| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2U INC COM USD0.001 | COM | 90214J101 | 114,697 | 3,899,925 | SH | | DFND | | 877,738 | 0 | 3,022,187 |
| AAC HLDGS INC COM | COM | 000307108 | 16,623 | 728,439 | SH | | DFND | | 96,789 | 0 | 631,650 |
| ABIOMED INC | COM | 003654100 | 215 | 1,969 | SH | | DFND | | 1,024 | 0 | 945 |
| ABLYNX N.V. NPV ISIN #BE0003877942 SEDOL #B28W603 | COM | B0031S109 | 190 | 14,574 | SH | | DFND | | 3,098 | 0 | 11,476 |
| ABRAXAS PETE CORP | COM | 003830106 | 595 | 526,789 | SH | | DFND | | 48,644 | 0 | 478,145 |
| ACACIA COMMUNICATIONS INC COM | COM | 00401C108 | 12,294 | 307,802 | SH | | DFND | | 13,415 | 0 | 294,387 |
| ACADIA HEALTHCARE COMPANY INC COM | COM | 00404A109 | 76,860 | 1,387,368 | SH | | DFND | | 212,187 | 0 | 1,175,181 |
| ACADIA PHARMACEUTICALS INC COM | COM | 004225108 | 151 | 4,639 | SH | | DFND | | 946 | 0 | 3,693 |
| ACCENTURE PLC CLS A USD0.0000225 | COM | G1151C101 | 809 | 7,138 | SH | | DFND | | 1,567 | 0 | 5,571 |
| ACTIVISION BLIZZARD INC COM | COM | 00507V109 | 36,275 | 915,341 | SH | | DFND | | 188,185 | 0 | 727,156 |
| ADESTO TECHNOLOGIES CORP COM | COM | 00687D101 | 5,704 | 1,739,084 | SH | | DFND | | 133,609 | 0 | 1,605,475 |
| ADIDAS AG NPV (REGD) ISIN #DE000A1EWWW0 SEDOL #4031976 | COM | D0066B185 | 4,487 | 31,309 | SH | | DFND | | 10,690 | 0 | 20,619 |
| ADOBE SYS INC | COM | 00724F101 | 42,310 | 441,697 | SH | | DFND | | 105,342 | 0 | 336,355 |
| ADVANCED MICRO DEVICES INC COM | COM | 007903107 | 129 | 25,072 | SH | | DFND | | 3,181 | 0 | 21,891 |
| ADVERUM BIOTECHNOLOGIES INC COM | COM | 00773U108 | 161 | 50,888 | SH | | DFND | | 20,510 | 0 | 30,378 |
| ALDER BIOPHARMACEUTICALS | COM | 014339105 | 80 | 3,193 | SH | | DFND | | 94 | 0 | 3,099 |
| ALIGN TECHNOLOGY INC COM | COM | 016255101 | 262 | 3,249 | SH | | DFND | | 716 | 0 | 2,533 |
| ALLEGIANT TRAVEL CO COM | COM | 01748X102 | 20,051 | 132,352 | SH | | DFND | | 9,706 | 0 | 122,646 |
| ALLERGAN PLC. COM USD0.0001 | COM | G0177J108 | 5,681 | 24,584 | SH | | DFND | | 607 | 0 | 23,977 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 77,350 | 1,393,947 | SH | | DFND | | 302,030 | 0 | 1,091,917 |
| ALPHABET INC CAP STK CL A | COM | 02079K305 | 35,207 | 50,043 | SH | | DFND | | 5,189 | 0 | 44,854 |
| ALPHABET INC CAP STK CL C | COM | 02079K107 | 69,782 | 100,827 | SH | | DFND | | 18,087 | 0 | 82,740 |
| AMAZON.COM INC | COM | 023135106 | 462,352 | 646,086 | SH | | DFND | | 221,524 | 0 | 424,562 |
| AMBER ROAD INC COM USD0.001 | COM | 02318Y108 | 585 | 75,831 | SH | | DFND | | 7,099 | 0 | 68,732 |
| AMERICAN INTL GROUP INC COM NEW | COM | 026874784 | 175 | 3,303 | SH | | DFND | | 91 | 0 | 3,212 |
| AMERICAN TOWER CORPORATION | COM | 03027X100 | 10,897 | 95,913 | SH | | DFND | | 7,582 | 0 | 88,331 |
| APPLE INC | COM | 037833100 | 2,904 | 30,373 | SH | | DFND | | 8,232 | 0 | 22,141 |
| APPLIED OPTOELECTRONICS INC COM | COM | 03823U102 | 5,338 | 478,787 | SH | | DFND | | 56,780 | 0 | 422,007 |
| ARISTA NETWORKS INC COM USD0.0001 | COM | 040413106 | 21,724 | 337,428 | SH | | DFND | | 23,279 | 0 | 314,149 |
