Myriad Genetics (MYGN) 10-Q 6 May 22 2022 Q1 Quarterly report Financial data

Cover

Cover - shares	3 Months Ended
	Mar. 31, 2022	Apr. 29, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2022
Document Transition Report	false
Entity File Number	0-26642
Entity Registrant Name	MYRIAD GENETICS, INC.
Entity Central Index Key	0000899923
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q1
Amendment Flag	false
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	87-0494517
Entity Address, Address Line One	320 Wakara Way
Entity Address, City or Town	Salt Lake City
Entity Address, State or Province	UT
Entity Address, Postal Zip Code	84108
City Area Code	801
Local Phone Number	584-3600
Title of 12(b) Security	Common Stock, $0.01 par value
Trading Symbol	MYGN
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		80,343,165

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 165.2	$ 258.4
Marketable investment securities	103.2	81.4
Trade accounts receivable	101.7	91.3
Inventory	15.6	15.3
Prepaid taxes	18.8	18.4
Prepaid expenses and other current assets	22.9	20
Total current assets	427.4	484.8
Operating lease right-of-use assets	70.9	81.8
Long-term marketable investment securities	70.8	59
Property, plant, and equipment, net	45.7	43.5
Intangibles, net	393.6	404.1
Goodwill	238.8	239.2
Other assets	8.2	8.3
Total assets	1,255.4	1,320.7
Current liabilities:
Accounts payable	27.1	29.6
Accrued liabilities	124.8	156.5
Current maturities of operating lease liabilities	13.4	13
Deferred revenues	0.7	5.2
Total current liabilities	166	204.3
Unrecognized tax benefits	28	27.9
Long-term deferred taxes	29.9	35.8
Noncurrent operating lease liabilities	76.5	79.3
Other long-term liabilities	4.9	5.6
Total liabilities	305.3	352.9
Commitments and contingencies
Stockholders’ equity:
Common stock, 80.3 million and 80.0 million shares outstanding at March 31, 2022 and December 31, 2021, respectively	0.8	0.8
Additional paid-in capital	1,231.6	1,226.3
Accumulated other comprehensive loss	(7.6)	(5.1)
Accumulated deficit	(274.7)	(254.2)
Total Myriad Genetics, Inc. stockholders’ equity	950.1	967.8
Non-controlling interest	0	0
Total stockholders' equity	950.1	967.8
Total liabilities and stockholders’ equity	$ 1,255.4	$ 1,320.7

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Parenthetical) - shares shares in Millions	Mar. 31, 2022	Dec. 31, 2021	Mar. 31, 2021	Dec. 31, 2020
Statement of Financial Position [Abstract]
Common stock, shares outstanding	80.3	80	76.7	75.4

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues:
Total revenue	$ 164.9	$ 173.1
Costs and expenses:
Research and development expense	21.2	23.1
Selling, general, and administrative expense	110.6	146.4
Goodwill and long-lived asset impairment charges	10.7	0
Total costs and expenses	190.5	219.8
Operating loss	(25.6)	(46.7)
Other income (expense):
Interest income	0.1	0.2
Interest expense	(0.9)	(3)
Other	0	(0.1)
Total other income (expense), net	(0.8)	(2.9)
Loss before income tax	(26.4)	(49.6)
Income tax benefit	(5.9)	(10.1)
Net loss	(20.5)	(39.5)
Net loss attributable to non-controlling interest	0	0
Net loss attributable to Myriad Genetics, Inc. stockholders	$ (20.5)	$ (39.5)
Net loss per share:
Basic (in dollars per share)	$ (0.26)	$ (0.52)
Diluted (in dollars per share)	$ (0.26)	$ (0.52)
Weighted average shares outstanding:
Basic (shares)	80.1	76
Diluted (shares)	80.1	76
Molecular diagnostic testing
Revenues:
Total revenue	$ 164.9	$ 159.6
Costs and expenses:
Cost of revenue	48	44.1
Pharmaceutical and clinical services
Revenues:
Total revenue	0	13.5
Costs and expenses:
Cost of revenue	$ 0	$ 6.2

Condensed Consolidated Statem_2

Condensed Consolidated Statements of Comprehensive Loss - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Statement of Comprehensive Income [Abstract]
Net loss attributable to Myriad Genetics, Inc. stockholders	$ (20.5)	$ (39.5)
Unrealized loss on available-for-sale debt securities, net of tax	(1.3)	(0.2)
Change in foreign currency translation adjustment, net of tax	(1.2)	(1.1)
Comprehensive loss	(23)	(40.8)
Comprehensive loss attributable to Myriad Genetics, Inc. stockholders	$ (23)	$ (40.8)

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Millions	Total	Common stock	Additional paid-in capital	Accumulated other comprehensive loss	Accumulated deficit
Beginning balance at Dec. 31, 2020	$ 881	$ 0.8	$ 1,109.5	$ (2.3)	$ (227)
Issuance of common stock under stock-based compensation plans, net of shares exchanged for withholding tax	26		26
Stock-based payment expense	9		9
Net income (loss)	(39.5)				(39.5)
Other comprehensive income (loss), net of tax	(1.3)			(1.3)
Ending balance at Mar. 31, 2021	875.2	0.8	1,144.5	(3.6)	(266.5)
Beginning balance at Dec. 31, 2021	967.8	0.8	1,226.3	(5.1)	(254.2)
Issuance of common stock under stock-based compensation plans, net of shares exchanged for withholding tax	(4.8)		(4.8)
Stock-based payment expense	10.1		10.1
Net income (loss)	(20.5)				(20.5)
Other comprehensive income (loss), net of tax	(2.5)			(2.5)
Ending balance at Mar. 31, 2022	$ 950.1	$ 0.8	$ 1,231.6	$ (7.6)	$ (274.7)

Condensed Consolidated Statem_4

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Millions	3 Months Ended		12 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss attributable to Myriad Genetics, Inc. stockholders	$ (20.5)	$ (39.5)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation and amortization	13	18.4
Non-cash interest expense	0.2	0.5
Non-cash lease expense	3.1	3.5
Stock-based compensation expense	10.1	9
Deferred income taxes	(5.9)	(11.8)
Unrecognized tax benefits	0.2	0.3
Impairment of goodwill and long-lived assets	10.7	0
Changes in assets and liabilities:
Prepaid expenses and other current assets	(3)	(2.5)
Trade accounts receivable	(10.5)	(4.7)
Inventory	(0.2)	2.4
Prepaid taxes	(0.4)	90.3
Other assets	(0.3)	(1.2)
Accounts payable	(3.2)	0.3
Accrued liabilities	(35.3)	8.4
Deferred revenues	(4.5)	(1.6)
Net cash provided by (used in) operating activities	(46.5)	71.8
CASH FLOWS FROM INVESTING ACTIVITIES:
Capital expenditures	(6.3)	(7.1)
Purchases of marketable investment securities	(52.1)	0
Proceeds from maturities and sales of marketable investment securities	17.1	15.3
Net cash provided by (used in) investing activities	(41.3)	8.2
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from common stock issued under stock-based compensation plans	0.3	26.5
Payment of tax withheld for common stock issued under stock-based compensation plans	(5.1)	(0.5)
Payment of contingent consideration recognized at acquisition	0	(3.3)
Fees associated with refinancing of revolving credit facility	0	(1.2)
Repayment of revolving credit facility	0	(70)
Net cash used in financing activities	(4.8)	(48.5)
Effect of foreign exchange rates on cash and cash equivalents	(0.6)	0.4
Net increase (decrease) in cash and cash equivalents	(93.2)	31.9
Cash and cash equivalents at beginning of the period	258.4	117	$ 117
Cash and cash equivalents at end of the period	$ 165.2	$ 148.9	$ 258.4

Basis of Presentation

Basis of Presentation	3 Months Ended
	Mar. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Basis of Presentation	BASIS OF PRESENTATION Myriad Genetics, Inc. and its subsidiaries (collectively, the “Company” or “Myriad”) is a leading genetic testing and precision medicine company dedicated to advancing health and well-being for all. Myriad provides insights that help people take control of their health and enable healthcare providers to better detect, treat, and prevent disease. Myriad develops and commercializes genetic tests that help assess the risk of developing disease or disease progression or guide treatment decisions across medical specialties. The Company generates revenue by performing molecular diagnostic tests and, prior to the sale of Myriad RBM, Inc. on July 1, 2021, by providing pharmaceutical services to the pharmaceutical and biotechnology industries and medical research institutions utilizing its multiplexed immunoassay technology. The Company currently operates as a single reporting segment. The Company’s corporate headquarters are located in Salt Lake City, Utah. The accompanying Condensed Consolidated Financial Statements for the Company have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and pursuant to the applicable rules and regulations of the Securities and Exchange Commission (“SEC”). All intercompany accounts and transactions have been eliminated in consolidation. In the opinion of management, the accompanying financial statements contain all adjustments (consisting of normal and recurring accruals) necessary to present fairly all financial statements in accordance with GAAP. The Condensed Consolidated Financial Statements herein should be read in conjunction with the Company’s audited Consolidated Financial Statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 (the “Form 10-K”). The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements, as well as the reported amounts of revenue and expenses during the reporting period. Operating results for the three months ended March 31, 2022 may not necessarily be indicative of results to be expected for any other interim period or for the full year. The Company has historically experienced seasonality in its testing business. In the quarters ended March 31, the Company has typically experienced a decrease in volumes due to the annual reset of patient deductibles. Additionally, the volume of testing is negatively impacted by the summer season, which is generally reflected in the quarter ended September 30th. The quarter ended December 31 is generally strong as the Company typically experiences an increase in volumes from patients who have met their annual insurance deductible. Due to the ongoing COVID-19 global pandemic, including variants of COVID-19 (“COVID-19”), seasonality may not follow the same pattern as in prior years. Volumes and results of operations were impacted negatively in calendar year 2021 and early 2022 by COVID-19. As such, the Company’s year over year results may not be comparable. Management continues to monitor the impact of COVID-19 on the Company’s financial condition, liquidity, operations, suppliers, industry, and workforce. Given the variants of COVID-19 that have surfaced around the world, the Company is not able to fully estimate the effects of COVID-19 on its results of operations, financial condition, or liquidity for future periods. Reclassifications Certain prior period amounts have been reclassified to conform with the current period's presentation. The reclassifications have no impact on the total assets, total liabilities, stockholders’ equity, cash flows from operations, or net loss for the period.

