| Cover | May 31, 2024 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | May 31, 2024 |
| Entity File Number | 0-22182 |
| Entity Registrant Name | MOSAIC IMMUNOENGINEERING, INC. |
| Entity Central Index Key | 0000836564 |
| Entity Tax Identification Number | 84-1070278 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 9114 Adams Ave. |
| Entity Address, City or Town | Huntington Beach |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 94646 |
| City Area Code | (657) |
| Local Phone Number | 208-0890 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | false |
