| Security Type | Security Class Title | Fee Calculation Rule | Amount Registered (1)(2) | Proposed Maximum Offering Price Per Share (3) | Maximum Aggregate Offering Price | Fee Rate | Amount of Registration Fee |
| Equity | Amended and Restated 2011 Equity Incentive Plan, Common Stock, par value $.001 per share | Other (3) | 5,500,000 shares | $39.41 | $216,755,000 | $0.00011020 | $23,886.40 |
| Total Offering Amounts | -- | ||||||
| Total Fee Offsets | -- | ||||||
| Net Fee Due | $23,886.40 | ||||||
(1) | In accordance with Rule 416(a) under the Securities Act, this Registration Statement shall be deemed to cover any additional securities that may from time to time be offered or issued by Ionis Pharmaceuticals, Inc. to prevent dilution resulting from stock splits, stock dividends or similar transactions. |
| (2) | Includes 5,500,000 shares issuable pursuant to the Registrant’s Amended and Restated 2011 Equity Incentive Plan. |
| (3) | Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) of the Securities Act. The price per share and the aggregate offering price are calculated on the basis of $39.41, the average of the high and low sales prices of Registrant’s Common Stock on August 8, 2023, as reported on the Nasdaq Global Market. |