Revenue

Revenue	3 Months Ended
	Mar. 31, 2022
Revenue from Contract with Customer [Abstract]
Revenue	REVENUE Myriad primarily generates revenue by performing molecular diagnostic testing. Molecular diagnostic revenues are derived from the following categories of products: Hereditary Cancer (myRisk, BRACAnalysis, BRACAnalysis CDx), Tumor Profiling (MyChoice CDx, Prolaris, EndoPredict, and Precise), Prenatal (Foresight and Prequel), Pharmacogenomics (GeneSight), Autoimmune (Vectra), and Other. The Company previously provided pharmaceutical services and clinical services prior to the sale of Myriad RBM, Inc. in July 2021 and Privatklinik Dr. Robert Schindlbeck GmbH & Co. KG (the “Clinic”) in February 2020, respectively. Prior to the sale of the Myriad myPath, LLC laboratory in May 2021 and the Myriad Autoimmune business in September 2021, the associated revenue from such businesses was included within Molecular diagnostic revenues. Revenue is recorded at the estimated transaction price. The Company has determined that the communication of test results or the completion of pharmaceutical and clinical services indicates transfer of control for revenue recognition purposes. The following table presents detail regarding the composition of the Company’s total revenue by type and by U.S. versus rest of world (“RoW”): Three months ended March 31, 2022 2021 (in millions) U.S. RoW Total U.S. RoW Total Molecular diagnostic revenues: Hereditary Cancer $ 60.7 $ 10.2 $ 70.9 $ 65.1 $ 11.0 $ 76.1 Tumor Profiling 19.7 12.8 32.5 24.2 6.8 31.0 Prenatal 31.7 0.2 31.9 23.6 0.1 23.7 Pharmacogenomics 29.3 — 29.3 17.6 — 17.6 Autoimmune 0.3 — 0.3 10.7 — 10.7 Other — — — — 0.5 0.5 Total molecular diagnostic revenue 141.7 23.2 164.9 141.2 18.4 159.6 Pharmaceutical and clinical services revenue — — — 13.5 — 13.5 Total revenue $ 141.7 $ 23.2 $ 164.9 $ 154.7 $ 18.4 $ 173.1 The Company performs its obligation under a contract with a customer by processing diagnostic tests and communicating the test results to customers, in exchange for consideration from the customer. The Company has the right to bill its customers upon the completion of performance obligations and thus does not record contract assets. Occasionally, customers make payments prior to the Company’s performance of its contractual obligations. When this occurs, the Company records a contract liability as deferred revenue. During the fiscal year ended June 30, 2020, the Company received approximately $29.7 million in advance Medicare payments to provide relief from the economic impacts of COVID-19 on the Company. The advanced Medicare payments were applied against services performed in April 2021 and continued until the funds previously received were fully earned, which occurred during the quarter ended March 31, 2022. A reconciliation of the beginning and ending balances of deferred revenue is shown in the table below: Three months ended (in millions) 2022 2021 Deferred revenue - beginning balance $ 5.2 $ 32.7 Revenue recognized (4.8) (6.7) Prepayments 0.3 5.1 Deferred revenue - ending balance $ 0.7 $ 31.1 In accordance with ASC Topic 606, Revenue from Contracts with Customers, the Company has elected not to disclose the aggregate amount of the transaction price allocated to remaining performance obligations for its contracts that are one year or less, as the revenue is expected to be recognized within the next year. Furthermore, the Company has elected not to disclose the aggregate amount of the transaction price allocated to remaining performance obligations for its agreements wherein the Company’s right to payment is in an amount that directly corresponds with the value of the Company’s performance to date. In determining the transaction price, the Company includes an estimate of the expected amount of consideration as revenue. The Company applies this method consistently for similar contracts when estimating the effect of any uncertainty on an amount of variable consideration to which it will be entitled. An estimate of transaction price does not include any estimated amount of variable consideration that is constrained. In addition, the Company considers all the information (historical, current, and forecast) that is reasonably available to identify possible consideration amounts. In determining the expected value, the Company considers the probability of the variable consideration for each possible scenario. The Company also has significant experience with historical discount patterns and uses this experience to estimate transaction prices. The estimate of revenue is affected by assumptions in payor behavior such as changes in payor mix, payor collections, current customer contractual requirements, and experience with collections from third-party payors. When assessing the total consideration for insurance carriers and patients, revenues are further constrained for estimated refunds. The Company reserves certain amounts in Accrued liabilities in the Company’s Condensed Consolidated Balance Sheets in anticipation of requests for refunds of payments made previously by insurance carriers, which are accounted for as reductions in revenues in the Condensed Consolidated Statements of Operations and Comprehensive Loss. Cash collections for certain diagnostic tests delivered may differ from rates originally estimated, primarily driven by changes in the estimated transaction price due to contractual adjustments, obtaining updated information from payors and patients that was unknown at the time the performance obligation was met, and settlements with third party payors. During the three months ended March 31, 2022, the Company recognized $12.4 million in revenue, which resulted in a $0.12 impact to earnings per share for tests in which the performance obligation of delivering the tests results was met in prior periods. The changes were primarily driven by changes in the estimated transaction price. The Company applies the practical expedient related to costs to obtain or fulfill a contract since the amortization period for such costs will be one year or less. Accordingly, no costs incurred to obtain or fulfill a contract have been capitalized. The Company also applies the practical expedient for not adjusting revenue recognized for the effects of the time value of money. This practical expedient has been elected because the Company collects very little cash from customers under payment terms and the vast majority of payment terms have a payback period of less than one year. Concentration of Credit Risk Financial instruments that potentially subject the Company to concentrations of credit risk consist primarily of cash and cash equivalents and accounts receivable. Substantially all of the Company’s accounts receivable are with companies in the healthcare industry, U.S. and state governmental agencies, and individuals. The Company does not believe that receivables due from U.S. and state governmental agencies, such as Medicare, represent a credit risk since the related healthcare programs are funded by the U.S. and state governments. The Company only has one payor, Medicare which represents greater than 10% of its revenues. Revenues received from Medicare represented 13% and 19% of total revenue for the three months ended March 31, 2022 and March 31, 2021, respectively. Concentrations of credit risk are mitigated due to the number of the Company’s customers as well as their dispersion across many geographic regions. No payor accounted for more than 10% of accounts receivable at March 31, 2022 or December 31, 2021. The Company does not require collateral from its customers.

Marketable Investment Securitie

Marketable Investment Securities	3 Months Ended
	Mar. 31, 2022
Investments, Debt and Equity Securities [Abstract]
Marketable Investment Securities	MARKETABLE INVESTMENT SECURITIES The amortized cost, gross unrealized holding gains, gross unrealized holding losses, and fair value for available-for-sale securities by major security type and class of security at March 31, 2022 and December 31, 2021 were as follows: (in millions) Amortized Gross Gross Estimated March 31, 2022 Cash and cash equivalents: Cash $ 138.0 $ — $ — $ 138.0 Cash equivalents 27.2 — — 27.2 Total cash and cash equivalents 165.2 — — 165.2 Available-for-sale: Corporate bonds and notes 109.1 — (1.0) 108.1 Municipal bonds 21.6 — (0.2) 21.4 Federal agency issues 18.0 — (0.3) 17.7 US government securities 27.0 — (0.2) 26.8 Total $ 340.9 $ — $ (1.7) $ 339.2 (in millions) Amortized Gross Gross Estimated December 31, 2021: Cash and cash equivalents: Cash $ 195.2 $ — $ — $ 195.2 Cash equivalents 63.2 — — 63.2 Total cash and cash equivalents 258.4 — — 258.4 Available-for-sale: Corporate bonds and notes 105.7 0.1 (0.2) 105.6 Municipal bonds 16.1 — — 16.1 Federal agency issues 6.8 — — 6.8 US government securities 11.9 — — 11.9 Total $ 398.9 $ 0.1 $ (0.2) $ 398.8 Cash, cash equivalents, and maturities of debt securities classified as available-for-sale securities were as follows at March 31, 2022: (in millions) Amortized Estimated Cash $ 138.0 $ 138.0 Cash equivalents 27.2 27.2 Available-for-sale: Due within one year 103.4 103.2 Due after one year through five years 72.3 70.8 Due after five years — — Total $ 340.9 $ 339.2 Additional information relating to fair value of marketable investment securities can be found in Note 4.

Fair Value Measurements

Fair Value Measurements	3 Months Ended
	Mar. 31, 2022
Fair Value Disclosures [Abstract]
Fair Value Measurements	FAIR VALUE MEASUREMENTS The fair value of the Company’s financial instruments reflects the amounts that the Company estimates it will receive in connection with the sale of an asset or pay in connection with the transfer of a liability in an orderly transaction between market participants at the measurement date (exit price). The fair value hierarchy prioritizes the use of inputs used in valuation techniques into the following three levels: Level 1—quoted prices in active markets for identical assets and liabilities. Level 2—observable inputs other than quoted prices in active markets for identical assets and liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. Some of the Company’s marketable securities primarily utilize broker quotes in a non-active market for valuation of these securities. Level 3—unobservable inputs. All of the Company’s financial instruments are valued using quoted prices in active markets or based on other observable inputs. For Level 2 securities, the Company uses a third party pricing service which provides documentation on an ongoing basis that includes, among other things, pricing information with respect to reference data, methodology, inputs summarized by asset class, pricing application and corroborative information. For Level 3 contingent consideration, the Company reassesses the fair value of expected contingent consideration and the corresponding liability each reporting period using the Monte Carlo Method, which is consistent with the initial measurement of the expected earn out liability. This fair value measurement is considered a Level 3 measurement because the Company estimates projections during the expected measurement period of approximately 13.3 years, utilizing various potential pay-out scenarios. Probabilities were applied to each potential scenario and the resulting values were discounted using a rate that considers weighted average cost of capital as well as a specific risk premium associated with the riskiness of the earn-out itself, the related projections, and the overall business. The contingent earn-out liabilities are classified as components of Accrued liabilities and Other long-term liabilities in the Company’s Condensed Consolidated Balance Sheets. Changes to contingent consideration liabilities are reflected in Selling, general and administrative expense in the Company’s Condensed Consolidated Statements of Operations. Changes to the unobservable inputs could have a material impact on the Company’s financial statements. The following table sets forth the fair value of the financial assets and liabilities that the Company re-measures on a regular basis: (in millions) Level 1 Level 2 Level 3 Total March 31, 2022 Money market funds (a) $ 27.2 $ — $ — $ 27.2 Corporate bonds and notes — 108.1 — 108.1 Municipal bonds — 21.4 — 21.4 Federal agency issues — 17.7 — 17.7 US government securities — 26.8 — 26.8 Contingent consideration — — (7.9) (7.9) Total $ 27.2 $ 174.0 $ (7.9) $ 193.3 (a) Money market funds are primarily comprised of exchange traded funds and accrued interest. (in millions) Level 1 Level 2 Level 3 Total December 31, 2021 Money market funds (a) $ 63.2 $ — $ — $ 63.2 Corporate bonds and notes — 105.6 — 105.6 Municipal bonds — 16.1 — 16.1 Federal agency issues — 6.8 — 6.8 US government securities — 11.9 — 11.9 Contingent consideration — — (8.6) (8.6) Total $ 63.2 $ 140.4 $ (8.6) $ 195.0 (a) Money market funds are primarily comprised of exchange traded funds and accrued interest. The following table reconciles the change in the fair value of the contingent consideration during the periods presented: (in millions) Carrying Balance December 31, 2021 $ 8.6 Change in fair value recognized in the Statement of Operations (0.5) Translation adjustments recognized in Other comprehensive loss (0.2) Ending balance March 31, 2022 $ 7.9

