 NASDAQ 19 th Investor Program Jack W. Cumming Chairman & CEO June 2007 Filed by Hologic, Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 of the Securities Exchange Act of 1934 Subject Company: Cytyc Corporation Commission File No.: 000-27558 |
 Disclaimer Regarding Forward-Looking Statements Information set forth in this communication contains forward-looking statements, which involve a number of risks and uncertainties. Such forward-looking statements include, but are not limited to, statements about the anticipated benefits of Hologic’s products, the timing of the completion of the transaction between Hologic and Cytyc, the anticipated benefits of the business combination transaction involving Hologic and Cytyc, including future financial and operating results, the expected permanent financing for the transaction, the combined company's plans, objectives, expectations and intentions and other statements that are not historical facts. Hologic and Cytyc caution readers that any forward-looking information is not a guarantee of future performance and that actual results could differ materially from those contained in the forward-looking information. These include risks and uncertainties relating to: the ability to obtain regulatory approvals of the transaction on the proposed terms and schedule; the parties may be unable to complete the transaction because conditions to the closing of the transaction may not be satisfied; the risk that the businesses will not be integrated successfully; the transaction may involve unexpected costs or unexpected liabilities; the risk that the cost savings and any other synergies from the transaction may not be fully realized or may take longer to realize than expected; disruption from the transaction making it more difficult to maintain relationships with customers, employees or suppliers; competition and its effect on pricing, spending, third-party relationships and revenues; the need to develop new products and adapt to significant technological change; implementation of strategies for improving internal |
 Disclaimer Regarding Forward-Looking Statements (continued) growth; use and protection of intellectual property; dependence on customers' capital spending policies and government funding policies, including third-party reimbursement; realization of potential future savings from new productivity initiatives; general worldwide economic conditions and related uncertainties; future legislative, regulatory, or tax changes as well as other economic, business and/or competitive factors; and the effect of exchange rate fluctuations on international operations. In addition, the transaction will require the combined company to obtain significant financing. While Hologic has obtained a commitment to obtain such financing, including a bridge to the permanent financing contemplated in the presentation, the combined company’s liquidity and results of operations could be materially adversely affected if such financing is not available on favorable terms. Moreover, the substantial leverage resulting from such financing will subject the combined company’s business to additional risks and uncertainties. The risks included above are not exhaustive. The annual reports on Form 10-K, the quarterly reports on Form 10-Q, current reports on Form 8-K and other documents Hologic and Cytyc have filed with the SEC contain additional factors that could impact the combined company’s businesses and financial performance. The parties expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in the parties’ expectations or any change in events, conditions or circumstances on which any such statement is based. |
 Important Information for Investors and Stockholders Hologic and Cytyc will file a joint proxy statement/prospectus with the SEC in connection with the proposed merger. HOLOGIC AND CYTYC URGE INVESTORS AND STOCKHOLDERS TO READ THE JOINT PROXY STATEMENT/PROSPECTUS WHEN IT BECOMES AVAILABLE AND ANY OTHER RELEVANT DOCUMENTS FILED BY EITHER PARTY WITH THE SEC BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION. Investors and stockholders will be able to obtain the joint proxy statement/prospectus and other documents filed with the SEC free of charge at the website maintained by the SEC at www.sec.gov. In addition, documents filed with the SEC by Hologic will be available free of charge on the investor relations portion of the Hologic website at www.hologic.com. Documents filed with the SEC by Cytyc will be available free of charge on the investor relations portion of the Cytyc website at www.cytyc.com. |
