Icos 10-Q 2006 Q3 Quarterly report

Exhibit 32.2

CERTIFICATION OF MICHAEL A. STEIN PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the quarterly report of ICOS Corporation (the Company) on Form 10-Q for the period ended September 30, 2006, as filed with the Securities and Exchange Commission (the Report), I, Michael A. Stein, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: November 2, 2006

/s/ MICHAEL A. STEIN

Michael A. Stein

Senior Vice President and Chief Financial Officer