Spectrum Pharmaceuticals (SPPI) S-3 Shelf registration

Exhibit 12.1

	YTD			Year End.			Year End.			Year End.			Year End.			Year End.
	2009			2008			2007			2006			2005			2004
RATIO OF EARNINGS TO FIXED CHARGES:
Earnings:
Pretax (loss)	$	(17,471	)	$	(15,467	)	$	(34,016	)	$	(23,281	)	$	(18,641	)	$	(12,290	)
Add:
Interest expense		22			36			4			3			0			2
Interest factor of rental expense (b)		147			178			175			100			100			131
Total Earnings		(17,302	)		(15,253	)		(33,837	)		(23,179	)		(18,541	)		(12,157	)
Fixed Charges:
Interest expense		22			36			4			3			0			2
Interest factor of rental expense (b)		147			178			175			100			100			131
Total fixed charges		169			214			179			102			100			133
Deficiency of earnings to cover fixed charges	$	(17,471	)	$	(15,467	)	$	(34,016	)	$	(23,281	)	$	(18,641	)	$	(12,290	)
RATIO OF EARNINGS TO FIXED CHARGES AND PREFERRED STOCK DIVIDENDS
Earnings	$	(17,302	)	$	(15,253	)	$	(33,837	)	$	(23,179	)	$	(18,541	)	$	(12,157	)
Fixed Charges:
Interest expense		22			36			4			3			0			2
Preference security dividends (a)		—			—			—			—			—			—
Interest factor of rental expense (b)		147			178			175			100			100			131
Preferred stock expense (c)		—			—			19			161			212			270
Total fixed charges & dividends		169			214			199			263			312			403
Deficiency to cover fixed charges and preferred dividends	$	(17,471	)	$	(15,467	)	$	(34,035	)	$	(23,442	)	$	(18,853	)	$	(12,560	)
(a) COMPUTATION OF PREFERENCE SECURITY DIVIDENDS:
Consolidated subsidiary preferred dividends
Tax effect		60	%		60	%		60	%		60	%		60	%		60	%
Total		—			—			—			—			—			—
(b) COMPUTATION OF INTEREST FACTOR OF RENTAL EXPENSE:
Operating rental expense	$	442			536			529			301			302			394
Interest factor		33	%		33	%		33	%		33	%		33	%		33	%
Total		147			178			175			100			100			131
(c) COMPUTATION OF PREFERRED STOCK EXPENSE:
Preferred dividends	$	—			—			12			96			127			162
Tax effect		60	%		60	%		60	%		60	%		60	%		60	%
Total		—			—			19			161			212			270