Geron (GERN) S-3ASR Automatic shelf registration

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” in this Registration Statement (Form S-3) and related Prospectus of Geron Corporation for the registration of common stock, preferred stock, debt securities and warrants and to the incorporation by reference therein of our report dated March 10, 2022, with respect to the financial statements of Geron Corporation included in its Annual Report (Form 10-K) for the year ended December 31, 2021, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

San Jose, California

January 4, 2023