EXHIBIT 4.3
AMENDMENT TO
BIOTIME, INC.
2002 STOCK OPTION PLAN
Effective December 10, 2004, Article I, Section 4 is amended to read as follows:
4. SHARES OF STOCK SUBJECT TO THE PLAN
The shares that may be issued under the Plan shall be authorized and unissued or reacquired common shares, no par value, of the Company (the "Shares"). The aggregate number of Shares which may be issued under the Plan shall not exceed 2,000,000, unless an adjustment is required in accordance with Article III.