Property, Plant and Equipment,

Property, Plant and Equipment, Net	3 Months Ended
	Mar. 31, 2022
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment, Net	PROPERTY, PLANT AND EQUIPMENT, NET (in millions) March 31, December 31, Leasehold improvements $ 34.2 $ 38.0 Equipment 114.9 112.4 Property, plant and equipment, gross 149.1 150.4 Less accumulated depreciation (103.4) (106.9) Property, plant and equipment, net $ 45.7 $ 43.5 During the three months ended March 31, 2022, the Company ceased the use of one of its leased Salt Lake City facilities. As a result, the Company recognized a $2.1 million impairment on the property, plant and equipment associated with the lease, which consisted primarily of leasehold improvements. See Note 15 for further discussion. Three months ended (in millions) 2022 2021 Depreciation expense $ 2.8 $ 2.9

Goodwill and Intangible Assets

Goodwill and Intangible Assets	3 Months Ended
	Mar. 31, 2022
Goodwill and Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets	GOODWILL AND INTANGIBLE ASSETS Goodwill The following table summarizes the changes in the carrying amount of goodwill for the three months ended March 31, 2022: (in millions) Total Beginning balance $ 239.2 Translation adjustments (0.4) Ending balance $ 238.8 Intangible Assets Intangible assets consists of purchased licenses and technologies. The following summarizes the amounts reported as intangible assets: (in millions) Gross Accumulated Net At March 31, 2022: Purchased licenses and technologies $ 616.1 $ (222.5) $ 393.6 Total intangible assets $ 616.1 $ (222.5) $ 393.6 (in millions) Gross Accumulated Net At December 31, 2021: Purchased licenses and technologies $ 616.6 $ (212.5) $ 404.1 Total intangible assets $ 616.6 $ (212.5) $ 404.1 The Company recorded amortization expense during the respective periods for these intangible assets as follows: Three months ended (in millions) 2022 2021 Amortization of intangible assets $ 10.2 $ 15.5

Accrued Liabilities

Accrued Liabilities	3 Months Ended
	Mar. 31, 2022
Payables and Accruals [Abstract]
Accrued Liabilities	ACCRUED LIABILITIES (in millions) March 31, December 31, Employee compensation and benefits $ 37.9 $ 52.8 Legal charges pending settlement 48.0 62.0 Accrued taxes payable 4.1 4.0 Refunds payable and reserves 9.2 9.8 Short-term contingent consideration 3.1 3.2 Accrued royalties 5.0 5.4 Other accrued liabilities 17.5 19.3 Total accrued liabilities $ 124.8 $ 156.5

Long-Term Debt

Long-Term Debt	3 Months Ended
	Mar. 31, 2022
Debt Disclosure [Abstract]
Long-Term Debt	LONG-TERM DEBT On December 23, 2016, the Company entered into a senior secured revolving credit facility (the “Facility”) as borrower, with the lenders from time to time party thereto. On July 31, 2018, the Company entered into Amendment No. 1 to the Facility, which effected an “amend and extend” transaction with respect to the Facility by which the maturity date thereof was extended to July 31, 2023 and the maximum aggregate principal commitment was increased from $300.0 million to $350.0 million. On May 1, 2020, the Company entered into Amendment No. 2 to the Facility, which waived the Company’s compliance with certain covenants and modified the interest rate and other terms during the modification period from March 31, 2020 through June 30, 2021 (“Modification Period”). This included a modification to the Amended Facility's compliance with the leverage covenant and the interest coverage ratio covenant, which were waived through March 31, 2021, as well as revision to certain negative covenants of the Amended Facility during the Modification Period. On February 22, 2021, the Company entered into Amendment No. 3 (the “Amended Facility”), which waived compliance with the leverage ratio and the interest coverage ratio covenants through the quarter ended March 31, 2022 and also lowered the minimum liquidity covenant, which was added by Amendment No. 2, to $150.0 million, and made it applicable through such quarter. Amendment No. 3 also restricted the Company from borrowing under the Amended Facility if unrestricted cash, cash equivalents and marketable investment securities exceed $150.0 million, unless such borrowings are in connection with permitted acquisitions, decreased the maximum aggregate principal commitment from $350.0 million to $300.0 million, with a further reduction in the maximum aggregate principal commitment from $300.0 million to $250.0 million by September 30, 2021, extended the Modification Period for an additional year through June 30, 2022, and revised certain negative covenants in connection with the extension. The amendments were accounted for as modifications pursuant to guidance in ASC 470-50, Debt. Covenants in the Amended Facility impose operating and financial restrictions on the Company. These restrictions may prohibit or place limitations on, among other things, the Company’s ability to incur additional indebtedness, create certain types of liens, and complete mergers, consolidations, or change in control transactions. The Amended Facility may also prohibit or place limitations on the Company’s ability to sell assets, pay dividends or provide other distributions to stockholders. Beginning with the quarter ended June 30, 2022, the Company must maintain specified leverage and interest ratios measured as of the end of each quarter as a financial covenant in the Amended Facility. The Company was in compliance with all applicable financial covenants at March 31, 2022. It is possible that the Company could be in violation of certain financial covenants contained in the Amended Facility in the future. If the Company is unable to comply with certain covenants and ratios in the Amended Facility, the Company may be in default under the Amended Facility, which could impact the Company's ability to borrow under the facility or result in the termination of the commitments under the Amended Facility or the Company being required to pay off any outstanding loans or fees and cash collateralize any outstanding letters of credit. In the future, the Company may seek waivers or amendments from lenders in order to avoid a future covenant violation, in addition to taking other potential actions. The Amended Facility contains customary loan terms, interest rates, representations and warranties, affirmative and negative covenants, in each case, subject to customary limitations, exceptions and exclusions. The Amended Facility also contains certain customary events of default. Amendment No. 2 modified the Amended Facility to increase the interest rate to be fixed at a spread of LIBOR plus 350 basis points on drawn balances and the undrawn fee was increased to 50 basis points during the Modification Period. At the end of the Modification Period, interest rates return to the previous pricing based on a spread of LIBOR plus 150-250 basis points on drawn balances and an undrawn fee ranging from 25 to 45 basis points, in each case, based on the Company's leverage ratio. The LIBOR floor was also increased to 1.0% during the Modification Period. During the year ended December 31, 2021, the Company made principal repayments totaling $226.4 million to pay off the remaining outstanding balances on the Amended Facility. As a result, the Company had no outstanding balances under the Amended Facility as of March 31, 2022 and December 31, 2021. The Company's maximum aggregate principal commitment on its Amended Facility is $250.0 million as of March 31, 2022.

Other Long-Term Liabilities

Other Long-Term Liabilities	3 Months Ended
	Mar. 31, 2022
Other Liabilities Disclosure [Abstract]
Other Long-Term Liabilities	OTHER LONG-TERM LIABILITIES (in millions) March 31, December 31, Contingent consideration $ 4.8 $ 5.4 Other 0.1 0.2 Total other long-term liabilities $ 4.9 $ 5.6

Preferred and Common Stockholde

Preferred and Common Stockholders' Equity	3 Months Ended
	Mar. 31, 2022
Equity [Abstract]
Preferred and Common Stockholders' Equity	PREFERRED AND COMMON STOCKHOLDERS' EQUITY The Company is authorized to issue up to 5.0 million shares of preferred stock, par value $0.01 per share. There were no preferred shares outstanding at March 31, 2022. The Company is authorized to issue up to 150.0 million shares of common stock, par value $0.01 per share. There were 80.3 million shares issued and outstanding at March 31, 2022. Common shares issued and outstanding Three months ended (in millions) 2022 2021 Beginning common stock issued and outstanding 80.0 75.4 Common stock issued upon exercise of options, vesting of restricted stock units, and purchases under employee stock purchase plan 0.3 1.3 Common stock issued and outstanding at end of period 80.3 76.7 Basic earnings per share is computed based on the weighted-average number of shares of common stock outstanding. Diluted earnings per share is computed based on the weighted-average number of shares of common stock, including the dilutive effect of common stock equivalents, outstanding. In periods when the Company has a net loss, stock awards are excluded from the calculation of diluted net loss per share as their inclusion would have an antidilutive effect. The following is a reconciliation of the denominators of the basic and diluted earnings per share (“EPS”) computations: Three months ended (in millions) 2022 2021 Denominator: Weighted-average shares outstanding used to compute basic EPS 80.1 76.0 Effect of dilutive shares — — Weighted-average shares outstanding and dilutive securities used to compute diluted EPS 80.1 76.0 Certain outstanding options and restricted stock units (“RSUs”) were excluded from the computation of diluted earnings per share because the effect would have been anti-dilutive. These potential dilutive common shares, which may be dilutive to future diluted earnings per share, are as follows: Three months ended (in millions) 2022 2021 Anti-dilutive options and RSUs excluded from EPS computation 5.5 0.3 Stock Repurchase Program In June 2016, the Company’s Board of Directors authorized a share repurchase program of $200.0 million of the Company’s outstanding common stock. The Company may repurchase its common stock from time to time or on an accelerated basis through open market transactions or privately negotiated transactions as determined by the Company's management. The amount and timing of stock repurchases under the program will depend on business and market conditions, stock price, trading restrictions, acquisition activity and other factors. As of March 31, 2022, the Company has $110.7 million remaining under its current share repurchase authorization. No shares were repurchased during the three months ended March 31, 2022 or 2021.