| ARM HOLDINGS PLC ORD GBP0.0005 ISIN #GB0000595859 SEDOL #0059585 | COM | G0483X122 | 50,028 | 3,308,885 | SH | | DFND | | 191,921 | 0 | 3,116,964 |
| ASPEN AEROGELS INC COM USD0.00001 | COM | 04523Y105 | 474 | 95,428 | SH | | DFND | | 14,860 | 0 | 80,568 |
| ATHENAHEALTH INC DELAWARE | COM | 04685W103 | 2,135 | 15,472 | SH | | DFND | | 3,443 | 0 | 12,029 |
| ATLASSIAN CORPORATION PLC COM USD0.1 CL A | COM | G06242104 | 14,101 | 544,446 | SH | | DFND | | 70,277 | 0 | 474,169 |
| AUTO TRADER GROUP PLC ORD GBP0.01 ISIN #GB00BVYVFW23 SEDOL #BVYV | COM | G06708104 | 9,854 | 2,085,931 | SH | | DFND | | 254,380 | 0 | 1,831,551 |
| AVINGER INC COM | COM | 053734109 | 986 | 82,679 | SH | | DFND | | 25,540 | 0 | 57,139 |
| AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN #US05462W1099 SEDOL # | COM | 05462W109 | 1,654 | 42,621 | SH | | DFND | | 35,556 | 0 | 7,065 |
| BAIDU INC SPON ADR REP A | COM | 056752108 | 55,933 | 338,678 | SH | | DFND | | 128,263 | 0 | 210,415 |
| BANCO MACRO S.A. ADR REP 10 CLS B SHS ARS1 | COM | 05961W105 | 87 | 1,167 | SH | | DFND | | 224 | 0 | 943 |
| BARRICK GOLD CORP COM NPV ISIN #CA0679011084 SEDOL #2024644 | COM | 067901108 | 36 | 1,666 | SH | | DFND | | 287 | 0 | 1,379 |
| BELLATRIX EXPLORATION LTD COM ISIN #CA0783141017 SEDOL #B580BW5 | COM | 078314101 | 915 | 924,269 | SH | | DFND | | 112,471 | 0 | 811,798 |
| BERKLEY W R CORP | COM | 084423102 | 4,185 | 69,838 | SH | | DFND | | 16,972 | 0 | 52,866 |
| BERKSHIRE HATHAWAY INC DEL CL B NEW | COM | 084670702 | 29 | 200 | SH | | DFND | | 0 | 0 | 200 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 35,919 | 461,689 | SH | | DFND | | 174,986 | 0 | 286,703 |
| BLUEBIRD BIO INC COM | COM | 09609G100 | 4,532 | 104,682 | SH | | DFND | | 39,521 | 0 | 65,161 |
| BMC STK HLDGS INC COM | COM | 05591B109 | 29,751 | 1,669,526 | SH | | DFND | | 187,020 | 0 | 1,482,506 |
| BOINGO WIRELESS INC COM USD0.0001 | COM | 09739C102 | 22,476 | 2,519,715 | SH | | DFND | | 359,827 | 0 | 2,159,888 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 | 1,103 | 47,178 | SH | | DFND | | 20,722 | 0 | 26,456 |
| BOX INC CL A | COM | 10316T104 | 169 | 16,319 | SH | | DFND | | 2,161 | 0 | 14,158 |
| BRIGHTCOVE INC COM USD0.001 | COM | 10921T101 | 5,324 | 604,955 | SH | | DFND | | 93,127 | 0 | 511,828 |
| BUFFALO WILD WINGS INC | COM | 119848109 | 162 | 1,167 | SH | | DFND | | 597 | 0 | 570 |
| BUILDERS FIRSTSOURCE INC COM | COM | 12008R107 | 2,268 | 201,637 | SH | | DFND | | 38,710 | 0 | 162,927 |
| CARROLS RESTAURANT GROUP INC COM | COM | 14574X104 | 10,794 | 907,021 | SH | | DFND | | 80,358 | 0 | 826,663 |
| CATAPULT GROUP INTL LTD ISIN #AU000000CAT9 SEDOL #BTL0Y76 | COM | Q2159P101 | 2,131 | 929,405 | SH | | DFND | | 82,238 | 0 | 847,167 |
| CBS CORP NEW CL B | COM | 124857202 | 1,638 | 30,090 | SH | | DFND | | 7,153 | 0 | 22,937 |
| CHARTER COMMUNICATIONS INC NEW CL A | COM | 16119P108 | 211 | 921 | SH | | DFND | | 28 | 0 | 893 |
| CHIPOTLE MEXICAN GRILL INC COM | COM | 169656105 | 2,067 | 5,132 | SH | | DFND | | 627 | 0 | 4,505 |
