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Content analysis
?Positive | ||
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Uncertain | ||
Constraining | ||
Legalese | ||
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8th grade Good
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New words:
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Removed:
accessing, accumulation, acquiring, activated, antagonism, antiretroviral, assimilating, attach, Bay, Beckman, blocking, Chase, comparable, conclude, condensed, conform, consecutive, controlling, damage, destruction, Diego, differentiate, Diplomat, disrupting, distributed, diverting, encompassing, equal, evidenced, explore, FAS, fit, forfeited, forgiven, fractional, frederick, GlaxoSmithKline, goodwill, group, harm, holder, immunodeficiency, improve, inappropriately, injured, inside, integrating, integration, Keller, loan, macrophage, Mellon, Microbiology, minimal, noncancelable, nucleoside, nucleotide, obese, partially, partnership, pecuniary, pharmacokinetic, Pharmasset, protease, reclassified, regional, replication, residence, retired, reverse, San, scavenge, scavenger, secured, Senomyx, Shareholder, signal, suggest, tender, transcriptase, uniform, withholding
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EXHIBIT 12.1
COMPUTATION OF RATIOS OF EARNINGS TO FIXED CHARGES
| Year Ended December 31, | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | 2005 | 2006 | 2007 | 2008 | ||||||||||||
| (in thousands) | ||||||||||||||||
Net income (loss) before income taxes | $ | (164,364 | ) | $ | (103,595 | ) | $ | (74,166 | ) | $ | (86,881 | ) | $ | (178,920 | ) | ||
Fixed charges | 19,450 | 17,426 | 19,362 | 25,553 | 26,537 | ||||||||||||
Total earnings and fixed charges | (144,914 | ) | (86,169 | ) | (54,804 | ) | (61,328 | ) | (152,383 | ) | |||||||
Fixed charges | 19,450 | 17,426 | 19,362 | 25,553 | 26,537 | ||||||||||||
Ratio of earnings to fixed charges(1)(2) | NM | NM | NM | NM | NM |
- (1)
- The ratio of earnings to fixed charges is computed by dividing loss before taxes plus fixed charges by fixed charges. Fixed charges consist of interest expense (including interest expense from capital leases) and the estimated portion of rental expense deemed by us to be representative of the interest factor of rental payments under operating leases, plus amortization of debt issuance expenses. Earnings were insufficient to cover fixed charges by $164.4 million, $103.6 million, $74.2 million, $86.9 million and $178.9 million for the years ended December 31, 2004, 2005, 2006, 2007 and 2008 respectively.
- (2)
- NM—Not meaningful.