2016USD ($)

Feb. 28, 2014USD ($)

Apr. 30, 2012EUR (€)

Nov. 30, 2009USD ($)

Oct. 31, 2008USD ($)shares

Mar. 31, 2016USD ($)

Dec. 31, 2015USD ($)

Mar. 31, 2014USD ($)

Sep. 30, 2016USD ($)shares

Sep. 30, 2016USD ($)Country

Sep. 30, 2015USD ($)

Dec. 31, 2010USD ($)

Jul. 31, 2014USD ($)

Jul. 17, 2013USD ($)

May 31, 2006USD ($)

Long-term Purchase Commitment [Line Items]

Potential milestone achievement

$ 100,000

$ 100,000

$ 100,000

Deferred revenue

6,513,000

5,199,000

5,199,000

Amount receivable on approval of oral form of FUSILEV

$ 200,000

Additional license fees

60,000,000

Acquisition-related contingent obligations, less current portion

1,439,000

$ 1,915,000

1,915,000

Common stock issued (shares) | shares

10,890,915

Consideration paid for the rights granted (shares)

$ 1,000,000

Cash paid for income taxes

11,000

$ 332,000

Deferrals and contributions

6,500,000

$ 7,800,000

$ 7,800,000

FOLOTYN ANDA [Member]

Long-term Purchase Commitment [Line Items]

Number of defendants | defendant

5

Number of Abbreviated New Drug Applications | ANDA

4

FOLOTYN [Member]

Long-term Purchase Commitment [Line Items]

Percentage of royalty on annual worldwide sales under condition one

8.00%

8.00%

Percentage of royalty on annual worldwide sales under condition two

9.00%

9.00%

Percentage of royalty on annual worldwide sales under condition three

11.00%

11.00%

Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Potential payment

$ 2,000,000

ZEVALIN, FOLOTYN, BELEODAQ, And MARQIBO [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

$ 6,000,000

Total Consideration [Member] | Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

18,000,000

Milestone net sales achievement

15,000,000

Payment One [Member] | Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

15,000,000

Payment Two [Member] | Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

$ 3,000,000

Milestone net sales achievement

$ 1,300,000

Deferred revenue

$ 1,700,000

1,700,000

Ligand Pharmaceuticals Inc [Member]

Long-term Purchase Commitment [Line Items]

Milestone payments

$ 6,000,000

$ 6,000,000

ZEVALIN [Member]

Long-term Purchase Commitment [Line Items]

Milestone payments

$ 5,000,000

ZEVALIN [Member] | Licensing Agreements [Member]

Long-term Purchase Commitment [Line Items]

Minimum number of countries outside U.S. approved ZEVALIN for treatment | Country

40

Fees paid to Bayer for acquiring licensing rights | €

€ 19

Percentage of royalty

20.00%

License agreement contractual terms

15 years

Talon Therapeutics, Inc. [Member]

Long-term Purchase Commitment [Line Items]

Acquisition-related contingent obligations, less current portion

$ 1,400,000

1,900,000

$ 1,900,000

Contingent value rights future cash payments

195,000,000

195,000,000

$ 195,000,000

SPI-2012 [Member]

Long-term Purchase Commitment [Line Items]

Milestone payments

$ 2,700,000

$ 1,900,000

Potential milestone achievement

$ 238,000,000

238,000,000

Issuance (shares) | shares

318,750

Cash paid for income taxes

$ 400,000

Poziotinib [Member] | Licensing Agreements [Member]

Long-term Purchase Commitment [Line Items]

Milestone net sales achievement

$ 358,000,000

Minimum [Member]

Long-term Purchase Commitment [Line Items]

Percentage of royalty on annual worldwide sales under condition one

20.00%

20.00%

Percentage of royalties on net sale of licensed products

20.00%

Minimum [Member] | FOLOTYN [Member]

Long-term Purchase Commitment [Line Items]

Amount of annual worldwide sales on which royalty is payable under condition two

$ 150,000,000

Amount of annual worldwide sales on which royalty is payable under condition three

300,000,000

Maximum [Member] | FOLOTYN [Member]

Long-term Purchase Commitment [Line Items]

Amount of annual worldwide sales on which royalty is payable under condition one

150,000,000

Amount of annual worldwide sales on which royalty is payable under condition two

$ 300,000,000

INDIA | ZEVALIN [Member] | Licensing Agreements [Member]

Long-term Purchase Commitment [Line Items]

Percentage of royalty

20.00%

License agreement contractual terms

15 years

Up-front non-refundable payment

$ 500,000

Recognition period for upfront payment

10 years

Licenses revenue

$ 3,000,000

Allergan [Member]

Long-term Purchase Commitment [Line Items]

Up-front non-refundable payment

$ 41,500,000

License fee

300,000

Allergan [Member] | Common Class A

Long-term Purchase Commitment [Line Items]

Stock issued

$ 100,000

Common stock issued (shares) | shares

25,000

Nippon Kayaku [Member]

Long-term Purchase Commitment [Line Items]

Upfront fee

$ 15,000,000

Payment related to agreement

10,000,000

Payment on achievement of commercialization milestones

126,000,000

TopoTarget [Member]

Long-term Purchase Commitment [Line Items]

Potential milestone achievement

$ 278,000,000

$ 278,000,000

Upfront fee

$ 30,000,000

Percentage of development cost

70.00%

Percentage of development cost that is funded by TopoTarget for joint development plan

30.00%

Additional payments based on the achievement of certain development

$ 10,000,000

Aggregate payout value

$ 17,800,000

Second milestone payment

$ 25,000,000

Principal executive office [Member] | Nevada [Member]

Long-term Purchase Commitment [Line Items]

Facility lease, non-cancelable operating lease expiring date

Apr. 30, 2019

Research and development facility [Member] | California [Member]

Long-term Purchase Commitment [Line Items]

Facility lease, non-cancelable operating lease expiring date

May 31, 2019

Income Taxes - Additional Infor

Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Income Tax Disclosure [Abstract]
Provision for income taxes	$ (464)	$ (78)	$ (635)	$ 37
U.S. federal statutory tax rate			35.00%
Tax on currency transactions	$ 300		$ 900

Stockholders' Equity (Details)

Stockholders' Equity (Details) - USD ($)	Dec. 23, 2015	Jun. 30, 2016	Sep. 30, 2016	Sep. 30, 2016	Sep. 30, 2015	Dec. 31, 2015
Class of Stock [Line Items]
Maximum proceeds	$ 100,000,000
No. of Common Shares Issued (in shares)			10,890,915
Proceeds Received (Net of Broker Commissions and Fees )			$ 73,869,000	$ 73,869,000	$ 0
Series E Preferred Stock [Member]
Class of Stock [Line Items]
Outstanding (shares)		20
Issued in conversion (shares)		40,000	40,000	40,000		40,000
Dividends in arrears		$ 6,000