| CHUYS HOLDINGS INC COM USD0.01 | COM | 171604101 | 1,420 | 41,026 | SH | | DFND | | 3,719 | 0 | 37,307 |
| CIRCASSIA PHARMACEUTICAL PLC ISIN #GB00BJVD3B28 SEDOL #BJVD3B2 | COM | G21477107 | 20 | 14,657 | SH | | DFND | | 1,965 | 0 | 12,692 |
| CLIFTON BANCORP INC COM | COM | 186873105 | 4,259 | 282,602 | SH | | DFND | | 35,935 | 0 | 246,667 |
| COGENT COMMUNICATION HLDGS INC COM NEW | COM | 19239V302 | 142 | 3,546 | SH | | DFND | | 518 | 0 | 3,028 |
| CONSTELLATION BRANDS INC CL A | COM | 21036P108 | 5,641 | 34,108 | SH | | DFND | | 825 | 0 | 33,283 |
| COSTAR GROUP INC COM | COM | 22160N109 | 17,889 | 81,813 | SH | | DFND | | 10,257 | 0 | 71,556 |
| CRAY INC COM NEW | COM | 225223304 | 49,544 | 1,655,887 | SH | | DFND | | 620,505 | 0 | 1,035,382 |
| CTRIP.COM INTERNATIONAL LTD ADS EACH REP 0.125 ORD USD0.01 | COM | 22943F100 | 6,353 | 154,205 | SH | | DFND | | 32,380 | 0 | 121,825 |
| CYNAPSUS THERAPEUTICS INC COM NPV ISIN #CA23257Y8595 SEDOL #BX84 | COM | 23257Y859 | 729 | 43,541 | SH | | DFND | | 13,085 | 0 | 30,456 |
| DBV TECHNOLOGIES SPON ADR EACH REPR 0.5 ORD | COM | 23306J101 | 98 | 2,990 | SH | | DFND | | 113 | 0 | 2,877 |
| DELTA AIR LINES INC DEL COM NEW | COM | 247361702 | 96 | 2,645 | SH | | DFND | | 465 | 0 | 2,180 |
| DEMANDWARE INC COM USD0.01 TENDER FROM 24802Y105 | COM | 248991606 | 584 | 7,800 | SH | | DFND | | 3,086 | 0 | 4,714 |
| DEXCOM INC | COM | 252131107 | 62,357 | 786,047 | SH | | DFND | | 184,215 | 0 | 601,832 |
| DIPLOMAT PHARMACY INC COM | COM | 25456K101 | 2,709 | 77,388 | SH | | DFND | | 19,447 | 0 | 57,941 |
| DIRTT ENVIRONMENTAL SOLUT LTD COM ISIN #CA25490H1064 SEDOL #BH13 | COM | 25490H106 | 43,241 | 10,438,029 | SH | | DFND | | 567,188 | 0 | 9,870,841 |
| EAGLE MATERIALS INC | COM | 26969P108 | 6,529 | 84,622 | SH | | DFND | | 2,112 | 0 | 82,510 |
| ECO STIM ENERGY SOLUTIONS INC COM | COM | 27888D101 | 2,950 | 1,017,404 | SH | | DFND | | 70,475 | 0 | 946,929 |
| ELECTRONIC ARTS | COM | 285512109 | 45,239 | 597,137 | SH | | DFND | | 124,034 | 0 | 473,103 |
| ELLIE MAE INC COM USD0.0001 | COM | 28849P100 | 269 | 2,936 | SH | | DFND | | 1,396 | 0 | 1,540 |
| ENPHASE ENERGY INC COM USD0.00001 | COM | 29355A107 | 76 | 37,988 | SH | | DFND | | 7,029 | 0 | 30,959 |
| ENZO BIOCHEM INC | COM | 294100102 | 5,089 | 852,438 | SH | | DFND | | 202,662 | 0 | 649,776 |
| EPAM SYS INC COM USD0.001 | COM | 29414B104 | 68,263 | 1,061,463 | SH | | DFND | | 170,585 | 0 | 890,878 |
| ESPERION THERAPEUTICS INC COM USD0.001 | COM | 29664W105 | 38 | 3,830 | SH | | DFND | | 373 | 0 | 3,457 |
| ETSY INC COM | COM | 29786A106 | 223 | 23,244 | SH | | DFND | | 5,517 | 0 | 17,727 |
| EXACT SCIENCES CORP | COM | 30063P105 | 19,759 | 1,613,010 | SH | | DFND | | 434,883 | 0 | 1,178,127 |
| FACEBOOK INC COM USD0.000006 CL A | COM | 30303M102 | 283,527 | 2,480,986 | SH | | DFND | | 618,222 | 0 | 1,862,764 |
| FAIRFAX INDIA HOLDINGS CORPORATION COM SUB VTG SHS ISIN #CA30389 | COM | 303897102 | 1,686 | 160,570 | SH | | DFND | | 33,250 | 0 | 127,320 |
