Biogen (BIIB) 8-K Page 1 Biogen Idec Reports Second Quarter 2008 Results

Exhibit 99.1

Page 1    Biogen Idec Reports Second Quarter 2008 Results

Media Contact:
Naomi Aoki
Director, Public Affairs
Biogen Idec
Tel: (617) 914-6524

Investment Community Contact:
Eric Hoffman
Director, Investor Relations
Biogen Idec
Tel: (617) 679-3916

FOR IMMEDIATE RELEASE

Biogen Idec Reports Second Quarter 2008 Results

28% Revenue Growth and 30% Earnings Growth

Cambridge, MA, July 22, 2008 — Biogen Idec Inc. (NASDAQ: BIIB), a global biotechnology leader in the discovery, development, manufacturing, and commercialization of innovative therapies, today reported its second quarter 2008 results.

Second Quarter 2008 Highlights:

• Second quarter revenues were $993 million, an increase of 28% from $773 million in the second quarter of 2007, driven primarily by AVONEX^Ò (interferon beta-1a) sales up 14% to $527 million, TYSABRI^Ò (natalizumab) sales up 210% to $147 million, and RITUXAN^Ò (rituximab) revenues from the unconsolidated joint business arrangement up 21% to $279 million.

• On a reported basis, calculated in accordance with accounting principles generally accepted in the U.S. (GAAP), second quarter 2008 diluted earnings per share (EPS) were $0.70, an increase of 30% from $0.54 in the second quarter of 2007. GAAP net income for the second quarter was $207 million, an increase of 11% from $186 million in the second quarter of 2007.

• Second quarter 2008 non-GAAP diluted EPS were $0.91, an increase of 30% from $0.70 in the second quarter of 2007. Non-GAAP net income for the second quarter was $269 million, an increase of 12% from $240 million in the second quarter of 2007. A reconciliation of our GAAP to non-GAAP results is included on Table 3 within this press release.

Page 2    Biogen Idec Reports Second Quarter 2008 Results

• Global in-market net sales of TYSABRI^Ò (natalizumab) in the second quarter of 2008 were $200 million. Based on our collaboration structure with Elan, Biogen Idec recognized revenue of $147 million related to TYSABRI in the second quarter of 2008.

“Our prospects for growth remain strong,” said James Mullen, Biogen Idec’s Chief Executive Officer. “TYSABRI sales nearly tripled compared to the same period last year, our core products continue to grow, our pipeline is overflowing, and our revenues have grown more than 25 percent year-over-year for three consecutive quarters. Given the strong momentum underway, we are raising our full-year guidance and setting an aspirational goal of generating a record $4 billion in revenues this year.”

Financial Performance

On a reported basis, calculated in accordance with GAAP, Biogen Idec reported net income of $207 million and diluted EPS of $0.70 in the second quarter of 2008. On a non-GAAP basis, Biogen Idec reported net income of $269 million in the second quarter of 2008. Non-GAAP diluted EPS were $0.91 for the second quarter of 2008.

As of June 30, 2008 Biogen Idec had cash, cash equivalents, loaned securities and marketable securities of $1.583 billion.

A reconciliation of our GAAP to non-GAAP results is included on Table 3 within this press release.

Revenue Performance

Revenues from AVONEX, one of Biogen Idec’s therapies for patients with relapsing forms of multiple sclerosis (MS), increased 14% in the second quarter to $527 million. U.S. sales increased 13% to $306 million and international sales increased 15% to $221 million.

Revenues for the second quarter of 2008 included $279 million from Biogen Idec’s joint business arrangement related to RITUXAN, a treatment for certain B-cell non-Hodgkin’s lymphomas (NHL) and rheumatoid arthritis (RA) that Biogen Idec co-promotes in the U.S. with Genentech, Inc. All U.S. sales of RITUXAN are recognized by Genentech, and Biogen Idec records its share of the pretax co-promotion profits. As reported by Genentech, U.S. net sales of RITUXAN were $651 million in the second quarter, as compared to $582 million in the second quarter of 2007.

During the second quarter of 2008, Biogen Idec recognized revenue of $147 million related to TYSABRI comprising:

• $46 million related to product sold through Elan in the U.S. (based on $99 million of in-market sales); and

• $101 million related to product sold by Biogen Idec Internationally.

