Southeastern Bank Financial (SBFC) 10-Q 2010 Q3 Quarterly report

Exhibit 32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350 AS ADOPTED PURSUANT TO SECTION 906 OF THE
SARBANES-OXLEY ACT OF 2002

Each of the undersigned hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that this Quarterly Report on Form 10-Q for the quarter ended September 30, 2010 fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, and the information contained in such report fairly presents, in all material respects, the financial condition and results of operations of the Company.

This 29^th day of October 2010

/s/ R. Daniel BlantonR. Daniel Blanton
President &
Chief Executive Officer

(Principal executive officer)

/s/ Darrell R. RainsDarrell R. Rains
Group Vice President &
Chief Financial Officer

(Principal financial officer)