| FARMER BROS CO COM | COM | 307675108 | 3,078 | 96,021 | SH | | DFND | | 21,645 | 0 | 74,376 |
| FEDERAL NATL MTG ASSN | COM | 313586109 | 60 | 30,028 | SH | | DFND | | 919 | 0 | 29,109 |
| FEVERTREE DRINKS PLC ORD GBP0.0025 ISIN #GB00BRJ9BJ26 SEDOL #BRJ | COM | G33929103 | 1,346 | 139,654 | SH | | DFND | | 76,601 | 0 | 63,053 |
| FIESTA RESTAURANT GROUP COM USD0.01 | COM | 31660B101 | 6,322 | 289,861 | SH | | DFND | | 28,413 | 0 | 261,448 |
| FIRST REP BK SAN FRANCISCO CAL COM | COM | 33616C100 | 36,940 | 527,792 | SH | | DFND | | 62,965 | 0 | 464,827 |
| FLEETCOR TECHNOLOGIES INC COM STK USD0.001 | COM | 339041105 | 11,724 | 81,913 | SH | | DFND | | 8,200 | 0 | 73,713 |
| FLEXION THERAPEUTICS INC COM | COM | 33938J106 | 64,467 | 4,307,870 | SH | | DFND | | 697,408 | 0 | 3,610,462 |
| FORTUNE BRANDS HOME & SECURITY INC USD0.01 | COM | 34964C106 | 115 | 1,986 | SH | | DFND | | 42 | 0 | 1,944 |
| FOUNDATION MEDICINE INC USD0.0001 | COM | 350465100 | 37,598 | 2,014,913 | SH | | DFND | | 501,638 | 0 | 1,513,275 |
| FRANCO NEVADA CORP COM ISIN #CA3518581051 SEDOL #B29NF31 | COM | 351858105 | 7,445 | 97,889 | SH | | DFND | | 2,715 | 0 | 95,174 |
| GALAPAGOS NV NPV ISIN #BE0003818359 SEDOL #B07Q2V5 | COM | B44170106 | 1,214 | 22,104 | SH | | DFND | | 8,350 | 0 | 13,754 |
| GCP APPLIED TECHNOLOGIES INC COM | COM | 36164Y101 | 2,818 | 108,204 | SH | | DFND | | 26,242 | 0 | 81,962 |
| GENERAL FIN CORP DEL COM | COM | 369822101 | 111 | 26,025 | SH | | DFND | | 26,025 | 0 | 0 |
| GIGAMON INC COM USD0.0001 | COM | 37518B102 | 46,931 | 1,255,168 | SH | | DFND | | 117,176 | 0 | 1,137,992 |
| GILDAN ACTIVEWEAR INC COM ISIN #CA3759161035 SEDOL #2254645 | COM | 375916103 | 11,590 | 395,172 | SH | | DFND | | 38,399 | 0 | 356,773 |
| GILEAD SCIENCES INC | COM | 375558103 | 355 | 4,257 | SH | | DFND | | 817 | 0 | 3,440 |
| GLAUKOS CORP COM | COM | 377322102 | 33,296 | 1,141,840 | SH | | DFND | | 87,550 | 0 | 1,054,290 |
| GLOBANT SA USD1.20 | COM | L44385109 | 44,002 | 1,118,220 | SH | | DFND | | 341,260 | 0 | 776,960 |
| GMS INC COM | COM | 36251C103 | 3,306 | 148,576 | SH | | DFND | | 17,211 | 0 | 131,365 |
| GODADDY INC CL A | COM | 380237107 | 8,287 | 265,688 | SH | | DFND | | 40,354 | 0 | 225,334 |
| GOLD STD VENTURES CORP COM ISIN #CA3807381049 SEDOL #B05J9S2 | COM | 380738104 | 2,199 | 1,182,374 | SH | | DFND | | 104,900 | 0 | 1,077,474 |
| GOLDEN MINERALS CO COM ISIN #US3811191069 SEDOL #B3K4M51 | COM | 381119106 | 67 | 103,272 | SH | | DFND | | 9,362 | 0 | 93,910 |
| GRACE W R & CO DEL NEW | COM | 38388F108 | 17,161 | 234,406 | SH | | DFND | | 37,657 | 0 | 196,749 |
| GREEN BRICK PARTNERS INC | COM | 392709101 | 3,548 | 487,988 | SH | | DFND | | 5,605 | 0 | 482,383 |
| GRUPO FINANCIERO GALICIA SA ADR EACH REPR 10 CLASS B ARS1 LVL11 | COM | 399909100 | 80 | 2,608 | SH | | DFND | | 519 | 0 | 2,089 |
| GRUPO SUPERVIELLE S A SPONSORED ADR | COM | 40054A108 | 30,018 | 2,346,971 | SH | | DFND | | 508,747 | 0 | 1,838,224 |
| GTT COMMUNICATIONS INC COM USD0.0001 | COM | 362393100 | 40,091 | 2,169,421 | SH | | DFND | | 361,743 | 0 | 1,807,678 |
