| Cover | 12 Months Ended |
| Dec. 31, 2022 | |
| Cover [Abstract] | |
| Document Type | DEF 14A |
| Entity Registrant Name | VERTEX PHARMACEUTICALS INC / MA |
| Entity Central Index Key | 0000875320 |
| Amendment Flag | false |
| Pay vs Performance Disclosure - USD ($) | 3 Months Ended | 9 Months Ended | 12 Months Ended | |||||
| Mar. 31, 2020 | Dec. 31, 2020 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | ||
| Pay vs Performance Disclosure [Table] | ||||||||
| Pay vs Performance [Table Text Block] | Pursuant to Item 402(v) of Regulation S-K, we are presenting information that describes the relationship between compensation actually paid, as computed under the rules prescribed by Item 402(v), to our NEOs and certain financial performance measures for the company’s five most recently completed fiscal years. For more information about our executive compensation program, refer to the Compensation Discussion and Analysis Year Summary Compensation Table Total for CEO (1) Summary Compensation Table Total for CEO (2) Compensation Actually Paid to CEO (1)(3) Compensation Actually Paid to CEO (2)(4) Average Summary Compensation Table Total for Non-CEO NEOs (5) Average Compensation Actually Paid to Non-CEO NEOs (6) Total Shareholder Return (Value of Initial Fixed $100 Investment) Net Income (9) Net Product Revenue (10) VRTX TSR (7) NBI TSR (8) 2022 $ 15,864,497 N/A $ 29,529,089 N/A $ 8,982,257 $ 18,263,330 $ 192.70 $ 129.59 $ 3.3 Billion $ 8.9 Billion 2021 $ 15,198,856 N/A $ 18,341,489 N/A $ 7,193,835 $ 8,969,051 $ 146.54 $ 144.18 $ 2.3 Billion $ 7.6 Billion 2020 $ 9,111,359 $ 16,473,245 $ 12,172,454 $ 31,319,824 $ 6,697,408 $ 10,584,384 $ 157.71 $ 144.15 $ 2.7 Billion $ 6.2 Billion 2019 N/A $ 18,789,985 N/A $ 37,124,321 $ 4,668,405 $ 7,828,475 $ 146.10 $ 114.02 $ 1.2 Billion $ 4.2 Billion 2018 N/A $ 18,799,147 N/A $ 27,646,261 $ 4,943,084 $ 7,193,181 $ 110.58 $ 91.14 $ 2.1 Billion $ 3.0 Billion (1) This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Reshma Kewalramani (2) This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Jeffrey Leiden (3) The amounts in this column reflect the Compensation Actually Paid for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021 and 2022. The amounts in the following table reflect the adjustments (additions/deductions) to the Summary Compensation Table Total to determine Compensation Actually Paid. Adjustments (additions/deductions) are not listed for Qualified Deferred Compensation because we do not offer these plans. Year Summary Amounts Deducted Amounts Added Amounts Added Amounts Add/ Amounts Added/ Change in Fair Value of Awards Outstanding at Fiscal Year End (a) Compensation 2022 $ 15,864,497 $ (10,640,784) $ 16,817,103 $ — $ 768,712 $ 6,719,561 $ 29,529,089 2021 $ 15,198,856 $ (10,924,599) $ 14,344,492 $ — $ (659,323) $ 382,063 $ 18,341,489 2020 $ 9,111,359 $ (5,250,411) $ 6,587,268 $ — $ 345,685 $ 1,378,553 $ 12,172,454 (a) Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2022, 2021, 2020 and 2019; and, the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020, respectively; the non-financial PSU award for 2021 was valued at 50% as of December 31, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 0% as of December 31, 2022. (4) This amounts in this column reflect the Compensation Actually Paid for Jeffrey Leiden, our CEO for 2018, 2019 and a portion of 2020 (until April 1, 2020). The amounts in the following table reflect the adjustments to the Summary Compensation Table Total to determine Compensation Actually Paid. Year Summary Amounts Deducted Amounts Added Amounts Added for Amounts Add/ Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End (a) Compensation 2020 $ 16,473,245 $ (13,335,168) $ 9,294,661 $ 7,362,423 $ 5,724,395 $ 5,800,268 $ 31,319,824 2019 $ 18,789,985 $ (13,906,720) $ 17,220,100 $ 509,338 $ 4,201,319 $ 10,310,299 $ 37,124,321 2018 $ 18,799,147 $ (14,044,261) $ 15,925,396 $ 541,085 $ 1,872,780 $ 4,552,114 $ 27,646,261 (a) Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2020, 2019, 2018 and 2017; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018 and 2017; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019, 2018 and 2017, respectively; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 100% and 50% as of December 31, 2020 and 2019, respectively; the non-financial PSU award for 2020 was valued at 50% as of December 31, 2020. (5) This column reflects the average of the amounts reported in the “Total” column of the Summary Compensation Table for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The NEOs included