Exhibit 21
SIGMA-ALDRICH CORPORATION
SUBSIDIARIES AS OF DECEMBER 31, 2011
Sigma-Aldrich Corporation (Delaware), the Registrant:
| 1) | Sigma-Aldrich Co. LLC (Delaware) |
| | (A) | Sigma-Aldrich Israel Ltd. (Israel) |
| | (B) | Aldrich Chemical Company, Inc. (Delaware) |
| | (1) | Aldrich-APL, LLC (Illinois) |
| | (C) | Sigma-Aldrich BV (Netherlands) |
| | (1) | Sigma-Aldrich Chemie Holding GmbH (Germany) |
| | (a) | Sigma-Aldrich Chemie GmbH (Germany) |
| | (b) | Sigma-Aldrich Producktions GmbH (Germany) |
| | (c) | Sigma-Aldrich Biochemie GmbH (Germany) |
| | i. | Sigma-Aldrich Laborchemikalien GmbH (Germany) |
| | (2) | Sigma-Aldrich Global S.a.r.l. (Luxembourg) |
| | i. | Sigma-Aldrich S.a.r.l. (Luxembourg) |
| | (D) | Sigma-Aldrich Grundstücks GmbH & Co. KG (Germany)1 |
| | (E) | Sigma-Aldrich Logistik GmbH (Germany) |
| | (F) | Supelco, Inc. (Delaware) |
| | (G) | Sigma-Genosys of Texas LLC (Texas) |
| | (H) | Sigma-Aldrich Business Holdings, Inc. (Delaware) |
| | (1) | Sigma-Aldrich Research Biochemicals, Inc. (Massachusetts) |
| | (I) | Sigma-Aldrich Lancaster, Inc. (Missouri) |
| | (1) | Techcare Systems, Inc. (California) |
| | (J) | KL Acquisition Corp. (Missouri) |
| | (1) | Chemical Trade Limited (Russia) |
| | (2) | MedChem Limited (Russia) |
| | (3) | “Sigma-Aldrich Rus” (Russia) |
| | (K) | Sigma-Aldrich China, Inc. (Missouri) |
| | (L) | Sigma-Aldrich Manufacturing LLC (Missouri) |
| | (M) | Cerilliant Corporation (Texas) |
| | (N) | S-A Ace, Inc. (Delaware) |
| | (O) | Sigma-Aldrich RTC, Inc. (Delaware) |
| 2) | Sigma-Aldrich, Inc. (Wisconsin) |
| 3) | Sigma-Aldrich Finance Co. (Missouri) |
| 5) | SAFC-JRH Holding Company, Inc. (Delaware) |
| | (A) | SAFC Biosciences, Inc. (Delaware) |
| 6) | SAFC Carlsbad, Inc. (California) |
| 7) | SAFC Hitech, Inc. (Delaware) |
| 8) | Sigma-Aldrich Verwaltungs GmbH (Germany) |
| 9) | Sigma-Aldrich Insurance Company Ltd. (Bermuda) |
| 10) | Sigma-Aldrich (Switzerland) Holding AG (Switzerland) |
| | (A) | Sigma-Aldrich International GmbH (Switzerland) |
| | (1) | Sigma-Aldrich Production GmbH (Switzerland) |
| | (2) | Sigma-Aldrich Chemie GmbH (Switzerland) |
| | (B) | Sigma-Aldrich Belgium NV/SA (Belgium)3 |
| | (1) | Sigma-Aldrich Chemie BV (Netherlands) |
| | (C) | Sigma-Aldrich Italia S.r.l. (Italy) |
| | (1) | Sigma-Aldrich S.r.l. (Italy) |
| | (2) | Sigma-Aldrich Handels GmbH (Austria) |
| | (D) | Sigma-Aldrich Holding S.a.r.l. (France) |
| | (1) | Aldrich Chemical Foreign Holding LLC (Missouri) |
| | (a) | Sigma-Aldrich Chimie SNC (France)4 |
| | i. | Sigma-Aldrich Chimie S.a.r.l. |
| | (2) | Sigma Chemical Foreign Holding LLC (Missouri) |
| | (E) | Sigma-Aldrich (Shanghai) Trading Co. Ltd. (China) |
| | (F) | Sigma-Aldrich Denmark A/S (Denmark) |
| | (G) | Sigma-Aldrich Finland OY (Finland) |
| | (H) | Sigma-Aldrich Norway AS (Norway) |
| | (I) | Sigma-Aldrich Sweden AB (Sweden) |
| | (J) | Sigma-Aldrich Hong Kong Holding Limited (Hong Kong) |
| | (1) | Sigma-Aldrich (Wuxi) Life Science & Technology Co., Ltd. (China) |
| | (K) | Sigma-Aldrich Quimica Ltda. (Chile)5 |
| | (L) | Sigma-Aldrich Company Limited (United Kingdom) |
| | (1) | SAFC Biosciences Limited (United Kingdom) |
| | (a) | SAFC Hitech Ltd. (United Kingdom) |
| | (b) | SAFC Hitech Taiwan Co. Ltd. (Taiwan) |