| GUIDEWIRE SOFTWARE INC COM USD0.0001 | COM | 40171V100 | 3,782 | 61,245 | SH | | DFND | | 13,532 | 0 | 47,713 |
| GYM GROUP PLC ORD GBP0.0001 144A ISIN #GB00BZBX0P70 SEDOL #BZBX0 | COM | G42114101 | 1,620 | 564,193 | SH | | DFND | | 150,298 | 0 | 413,895 |
| H &E EQUIPMENT SERVICES INC COM | COM | 404030108 | 6,250 | 328,421 | SH | | DFND | | 41,421 | 0 | 287,000 |
| HAIN CELESTIAL GROUP INC | COM | 405217100 | 325 | 6,528 | SH | | DFND | | 410 | 0 | 6,118 |
| HDFC BANK LTD ADS EACH REPR 3 INR10(MGT) | COM | 40415F101 | 69,061 | 1,040,857 | SH | | DFND | | 265,448 | 0 | 775,409 |
| HEALTHEQUITY INC COM | COM | 42226A107 | 4,538 | 149,360 | SH | | DFND | | 8,213 | 0 | 141,147 |
| HORIZON PHARMA PLC COM USD0.0001 | COM | G4617B105 | 78 | 4,709 | SH | | DFND | | 138 | 0 | 4,571 |
| HOTELES CITY EXPRESS SAB DE CV COM NPV ISIN #MX01HC000001 SEDOL | COM | P5184Q102 | 6,880 | 6,766,268 | SH | | DFND | | 372,161 | 0 | 6,394,107 |
| HUBSPOT INC COM | COM | 443573100 | 94,592 | 2,178,535 | SH | | DFND | | 367,946 | 0 | 1,810,589 |
| HYPOPORT FINANCE AG NPV (REGD) ISIN #DE0005493365 SEDOL #B28XLF6 | COM | ZZC39YMG4 | 77 | 798 | SH | | DFND | | 158 | 0 | 640 |
| ICICI BANK LIMITED ADR EACH REPR 2 ORD INR10(SPON) | COM | 45104G104 | 3,312 | 461,242 | SH | | DFND | | 17,345 | 0 | 443,897 |
| ILLUMINA INC COM | COM | 452327109 | 902 | 6,428 | SH | | DFND | | 1,670 | 0 | 4,758 |
| IMPRIVATA INC USD0.001 | COM | 45323J103 | 3,601 | 257,180 | SH | | DFND | | 52,240 | 0 | 204,940 |
| IMS HEALTH HLDGS INC COM | COM | 44970B109 | 2,618 | 103,238 | SH | | DFND | | 5,453 | 0 | 97,785 |
| INCYTE CORP COM | COM | 45337C102 | 66,960 | 837,209 | SH | | DFND | | 288,832 | 0 | 548,377 |
| INFINERA CORPORATION COM | COM | 45667G103 | 4,772 | 423,021 | SH | | DFND | | 69,815 | 0 | 353,206 |
| INPHI CORPORATION COM USD0.001 | COM | 45772F107 | 9,296 | 290,237 | SH | | DFND | | 44,798 | 0 | 245,439 |
| INTL BUSINESS MACH | COM | 459200101 | 707 | 4,661 | SH | | DFND | | 2,432 | 0 | 2,229 |
| INTRA CELLULAR THERAPIES INC COM | COM | 46116X101 | 11,683 | 300,952 | SH | | DFND | | 109,811 | 0 | 191,141 |
| ITAU UNIBANCO HOLDINGS S.A. ADR EACH REPR 1 PRF NPV | COM | 465562106 | 3,004 | 318,209 | SH | | DFND | | 47,278 | 0 | 270,931 |
| JD COM INC SPONSORED ADR REPSTG COM CL A | COM | 47215P106 | 141 | 6,640 | SH | | DFND | | 440 | 0 | 6,200 |
| KANSAS CITY SOUTHERN COM | COM | 485170302 | 22,408 | 248,727 | SH | | DFND | | 22,384 | 0 | 226,343 |
| KINDER MORGAN INC COM USD0.01 | COM | 49456B101 | 1,977 | 105,616 | SH | | DFND | | 2,298 | 0 | 103,318 |
| KINDER MORGAN INC DEL PFD SER A 9.75% 10/26/2018 | COM | 49456B200 | 114 | 2,334 | SH | | DFND | | 87 | 0 | 2,247 |
| KORNIT DIGITAL LTD ORD ILS0.01 | COM | M6372Q113 | 6,303 | 645,811 | SH | | DFND | | 44,819 | 0 | 600,992 |
| KRAFT HEINZ CO COM | COM | 500754106 | 2,735 | 30,907 | SH | | DFND | | 5,707 | 0 | 25,200 |
| LDR HOLDING CORP COM USD0.001 | COM | 50185U105 | 21,850 | 591,347 | SH | | DFND | | 266,263 | 0 | 325,084 |