for purposes of computing the amounts in this column were as follows: for 2022, Mr. Wagner Dr. Altshuler Mr. Arbuckle Dr. Leiden Mr. Wagner Mr. Arbuckle Dr. Leiden Nia Tatsis Mr. Wagner Dr. Altshuler Mr. Arbuckle Michael Parini Ms. Kewalramani Mr. Wagner Mr. Arbuckle Amit Sachdev Paul Silva Ian Smith Mr. Arbuckle Mr. Parini Mr. Sachdev Jeffrey Chodakewitz Thomas Graney Mr. Smith (6) This column reflects the average of the Compensation Actually Paid for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The amounts in the following table reflect the adjustments to the Summary Compensation Table Total to determine Compensation Actually Paid. The NEOs included for purposes of computing the amounts in this column are listed in footnote (5) above. Year Summary Amounts Amounts Added Amounts Added Amounts Add/ Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End (a) Compensation 2022 $ 8,982,257 $ (7,261,199) $ 9,489,852 $ 1,062,531 $ 538,093 $ 5,451,796 $ 18,263,330 2021 $ 7,193,835 $ (5,687,759) $ 6,319,320 $ 1,125,037 $ (778,741) $ 797,359 $ 8,969,051 2020 $ 6,697,408 $ (4,812,998) $ 6,038,487 $ — $ 1,048,920 $ 1,612,567 $ 10,584,384 2019 $ 4,668,405 $ (3,093,700) $ 4,011,590 $ 103,204 $ 866,837 $ 1,272,139 $ 7,828,475 2018 $ 4,943,084 $ (3,720,284) $ 4,253,936 $ 143,306 $ 474,492 $ 1,098,647 $ 7,193,181 (a) Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2022, 2021, 2020, 2019, 2018 and 2017; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018 and 2017; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019, 2018 and 2017, respectively; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 200%, 100% and 50% as of December 31, 2021, 2020 and 2019; the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020; the non-financial PSU award for 2021 was valued at 50% as of December 31, 2022 and 2021; the non-financial PSU award for 2022 was valued at 50% as of December 31, 2022. (7) This column represents our cumulative total shareholder return (“TSR”) under SEC rules from December 29, 2017, the last trading day before the start of 2018, through the last trading day for the applicable fiscal year in the table. TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our share price at the end and the beginning of the measurement period by our share price at the beginning of the measurement period. (8) This column represents the TSR of the NBI, our selected peer group as discussed above, under SEC rules from December 29, 2017, the last trading day before the start of 2018, through the last trading day for the applicable fiscal year in the table, assuming reinvestment of dividends and weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated. (9) This column reflects net income as reported for each year in our Annual Report on Form 10-K. (10) This column reflects net product revenue as reported for each year in our Annual Report on Form 10-K. For purposes of the table above, we have selected net product revenue as the financial performance measure representing the most important financial performance measure used to link executive compensation actually paid to our financial performance in the most recently completed fiscal year. Please see the Compensation Discussion and Analysis | |||||||
| Named Executive Officers, Footnote [Text Block] | This column reflects the average of the amounts reported in the “Total” column of the Summary Compensation Table for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The NEOs included for purposes of computing the amounts in this column were as follows: for 2022, Mr. Wagner Dr. Altshuler Mr. Arbuckle Dr. Leiden Mr. Wagner Mr. Arbuckle Dr. Leiden Nia Tatsis Mr. Wagner Dr. Altshuler Mr. Arbuckle Michael Parini Ms. Kewalramani Mr. Wagner Mr. Arbuckle Amit Sachdev Paul Silva Ian Smith Mr. Arbuckle Mr. Parini Mr. Sachdev Jeffrey Chodakewitz Thomas Graney Mr. Smith | |||||||
| Peer Group Issuers, Footnote [Text Block] | This column represents the TSR of the NBI, our selected peer group as discussed above, under SEC rules from December 29, 2017, the last trading day before the start of 2018, through the last trading day for the applicable fiscal year in the table, assuming reinvestment of dividends and weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated. | |||||||
