Hartford Life & Annuity Insurance Co Separate Account One CORRESP Correspondence with SEC

Jonathan D. Hatch

Assistant General Counsel

Talcott Resolution Law Group

The Hartford

One Hartford Plaza (NP4-TR1)

Hartford, CT 06115

Tel. +1-860-547-4496

jonathan.hatch@thehartford.com

December 1, 2015Ms. Deborah Skeens

Senior Counsel

Office of Insurance Products

U.S. Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re:    Director Plus 333-91933: Accession 0001628280-15-007172    Director Access 333-45303: Accession 0001628280-15-007174    Director 4-5 033-56790: Accession 0001628280-15-007176

Dear Ms. Skeens:
We have made conforming changes to the Supplements listed above consistent with the changes described in my correspondence to you dated November 4, 2015, and November 16, 2105. We plan to file the various supplements later today.

Tandy Representations

Registrant hereby acknowledges that the Staff of the Commission has not passed upon the accuracy or adequacy of the prospectus supplement or prospectus for the above referenced registration statement. Registrant further acknowledges that the review of the filing by the Staff of the Commission does not relieve it of its full responsibility for the adequacy and accuracy of the disclosure of this filing nor does it foreclose the Commission from taking any action with respect to the filing. Further, Registrant acknowledges that it may not assert as a defense in any proceeding initiated by the Commission or any person under federal securities law that the Staff of the Commission reviewed the filing and provided comments to the Registrant or that the filing became automatically effective thereafter.

1

If you have any questions, please contact me at 860-547-4496 or at jonathan.hatch@thehartford.com.

Very truly yours,

/s/ Jonathan D. Hatch

Jonathan D. Hatch

2