| LGI HOMES INC COM | COM | 50187T106 | 62,888 | 1,968,944 | SH | | DFND | | 315,463 | 0 | 1,653,481 |
| LIBERTY MEDIA CORP DELAWARE COM A BRAVES GRP | COM | 531229706 | 3,385 | 225,078 | SH | | DFND | | 5,605 | 0 | 219,473 |
| LIBERTY MEDIA CORP DELAWARE COM C BRAVES GRP | COM | 531229888 | 4,028 | 274,784 | SH | | DFND | | 6,918 | 0 | 267,866 |
| LINKEDIN CORP COM USD0.0001 | COM | 53578A108 | 211 | 1,117 | SH | | DFND | | 621 | 0 | 496 |
| LIPOCINE INC NEW COM | COM | 53630X104 | 1,231 | 404,796 | SH | | DFND | | 167,532 | 0 | 237,264 |
| LIVEPERSON INC | COM | 538146101 | 3,498 | 551,679 | SH | | DFND | | 19,466 | 0 | 532,213 |
| LULULEMON ATHLETICA INC COM | COM | 550021109 | 4,419 | 59,830 | SH | | DFND | | 7,435 | 0 | 52,395 |
| LUMBER LIQUIDATORS HLDGS INC COM | COM | 55003T107 | 631 | 40,891 | SH | | DFND | | 12,320 | 0 | 28,571 |
| LUMENTUM HLDGS INC COM | COM | 55024U109 | 45 | 1,865 | SH | | DFND | | 194 | 0 | 1,671 |
| LYON WILLIAM HOMES CL A NEW | COM | 552074700 | 336 | 20,830 | SH | | DFND | | 9,655 | 0 | 11,175 |
| MALIBU BOATS INC COM CL A | COM | 56117J100 | 2,843 | 235,330 | SH | | DFND | | 34,410 | 0 | 200,920 |
| MARTIN MARIETTA MATLS INC | COM | 573284106 | 63,580 | 331,148 | SH | | DFND | | 32,327 | 0 | 298,821 |
| MASONITE INTERNATIONAL CORP COM NPV | COM | 575385109 | 57,706 | 872,486 | SH | | DFND | | 78,059 | 0 | 794,427 |
| MASTERCARD INC CL A | COM | 57636Q104 | 10,202 | 115,854 | SH | | DFND | | 20,949 | 0 | 94,905 |
| MEETME INC COM USD0.001 | COM | 585141104 | 3,166 | 593,991 | SH | | DFND | | 97,306 | 0 | 496,685 |
| MEG ENERGY CORP COM ISIN #CA5527041084 SEDOL #B4XF9J1 | COM | 552704108 | 80 | 15,285 | SH | | DFND | | 3,600 | 0 | 11,685 |
| MERCADOLIBRE INC | COM | 58733R102 | 494 | 3,509 | SH | | DFND | | 853 | 0 | 2,656 |
| METRO BANK PLC ORD GBP0.000001 ISIN #GB00BZ6STL67 SEDOL #BZ6STL6 | COM | G60640102 | 278 | 11,487 | SH | | DFND | | 6,446 | 0 | 5,041 |
| MICROSOFT CORP | COM | 594918104 | 5,628 | 109,992 | SH | | DFND | | 17,085 | 0 | 92,907 |
| MOBILEYE NV EUR0.01 | COM | N51488117 | 981 | 21,272 | SH | | DFND | | 1,613 | 0 | 19,659 |
| NANOSTRING TECHNOLOGIES INC COM USD0.0001 | COM | 63009R109 | 963 | 76,423 | SH | | DFND | | 17,775 | 0 | 58,648 |
| NATIONAL BEVERAGE CORP COM | COM | 635017106 | 100 | 1,588 | SH | | DFND | | 306 | 0 | 1,282 |
| NETFLIX COM INC COM | COM | 64110L106 | 321,695 | 3,516,558 | SH | | DFND | | 790,549 | 0 | 2,726,009 |
| NETSUITE INC COM | COM | 64118Q107 | 71,477 | 981,831 | SH | | DFND | | 171,655 | 0 | 810,176 |
| NEW HOME CO INC COM | COM | 645370107 | 318 | 33,300 | SH | | DFND | | 2,500 | 0 | 30,800 |
| NEW RELIC INC COM | COM | 64829B100 | 3,915 | 133,254 | SH | | DFND | | 21,650 | 0 | 111,604 |
| NEXON CO LTD NPV ISIN #JP3758190007 SEDOL #B63QM77 | COM | J4914X104 | 79 | 5,410 | SH | | DFND | | 1,170 | 0 | 4,240 |
| NIKE INC CLASS B | COM | 654106103 | 2,016 | 36,527 | SH | | DFND | | 6,451 | 0 | 30,076 |
| NUVASIVE INC COM | COM | 670704105 | 1,829 | 30,628 | SH | | DFND | | 6,797 | 0 | 23,831 |
