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Exhibit 15
August 4, 2016
Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549
Commissioners:
We are aware that our report dated August 4, 2016 on our review of interim financial information of CTI BioPharma Corp. for the three- and six-month periods ended June 30, 2016 and 2015, and included in the Company’s quarterly report on Form 10-Q for the quarter ended June 30, 2016, is incorporated by reference in the Registration Statements of CTI BioPharma Corp. on Forms S-3 (Nos. 333-108926, 333-134126, 333-149980, 333-149981, 333-152171, 333-157376, 333-160969, 333-161442, 333-163479, 333-177506, 333-182330, 333-183037, 333-192748, 333-192749, 333-200452 and 333-200453) and Forms S-8 (Nos. 333-146624, 333-152168, 333-158260, 333-162955, 333-170044, 333-178158, 333-184004, 333-189611, 333-196510, 333-207176, 333-207177 and 333-211006).
Yours very truly,
/s/ Marcum LLP
Marcum LLP
San Francisco, California