As of the end of June 2008, more than 31,800 patients were on commercial and clinical TYSABRI therapy worldwide. According to data available as of the end of June 2008:

Page 3    Biogen Idec Reports Second Quarter 2008 Results

• In the U.S., more than 17,800 patients were on TYSABRI therapy commercially and more than 3,100 physicians have prescribed the therapy;

• Outside of the U.S., nearly 13,400 patients were on TYSABRI therapy commercially;

• In global clinical trials, more than 600 patients were on TYSABRI therapy; and

• There have been no confirmed cases of progressive multifocal leukoencephalopathy (PML) since re-launch in the US and the first international approval in July 2006.

Cumulatively, in the combined clinical trial and post-marketing settings:

• More than 43,300 patients have been treated with TYSABRI; and

• Of those patients, nearly 13,900 have received at least one year of TYSABRI therapy and approximately 6,600 patients have been on therapy for 18 months or longer.

Revenues from other products were $10 million and $9 million in the second quarter of 2008 and 2007, respectively. Current quarter revenues consist primarily of FUMADERM^Ò (fumaric acid esters).

Table 4 provides individual product revenues.

Royalties were $28 million and $23 million in the second quarter of 2008 and 2007, respectively.

Share Repurchase Program

Biogen Idec repurchased 4,971,804 shares in the second quarter of 2008 under the 20 million share repurchase program authorized by Biogen Idec’s Board of Directors in October 2006.

Financial Guidance

Following its strong performance, Biogen Idec raised its 2008 financial guidance:

• Total revenue growth in the mid 20% range over 2007 as TYSABRI market penetration and favorable foreign exchange continue.

• Operating margins similar to previous guidance, and total GAAP and non-GAAP R&D and SG&A expenses to be in the range of $2 billion.

• Non-GAAP tax rate expected to be 28%-30%. GAAP Tax rate expected to be 31%-33%. The difference between the GAAP and non-GAAP tax rate is a result of the full year effects of the reconciling items detailed in Table 3 within this press release.

• Non-GAAP diluted EPS at or above $3.50, representing growth consistent with the Company’s stated goal of achieving 20% non-GAAP EPS compounded annual growth through 2010. GAAP diluted EPS at or above $2.51. Both Non-GAAP and GAAP diluted EPS estimates exclude the impact of any future acquisitions or transactions.

• Capital expenditures of $270 to $290 million.

The reconciling items between the GAAP diluted EPS and non-GAAP diluted EPS for full year 2008 are itemized in Table 3 within this press release.

Page 4    Biogen Idec Reports Second Quarter 2008 Results

Recent Highlights

• On May 29, 2008, Biogen Idec named Hans Peter Hasler Chief Operating Officer (COO) of the company. Mr. Hasler, age 52, has served as Executive Vice President, Global Neurology and Head of International. In his new role, Mr. Hasler will oversee all commercial operations as well as the company’s business development function.

• On June 19, 2008, the Board of Directors announced that Biogen Idec stockholders elected all of its four nominees — Cecil B. Pickett, Ph.D., the Honorable Lynn Schenk, Phillip A. Sharp, Ph.D., and Stelios Papadopoulos, Ph.D. — to the Biogen Idec Board of Directors. Based on the final tabulation, announced on July 9, 2008, Dr. Sharp received 98 percent of the votes cast and each of the Board’s three other nominees received nearly 75 percent of the votes cast.

Conference Call and Webcast

The Company’s earnings conference call for the second quarter will be broadcast via the internet at 8:30 a.m. ET on July 22, 2008, and will be accessible through the investor relations section of Biogen Idec’s homepage,http://www.biogenidec.com. Supplemental information in the form of a slide presentation will also be accessible at the same location on the internet at the time of the earnings conference call and will be available on our web site subsequently through August 22, 2008.

About Biogen Idec

Biogen Idec creates new standards of care in therapeutic areas with high unmet medical needs. Founded in 1978, Biogen Idec is a global leader in the discovery, development, manufacturing, and commercialization of innovative therapies. Patients in more than 90 countries benefit from Biogen Idec’s significant products that address diseases such as lymphoma, multiple sclerosis, and rheumatoid arthritis. For product labeling, press releases and additional information about the company, please visitwww.biogenidec.com.