Stock-Based Compensation

Stock-Based Compensation	3 Months Ended
	Mar. 31, 2022
Share-based Payment Arrangement [Abstract]
Stock-Based Compensation	STOCK-BASED COMPENSATION On November 30, 2017, the Company’s stockholders approved the adoption of the 2017 Employee, Director and Consultant Equity Incentive Plan (as amended, the “2017 Plan”). The 2017 Plan allows the Company, under the direction of the Compensation and Human Capital Committee of the Board of Directors, to make grants of restricted and unrestricted stock awards to employees, consultants, and directors. Stockholders have approved amendments to the 2017 Plan increasing the shares available to grant. As of March 31, 2022, the Company has 2.0 million shares of common stock available for grant under the 2017 Plan. If an RSU awarded under the 2017 Plan is cancelled or forfeited without the issuance of shares of common stock, the unissued or reacquired shares that were subject to the RSU will again be available for issuance pursuant to the 2017 Plan. To the extent that awards outstanding under the Company's prior equity plans expire or are cancelled without delivery of shares of common stock, they also will be available for issuance pursuant to the 2017 Plan. The number of shares, terms, and vesting periods are generally determined by the Company’s Board of Directors or a committee thereof on an award-by-award basis. RSUs granted to employees generally vest ratably over four years either on the anniversary of the date on which the RSUs were granted or during the month in which such anniversary dates occur. The number of performance-based RSUs ("PSUs") awarded to certain employees may be increased or may be reduced based on certain additional performance and market metrics. Options and RSUs granted to non-employee directors vest in full upon the earlier of the completion of one year of service following the date of the grant or the date of the next annual meeting of stockholders following such grant. Options granted generally expire ten years from the date of grant. Options granted to the Company's President and Chief Executive Officer as an inducement to his employment expire seven years from the grant date. The performance and market conditions associated with PSU awards granted during the quarter ended March 31, 2022 include vesting that is based on revenue growth targets (34% weighting), adjusted earnings per share targets (33% weighting), and relative total stockholder return (33% weighting) measured against the Nasdaq Health Care Index (IXHC) using the 20-trading day averages at the beginning and end of the measurement period. The measurement period for the PSUs is January 1, 2022 through December 31, 2024. The Company estimates the likelihood of achievement of performance conditions at the end of each period. Stock Options A summary of the stock option activity under the Company’s equity plans and inducement awards, for the three months ended March 31, 2022 is as follows: (number of shares in millions) Number Weighted Options outstanding at December 31, 2021 1.4 $ 20.36 Less: Options exercised — $ 23.98 Options canceled or expired (0.1) $ 24.24 Options outstanding at March 31, 2022 1.3 $ 20.17 Options exercisable at March 31, 2022 0.9 $ 22.99 As of March 31, 2022, there was $2.0 million of total unrecognized stock-based compensation expense related to stock options that will be recognized over a weighted-average period of 1.8 years. There were no options granted during the three months ended March 31, 2022. Restricted Stock Units A summary of the RSU awards activity under the Company’s equity plans and inducement awards, including RSU awards with performance metrics, for the three months ended March 31, 2022 is as follows: (number of shares in millions) Number Weighted RSUs outstanding at December 31, 2021 3.1 $ 24.96 RSUs granted 1.6 $ 27.17 Less: RSUs vested (0.4) $ 28.24 RSUs canceled (0.1) $ 24.26 RSUs outstanding at March 31, 2022 4.2 $ 25.43 As of March 31, 2022, there was $90.8 million of total unrecognized stock-based compensation expense related to RSUs that will be recognized over a weighted-average period of 2.7 years. Employee Stock Purchase Plan The Company also has an Employee Stock Purchase Plan that was approved by stockholders in 2012 (the “2012 Purchase Plan”), under which 2.0 million shares of common stock have been authorized. On September 23, 2021, the Board of Directors of the Company approved an Amended and Restated 2012 Employee Stock Purchase Plan, which authorizes an additional 2.0 million shares of common stock and extends the term of the 2012 Purchase Plan to November 30, 2032, subject in each case to obtaining stockholder approval. The Company is seeking stockholder approval of the Amended and Restated 2012 Employee Stock Purchase Plan at its 2022 Annual Meeting of Stockholders to be held on June 2, 2022. The Amended and Restated 2012 Employee Stock Purchase Plan also amended certain provisions of the 2012 Purchase Plan effective upon approval by the Board of Directors, including expanding the definition of "offering period" to provide that the Board of Directors may determine the period in accordance with the terms of the plan, and capping the number of shares that may be purchased by any participant during an offering period at 5,000 shares. Shares are issued under the 2012 Purchase Plan twice yearly at the end of each offering period. As of March 31, 2022, a total of approximately 2.0 million shares of common stock had been purchased under the 2012 Purchase Plan. Stock-Based Compensation Expense Stock-based compensation expense recognized and included in the Condensed Consolidated Statements of Operations and Comprehensive Loss was allocated as follows: Three months ended (in millions) 2022 2021 Cost of molecular diagnostic testing $ 0.3 $ 0.3 Cost of pharmaceutical and clinical services — 0.1 Research and development expense 2.4 1.5 Selling, general, and administrative expense 7.4 7.1 Total stock-based compensation expense $ 10.1 $ 9.0

Income Taxes

Income Taxes	3 Months Ended
	Mar. 31, 2022
Income Tax Disclosure [Abstract]
Income Taxes	INCOME TAXES In order to determine the Company’s quarterly provision for income taxes, the Company used an estimated annual effective tax rate that is based on expected annual income and statutory tax rates in the various jurisdictions in which the Company operates. Certain significant or unusual items are separately recognized in the quarter during which they occur and can be a source of variability in the effective tax rate from quarter to quarter. Income tax benefit for the three months ended March 31, 2022 was $5.9 million, or approximately 22.3% of pre-tax income compared to an income tax benefit of $10.1 million, or approximately 20.4% of pre-tax loss, for the three months ended March 31, 2021. Income tax expense for the three months ended March 31, 2022 is based on the Company’s estimated annualized effective tax rate for the fiscal year ending December 31, 2022, adjusted for discrete items recognized during the respective periods. For the three months ended March 31, 2022, the Company’s recognized effective tax rate differs from the U.S. federal statutory rate primarily due to disallowed executive compensation expenses, disallowed meals and entertainment expenses, stock compensation expenses, and asset impairment expenses. The Company files U.S., foreign and state income tax returns in jurisdictions with various statutes of limitations. The Company is currently under audit by the State of California for the fiscal years ended June 30, 2017-2018, the State of New Jersey for the fiscal years ended June 30, 2013-2017; and Switzerland for the fiscal years ended June 30, 2015-2016. Annual and interim tax provisions include amounts considered necessary to pay assessments that may result from examination of prior year tax returns; however, the amount ultimately paid upon resolution of issues may differ materially from the amount accrued.