| NUVECTRA CORP COM | COM | 67075N108 | 5,605 | 757,425 | SH | | DFND | | 108,393 | 0 | 649,032 |
| NV5 GLOBAL INC COM | COM | 62945V109 | 5,397 | 189,753 | SH | | DFND | | 8,060 | 0 | 181,693 |
| NVIDIA CORP | COM | 67066G104 | 37 | 778 | SH | | DFND | | 214 | 0 | 564 |
| NXSTAGE MED INC COM | COM | 67072V103 | 130,472 | 6,018,076 | SH | | DFND | | 910,956 | 0 | 5,107,120 |
| OCADO GROUP PLC ORD GBP0.02 ISIN #GB00B3MBS747 SEDOL #B3MBS74 | COM | G6718L106 | 62,899 | 20,395,179 | SH | | DFND | | 3,473,587 | 0 | 16,921,592 |
| OCLARO INC COM NEW | COM | 67555N206 | 4,831 | 990,021 | SH | | DFND | | 158,681 | 0 | 831,340 |
| OCULAR THERAPEUTIX INC COM | COM | 67576A100 | 223 | 45,150 | SH | | DFND | | 13,430 | 0 | 31,720 |
| OPHTHOTECH CORP COM | COM | 683745103 | 77 | 1,503 | SH | | DFND | | 44 | 0 | 1,459 |
| ORBITAL ATK INC COM | COM | 68557N103 | 76 | 896 | SH | | DFND | | 161 | 0 | 735 |
| PACIFIC BIOSCIENCES CALIFORNIA INC COM USD0.0001 | COM | 69404D108 | 22,312 | 3,171,538 | SH | | DFND | | 962,427 | 0 | 2,209,111 |
| PACIFIC ETHANOL INC COM PAR $.001 | COM | 69423U305 | 12 | 2,218 | SH | | DFND | | 646 | 0 | 1,572 |
| PACIRA PHARMACEUTICALS INC COM USD0.001 | COM | 695127100 | 68,588 | 2,033,432 | SH | | DFND | | 552,845 | 0 | 1,480,587 |
| PALO ALTO NETWORKS INC COM USD0.0001 | COM | 697435105 | 6,299 | 51,364 | SH | | DFND | | 10,029 | 0 | 41,335 |
| PANDORA MEDIA INC COM | COM | 698354107 | 648 | 52,063 | SH | | DFND | | 15,445 | 0 | 36,618 |
| PAPA MURPHYS HLDGS INC COM | COM | 698814100 | 4,450 | 670,670 | SH | | DFND | | 388,575 | 0 | 282,095 |
| PARROT EUR0.1524 ISIN #FR0004038263 SEDOL #B04VST3 | COM | F7096P108 | 24,738 | 1,772,873 | SH | | DFND | | 358,282 | 0 | 1,414,591 |
| PAYCOM SOFTWARE INC COM USD0.01 | COM | 70432V102 | 111,740 | 2,585,965 | SH | | DFND | | 349,674 | 0 | 2,236,291 |
| PAYLOCITY HOLDING CORPORATION COM USD0.001 | COM | 70438V106 | 6,717 | 155,482 | SH | | DFND | | 25,601 | 0 | 129,881 |
| PDF SOLUTIONS INC | COM | 693282105 | 175 | 12,526 | SH | | DFND | | 1,583 | 0 | 10,943 |
| PDVWIRELESS INC COM | COM | 69290R104 | 586 | 27,407 | SH | | DFND | | 10,390 | 0 | 17,017 |
| PENSKE AUTOMOTIVE GROUP INC | COM | 70959W103 | 1,872 | 59,507 | SH | | DFND | | 17,839 | 0 | 41,668 |
| PENUMBRA INC COM | COM | 70975L107 | 1,831 | 30,765 | SH | | DFND | | 5,514 | 0 | 25,251 |
| POOL CORP COM | COM | 73278L105 | 44,116 | 469,168 | SH | | DFND | | 62,409 | 0 | 406,759 |
| POWER SOLUTIONS INTL INC COM NEW | COM | 73933G202 | 349 | 19,566 | SH | | DFND | | 7,168 | 0 | 12,398 |
| PRESTIGE BRANDS HLDGS INC | COM | 74112D101 | 1,049 | 18,933 | SH | | DFND | | 6,151 | 0 | 12,782 |
| PROOFPOINT INC COM USD0.0001 | COM | 743424103 | 8,807 | 139,595 | SH | | DFND | | 16,459 | 0 | 123,136 |
| PURE STORAGE INC CL A | COM | 74624M102 | 3,524 | 323,259 | SH | | DFND | | 32,981 | 0 | 290,278 |
| PURE TECHNOLOGIES LTD COM ISIN #CA7459151089 SEDOL #2797816 | COM | 745915108 | 6,254 | 1,379,067 | SH | | DFND | | 228,258 | 0 | 1,150,809 |