 Participants in the Solicitation Hologic, and certain of its directors and executive officers, may be deemed participants in the solicitation of proxies from the stockholders of Hologic in connection with the merger. The names of Hologic’s directors and executive officers and a description of their interests in Hologic are set forth in the proxy statement for Hologic’s 2006 annual meeting of stockholders, which was filed with the SEC on January 25, 2007. Cytyc, and certain of its directors and executive officers, may be deemed to be participants in the solicitation of proxies from its stockholders in connection with the merger. The names of Cytyc’s directors and executive officers and a description of their interests in Cytyc is set forth in Cytyc’s Annual Report on Form 10-K/A for the fiscal year ended December 31, 2006, which was filed with the SEC on April 30, 2007. Investors and stockholders can obtain more detailed information regarding the direct and indirect interests of Hologic’s and Cytyc’s directors and executive officers in the merger by reading the definitive joint proxy statement/prospectus when it becomes available. |
 Use of Non-GAAP Financial Measures In addition to the financial measures prepared in accordance with generally accepted accounting principles (GAAP), we use the non-GAAP financial measures "adjusted EPS" and “EBITDA”. Adjusted EPS excludes the write-off and amortization of acquisition-related intangible assets, and tax provisions/benefits related thereto. EBITDA is defined as net earnings (loss) before interest, taxes, depreciation and amortization expense. Neither adjusted EPS nor EBITDA is a measure of operating performance under GAAP. We believe that the use of these non-GAAP measures helps investors to gain a better understanding of our core operating results and future prospects, consistent with how management measures and forecasts our performance, especially when comparing such results to previous periods or forecasts. When analyzing our operating performance, investors should not consider these non-GAAP measures as a substitute for net income prepared in accordance with GAAP. |
 A History of Innovation Delphi HOLOGIC Goes Public Acquisition of Trex Medical Including LORAD Selenia Launched in U.S. Introduced 3D DEXA Acquisition of R2, Suros and AEG Fan-Beam Technology Founding of HOLOGIC Announced Agreement with Cytyc Introduced Tomosynthesis at RSNA Launched Discovery Acquisition of Direct Radiography 1986 1990 1995 1998 1999 2000 2002 2003 2004 2005 2006 2007 $463M $288M $720E $229M |
 Financial Overview Record Q2 FY07 revenues of $180 million Record Q2 FY07 pre-tax income of $33.9 million Backlog of $216 million as of quarter-end 3/31/07 Q2 FY07 Performance (March 31st) up 79% over Q2 FY06 up 94% over Q2 FY06 up 41% or $63 million over 3/25/06 Strong Growth |
 Up 99% Over 1 st Half FY06 Mammography / Breast Health Recognized technology leader worldwide Market share leader in the U.S. > 55% share in analog/digital 78% of total revenues Unsurpassed image quality – High transmission cellular grid - patented Largest installed base – 13,000 system $129 $189 $270 $336 '04 '05 '06 1st Half '07 Fiscal Year Mammography/Breast Care Revenue $ in Millions Up 77% Over FY05 |
 MQSA U.S. Scorecard* (Mammography Quality Standards Act of 1992) Total Certified Facilities 8,812 Total Accredited Units 13,446 Certified Facilities with FFDM Units 1,884 21.4% Accredited FFDM Units 2,773 20.6% Total U.S. Annual = 34.8 Million Mammography Procedures Hologic U.S. Installed Base approximately 45% of FFDM units *(http://www.fda.gov/cdrh/mammography) Certified Statistics as of June 1, 2007 |