| Adjustment To PEO Compensation, Footnote [Text Block] | Year Summary Amounts Deducted Amounts Added Amounts Added Amounts Add/ Amounts Added/ Change in Fair Value of Awards Outstanding at Fiscal Year End (a) Compensation 2022 $ 15,864,497 $ (10,640,784) $ 16,817,103 $ — $ 768,712 $ 6,719,561 $ 29,529,089 2021 $ 15,198,856 $ (10,924,599) $ 14,344,492 $ — $ (659,323) $ 382,063 $ 18,341,489 2020 $ 9,111,359 $ (5,250,411) $ 6,587,268 $ — $ 345,685 $ 1,378,553 $ 12,172,454 (a) Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2022, 2021, 2020 and 2019; and, the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020, respectively; the non-financial PSU award for 2021 was valued at 50% as of December 31, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 0% as of December 31, 2022. (4) This amounts in this column reflect the Compensation Actually Paid for Jeffrey Leiden, our CEO for 2018, 2019 and a portion of 2020 (until April 1, 2020). The amounts in the following table reflect the adjustments to the Summary Compensation Table Total to determine Compensation Actually Paid. Year Summary Amounts Deducted Amounts Added Amounts Added for Amounts Add/ Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End (a) Compensation 2020 $ 16,473,245 $ (13,335,168) $ 9,294,661 $ 7,362,423 $ 5,724,395 $ 5,800,268 $ 31,319,824 2019 $ 18,789,985 $ (13,906,720) $ 17,220,100 $ 509,338 $ 4,201,319 $ 10,310,299 $ 37,124,321 2018 $ 18,799,147 $ (14,044,261) $ 15,925,396 $ 541,085 $ 1,872,780 $ 4,552,114 $ 27,646,261 (a) Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2020, 2019, 2018 and 2017; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018 and 2017; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019, 2018 and 2017, respectively; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 100% and 50% as of December 31, 2020 and 2019, respectively; the non-financial PSU award for 2020 was valued at 50% as of December 31, 2020. (5) This column reflects the average of the amounts reported in the “Total” column of the Summary Compensation Table for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The NEOs included for purposes of computing the amounts in this column were as follows: for 2022, Mr. Wagner Dr. Altshuler Mr. Arbuckle Dr. Leiden Mr. Wagner Mr. Arbuckle Dr. Leiden Nia Tatsis Mr. Wagner Dr. Altshuler Mr. Arbuckle Michael Parini Ms. Kewalramani Mr. Wagner Mr. Arbuckle Amit Sachdev Paul Silva Ian Smith Mr. Arbuckle Mr. Parini Mr. Sachdev Jeffrey Chodakewitz Thomas Graney Mr. Smith (6) This column reflects the average of the Compensation Actually Paid for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The amounts in the following table reflect the adjustments to the Summary Compensation Table Total to determine Compensation Actually Paid. The NEOs included for purposes of computing the amounts in this column are listed in footnote (5) above. Year Summary Amounts Amounts Added Amounts Added Amounts Add/ Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End (a) Compensation 2022 $ 8,982,257 $ (7,261,199) $ 9,489,852 $ 1,062,531 $ 538,093 $ 5,451,796 $ 18,263,330 2021 $ 7,193,835 $ (5,687,759) $ 6,319,320 $ 1,125,037 $ (778,741) $ 797,359 $ 8,969,051 2020 $ 6,697,408 $ (4,812,998) $ 6,038,487 $ — $ 1,048,920 $ 1,612,567 $ 10,584,384 2019 $ 4,668,405 $ (3,093,700) $ 4,011,590 $ 103,204 $ 866,837 $ 1,272,139 $ 7,828,475 2018 $ 4,943,084 $ (3,720,284) $ 4,253,936 $ 143,306 $ 474,492 $ 1,098,647 $ 7,193,181 (a) Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2022, 2021, 2020, 2019, 2018 and 2017; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018 and 2017; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019, 2018 and 2017, respectively; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 200%, 100% and 50% as of December 31, 2021, 2020 and 2019; the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020; the non-financial PSU award for 2021 was valued at 50% as of December 31, 2022 and 2021; the non-financial PSU award for 2022 was valued at 50% as of December 31, 2022. (7) This column represents our cumulative total shareholder return (“TSR”) under SEC rules from December 29, 2017, the last trading day before the start of 2018, through the last trading day for the applicable fiscal year in the table. TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our share price at the end and the beginning of the measurement period by our share price at the beginning of the measurement period. (8) This column represents the TSR of the NBI, our selected peer group as discussed above, under SEC rules from December 29, 2017, the last trading day before the start of 2018, through the last trading day for the applicable fiscal year in the table, assuming reinvestment of dividends and weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated. (9) This column reflects net income as reported for each year in our Annual Report on Form 10-K. (10) This column reflects net product revenue as reported for each year in our Annual Report on Form 10-K. For purposes of the table above, we have selected net product revenue as the financial performance measure representing the most important financial performance measure used to link executive compensation actually paid to our financial performance in the most recently completed fiscal year. Please see the Compensation Discussion and Analysis | |||||||
