The Arena Group Holdings, Inc. (AREN) 8-K Changes in Registrant's Certifying Accountant

January 12, 2012

Securities and Exchange Commission

Washington, D.C. 20549

Commissioners:

We have read Integrated Surgical Systems, Inc.’s statements included under Item 4.01 of its Form 8-K filed on January 12, 2012 and we agree with such statements concerning our firm.

/s/ SingerLewak LLP

SingerLewak LLP

Los Angeles, California