Exhibit 21
SIGMA-ALDRICH CORPORATION
SUBSIDIARIES
Sigma-Aldrich Corporation (Delaware), the Registrant:
| 1) | Sigma-Aldrich Co. (Illinois) |
| (A) | Sigma-Aldrich Israel, Ltd. (Israel) |
| (B) | Aldrich Chemical Company, Inc. (Delaware) |
| (C) | Sigma-Aldrich B.V. (Netherlands) |
| (1) | Sigma-Aldrich Holding B.V. (Netherlands) |
| (a) | Sigma-Aldrich Chemie Holding GmbH (Germany) |
| (i) | Sigma-Aldrich Chemie GmbH (Germany) |
| (ii) | Sigma-Aldrich Produktions GmbH (Germany) |
| (iii) | Sigma Ark GmbH (Germany) |
| (iv) | Proligo International GmbH (Germany) |
| a. | Proligo Biochemie GmbH (Germany) |
| i. | Sigma-Aldrich Laborchemikalien GmbH (Germany) |
| b. | Proligo France SAS (France) |
| c. | Proligo Singapore Pte. Ltd. (Singapore) |
| d. | Proligo Japan GK (Japan) |
| e. | Proligo Australia Pty. Ltd. (Australia) |
| (E) | Sigma-Aldrich Chemie Verwaltungs GmbH (Germany) |
| (F) | Sigma-Aldrich GrundsteucksVerwaltungs GmbH & Co. KG (Germany) |
| (G) | Aldrich Chemical Foreign Holding LLC (Missouri) |
| (1) | Sigma-Aldrich Chimie S.N.C. (France) |
| (a) | Sigma-Aldrich Chimie S.a.r.l. (France) |
| (H) | Sigma Chemical Foreign Holding LLC (Missouri) |
| (I) | Supelco, Inc. (Delaware) |
| (1) | Advanced Separation Technologies, Inc. (New Jersey) |
| (a) | Advanced Separation Technologies Ltd. (UK) |
| (J) | Sigma-Aldrich Biotechnology Holding Co., Inc. (Missouri) |
| (K) | Sigma-Aldrich Biotechnology Investment LLC (Missouri) |
| (L) | Sigma-Aldrich Biotechnology LP (Missouri) |
| (M) | Sigma-Genosys of Texas, Inc. (Texas) |
| (N) | Sigma-Genosys Holdings LLC (Missouri) |
| (O) | Sigma-Genosys LP (Texas) |
| (P) | Sigma-Aldrich Business Holdings, Inc. (Delaware) |
| (1) | Sigma-Aldrich Research Biochemicals, Inc. (Massachusetts) |
| (Q) | Sigma-Aldrich Lancaster, Inc. (Missouri) |
| (1) | Techcare Systems, Inc. (California) |
| (R) | KL Acquisition Corp (Missouri) |
| (1) | Chemical Trade, Limited (Russia) |
| (2) | MedChem, Limited (Russia) |
| (a) | SAF-LAB (Russia) |
| (3) | Sigma-Aldrich Rus (Russia) |
| (S) | Sigma-Aldrich China, Inc. (Missouri) |
| (T) | Sigma-Aldrich Logistik GmbH (Germany) |
| (U) | Sigma-Aldrich Manufacturing, LLC (Missouri) |
Exhibit 21 (continued)
| 2) | Sigma-Aldrich, Inc. (Wisconsin) |
| 3) | Sigma-Aldrich Finance Co. (Missouri) |
| 4) | Sigma-Aldrich & Subs Foreign Sales Corporation (Barbados) |
| 5) | Sigma-Aldrich (Switzerland) Holding AG (Switzerland) |
| (A) | Sigma-Aldrich Chemie GmbH (Switzerland) |
| (B) | Sigma-Aldrich Production GmbH (Switzerland) |
| (1) | Sigma-Aldrich GmbH (Switzerland) |
| (C) | Sigma-Aldrich N.V./S.A. (Belgium) |
| (1) | Sigma-Aldrich Chemie B.V. (Netherlands) |
| (D) | Sigma-Aldrich Italia S.r.l. (Italy) |
| (1) | Sigma-Aldrich S.r.l. (Italy) |
| (E) | Sigma-Aldrich (Shanghai) Trading Co. Ltd. (China) |
| (F) | Sigma-Aldrich Denmark A/S (Denmark) |
| (G) | Sigma-Aldrich Finland Oy (Finland) |
| (H) | Sigma-Aldrich Norway AS (Norway) |
| (I) | Sigma-Aldrich Sweden AB (Sweden) |
| 6) | Sigma-Aldrich Company, Ltd. (UK) |
| (A) | SAFC Biosciences Limited (UK) |
| (B) | Pharmorphix Limited (UK) |
| 7) | Sigma-Aldrich Foreign Holding Co. (Missouri) |
| (A) | Sigma-Aldrich Handels GmbH (Austria) |
| (B) | Sigma-Aldrich spol.s.r.o. (Czech Republic) |
| (C) | Sigma-Aldrich (O M) Ltd. (Greece) |
| (D) | Sigma-Aldrich Kft (Hungary) |
| (E) | Sigma-Aldrich Financial Services Limited (Ireland) |
| (F) | Sigma-Aldrich Ireland Ltd. (Ireland) |
| (G) | Sigma-Aldrich Sp. z.o.o. (Poland) |
| (H) | Sigma-Aldrich Quimica S.A. (Spain) |
| (J) | Sigma-Aldrich de Argentina S.A. (Argentina) |
| (K) | Sigma-Aldrich Pty., Limited (Australia) |
| (L) | Sigma-Aldrich Oceania Pty. Limited (Australia) |
| (M) | Sigma-Aldrich Australia General Partnership (Australia) |
| (1) | Sigma-Aldrich New Zealand Ltd. (New Zealand) |
| (N) | SAFC Biosciences Pty. Ltd. (Australia) |
| (L) | Sigma-Aldrich Quimica Brasil Ltda. (Brazil) |
| (P) | Sigma-Aldrich Canada Ltd. (Canada) |
| (Q) | Sigma-Aldrich Chemicals Private Ltd. (India) |
| (R) | Sigma-Aldrich Japan KK (Japan) |
| (S) | Sigma-Aldrich Holding Ltd. (Korea) |
| (1) | Sigma-Aldrich Korea Ltd. |
| (T) | Sigma-Aldrich Quimica S.A. de C.V. (Mexico) |
| (U) | Sigma-Aldrich Pte. Ltd. (Singapore) |
| (1) | Sigma-Aldrich (M) Sdn. Bhd. (Malaysia) |
| (V) | Sigma-Aldrich Pty. Ltd. (South Africa) |
| (W) | Silverberry Limited (Ireland) |
| (1) | Shrawdine Limited (Ireland) |
| (a) | Sigma-Aldrich Ireland Ltd. (Ireland) |
| i. | SAFC Arklow Limited (Ireland) |
| 8) | Sigma-Aldrich Insurance Company Ltd. (Bermuda) |
| 9) | SAFC, Inc. (Wisconsin) |
| 10) | SAFC-JRH Holding Company, Inc. (Delaware) |
| (A) | SAFC Biosciences, Inc. (Delaware) |