| Non-PEO NEO Average Total Compensation Amount | $ 8,982,257 | $ 7,193,835 | $ 6,697,408 | $ 4,668,405 | $ 4,943,084 | |||
| Non-PEO NEO Average Compensation Actually Paid Amount | $ 18,263,330 | 8,969,051 | 10,584,384 | 7,828,475 | 7,193,181 | |||
| Compensation Actually Paid vs. Total Shareholder Return [Text Block] | Compensation Actually Paid vs TSR (1) 2020 Compensation Actually Paid represented here reflects 2020 compensation of Reshma Kewalramani, our current CEO, and excludes 2020 compensation paid to Jeffrey Leiden, our former CEO. | |||||||
| Compensation Actually Paid vs. Net Income [Text Block] | Compensation Actually Paid vs Net Income (1) 2020 Compensation Actually Paid represented here reflects 2020 compensation of Reshma Kewalramani, our current CEO, and excludes 2020 compensation paid to Jeffrey Leiden, our former CEO. | |||||||
| Compensation Actually Paid vs. Company Selected Measure [Text Block] | Compensation Actually Paid vs Net Product Revenue (1) 2020 Compensation Actually Paid represented here reflects 2020 compensation of Reshma Kewalramani, our current CEO, and excludes 2020 compensation paid to Jeffrey Leiden, our former CEO. | |||||||
| Tabular List [Table Text Block] | List of Performance Measures The tabular list below includes the three financial and non-financial performance measures that represent the most important performance measures used to link compensation actually paid to company performance in 2022. The performance measures included in this list are not ranked by relative importance. Performance Measures Used to Link Executive Compensation Actually Paid to Company Net Product Revenue Pipeline Progression (1) Adjusted Non-GAAP EBITDA (2) (1) Pipeline progression is a non-financial performance measure used to link executive compensation to company performance, as described in Goals – Pipeline Growth (Late and Early Stage) Performance Units Results Table. (2) Adjusted non-GAAP EBITDA is a financial performance measure used to link compensation actually paid to company financial performance, as described in Goals – Financial Strength | |||||||
| Total Shareholder Return Amount | $ 192.70 | 146.54 | 157.71 | 146.10 | 110.58 | |||
| Peer Group Total Shareholder Return Amount | 129.59 | 144.18 | 144.15 | 114.02 | 91.14 | |||
| Net Income (Loss) | $ 3,300,000,000 | $ 2,300,000,000 | $ 2,700,000,000 | $ 1,200,000,000 | $ 2,100,000,000 | |||
| Company Selected Measure Amount | 8,900,000,000 | 7,600,000,000 | 6,200,000,000 | 4,200,000,000 | 3,000,000,000 | |||
| Measure [Axis]: 1 | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Measure Name | Net Product Revenue | |||||||
| Measure [Axis]: 2 | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Measure Name | Pipeline Progression | |||||||
| Measure [Axis]: 3 | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Measure Name | Adjusted Non-GAAP EBITDA | |||||||
| Non-PEO NEO [Member] | Amounts Deducted from Grant Date Value of Annual Equity | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [1] | $ (7,261,199) | $ (5,687,759) | $ (4,812,998) | $ (3,093,700) | $ (3,720,284) | ||
| Non-PEO NEO [Member] | Amounts Added for the Fair Value of Granted During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [1] | 9,489,852 | 6,319,320 | 6,038,487 | 4,011,590 | 4,253,936 | ||
| Non-PEO NEO [Member] | Amounts Added for Awards Granted and Vested During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [1] | 1,062,531 | 1,125,037 | 103,204 | 143,306 | |||
| Non-PEO NEO [Member] | Amounts Add/Deducted for Awards that Vested During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [1] | 538,093 | (778,741) | 1,048,920 | 866,837 | 474,492 | ||
| Non-PEO NEO [Member] | Amounts Added/Deducted for the Change in Fair of Awards Outstanding at Fiscal Year End | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [1] | 5,451,796 | 797,359 | 1,612,567 | 1,272,139 | 1,098,647 | ||
| Reshma Kewalramani | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Total Compensation Amount | [2] | 15,864,497 | 15,198,856 | 9,111,359 | ||||