Commitments and Contingencies

Commitments and Contingencies	3 Months Ended
	Mar. 31, 2022
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	COMMITMENTS AND CONTINGENCIES Legal Proceedings The Company is involved from time to time in various disputes, claims and legal actions, including class actions and other litigation, including the matters described below, arising in the ordinary course of business. Such actions may include allegations of negligence, product or professional liability or other legal claims, and could involve claims for substantial compensatory and punitive damages or claims for indeterminate amount of damages. The Company is also involved, from time to time, in investigations by governmental agencies regarding the Company's business which may result in adverse judgments, settlements, fines, penalties, injunctions or other relief. In addition, certain federal and state statutes, including the qui tam provisions of the federal False Claims Act, allow private individuals to bring lawsuits against healthcare companies on behalf of the government or private payors. The Company is involved, and has received subpoenas, from time to time, related to billing or other practices based on the False Claims Act or other federal and state statutes, regulations or other laws. The Company intends to vigorously defend its current litigation matters, but cannot provide any assurance as to the ultimate outcome or that an adverse resolution would not have a material adverse effect on its financial condition, results of operations or cash flows. The Company assesses legal contingencies to determine the degree of probability and range of possible loss for potential accrual in its financial statements. When evaluating legal contingencies, the Company may be unable to provide a meaningful estimate due to a number of factors, including the proceedings may be in early stages, there may be uncertainty as to the outcome of pending appeals or motions, there may be significant factual issues to be resolved, and there may be complex or novel legal theories to be presented. In addition, damages may not be specified or the damage amounts claimed may be unsupported, exaggerated or unrelated to possible outcomes, and therefore, such amounts are not a reliable indicator of potential liability. Except as noted below, as of March 31, 2022, the Company has not recorded any accrual for loss contingencies associated with legal proceedings or other matters or determined that an unfavorable outcome is probable and reasonably estimable in accordance with ASC 450, Contingencies. However, it is possible that the ultimate resolution of legal proceedings or other matters, if unfavorable, may be material to the Company's results of operations, financial condition or cash flows. Qui Tam Lawsuit In June 2016, the Company's wholly owned subsidiary, Crescendo Bioscience, LLC (formerly known as Crescendo Biosciences, Inc. (“CBI”), received a subpoena from the Office of Inspector General of the Department of Health and Human Services (the "Office of Inspector General") requesting that CBI produce documents relating to entities that received payment from CBI for the collection and processing of blood specimens for testing, including a named unrelated company, healthcare providers and other third party entities. The Office of Inspector General subsequently requested additional documentation in December 2017. CBI provided to the Office of Inspector General the documents requested. On January 30, 2020, the United States District Court for the Northern District of California unsealed a qui tam complaint, filed on April 16, 2016 against CBI and the Company, alleging violations of the Federal and California False Claims Acts and the California Insurance Fraud Prevention Act ("CIFPA"). On January 22, 2020, after a multi-year investigation into CBI’s and the Company’s alleged conduct, the United States declined to intervene. On January 27, 2020, the State of California likewise filed its notice of declination. The Company was not aware of the complaint until after it was unsealed. On May 23, 2020, the court denied CBI and the Company’s motion to dismiss. As of March 31, 2022, the Company has accrued $48.0 million for a potential settlement of this qui tam lawsuit against CBI and the Company, which is included in accrued liabilities in the Company's Condensed Consolidated Balance Sheet as of March 31, 2022. On April 1, 2022, the Company settled the qui tam lawsuit with the relator, STF, LLC (the "Relator"). Pursuant to the terms of the settlement agreements, the Company agreed to pay a total of $45.25 million to the United States and the State of California and $2.75 million to Relator’s counsel. The Relator agreed to the dismissal of the lawsuit with prejudice as to the Relator and fully released all claims against the defendants and their affiliates, directors, officers, and employees. The State of California agreed to the dismissal of the lawsuit with prejudice as to the State of California and released the defendants from any claims submitted to the State’s Medicaid program or under the CIFPA as a result of certain alleged conduct. The United States Department of Justice approved the settlement of federal claims, including dismissal of the lawsuit without prejudice as to the United States. The settlement agreements contain no admission of liability, wrongdoing or responsibility on the part of the defendants. The Company expressly denies any and all liability for claims alleged in the lawsuit. On May 4, 2022, the qui tam lawsuit was formally dismissed by the United States District Court for the Northern District of California. Securities Class Action On September 27, 2019, a class action complaint was filed in the United States District Court for the District of Utah against the Company, its former President and Chief Executive Officer, Mark C. Capone, and its Chief Financial Officer, R. Bryan Riggsbee (the “Defendants”). On February 21, 2020, the plaintiff filed an amended class action complaint, which added the Company's former Executive Vice President of Clinical Development, Bryan M. Dechairo, as an additional Defendant. This action, captioned In re Myriad Genetics, Inc. Securities Litigation (No. 2:19-cv-00707-DBB), is premised upon allegations that the Defendants made false and misleading statements regarding the Company's business, operations, and acquisitions. The lead plaintiff seeks the payment of damages allegedly sustained by it and the purported class by reason of the allegations set forth in the amended complaint, plus interest, and legal and other costs and fees. On March 16, 2021, the United States District Court for the District of Utah denied the Company's motion to dismiss. On December 1, 2021, the United States District Court for the District of Utah granted plaintiff's motion for class certification. Stockholder Derivative Actions On August 9, 2021, a stockholder derivative complaint was filed in the Delaware Court of Chancery against the Company's former President and Chief Executive Officer, Mark C. Capone, its Chief Financial Officer, R. Bryan Riggsbee, its former Executive Vice President of Clinical Development, Bryan M. Dechairo, and certain of its current and former directors, Lawrence C. Best, Walter Gilbert, John T. Henderson, Heiner Dreismann, Dennis Langer, Lee N. Newcomer, S. Louise Phanstiel, and Colleen F. Reitan (collectively, the "Individual Defendants"), and the Company, as nominal defendant. The complaint is premised upon similar allegations as set forth in the securities class action, including that the Individual Defendants made false and misleading statements regarding the Company's business and operations. The plaintiff, Donna Hickock, asserts breach of fiduciary duty and unjust enrichment claims against the Individual Defendants and seeks, on behalf of the Company, damages allegedly sustained by the Company as a result of the alleged breaches, or disgorgement or restitution, from each of the Individual Defendants, plus interest. Plaintiff Hickock also seeks legal and other costs and fees relating to this action. On November 19, 2021, this action was stayed by the Delaware Court of Chancery pending the resolution of the securities class action lawsuit. On January 18, 2022, a stockholder derivative complaint was filed in the Delaware Court of Chancery against the Individual Defendants, and the Company, as nominal defendant. The action is premised upon similar allegations as set forth in the securities class action and the Hickock stockholder derivative action. The plaintiff, Esther Kogus, asserts that the Individual Defendants breached their fiduciary duties and also asserts unjust enrichment and aiding and abetting breaches of fiduciary duty claims against the Individual Defendants. Plaintiff Kogus seeks, on behalf of the Company, damages allegedly sustained by the Company as a result of the alleged breaches and claims, and restitution from the Individual Defendants. On behalf of herself, plaintiff Kogus seeks legal and other costs and fees relating to this action. On March 3, 2022, the Delaware Court of Chancery consolidated the Hickock and Kogus derivative actions and stayed the consolidated action. On September 17, 2021, a stockholder derivative complaint was filed in the United States District Court in the District of Delaware against the Individual Defendants, and the Company, as nominal defendant. The action is premised upon similar allegations as set forth in the securities class action and Hickock stockholder derivative action. The plaintiff, Karen Marcey, asserts that the Individual Defendants violated U.S. securities laws and breached their fiduciary duties, and also asserts unjust enrichment, waste of corporate assets and insider trading claims against all or some of the Individual Defendants. Plaintiff Marcey seeks, on behalf of the Company, damages allegedly sustained by the Company as a result of the alleged violations and restitution from the Individual Defendants, plus interest and, on behalf of herself, legal and other costs and fees relating to this action. On January 4, 2022, this action was stayed by the United States District Court for the District of Delaware pending the resolution of the securities class action lawsuit. Other Legal Matters On February 3, 2022, a purported class action lawsuit was filed against the Company in the United States District Court in the Northern District of California by Ashley Carroll. Plaintiff alleges, among other things, that the Company made false statements about the accuracy of its Prequel prenatal screening test. The complaint seeks unspecified monetary damages and injunctive relief. On April 1, 2022, the Company filed a motion to dismiss the lawsuit.

Supplemental Cash Flow Informat

Supplemental Cash Flow Information	3 Months Ended
	Mar. 31, 2022
Supplemental Cash Flow Elements [Abstract]
Supplemental Cash Flow Information	SUPPLEMENTAL CASH FLOW INFORMATION Three months ended (in millions) 2022 2021 Cash paid during the period for income taxes $ 0.3 $ — Cash paid for interest — 2.3 Establishment of operating lease right-of-use assets and lease liabilities Operating lease right-of-use assets $ — $ 2.7 Operating lease liabilities 0.8 2.7 Purchases of property, plant and equipment in accounts payable 0.9 —

Leases

Leases	3 Months Ended
	Mar. 31, 2022
Leases [Abstract]
Leases	LEASES The Company leases certain office spaces and research and development laboratory facilities, vehicles, and office equipment with remaining lease terms ranging from one to fourteen years. During the quarter ended March 31, 2022, in an effort to reduce its real estate footprint, the Company ceased the use of one of its leased Salt Lake City facilities. As a result, the Company recorded an impairment charge on right-of-use assets of $8.6 million and an impairment charge of $2.1 million on the related leasehold improvements. The total $10.7 million impairment is included in Goodwill and long-lived asset impairment charges in the Condensed Consolidated Statement of Operations. In the first quarter of 2022, we entered into a non-cancelable operating lease for approximately 230,000 square feet in west Salt Lake City, Utah. The lease has a term of 15 years, which, along with rent payments, are expected to commence in the third quarter of 2023. Total future rent payments under the lease is approximately $77.8 million.

Subsequent Events

Subsequent Events	3 Months Ended
	Mar. 31, 2022
Subsequent Events [Abstract]
Subsequent Events	SUBSEQUENT EVENTSAs previously noted, on April 1, 2022, the Company settled the qui tam lawsuit with the Relator. Pursuant to the terms of the settlement agreements, the Company agreed to pay a total of $45.25 million to the United States and the State of California and $2.75 million to Relator’s counsel. On April 7, 2022, the Company paid the settlement amounts in full. On May 4, 2022, the qui tam lawsuit was formally dismissed by the United States District Court for the Northern District of California.

Basis of Presentation (Policies

Basis of Presentation (Policies)	3 Months Ended
	Mar. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Basis of Presentation	The accompanying Condensed Consolidated Financial Statements for the Company have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and pursuant to the applicable rules and regulations of the Securities and Exchange Commission (“SEC”). All intercompany accounts and transactions have been eliminated in consolidation. In the opinion of management, the accompanying financial statements contain all adjustments (consisting of normal and recurring accruals) necessary to present fairly all financial statements in accordance with GAAP. The Condensed Consolidated Financial Statements herein should be read in conjunction with the Company’s audited Consolidated Financial Statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 (the “Form 10-K”). The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements, as well as the reported amounts of revenue and expenses during the reporting period. Operating results for the three months ended March 31, 2022 may not necessarily be indicative of results to be expected for any other interim period or for the full year.
Reclassifications	Reclassifications Certain prior period amounts have been reclassified to conform with the current period's presentation. The reclassifications have no impact on the total assets, total liabilities, stockholders’ equity, cash flows from operations, or net loss for the period.

Revenue (Tables)

Revenue (Tables)	3 Months Ended
	Mar. 31, 2022
Revenue from Contract with Customer [Abstract]
Schedule of Total Revenue by Category and by U.S versus Rest of World	The following table presents detail regarding the composition of the Company’s total revenue by type and by U.S. versus rest of world (“RoW”): Three months ended March 31, 2022 2021 (in millions) U.S. RoW Total U.S. RoW Total Molecular diagnostic revenues: Hereditary Cancer $ 60.7 $ 10.2 $ 70.9 $ 65.1 $ 11.0 $ 76.1 Tumor Profiling 19.7 12.8 32.5 24.2 6.8 31.0 Prenatal 31.7 0.2 31.9 23.6 0.1 23.7 Pharmacogenomics 29.3 — 29.3 17.6 — 17.6 Autoimmune 0.3 — 0.3 10.7 — 10.7 Other — — — — 0.5 0.5 Total molecular diagnostic revenue 141.7 23.2 164.9 141.2 18.4 159.6 Pharmaceutical and clinical services revenue — — — 13.5 — 13.5 Total revenue $ 141.7 $ 23.2 $ 164.9 $ 154.7 $ 18.4 $ 173.1
Reconciliation of Deferred Revenue Balances	A reconciliation of the beginning and ending balances of deferred revenue is shown in the table below: Three months ended (in millions) 2022 2021 Deferred revenue - beginning balance $ 5.2 $ 32.7 Revenue recognized (4.8) (6.7) Prepayments 0.3 5.1 Deferred revenue - ending balance $ 0.7 $ 31.1

Marketable Investment Securit_2

Marketable Investment Securities (Tables)	3 Months Ended
	Mar. 31, 2022
Investments, Debt and Equity Securities [Abstract]
Schedule of Fair Value for Available-for-Sale Securities by Major Security Type and Class of Security	The amortized cost, gross unrealized holding gains, gross unrealized holding losses, and fair value for available-for-sale securities by major security type and class of security at March 31, 2022 and December 31, 2021 were as follows: (in millions) Amortized Gross Gross Estimated March 31, 2022 Cash and cash equivalents: Cash $ 138.0 $ — $ — $ 138.0 Cash equivalents 27.2 — — 27.2 Total cash and cash equivalents 165.2 — — 165.2 Available-for-sale: Corporate bonds and notes 109.1 — (1.0) 108.1 Municipal bonds 21.6 — (0.2) 21.4 Federal agency issues 18.0 — (0.3) 17.7 US government securities 27.0 — (0.2) 26.8 Total $ 340.9 $ — $ (1.7) $ 339.2 (in millions) Amortized Gross Gross Estimated December 31, 2021: Cash and cash equivalents: Cash $ 195.2 $ — $ — $ 195.2 Cash equivalents 63.2 — — 63.2 Total cash and cash equivalents 258.4 — — 258.4 Available-for-sale: Corporate bonds and notes 105.7 0.1 (0.2) 105.6 Municipal bonds 16.1 — — 16.1 Federal agency issues 6.8 — — 6.8 US government securities 11.9 — — 11.9 Total $ 398.9 $ 0.1 $ (0.2) $ 398.8
Schedule of Cash, Cash Equivalents, and Maturities of Debt Securities Classified as Available-For-Sale Securities	Cash, cash equivalents, and maturities of debt securities classified as available-for-sale securities were as follows at March 31, 2022: (in millions) Amortized Estimated Cash $ 138.0 $ 138.0 Cash equivalents 27.2 27.2 Available-for-sale: Due within one year 103.4 103.2 Due after one year through five years 72.3 70.8 Due after five years — — Total $ 340.9 $ 339.2