| | (c) | SAFC Hitech (Shanghai) Chemical Co. Ltd. (China) |
| | (M) | Sigma-Aldrich spol. s.r.o. (Czech Republic) |
| | (N) | Sigma-Aldrich Kft (Hungary) |
| | (O) | Sigma-Aldrich Sp. z.o.o. (Poland) |
| | (P) | Sigma-Aldrich Quimica S.A. (Spain) |
| | (Q) | Sigma-Aldrich de Argentina S.A. (Argentina)6 |
| | (R) | Sigma-Aldrich Canada Ltd. (Canada) |
| | (S) | Sigma-Aldrich Japan KK (Japan)7 |
| | (T) | Sigma-Aldrich (Pty.) Ltd. (South Africa) |
| 11) | Sigma-Aldrich Foreign Holding Co. (Missouri) |
| | (A) | Sigma-Aldrich (OM) Ltd. (Greece) |
| | (B) | Sigma-Aldrich Financial Services Limited (United Kingdom) |
| | (C) | Sigma-Aldrich Brasil Ltda. (Brazil)2 |
| | (1) | Vetec Quimica Fina Ltda. (Brazil) |
| | (D) | Sigma-Aldrich (Thailand) Co., Ltd. (Thailand)8 |
| | (E) | Silverberry Limited (Ireland) |
| | (1) | Shrawdine Limited (Ireland) |
| | (a) | Sigma-Aldrich Ireland Ltd. (Ireland) |
| | (F) | Sigma-Aldrich Oceania Pty. Limited (Australia) |
| | (1) | Sigma-Aldrich Pty. Limited (Australia) |
| | (a) | SAFC Biosciences Pty. Ltd. (Australia) |
| | (2) | Sigma-Aldrich Australia General Partnership (Australia)9 |
| | (3) | Sigma-Aldrich New Zealand Ltd. (New Zealand) |
| | (G) | Sigma-Aldrich Pte. Ltd. (Singapore) |
| | (1) | Sigma-Aldrich (M) Sdn. Bhd. (Malaysia) |
| | (2) | Sigma-Aldrich Chemicals Private Ltd. (India)10 |
| | (3) | Sigma-Aldrich Holding Ltd. (Korea) |
| | (a) | Sigma-Aldrich Korea Ltd. (Korea) |
| | (4) | Sigma-Aldrich Quimica, S.A. de C.V. (Mexico)11 |
| 1 | Ownership interest in Sigma-Aldrich Grundstücks GmbH & Co. KG (Germany) is Sigma-Aldrich Co. LLC- 94% and Sigma-Aldrich Verwaltungs GmbH- 6% |
| 2 | Ownership interest in Sigma-Aldrich Brasil Ltda. (Brazil) is Sigma-Aldrich Foreign Holding Co. – 76.7% and Sigma-Aldrich, Inc. – 23.3% |
| 3 | Ownership interest in Sigma-Aldrich N.V./S.A. (Belgium) – Sigma-Aldrich (Switzerland) Holding AG (Switzerland) – 99.92%, Sigma-Aldrich Corporation – .08% |
| 4 | Ownership interest in Sigma-Aldrich Chimie SNC (France) is Aldrich Chemical Foreign Holding LLC - 77% and Sigma Chemical Foreign Holding LLC- 23% |
| 5 | Ownership interest in Sigma-Aldrich Quimica Ltda. (Chile) is Sigma-Aldrich (Switzerland) Holding AG (Switzerland) – 99.9% and Sigma-Aldrich de Argentina SA (Argentina) - 0.1% |
| 6 | Ownership interest in Sigma-Aldrich de Argentina SA (Argentina) is Sigma-Aldrich (Switzerland) Holding AG (Switzerland) – 68.54% and Sigma-Aldrich, Inc. – 31.46% |
| 7 | Ownership interest in Sigma-Aldrich Japan KK (Japan) is Sigma-Aldrich (Switzerland) Holding AG (Switzerland) – 77.9% and Sigma-Genosys of Texas LLC 22.1% |
| 8 | Ownership interest in Sigma-Aldrich (Thailand) Co., Ltd. (Thailand) is Sigma-Aldrich Foreign Holding Co. – 98%, Sigma-Aldrich Corporation – 1% and Sigma-Aldrich, Inc. – 1% |
| 9 | Ownership interest in Sigma-Aldrich Australia General Partnership (Australia) is Sigma-Aldrich Oceania Pty. Ltd.(Australia) – 99% and Sigma-Aldrich Pty. Ltd.(Australia) – 1% |
| 10 | Ownership interest in Sigma-Aldrich Chemicals Private Limited (India) is Sigma-Aldrich Pte. Ltd. (Singapore) - 99.9999% and 2 resident directors - ..00005% each. |
| 11 | Ownership interest in Sigma-Aldrich Quimica, S.A. de C.V. (Mexico) is Sigma-Aldrich Pte. Ltd. (Singapore) – 99.998% and 1 resident director - ..002%. |