| PEO Actually Paid Compensation Amount | [2],[3] | 29,529,089 | 18,341,489 | 12,172,454 | ||||
| Reshma Kewalramani | Amounts Deducted from Grant Date Value of Annual Equity | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [4] | (10,640,784) | (10,924,599) | (5,250,411) | ||||
| Reshma Kewalramani | Amounts Added for the Fair Value of Granted During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [4] | 16,817,103 | 14,344,492 | 6,587,268 | ||||
| Reshma Kewalramani | Amounts Added for Awards Granted and Vested During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [4] | |||||||
| Reshma Kewalramani | Amounts Add/Deducted for Awards that Vested During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [4] | 768,712 | (659,323) | 345,685 | ||||
| Reshma Kewalramani | Amounts Added/Deducted for the Change in Fair of Awards Outstanding at Fiscal Year End | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [4] | $ 6,719,561 | $ 382,063 | 1,378,553 | ||||
| Reshma Kewalramani | PEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Reshma Kewalramani | Reshma Kewalramani | Reshma Kewalramani | |||||
| Jeffrey Leiden | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Total Compensation Amount | [5] | 16,473,245 | 18,789,985 | 18,799,147 | ||||
| PEO Actually Paid Compensation Amount | [5] | 31,319,824 | $ 37,124,321 | $ 27,646,261 | ||||
| Jeffrey Leiden | Amounts Deducted from Grant Date Value of Annual Equity | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [6] | $ (13,335,168) | $ (13,906,720) | (14,044,261) | ||||
| Jeffrey Leiden | Amounts Added for the Fair Value of Granted During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [6] | 9,294,661 | 17,220,100 | 15,925,396 | ||||
| Jeffrey Leiden | Amounts Added for Awards Granted and Vested During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [6] | 7,362,423 | 509,338 | 541,085 | ||||
| Jeffrey Leiden | Amounts Add/Deducted for Awards that Vested During Fiscal Year | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [6] | 5,724,395 | 4,201,319 | 1,872,780 | ||||
| Jeffrey Leiden | Amounts Added/Deducted for the Change in Fair of Awards Outstanding at Fiscal Year End | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| Adjustment to Compensation Amount | [6] | $ 5,800,268 | $ 10,310,299 | $ 4,552,114 | ||||
| Jeffrey Leiden | PEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Jeffrey Leiden | Jeffrey Leiden | Jeffrey Leiden | |||||
| Mr Wagner | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Mr. Wagner | Mr. Wagner | Mr. Wagner | Mr. Wagner | ||||
| Dr Altshuler | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Dr. Altshuler | Dr. Altshuler | ||||||
| Mr Arbuckle | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Mr. Arbuckle | Mr. Arbuckle | Mr. Arbuckle | Mr. Arbuckle | Mr. Arbuckle | |||
| Dr Leiden | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Dr. Leiden | Dr. Leiden | ||||||
| Nia Tatsis | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Nia Tatsis | |||||||
| Michael Parini | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Michael Parini | |||||||
| Ms Kewalramani | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Ms. Kewalramani | |||||||
| Amit Sachdev | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Amit Sachdev | Mr. Sachdev | ||||||
| Paul Silva | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Paul Silva | |||||||
| Ian Smith | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Ian Smith | |||||||
| Mr Parini | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Mr. Parini | |||||||
| Jeffery Chodakewitz | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Jeffrey Chodakewitz | |||||||
| Thomas Graney | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Thomas Graney | |||||||
| Mr Smith | Non-PEO NEO [Member] | ||||||||
| Pay vs Performance Disclosure [Table] | ||||||||
| PEO Name | Mr. Smith | |||||||
| [1]Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2022, 2021, 2020, 2019, 2018 and 2017; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018 and 2017; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019, 2018 and 2017, respectively; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 200%, 100% and 50% as of December 31, 2021, 2020 and 2019; the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020; the non-financial PSU award for 2021 was valued at 50% as of December 31, 2022 and 2021; the non-financial PSU award for 2022 was valued at 50% as of December 31, 2022.[2]This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Reshma Kewalramani Jeffrey Leiden | ||||||||
