Highland Funds Ii N-CSRS Certified semi-annual shareholder report (management investment company)

Certification Pursuant to Rule 30a-2(b) under the 1940 Act and Section 906 of the Sarbanes-Oxley Act

I, Ethan Powell, Chief Executive Officer and President of Pyxis Funds II (formerly, Highland Funds II) (the “Registrant”), certify that:

1. The Form N-CSR of the Registrant (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

Date:	June 8, 2012	/s/    Ethan Powell
		Ethan Powell, Chief Executive Officer and President (principal executive officer)

I, Brian Mitts, Chief Financial Officer and Treasurer of Pyxis Funds II (formerly, Highland Funds II) (the “Registrant”), certify that:

1. The Form N-CSR of the Registrant (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

Date:	June 8, 2012	/s/    Brian Mitts
		Brian Mitts, Chief Financial Officer and Treasurer (principal financial officer)