Safe Harbor

This press release contains forward-looking statements, which appear under the heading “Financial Guidance” above and in the comments from James Mullen, our CEO. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from that which we expect, including our continued dependence on our two principal products, AVONEX and RITUXAN, the uncertainty of success in commercializing other products including TYSABRI, the occurrence of adverse safety events with our products, the failure to execute our growth strategy successfully or to compete effectively in our markets, our dependence on collaborations over which we may not always have full control, possible adverse impact of government regulation and changes in the availability of reimbursement for our products, problems

Page 5    Biogen Idec Reports Second Quarter 2008 Results

with our manufacturing processes and our reliance on third parties, our ability to attract and retain qualified personnel, the risks of doing business internationally, fluctuations in our operating results, our ability to protect our intellectual property rights and the cost of doing so, product liability claims, our significant investments in marketable securities, fluctuations in our effective tax rate, our substantial indebtedness, environmental risks, the actions of activist shareholders and the other risks and uncertainties that are described in Item 1.A. Risk Factors in our annual report on Form 10-K and our quarterly reports on Form 10-Q and in other reports we file with the SEC. These forward-looking statements speak only as of the date of this press release, and we do not undertake any obligation to publicly update any forward-looking statements, whether as a result of new information, future events, or otherwise.

TABLE 1

Biogen Idec Inc.
June 30, 2008
Consolidated Statements of Income
(in thousands, except per share amounts)
(unaudited)

	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2008			2007			2008			2007
REVENUES
Product	$	684,486		$	518,625		$	1,349,556		$	1,003,013
Unconsolidated joint business		278,822			230,590			526,045			437,754
Royalties		28,115			22,648			52,096			45,635
Corporate partner		2,021			1,313			7,933			2,684
Total revenues		993,444			773,176			1,935,630			1,489,086
COST AND EXPENSES
Cost of sales		92,401			84,063			193,335			166,013
Research and development		252,259			218,149			510,491			409,598
Selling, general and administrative		245,689			203,668			461,518			391,729
Amortization of acquired intangible assets		72,869			60,961			147,650			120,881
Collaboration profit (loss) sharing		33,429			(105	)		54,835			(5,672	)
In-process research and development		—			—			25,000			18,405
Total cost and expenses		696,647			566,736			1,392,829			1,100,954
Income from operations		296,797			206,440			542,801			388,132
Other income (expense), net		(5,463	)		31,586			(5,093	)		53,288
INCOME BEFORE INCOME TAXES		291,334			238,026			537,708			441,420
Income taxes		84,706			51,886			167,983			123,779
NET INCOME	$	206,628		$	186,140		$	369,725		$	317,641
BASIC EARNINGS PER SHARE	$	0.71		$	0.55		$	1.26		$	0.93
DILUTED EARNINGS PER SHARE	$	0.70		$	0.54		$	1.24		$	0.92
WEIGHTED-AVERAGE SHARES USED IN CALCULATING:
BASIC EARNINGS PER SHARE		290,356			340,315			293,268			340,312
DILUTED EARNINGS PER SHARE		293,476			343,389			296,554			343,713

TABLE 2

Biogen Idec Inc.
June 30, 2008
Condensed Consolidated Balance Sheets
(in thousands)
(unaudited)

	June 30,		December 31,
	2008		2007
ASSETS
Cash, cash equivalents and marketable securities	$	701,008	$	979,070
Cash collateral received for loaned securities		146,956		208,209
Accounts receivable, net		482,797		392,646
Loaned securities		191,244		204,433
Inventory		255,028		233,987
Other current assets		383,995		350,062
Total current assets		2,161,028		2,368,407
Marketable securities		691,044		932,271
Property, plant and equipment, net		1,629,398		1,497,383
Intangible assets, net		2,347,561		2,492,354
Goodwill		1,139,597		1,137,372
Investments and other assets		204,198		201,028
TOTAL ASSETS	$	8,172,826	$	8,628,815
LIABILITIES AND SHAREHOLDERS’ EQUITY
Collateral payable on loaned securities	$	146,956	$	208,209
Current portion of notes payable		11,544		1,511,135
Other current liabilities		726,941		469,831
Long-term deferred tax liability		501,452		521,525
Notes payable		1,038,086		51,843
Other long-term liabilities		224,916		331,977
Shareholders’ equity		5,522,931		5,534,295
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY	$	8,172,826	$	8,628,815

TABLE 3

Biogen Idec Inc.
June 30, 2008
Condensed Consolidated Statements of Income — Non-GAAP
(in millions, except per share amounts)
(unaudited)