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	3 Months Ended
	Mar. 31, 2022
Fair Value Disclosures [Abstract]
Schedule of Fair Value of Financial Assets and Liabilities	The following table sets forth the fair value of the financial assets and liabilities that the Company re-measures on a regular basis: (in millions) Level 1 Level 2 Level 3 Total March 31, 2022 Money market funds (a) $ 27.2 $ — $ — $ 27.2 Corporate bonds and notes — 108.1 — 108.1 Municipal bonds — 21.4 — 21.4 Federal agency issues — 17.7 — 17.7 US government securities — 26.8 — 26.8 Contingent consideration — — (7.9) (7.9) Total $ 27.2 $ 174.0 $ (7.9) $ 193.3 (a) Money market funds are primarily comprised of exchange traded funds and accrued interest. (in millions) Level 1 Level 2 Level 3 Total December 31, 2021 Money market funds (a) $ 63.2 $ — $ — $ 63.2 Corporate bonds and notes — 105.6 — 105.6 Municipal bonds — 16.1 — 16.1 Federal agency issues — 6.8 — 6.8 US government securities — 11.9 — 11.9 Contingent consideration — — (8.6) (8.6) Total $ 63.2 $ 140.4 $ (8.6) $ 195.0 (a) Money market funds are primarily comprised of exchange traded funds and accrued interest.
Change in Fair Value of Contingent Consideration	The following table reconciles the change in the fair value of the contingent consideration during the periods presented: (in millions) Carrying Balance December 31, 2021 $ 8.6 Change in fair value recognized in the Statement of Operations (0.5) Translation adjustments recognized in Other comprehensive loss (0.2) Ending balance March 31, 2022 $ 7.9

Property, Plant and Equipment_2

Property, Plant and Equipment, Net (Tables)	3 Months Ended
	Mar. 31, 2022
Property, Plant and Equipment [Abstract]
Schedule of Property, Plant and Equipment, Net	(in millions) March 31, December 31, Leasehold improvements $ 34.2 $ 38.0 Equipment 114.9 112.4 Property, plant and equipment, gross 149.1 150.4 Less accumulated depreciation (103.4) (106.9) Property, plant and equipment, net $ 45.7 $ 43.5 During the three months ended March 31, 2022, the Company ceased the use of one of its leased Salt Lake City facilities. As a result, the Company recognized a $2.1 million impairment on the property, plant and equipment associated with the lease, which consisted primarily of leasehold improvements. See Note 15 for further discussion. Three months ended (in millions) 2022 2021 Depreciation expense $ 2.8 $ 2.9

Goodwill and Intangible Assets

Goodwill and Intangible Assets (Tables)	3 Months Ended
	Mar. 31, 2022
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of Changes in Carrying Amount of Goodwill	The following table summarizes the changes in the carrying amount of goodwill for the three months ended March 31, 2022: (in millions) Total Beginning balance $ 239.2 Translation adjustments (0.4) Ending balance $ 238.8
Schedule of Amortizable Intangible Assets	The following summarizes the amounts reported as intangible assets: (in millions) Gross Accumulated Net At March 31, 2022: Purchased licenses and technologies $ 616.1 $ (222.5) $ 393.6 Total intangible assets $ 616.1 $ (222.5) $ 393.6 (in millions) Gross Accumulated Net At December 31, 2021: Purchased licenses and technologies $ 616.6 $ (212.5) $ 404.1 Total intangible assets $ 616.6 $ (212.5) $ 404.1
Schedule of Non-amortizable Intangible Assets	The following summarizes the amounts reported as intangible assets: (in millions) Gross Accumulated Net At March 31, 2022: Purchased licenses and technologies $ 616.1 $ (222.5) $ 393.6 Total intangible assets $ 616.1 $ (222.5) $ 393.6 (in millions) Gross Accumulated Net At December 31, 2021: Purchased licenses and technologies $ 616.6 $ (212.5) $ 404.1 Total intangible assets $ 616.6 $ (212.5) $ 404.1
Schedule of Recorded Amortization Expense for Intangible Assets	The Company recorded amortization expense during the respective periods for these intangible assets as follows: Three months ended (in millions) 2022 2021 Amortization of intangible assets $ 10.2 $ 15.5

Accrued Liabilities (Tables)

Accrued Liabilities (Tables)	3 Months Ended
	Mar. 31, 2022
Payables and Accruals [Abstract]
Schedule of Accrued Liabilities	(in millions) March 31, December 31, Employee compensation and benefits $ 37.9 $ 52.8 Legal charges pending settlement 48.0 62.0 Accrued taxes payable 4.1 4.0 Refunds payable and reserves 9.2 9.8 Short-term contingent consideration 3.1 3.2 Accrued royalties 5.0 5.4 Other accrued liabilities 17.5 19.3 Total accrued liabilities $ 124.8 $ 156.5

Other Long-Term Liabilities (Ta

Other Long-Term Liabilities (Tables)	3 Months Ended
	Mar. 31, 2022
Other Liabilities Disclosure [Abstract]
Schedule of Other Long-Term Liabilities	(in millions) March 31, December 31, Contingent consideration $ 4.8 $ 5.4 Other 0.1 0.2 Total other long-term liabilities $ 4.9 $ 5.6

Preferred and Common Stockhol_2

Preferred and Common Stockholders' Equity (Tables)	3 Months Ended
	Mar. 31, 2022
Equity [Abstract]
Summary of Common Shares Issued and Outstanding	Common shares issued and outstanding Three months ended (in millions) 2022 2021 Beginning common stock issued and outstanding 80.0 75.4 Common stock issued upon exercise of options, vesting of restricted stock units, and purchases under employee stock purchase plan 0.3 1.3 Common stock issued and outstanding at end of period 80.3 76.7
Reconciliation of Denominators of Basic and Diluted Earnings Per Share Computations	The following is a reconciliation of the denominators of the basic and diluted earnings per share (“EPS”) computations: Three months ended (in millions) 2022 2021 Denominator: Weighted-average shares outstanding used to compute basic EPS 80.1 76.0 Effect of dilutive shares — — Weighted-average shares outstanding and dilutive securities used to compute diluted EPS 80.1 76.0
Schedule of Potential Dilutive Common Shares	These potential dilutive common shares, which may be dilutive to future diluted earnings per share, are as follows: Three months ended (in millions) 2022 2021 Anti-dilutive options and RSUs excluded from EPS computation 5.5 0.3

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	3 Months Ended
	Mar. 31, 2022
Share-based Payment Arrangement [Abstract]
Schedule of Stock Option Activity	A summary of the stock option activity under the Company’s equity plans and inducement awards, for the three months ended March 31, 2022 is as follows: (number of shares in millions) Number Weighted Options outstanding at December 31, 2021 1.4 $ 20.36 Less: Options exercised — $ 23.98 Options canceled or expired (0.1) $ 24.24 Options outstanding at March 31, 2022 1.3 $ 20.17 Options exercisable at March 31, 2022 0.9 $ 22.99
Schedule of Restricted Stock Unit Activity	A summary of the RSU awards activity under the Company’s equity plans and inducement awards, including RSU awards with performance metrics, for the three months ended March 31, 2022 is as follows: (number of shares in millions) Number Weighted RSUs outstanding at December 31, 2021 3.1 $ 24.96 RSUs granted 1.6 $ 27.17 Less: RSUs vested (0.4) $ 28.24 RSUs canceled (0.1) $ 24.26 RSUs outstanding at March 31, 2022 4.2 $ 25.43
Schedule of Stock-Based Compensation Expense	Stock-based compensation expense recognized and included in the Condensed Consolidated Statements of Operations and Comprehensive Loss was allocated as follows: Three months ended (in millions) 2022 2021 Cost of molecular diagnostic testing $ 0.3 $ 0.3 Cost of pharmaceutical and clinical services — 0.1 Research and development expense 2.4 1.5 Selling, general, and administrative expense 7.4 7.1 Total stock-based compensation expense $ 10.1 $ 9.0

Supplemental Cash Flow Inform_2

Supplemental Cash Flow Information (Tables)	3 Months Ended
	Mar. 31, 2022
Supplemental Cash Flow Elements [Abstract]
Schedule of Supplemental Cash Flow Information	Three months ended (in millions) 2022 2021 Cash paid during the period for income taxes $ 0.3 $ — Cash paid for interest — 2.3 Establishment of operating lease right-of-use assets and lease liabilities Operating lease right-of-use assets $ — $ 2.7 Operating lease liabilities 0.8 2.7 Purchases of property, plant and equipment in accounts payable 0.9 —

