Exhibit No. | | Description |
(3.1) | | Restated Articles of Organization(1) |
(3.2) | | Articles of Amendment to Restated Articles of Organization(16) |
(3.3) | | By-Laws, as amended(2) |
(4.1) | | Article 4 of the Restated Articles of Organization as amended (See Exhibits 3.1 and 3.2)(1) |
(4.2) | | Form of Common Stock Certificate(6) |
(10.1) | | Research and License Agreement dated as of May 22, 1981 by and between the Registrant and Sidney Farber Cancer Institute, Inc. (now Dana-Farber Cancer Institute, Inc.) with addenda dated as of August 13, 1987 and August 22, 1989(4) |
(10.2) | | Amended and Restated Registration Rights Agreement dated as of December 23, 1988 by and among the Registrant and various beneficial owners of the Registrant's securities(4) |
(10.3) | x | Restated Stock Option Plan(21) |
(10.3.1) | x | Form of Incentive Stock Option Agreement(21) |
(10.3.2) | x | Form of Non-Qualified Stock Option Agreement(21) |
(10.4) | x | Letter Agreement Regarding Employment dated as of October 1, 1987 between the Registrant and Dr. Walter A. Bl’ttler(4) |
(10.5) | | Lease dated May 15, 1997 by and between Harry F. Stimpson, III, as trustees, lessor, and the Registrant, lessee(3) |
(10.6) | | Leases dated as of December 1, 1986 and June 21, 1988 by and between James H. Mitchell, Trustee of New Providence Realty Trust, lessor, and Charles River Biotechnical Services, Inc. ("Lessee") together with Assignment of Leases dated June 29, 1989 between Lessee and the Registrant(6) |
(10.7) | | First Amendment, dated as of May 9, 1991, to Lease dated as of June 21, 1988 by and between James A. Mitchell, Trustee of New Providence Realty Trust, lessor, and the Registrant(7) |
(10.8) | | Confirmatory Second Amendment to Lease dated June 21, 1988 by and between James A. Mitchell, Trustee of New Providence Realty Trust, lessor, and the Registrant, Lessee(3) |
(10.9) | x | Letter Agreement Regarding Compensation of Mitchel Sayare, dated April 29, 1994 (8) |
(10.10) | | Lease dated as of December 23, 1992 by and between Massachusetts Institute of Technology, lessor, and the Registrant, lessee(5) |
(10.11) | | Option Agreement dated April 5, 1990 by and between the Registrant and Takeda Chemical Industries, Ltd.(9) |
(10.12) | | Amendment to Lease dated August 31, 1995 between Massachusetts Institute of Technology, as lessor, and the Registrant, as lessee(10) |
(10.13) | | Letter Agreement dated as of June 6, 1996 by and among the Registrant and Capital Ventures International regarding an amendment to their agreement dated March 15, 1996(11) |
(10.14) | | Registration Agreement dated July 31, 1997 between Apoptosis Technology, Inc. and the Registrant(3) |
(10.15) | | License Agreement dated effective June 1, 1998 by and between the Registrant and Pharmacia & Upjohn AB*(3) |
(10.16) | | License Agreement dated February 1, 1999 between the Registrant and SmithKline Beecham Corporation*(12) |
(10.17) | | Stock Purchase Agreement dated February 1, 1999 between the Registrant and SmithKline Beecham plc*(12) |
(10.18) | | License Agreement dated effective May 2, 2000 by and between the Registrant and Genentech, Inc.*(13) |
(10.19) | | Heads of Agreement dated effective May 2, 2000 by and between the Registrant and Genentech, Inc.*(13) |
(10.20) | | Development, Commercialization and License Agreement dated effective May 4, 2000 by and between the Registrant and British Biotech Pharmaceuticals Limited*(13) |
(10.21) | | Collaboration and License Agreement dated as of September 29, 2000 by and between the Company and MorphoSys AG*(14) |
(10.22) | | Option and License Agreement dated September 5, 2000 by and between Abgenix, Inc. and the Company*(15) |
(10.23) | | Letter Agreement for Stock Purchase dated September 6, 2000 by and between Abgenix, Inc. and the Company*(15) |
(10.24) | | Agreement between ImmunoGen, Inc. and Millennium Pharmaceuticals, Inc., dated March 30, 2001*(16) |
(10.25) | | Agreement between ImmunoGen, Inc. and Raven Biotechnologies, Inc., dated March 28, 2001*(16) |
(10.26) | | Development and License Agreement dated effective November 27, 2001 by and between the Registrant and Boehringer Ingelheim International GmbH*(18) |
(10.28) | | Termination of the Developmental, Commercialization and License Agreement made between Vernalis (R&D) Limited, dated January 2004*(19) |
(10.29) | | Biopharmaceutical Development and Services Agreement dated April 16, 2004 by and between Laureate Pharma, L.P. and the Company*(20) |
(10.30) | x | Letter Agreement Regarding Employment dated as of April 18, 2005 between the Registrant and Mr. Daniel M. Junius(25) |
(10.31) | | Process Development Agreement between the Registrant and Genentech, Inc., dated as of May 3, 2006*(26) |
(10.32) | | Amendment to License Agreement for Anti-HER2 Antibodies between the Registrant and Genentech, dated as of May 3, 2006*(26) |
(10.33) | x | 2004 Non-Employee Director Compensation and Deferred Share Unit Plan(20) |
(10.34) | x | Separation Agreement with Virginia A. Lavery, dated October 22, 2004(22) |
(10.35) | x | Offer Letter issued to Christopher U. Missling, Ph.D., dated September 27, 2004(22) |
(10.36) | | Sublease Agreement by and between the Registrant and Alkermes, Inc., dated as of September 15, 2004(22) |
(10.37) | | Development and License Agreement by and between the Registrant and Biogen Idec, Inc., dated October 1, 2004(23) |
(10.38) | | Development and License Agreement by and between the Registrant and Centocor, Inc., dated December 23, 2004(23) |
(10.39) | x | Separation Agreement with Christopher Missling, Ph.D., dated January 5, 2005 (24) |
(21) | | Subsidiaries of the Registrant (26) |
(23) | | Consent of Ernst & Young LLP(26) |
(31.1) | | Certification of Chief Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002, filed herewith |
(31.2) | | Certification of Chief Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002, filed herewith |
(32) | | Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002(26) |