	Three Months Ended						Six Months Ended
	June 30,						June 30,
EARNINGS PER SHARE	2008			2007			2008			2007
GAAP earnings per share — Diluted	$	0.70		$	0.54		$	1.24		$	0.92
Adjustment to net income (as detailed below)		0.21			0.16			0.51			0.37
Non-GAAP earnings per share — Diluted	$	0.91		$	0.70		$	1.75		$	1.29
An itemized reconciliation between net income on a GAAP basis and net income on a non-GAAP basis is as follows:
GAAP net income	$	206.6		$	186.1		$	369.7		$	317.6
Adjustments:
COGS: Stock Option Expense		—			0.1			—			0.1
R&D: Restructuring		—			0.4			—			0.4
R&D: Stock option expense		1.4			2.9			4.1			5.9
R&D: FIN 46 consolidation of Cardiokine		1.5			—			2.3			—
SG&A: Restructuring		—			0.5			—			0.6
SG&A: Stock option expense		3.8			5.3			6.9			11.4
Amortization of acquired intangible assets		72.8			61.0			147.6			120.9
In-process research and development related to the contingent consideration payment in 2008 associated with Conforma acquisition and the acquisition of Syntonix in 2007		—			—			25.0			18.4
Other income (expense), net: FIN 46 consolidation of Cardiokine		(1.5	)		—			(2.3	)		—
Income taxes: Income tax effect of reconciling items		(16.1	)		(16.0	)		(34.5	)		(32.6	)
Non-GAAP net income	$	268.5		$	240.3		$	518.8		$	442.7

2008 Full Year Guidance GAAP to non-GAAP adjustments

An itemized reconciliation between projected EPS on a GAAP basis and on a non-GAAP basis is as follows:

	Shares					Diluted EPS
Projected GAAP net income Adjustments:	$	740.0		295.0	$	2.51
R&D: Stock option expense		8.5
SG&A: Stock option expense		17.0
In process research and development		25.0
Amortization of acquired intangible assets		317.5
Income taxes: Income tax effect of reconciling items		(76.5	)
Projected Non-GAAP net income	$	1,031.5		295.0	$	3.50

Use of Non-GAAP Financial Measures
Our “non-GAAP net income” and “non-GAAP diluted EPS” financial measures exclude the following items from GAAP net income and diluted EPS:

1. Purchase accounting and merger-related adjustments.

We exclude certain purchase accounting impacts, such as those related to our 2003 merger with Biogen, Inc., the acquisitions of Fumapharm AG, Conforma Therapeutics and Syntonix Pharmaceuticals, and the consolidation of Cardiokine and Neurimmune. These include charges for in-process research and development and the incremental charges related to the amortization of the acquired intangible assets. Excluding these charges provides management and investors with a supplemental measure of performance in which the Company’s acquired intellectual property is treated in a comparable manner to its internally developed intellectual property.

2. Stock option expense recorded in accordance with SFAS 123R.

We believe that excluding the impact of expensing stock options better reflects the recurring economic characteristics of our business. We also exclude stock option expense from our non-GAAP R&D expenses and SG&A expenses, but include the P&L impact of restricted stock awards and cash incentives in our non-GAAP results.

3. Unusual or non-recurring items.

We evaluate these on an individual basis, and consider both the quantitative and qualitative aspects of the item, including (i) its size and nature, (ii) whether or not it relates to our ongoing business operations, and (iii) whether or not we expect it to occur as part of our normal business on a regular basis.

We believe it is important to share these non-GAAP financial measures with shareholders as they better represent the ongoing economics of the business, reflect how we manage the business internally and set operational goals, and form the basis of our management incentive programs. Non-GAAP net income and diluted EPS should not be viewed in isolation or as a substitute for reported, or GAAP, net income and diluted EPS.

TABLE 4

Biogen Idec Inc.
June 30, 2008
Product Revenues
(in thousands)
(unaudited)

	Three Months Ended
	June 30,
	2008		2007
PRODUCT REVENUES
Avonex®	$	527,152	$	461,618
Tysabri®		147,173		47,539
Amevive®		113		2
Zevalin®		59		4,290
Fumaderm®		9,989		5,176
Total product revenues	$	684,486	$	518,625

	Six Months Ended
	June 30,
	2008		2007
PRODUCT REVENUES
Avonex®	$	1,063,261	$	910,427
Tysabri®		261,836		77,299
Amevive®		252		218
Zevalin®		2,504		9,893
Fumaderm®		21,703		5,176
Total product revenues	$	1,349,556	$	1,003,013