Revenue - Total Revenue by Cate

Revenue - Total Revenue by Category and by US versus Rest of World (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Disaggregation of Revenue [Line Items]
Total revenue	$ 164.9	$ 173.1
U.S.
Disaggregation of Revenue [Line Items]
Total revenue	141.7	154.7
RoW
Disaggregation of Revenue [Line Items]
Total revenue	23.2	18.4
Molecular diagnostic testing
Disaggregation of Revenue [Line Items]
Total revenue	164.9	159.6
Molecular diagnostic testing | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	141.7	141.2
Molecular diagnostic testing | RoW
Disaggregation of Revenue [Line Items]
Total revenue	23.2	18.4
Molecular diagnostic - Hereditary Cancer
Disaggregation of Revenue [Line Items]
Total revenue	70.9	76.1
Molecular diagnostic - Hereditary Cancer | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	60.7	65.1
Molecular diagnostic - Hereditary Cancer | RoW
Disaggregation of Revenue [Line Items]
Total revenue	10.2	11
Molecular diagnostic - Tumor Profiling
Disaggregation of Revenue [Line Items]
Total revenue	32.5	31
Molecular diagnostic - Tumor Profiling | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	19.7	24.2
Molecular diagnostic - Tumor Profiling | RoW
Disaggregation of Revenue [Line Items]
Total revenue	12.8	6.8
Molecular diagnostic - Prenatal
Disaggregation of Revenue [Line Items]
Total revenue	31.9	23.7
Molecular diagnostic - Prenatal | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	31.7	23.6
Molecular diagnostic - Prenatal | RoW
Disaggregation of Revenue [Line Items]
Total revenue	0.2	0.1
Molecular Diagnostic - Pharmacogenomics
Disaggregation of Revenue [Line Items]
Total revenue	29.3	17.6
Molecular Diagnostic - Pharmacogenomics | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	29.3	17.6
Molecular Diagnostic - Pharmacogenomics | RoW
Disaggregation of Revenue [Line Items]
Total revenue	0	0
Molecular Diagnostic - Autoimmune
Disaggregation of Revenue [Line Items]
Total revenue	0.3	10.7
Molecular Diagnostic - Autoimmune | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	0.3	10.7
Molecular Diagnostic - Autoimmune | RoW
Disaggregation of Revenue [Line Items]
Total revenue	0	0
Molecular diagnostic - Other
Disaggregation of Revenue [Line Items]
Total revenue	0	0.5
Molecular diagnostic - Other | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	0	0
Molecular diagnostic - Other | RoW
Disaggregation of Revenue [Line Items]
Total revenue	0	0.5
Pharmaceutical and clinical services
Disaggregation of Revenue [Line Items]
Total revenue	0	13.5
Pharmaceutical and clinical services | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	0	13.5
Pharmaceutical and clinical services | RoW
Disaggregation of Revenue [Line Items]
Total revenue	$ 0	$ 0

Revenue - Reconciliation of Def

Revenue - Reconciliation of Deferred Revenue Balances (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Reconciliation of Deferred Revenue
Deferred revenue - beginning balance	$ 5.2	$ 32.7
Revenue recognized	(4.8)	(6.7)
Prepayments	0.3	5.1
Deferred revenue - ending balance	$ 0.7	$ 31.1

Revenue - Narrative (Details)

Revenue - Narrative (Details) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Jun. 30, 2020
Revenue from Contract with Customer [Abstract]
Advance Medicare payments to provide relief from economic impacts of COVID-19			$ 29,700,000
Revenue increase (decrease) due to changes in estimated transaction price due to contractual adjustments	$ 12,400,000
Capitalized costs incurred to obtain or fulfill contract	$ 0
Performance obligation estimate
Revenue and Concentration Risk [Line Items]
Change in earnings per share (dollars per share)	$ 0.12
Government contracts concentration risk | Medicare | Revenues
Revenue and Concentration Risk [Line Items]
Concentration risk (percent)	13.00%	19.00%

Marketable Investment Securit_3

Marketable Investment Securities - Fair Value for Available-for-Sale Securities by Major Security Type and Class of Security (Details) - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Cash and cash equivalents:
Cash and cash equivalents, Amortized cost	$ 165.2	$ 258.4
Cash and cash equivalents, Estimated fair value	165.2	258.4
Total:
Total, Amortized cost	340.9	398.9
Total, Gross unrealized holding gains	0	0.1
Total, Gross unrealized holding losses	(1.7)	(0.2)
Total, Estimated fair value	339.2	398.8
Cash
Cash and cash equivalents:
Cash and cash equivalents, Amortized cost	138	195.2
Cash and cash equivalents, Estimated fair value	138	195.2
Cash equivalents
Cash and cash equivalents:
Cash and cash equivalents, Amortized cost	27.2	63.2
Cash and cash equivalents, Estimated fair value	27.2	63.2
Corporate bonds and notes
Available-for-sale:
Available-for-sale, Amortized cost	109.1	105.7
Available-for-sale, Gross unrealized holding gains	0	0.1
Available-for-sale, Gross unrealized holding losses	(1)	(0.2)
Available-for-sale, Estimated fair value	108.1	105.6
Municipal bonds
Available-for-sale:
Available-for-sale, Amortized cost	21.6	16.1
Available-for-sale, Gross unrealized holding gains	0	0
Available-for-sale, Gross unrealized holding losses	(0.2)	0
Available-for-sale, Estimated fair value	21.4	16.1
Federal agency issues
Available-for-sale:
Available-for-sale, Amortized cost	18	6.8
Available-for-sale, Gross unrealized holding gains	0	0
Available-for-sale, Gross unrealized holding losses	(0.3)	0
Available-for-sale, Estimated fair value	17.7	6.8
US government securities
Available-for-sale:
Available-for-sale, Amortized cost	27	11.9
Available-for-sale, Gross unrealized holding gains	0	0
Available-for-sale, Gross unrealized holding losses	(0.2)	0
Available-for-sale, Estimated fair value	$ 26.8	$ 11.9

Marketable Investment Securit_4

Marketable Investment Securities - Cash, Cash Equivalents, and Maturities of Debt Securities Classified as Available-For-Sale Securities (Details) - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Amortized cost
Cash and cash equivalents	$ 165.2	$ 258.4
Available-for-sale, Due within one year	103.4
Available-for-sale, Due after one year through five years	72.3
Available-for-sale, Due after five years	0
Total, Amortized cost	340.9	398.9
Estimated fair value
Cash and cash equivalents	165.2	258.4
Available-for-sale, Due within one year	103.2
Available-for-sale, Due after one year through five years	70.8
Available-for-sale, Due after five years	0
Total, Estimated fair value	339.2	398.8
Cash
Amortized cost
Cash and cash equivalents	138	195.2
Estimated fair value
Cash and cash equivalents	138	195.2
Cash equivalents
Amortized cost
Cash and cash equivalents	27.2	63.2
Estimated fair value
Cash and cash equivalents	$ 27.2	$ 63.2

Fair Value Measurements - Narra

Fair Value Measurements - Narrative (Details)	3 Months Ended
	Mar. 31, 2022
Level 3 | Measurement input, expected term
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Measurement period for earn out liability	13 years 3 months 18 days

Fair Value Measurements - Fair

Fair Value Measurements - Fair Value of Financial Assets and Liabilities (Details) - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total	$ 193.3	$ 195
Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	27.2	63.2
Corporate bonds and notes
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	108.1	105.6
Municipal bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	21.4	16.1
Federal agency issues
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	17.7	6.8
US government securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	26.8	11.9
Contingent consideration
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial liabilities	(7.9)	(8.6)
Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total	27.2	63.2
Level 1 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	27.2	63.2
Level 1 | Corporate bonds and notes
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 1 | Municipal bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 1 | Federal agency issues
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 1 | US government securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 1 | Contingent consideration
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial liabilities	0	0
Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total	174	140.4
Level 2 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 2 | Corporate bonds and notes
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	108.1	105.6
Level 2 | Municipal bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	21.4	16.1
Level 2 | Federal agency issues
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	17.7	6.8
Level 2 | US government securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	26.8	11.9
Level 2 | Contingent consideration
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial liabilities	0	0
Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total	(7.9)	(8.6)
Level 3 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 3 | Corporate bonds and notes
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 3 | Municipal bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 3 | Federal agency issues
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 3 | US government securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets	0	0
Level 3 | Contingent consideration
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial liabilities	$ (7.9)	$ (8.6)

Fair Value Measurements - Chang

Fair Value Measurements - Change in Fair Value of Contingent Consideration (Details) $ in Millions	3 Months Ended
	Mar. 31, 2022USD ($)
Reconciliation of change in fair value of contingent consideration
Beginning balance	$ 8.6
Change in fair value recognized in the Statement of Operations	(0.5)
Translation adjustments recognized in Other comprehensive loss	(0.2)
Ending balance	$ 7.9

Property, Plant and Equipment_3

Property, Plant and Equipment, Net - Balances (Details) - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 149.1	$ 150.4
Less accumulated depreciation	(103.4)	(106.9)
Property, plant and equipment, net	45.7	43.5
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	34.2	38
Equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 114.9	$ 112.4

Property, Plant and Equipment_4

Property, Plant and Equipment, Net - Depreciation Expense (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 2.8	$ 2.9

Property, Plant and Equipment_5

Property, Plant and Equipment, Net - Narrative (Details) $ in Millions	3 Months Ended
	Mar. 31, 2022USD ($)
Leasehold improvements
Property, Plant and Equipment [Line Items]
Impairment charge	$ 2.1

Goodwill and Intangible Asset_2

Goodwill and Intangible Assets - Carrying Amount of Goodwill (Details) $ in Millions	3 Months Ended
	Mar. 31, 2022USD ($)
Goodwill [Roll Forward]
Beginning balance	$ 239.2
Translation adjustments	(0.4)
Ending balance	$ 238.8

Goodwill and Intangible Asset_3

Goodwill and Intangible Assets - Intangible Assets (Details) - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Intangible Assets [Line Items]
Accumulated Amortization	$ (222.5)	$ (212.5)
Gross Carrying Amount, total	616.1	616.6
Net, total	393.6	404.1
Purchased licenses and technologies
Intangible Assets [Line Items]
Gross Carrying Amount, amortizable	616.1	616.6
Accumulated Amortization	(222.5)	(212.5)
Net, amortizable	$ 393.6	$ 404.1

Goodwill and Intangible Asset_4

Goodwill and Intangible Assets - Amortization on Intangible Assets (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Goodwill and Intangible Assets Disclosure [Abstract]
Amortization of intangible assets	$ 10.2	$ 15.5

Accrued Liabilities (Details)

Accrued Liabilities (Details) - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Employee compensation and benefits	$ 37.9	$ 52.8
Legal charges pending settlement	48	62
Accrued taxes payable	4.1	4
Refunds payable and reserves	9.2	9.8
Short-term contingent consideration	3.1	3.2
Accrued royalties	5	5.4
Other accrued liabilities	17.5	19.3
Total accrued liabilities	$ 124.8	$ 156.5