 Product Pipeline Interventional products to address extraction of benign fibroid adenomas – 350-500k procedures per year Percutaneous removal of confirmed breast cancer – 75-100k procedures per year Radiation oncology for treatment of breast cancer Digital Tomosynthesis |
         Product Pipeline - Current/Near and Mid/Long Term Revenue Potential $60 50 40 30 0 Current Products/New Markets New Products/New Markets Immediate 3 Years + 4 Years Availability Timeline Core Biopsy to Surgery FFDM to Gynecology MI Fibroid Adenoma Extraction to Surgery Radiation Therapy to Rad Onc MI Cancer Extraction to Surgery Hologic proprietary development of new products for Cytyc Sales Channel Tomosynthesis |
 Normal Mammogram Tomosynthesis: 3-D Visualization of Breast Tissue The Next Frontier for Digital Mammography Multiple views reconstructed into 3D image Helps solve tissue overlap problems Lower recall rates - Improved detection Tomosynthesis Slices * Works-in-progress |
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 Vacuum Assist Breast Biopsy Systems Leading technology for VABB Leverages U.S. sales and distribution channels FY06 sales of approximately $38 million – High gross margin product exceeding 65% – Over 70% of revenues derived from recurring disposable sales – Expected growth rate of over 50% in each of next two years Worldwide market currently estimated at $250 million – 1.8m biopsies in U.S. - 1/3 vacuum assisted – International market represents new opportunity |
 Celero™ - The First Vacuum-Assisted, Spring- Loaded Core Biopsy Device for Breast Ultrasound Celero breast biopsy device with CeleroMark™ biopsy marker system and introducer Celero Advantages - Faster and less traumatic for the patient - Provides better access to hard-to-reach lesions - Better cores that are more than two times the size of conventional spring loaded core devices - More accurate clinical diagnosis - Better confirmation with the needle clearly visible under ultrasound imaging Celero Market - 600,000 Core Needle Biopsies per year - Surgery Call Point |
 Ultrasound Stereotactic MRI 500,000 (ATEC Market) 1.8 Million Breast Biopsy Procedures Annually in the U.S. 600,000 (Celero Market) 700,000 Suros ATEC ® and Celero Systems Ideally Positioned to Capture the Biopsy Market |
 Creating a Global Leader in Women’s Healthcare Continuing a legacy of leading technology, innovation and rapid growth |
 Company Strategy Drive market growth through a combination of advanced technology and comprehensive sales channel coverage Continue 20%+ revenue and earnings growth Increase profitability and maintain cost-effective and efficient operating model Continue innovation in women’s health technology Develop additional best-in-class products that provide earlier and better detection, improved diagnosis and less invasive treatment Apply free cash flow to pay down debt Maintain solid liquidity Drive profitability through operating leverage #1 market position with best-in-class products Differentiate from competition with leading technology and customer service Provide screening, diagnostic and therapeutic tools in major areas of women’s health Top-line Growth Financial Discipline Leading Edge Technology Maintain Market Leadership Mission: Create the Global Leader in Women’s Healthcare |
 Best-in-Class Technology Hologic Remains the Technology Leader in an Expanding Market Leading innovator in women’s health technology – 1996: Liquid-based pap testing transforms cervical cancer testing – 2003: Digital mammography improves breast cancer screening outcomes Strong research and development – $80 million spent on R&D in LTM - 3/31/07 – Enhancing existing products and developing new products – Research and development personnel play an active role in the review of product specifications, clinical protocols and FDA submissions Full spectrum of diagnostic products – Addresses major health issues for women – Market leader in major disease states affecting women including breast cancer, cervical cancer, menorrhagia, preterm labor, permanent contraception, and osteoporosis – New products such as Breast Tomosynthesis and Adiana expand range of product offerings |
