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Content analysis
?Positive | ||
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Uncertain | ||
Constraining | ||
Legalese | ||
Litigous | ||
Readability |
8th grade V good
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New words:
ACADIA, accretive, acetylcholine, afflicting, ago, aimed, ambulatory, anniversary, ANVISA, ASC, ASH, Asia, ASU, begun, behavioral, binary, BLA, blend, blocker, Boston, Brazil, Brazilian, buying, cariodmyopathy, CCPA, cerebral, CF, CFTR, channel, chelation, chloride, chromosome, clogging, Coast, Codification, commenced, commencement, compel, contra, cortex, country, crawling, CRL, cure, damien, danvatirsen, deadly, deconsolidating, deplete, deployment, destruction, developmental, device, disfigurement, distance, distributor, diversify, driven, durable, EC, enac, engineering, epithelial, equitable, excellence, Exposition, FDG, Firdapse, FIREFISH, forecasted, frame, freight, frequency, frontal, GA, gap, GDPR, German, Germany, GH, globe, hand, handheld, hearing, Hematology, home, honor, hydroxyurea, Iceland, immune, input, intermedia, intravitreal, intrusion, invoice, Italy, Laquinimod, Latin, lesser, lessor, Liechtenstein, lifted, Likewise, limb, longest, main, malware, manifest, manifestation, mcdevitt, medium, memory, methodology, minute, mobile, multicenter, multisystem, multitude, ncome, neuropathic, Norway, notification, NTDT, numerical, onpattro, orderly, outlook, overgrowth, overhead, overturn, parietal, passage, payer, peer, peter, petition, polymorphism, posture, potassium, PRIME, prompt, ProQR, psychological, PTC, pulmonary, question, reallocate, rebate, recessive, reldesemtiv, relieved, remitted, Risdiplam, satisfaction, saturation, secondary, Selistat, smaller, SNP, social, solution, somatostatin, subdivided, sublease, SUNFISH, suppressed, Supreme, TDT, tegsedi, tenant, title, Topic, transferrin, transgenic, transportation, unconditional, unconditionally, underway, unsuccessful, urine, verdict, verify, version, vi, Vutrisiran, WAYLIVRA, West, wherewithal, ZEMDRI, Zolgensma
Removed:
adhesion, afforded, age, Alexion, alicaforsen, allocable, Alport, aminoglycoside, amplification, Antitrust, antiviral, arise, assumed, attractive, Australian, bacterial, benign, BESP, bowel, Boyce, buildup, Cambridge, clear, clearance, closest, coincide, colon, comparative, competitor, complicated, congestive, constant, constructed, contemplated, CRE, decreasing, defer, define, deliverable, density, deprivation, diffuse, discounted, diseased, dollar, driver, element, encouraging, enhancement, Enterobacteriaceae, examine, exceeding, exist, Fast, favor, FH, fifteen, Forest, formulated, gather, gathered, GCGR, Genzyme, glaucoma, glucagon, glucose, hofh, hope, hypercholesterolemia, IBD, IND, infusion, inhibitor, initiating, innovator, insolvent, intent, intercellular, interdependent, interrelated, intestine, intravenously, largely, larger, Lastly, lawsuit, MAA, master, microRNA, mipomersen, monoclonal, mutually, negligible, negotiation, Nephrology, neuromuscular, nonclinical, opposing, outlining, pace, package, pancreatic, participated, path, penetration, percentin, permanent, plaque, plazomicin, positively, pouch, pretreated, pretreatment, prosecution, prove, purpose, readily, realization, reimburse, relation, removed, removing, resell, retail, revusiran, Sanofi, sight, signaling, stable, subset, substantive, supplying, supporting, surgically, symptom, tied, tolcapone, tool, track, UC, ulcerative, uncured, unexercised, unlimited, unutilized, validating, valuable, vendor, ventilation, volume, warrant, wholly
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Exhibit 21.1
LIST OF SUBSIDIARIES FOR THE REGISTRANT
Subsidiaries of Ionis Pharmaceuticals, Inc:
Ionis USA Limited, a United Kingdom Limited Private Company
Osprey Therapeutics, Inc., a Delaware Corporation
PerIsis I Development Corporation, a Delaware Corporation
Symphony GenIsis, Inc., a Delaware Corporation
Ionis Development (Ireland) Limited, an Ireland Limited Private Company
Akcea Therapeutics, Inc., a Delaware Corporation
Subsidiaries of Akcea Therapeutics, Inc.:
Akcea Therapeutics Canada Inc., a Canadian Corporation
Akcea Therapeutics France SAS, a French Company
Akcea Therapeutics Germany GmbH, a German Corporation
Akcea Therapeutics UK Limited, a United Kingdom Limited Private Company
Akcea Securities Corporation., a Massachusetts Corporation
Akcea Therapeutics Ireland Limited, an Ireland Limited Private Company