Long-Term Debt - Narrative (Det

Long-Term Debt - Narrative (Details) - USD ($)	Jul. 01, 2022	Jul. 31, 2018	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021	Jun. 30, 2022	Sep. 30, 2021	Feb. 21, 2021	Dec. 31, 2020	Dec. 23, 2016
Debt Instrument [Line Items]
Principal repayment			$ 0	$ 70,000,000
Outstanding balances			0		$ 0
Revolving credit facility
Debt Instrument [Line Items]
Maximum aggregate principal commitment										$ 300,000,000
Principal repayment					$ 226,400,000
Revolving credit facility | Amended facility
Debt Instrument [Line Items]
Maturity date		Jul. 31, 2023
Maximum aggregate principal commitment		$ 350,000,000	$ 250,000,000				$ 250,000,000	$ 300,000,000	$ 350,000,000
Minimum liquidity covenant								150,000,000
Minimum unrestricted cash and cash equivalents threshold per covenant								$ 150,000,000
Revolving credit facility | Amended facility | Forecast
Debt Instrument [Line Items]
Undrawn fee (percent)						0.50%
LIBOR floor (percent)						1.00%
Revolving credit facility | Amended facility | Forecast | Minimum
Debt Instrument [Line Items]
Undrawn fee (percent)	0.25%
Revolving credit facility | Amended facility | Forecast | Maximum
Debt Instrument [Line Items]
Undrawn fee (percent)	0.45%
Revolving credit facility | Amended facility | LIBOR | Forecast
Debt Instrument [Line Items]
Basis spread on rate (percent)						3.50%
Revolving credit facility | Amended facility | LIBOR | Forecast | Minimum
Debt Instrument [Line Items]
Basis spread on rate (percent)	1.50%
Revolving credit facility | Amended facility | LIBOR | Forecast | Maximum
Debt Instrument [Line Items]
Basis spread on rate (percent)	2.50%

Other Long-Term Liabilities (De

Other Long-Term Liabilities (Details) - USD ($) $ in Millions	Mar. 31, 2022	Dec. 31, 2021
Other Liabilities Disclosure [Abstract]
Contingent consideration	$ 4.8	$ 5.4
Other	0.1	0.2
Total other long-term liabilities	$ 4.9	$ 5.6

Preferred and Common Stockhol_3

Preferred and Common Stockholders' Equity - Narrative (Details) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Jun. 30, 2016
Equity [Abstract]
Preferred stock authorized (shares)	5,000,000
Preferred stock, par value (dollars per share)	$ 0.01
Preferred stock outstanding (shares)	0
Common stock authorized (shares)	150,000,000
Common stock, par value (dollars per share)	$ 0.01
Common stock issued (shares)	80,300,000	76,700,000	80,000,000	75,400,000
Common stock outstanding (shares)	80,300,000	76,700,000	80,000,000	75,400,000
Share repurchase program, authorized amount					$ 200,000,000
Share repurchase program, remaining repurchase authorization	$ 110,700,000
Shares repurchased	0	0

Preferred and Common Stockhol_4

Preferred and Common Stockholders' Equity - Common Shares Issued and Outstanding (Details) - shares shares in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Common shares issued and outstanding
Beginning common stock issued	80	75.4
Beginning common stock outstanding	80	75.4
Common stock issued upon exercise of options, vesting of restricted stock units, and purchases under employee stock purchase plan	0.3	1.3
Common stock issued at end of period	80.3	76.7
Common stock outstanding at end of period	80.3	76.7

Preferred and Common Stockhol_5

Preferred and Common Stockholders' Equity - Reconciliation of Denominators of Basic and Diluted Earnings Per Share Computations (Details) - shares shares in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Equity [Abstract]
Weighted-average shares outstanding used to compute basic EPS	80.1	76
Effect of dilutive shares	0	0
Weighted-average shares outstanding and dilutive securities used to compute diluted EPS	80.1	76

Preferred and Common Stockhol_6

Preferred and Common Stockholders' Equity - Potentially Dilutive Common Shares Excluded from EPS Computation (Details) - shares shares in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Equity [Abstract]
Anti-dilutive options and RSUs excluded from EPS computation	5.5	0.3

Stock-Based Compensation - Narr

Stock-Based Compensation - Narrative (Details) - USD ($) $ in Millions	Sep. 23, 2021	Mar. 31, 2022	Mar. 31, 2022	Dec. 31, 2012
Share-Based Compensation [Line Items]
Unrecognized stock-based compensation expense related to stock options		$ 2	$ 2
2017 Plan
Share-Based Compensation [Line Items]
Shares available for grant		2,000,000	2,000,000
2012 Purchase Plan
Share-Based Compensation [Line Items]
Number of shares authorized				2,000,000
Number of additional shares authorized	2,000,000
Maximum number of shares per participant per offering period	5,000
Shares issued under the Plan			2,000,000
Options and RSUs | Non-employee director
Share-Based Compensation [Line Items]
Service period for award vesting (in years)		1 year
Stock options
Share-Based Compensation [Line Items]
Award expiration period (in years)		10 years
Weighted-average period for recognition (in years)		1 year 9 months 18 days
Stock options | President and Chief Executive Officer
Share-Based Compensation [Line Items]
Award expiration period (in years)		7 years
RSUs
Share-Based Compensation [Line Items]
Service period for award vesting (in years)		4 years
Unrecognized stock-based compensation expense related to RSUs		$ 90.8	$ 90.8
Weighted-average period for recognition (in years)		2 years 8 months 12 days
RSUs | Achievement levels based on EPS targets
Share-Based Compensation [Line Items]
Vesting weight (percent)		34.00%
RSUs | Relative total stockholders return
Share-Based Compensation [Line Items]
Vesting weight (percent)		33.00%
RSUs | Performance based on Nasdaq Healthcare Provider Index
Share-Based Compensation [Line Items]
Vesting weight (percent)		33.00%

Stock-Based Compensation - Stoc

Stock-Based Compensation - Stock Option Activity (Details) shares in Millions	3 Months Ended
	Mar. 31, 2022$ / sharesshares
Options, Number of shares
Options outstanding, beginning (shares) | shares	1.4
Options exercised (shares) | shares	0
Options canceled or expired (shares) | shares	(0.1)
Options outstanding, ending (shares) | shares	1.3
Options exercisable at end of period (shares) | shares	0.9
Options, Weighted average exercise price
Options outstanding, beginning (dollars per share) | $ / shares	$ 20.36
Options exercised (dollars per share) | $ / shares	23.98
Options canceled or expired (dollars per share) | $ / shares	24.24
Options outstanding, ending (dollars per share) | $ / shares	20.17
Options exercisable at end of period (dollars per share) | $ / shares	$ 22.99

Stock-Based Compensation - RSU

Stock-Based Compensation - RSU Activity (Details) - RSUs shares in Millions	3 Months Ended
	Mar. 31, 2022$ / sharesshares
RSUs, Number of shares
RSUs outstanding, beginning (shares) | shares	3.1
RSUs granted (shares) | shares	1.6
RSUs vested (shares) | shares	(0.4)
RSUs canceled (shares) | shares	(0.1)
RSUs outstanding, ending (shares) | shares	4.2
RSUs, Weighted average grant date fair value
RSUs outstanding, beginning (dollars per share) | $ / shares	$ 24.96
RSUs granted (dollars per share) | $ / shares	27.17
RSUs vested (dollars per share) | $ / shares	28.24
RSUs canceled (dollars per share) | $ / shares	24.26
RSUs outstanding, ending (dollars per share) | $ / shares	$ 25.43

Stock-Based Compensation - St_2

Stock-Based Compensation - Stock-Based Compensation Expense (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Share-Based Compensation Expense [Line Items]
Total stock-based compensation expense	$ 10.1	$ 9
Cost of molecular diagnostic testing
Share-Based Compensation Expense [Line Items]
Total stock-based compensation expense	0.3	0.3
Cost of pharmaceutical and clinical services
Share-Based Compensation Expense [Line Items]
Total stock-based compensation expense	0	0.1
Research and development expense
Share-Based Compensation Expense [Line Items]
Total stock-based compensation expense	2.4	1.5
Selling, general, and administrative expense
Share-Based Compensation Expense [Line Items]
Total stock-based compensation expense	$ 7.4	$ 7.1

Income Taxes (Details)

Income Taxes (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Income Taxes [Line Items]
Income tax benefit	$ (5.9)	$ (10.1)
Approximate tax rate	22.30%	20.40%
State | California | Earliest tax year
Income Taxes [Line Items]
Tax year being audited in income tax examination	2017
State | California | Latest tax year
Income Taxes [Line Items]
Tax year being audited in income tax examination	2018
State | New Jersey | Earliest tax year
Income Taxes [Line Items]
Tax year being audited in income tax examination	2013
State | New Jersey | Latest tax year
Income Taxes [Line Items]
Tax year being audited in income tax examination	2017
Foreign | Switzerland | Earliest tax year
Income Taxes [Line Items]
Tax year being audited in income tax examination	2015
Foreign | Switzerland | Latest tax year
Income Taxes [Line Items]
Tax year being audited in income tax examination	2016

Commitments and Contingencies (

Commitments and Contingencies (Details) - USD ($) $ in Thousands	Apr. 01, 2022	Mar. 31, 2022	Dec. 31, 2021
Loss Contingencies [Line Items]
Potential settlement accrual		$ 48,000	$ 62,000
CBI CIFPA | United States and State of California | Subsequent event
Loss Contingencies [Line Items]
Settlement agreement	$ 45,250
CBI CIFPA | Relator's counsel | Subsequent event
Loss Contingencies [Line Items]
Settlement agreement	$ 2,750

Supplemental Cash Flow Inform_3

Supplemental Cash Flow Information (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Supplemental Cash Flow Elements [Abstract]
Cash paid during the period for income taxes	$ 0.3	$ 0
Cash paid for interest	0	2.3
Establishment of operating lease right-of-use assets and lease liabilities
Operating lease right-of-use assets	0	2.7
Operating lease liabilities	0.8	2.7
Purchases of property, plant and equipment in accounts payable	$ 0.9	$ 0

Leases (Details)

Leases (Details) ft² in Thousands, $ in Millions	3 Months Ended
	Mar. 31, 2022USD ($)ft²	Mar. 31, 2021USD ($)
Lessee, Lease, Description [Line Items]
Loss due to abandonment of facility	$ 8.6
Goodwill and long-lived asset impairment charges	10.7	$ 0
Leasehold improvements
Lessee, Lease, Description [Line Items]
Impairment charge	$ 2.1
West Salt Lake City
Lessee, Lease, Description [Line Items]
Operating lease area (sq ft) | ft²	230
Lease term (in years)	15 years
Total expected future rent payments	$ 77.8

Subsequent Events (Details)

Subsequent Events (Details) - Subsequent event - CBI CIFPA $ in Thousands	Apr. 01, 2022USD ($)
United States and State of California
Subsequent Event [Line Items]
Settlement agreement	$ 45,250
Relator's counsel
Subsequent Event [Line Items]
Settlement agreement	$ 2,750