 MultiCare Stereotactic Biopsy #1 Discovery Osteoporosis Screening #1 Selenia Breast Cancer Screening #1 MammoSite Radiation Therapy #1 ThinPrep Pap Test Cervical Cancer Screening #1 Adiana Contraception NM FullTerm - Adeza Preterm Labor #1 Suros Biopsy Systems #2 Comprehensive Women’s Healthcare Platform Best-in-Class Solutions in Women’s Healthcare Note: Market positions shown in red. NovaSure Endometrial Ablation #1 ThinPrep Imaging System Cervical Cancer Screening #1 |
   OB/Gyn Screening Test Diagnostic Test Treatment Specialist Therapeutic Improved Outcomes Our Mission Leveraging the OB/GYN Channel Best Technology Selenia, ThinPrep, Adeza, Discovery Minimally Invasive Most Specific Suros, MultiCare, Selenia, Discovery Channel Access to Gatekeeper 230 OB/Gyn sales reps Channel Access to Treatment Decision maker 288 Breast surgeon, oncologist, OB/Gyn sales reps Targeted Minimally Invasive NovaSure, MammoSite, Gestiva, Adiana |
   Over 440 U.S. Sales Representatives Multiple call points to women’s healthcare providers Access to – 30,000 OB/Gyn’s – 40,000 Radiologists – 10,000 Hospitals & Imaging centers – 4,000 Radiation Oncologists – 4,000 Gyn Surgeons – 2,500 Breast Surgeons – 5,000 Neurosurgeons – 80,000 Primary Care Physicians – 23,000 Orthopedists – 4,000 Rheumatologists Best-in-class brand recognition In-Depth Channel Coverage 46 Breast Surgery 77 Radiology & Imaging Center 5 Ortho/Rheumo 45 Clinical Lab 8 Neurosurgery 110 Gynecology Surgery 12 Radiation Oncology 143 OB/Gyn & Primary Care |
 Diversified and Balanced Revenue Mix Combined Company (03/31/07 Revenue = $1.4 billion) Hologic (LQA 03/31/07 Revenue = $724 million) Cytyc (LTM 03/31/07 Revenue = $689 million) Breast Biopsy 9% Digital Mammography 68% Osteoporosis 11% Other 12% Breast Health 40% Gynecology Interventional 16% Gynecology Diagnostics 33% Osteoporosis & Other 11% Significant revenue diversification in terms of both product and customer mix Customers include individual physician groups, hospitals, laboratory companies and radiology practices/companies 60/40 split between single-use consumables and capital equipment 60% Consumable / 40% Capital Equipment Menorrhagia 28% Other 1% Pre-Term Labor 8% Cancer Radiation 4% Pap 59% |
 Transaction Overview Permanent financing anticipated to be combination of pre-payable term loan and equity-linked securities Financing: Hologic, Inc. (NASDAQ: HOLX), continue Cytyc name Name of NewCo: Third Quarter of CY2007 Timing to Close: Shareholders of both companies, customary closing conditions and anti-trust clearance, including HSR and various country filings Customary Approvals: Chief Executive Officer: Jack Cumming Management: Chairman of the Board: Patrick Sullivan Hologic: 6 Directors Cytyc: 5 Directors Board Composition: Hologic: 45% Cytyc: 55% Pro Forma Ownership: 0.520 Hologic shares and $16.50 for each Cytyc share valued at $46.46 per share or 33% premium, for approximate total consideration of $2.2B in cash and $4.0B in stock Purchase Consideration: |
 Combined Financial Strength 46% Gross Margin $161M EBITDA $724M Revenue LQA Hologic 75% Gross Margin $275M EBITDA $720M Revenue LQA Cytyc 60% Gross Margin $436M EBITDA $1.44B Revenue LQA Combined Company Estimated more than $0.10 accretive to adjusted EPS 1 within the first full year after close - significantly more accretive thereafter ( 1 Adjusted EPS excludes the write-off and amortization of acquisition-related intangible assets, and related tax effect.) s |
 FY2008 Guidance and Long Term Outlook 2008 Guidance Revenue: In excess of $1.70B Adjusted EPS 1 : $2.35-$2.40 / share Gross margin: 65% Long-Term Outlook Revenue Growth: 20% Adjusted EPS 1 Growth: 20%+ 1 Adjusted EPS excludes the write-off and amortization of acquisition-related intangible assets, and related tax effect. |
 Creating a Global Leader in Women’s Healthcare Comprehensive Women’s Healthcare Product Portfolio – Complementary best-in-class technologies Expanded Commercial Capabilities – Expansive U.S. sales channel coverage – Enhanced presence in key international markets – Platform for entry into new markets Opportunity to offer Integrated Solutions – Screening – Diagnostics – Therapeutics |
 Creating A Global Leader In Women’s Healthcare |