| PURPLEBRICKS GROUP PLC ORD GBP0.01 ISIN #GB00BYV2MV74 SEDOL #BYV | COM | G7S98A108 | 491 | 272,015 | SH | | DFND | | 115,315 | 0 | 156,700 |
| Q2 HLDGS INC COM | COM | 74736L109 | 22,563 | 805,248 | SH | | DFND | | 61,865 | 0 | 743,383 |
| REAL IND INC COM | COM | 75601W104 | 6,489 | 835,198 | SH | | DFND | | 166,611 | 0 | 668,587 |
| RED HAT INC COM | COM | 756577102 | 3,375 | 46,490 | SH | | DFND | | 8,747 | 0 | 37,743 |
| REGUS PLC ORD GBP0.01 ISIN #JE00B3CGFD43 SEDOL #B3CGFD4 | COM | G7477W101 | 38,387 | 9,936,195 | SH | | DFND | | 635,303 | 0 | 9,300,892 |
| RENAISSANCERE HOLDINGS LTD COM STK USD1 | COM | G7496G103 | 20 | 167 | SH | | DFND | | 0 | 0 | 167 |
| RIGHTMOVE PLC WINTERHILL SHS ISIN #GB00B2987V85 SEDOL #B2987V8 | COM | G75657109 | 27,932 | 572,773 | SH | | DFND | | 61,274 | 0 | 511,499 |
| RINGCENTRAL INC-CLASS A | COM | 76680R206 | 74,008 | 3,752,961 | SH | | DFND | | 564,578 | 0 | 3,188,383 |
| SABRE CORP COM | COM | 78573M104 | 1,054 | 39,347 | SH | | DFND | | 10,191 | 0 | 29,156 |
| SAFETY INS GROUP INC | COM | 78648T100 | 2,364 | 38,382 | SH | | DFND | | 1,210 | 0 | 37,172 |
| SAGE THERAPEUTICS INC COM | COM | 78667J108 | 9,772 | 324,344 | SH | | DFND | | 91,589 | 0 | 232,755 |
| SALESFORCE COM INC | COM | 79466L302 | 15,013 | 189,059 | SH | | DFND | | 39,346 | 0 | 149,713 |
| SAREPTA THERAPEUTICS INC COM | COM | 803607100 | 343 | 17,990 | SH | | DFND | | 7,416 | 0 | 10,574 |
| SCOUT24 AG NPV 144A ISIN #DE000A12DM80 SEDOL #BYT9340 | COM | D345XT105 | 81 | 2,177 | SH | | DFND | | 422 | 0 | 1,755 |
| SECTOR SPDR TR SHS BEN INT TECHNOLOGY | COM | 81369Y803 | 1,479 | 34,100 | SH | | DFND | | 8,017 | 0 | 26,083 |
| SERVICENOW INC COM USD0.001 | COM | 81762P102 | 2,349 | 35,377 | SH | | DFND | | 3,142 | 0 | 32,235 |
| SHAKE SHACK INC CL A | COM | 819047101 | 62,687 | 1,720,760 | SH | | DFND | | 393,061 | 0 | 1,327,699 |
| SHERWIN WILLIAMS CO | COM | 824348106 | 182 | 619 | SH | | DFND | | 19 | 0 | 600 |
| SHOPIFY INC NPV SUBORDINATED A ISIN #CA82509L1076 SEDOL #BX865C7 | COM | 82509L107 | 3,505 | 113,931 | SH | | DFND | | 28,867 | 0 | 85,064 |
| SHUTTERSTOCK INC COM USD0.01 | COM | 825690100 | 353 | 7,700 | SH | | DFND | | 430 | 0 | 7,270 |
| SIENTRA INC COM USD0.01 | COM | 82621J105 | 851 | 129,354 | SH | | DFND | | 45,140 | 0 | 84,214 |
| SIGNATURE BK NEW YORK N Y COM | COM | 82669G104 | 5,267 | 42,163 | SH | | DFND | | 6,909 | 0 | 35,254 |
| SILVER SPRING NETWORKS INC COM USD0.001 | COM | 82817Q103 | 5,536 | 455,625 | SH | | DFND | | 67,314 | 0 | 388,311 |
| SILVER WHEATON CORPORATION COM NPV ISIN #CA8283361076 SEDOL #B05 | COM | 828336107 | 2,398 | 101,916 | SH | | DFND | | 910 | 0 | 101,006 |
| SIRIUS XM HLDGS INC COM | COM | 82968B103 | 2,503 | 633,613 | SH | | DFND | | 79,868 | 0 | 553,745 |
| SITEONE LANDSCAPE SUPPLY INC COM | COM | 82982L103 | 11,877 | 349,437 | SH | | DFND | | 36,242 | 0 | 313,195 |
| SIX FLAGS ENTMT CORP NEW COM | COM | 83001A102 | 13,361 | 230,553 | SH | | DFND | | 65,170 | 0 | 165,383 |
| SLM CORP PFD SER B 2.18056% | COM | 78442P502 | 14 | 300 | SH | | DFND | | 118 | 0 | 182 |
| SOLARCITY CORP COM USD0.0001 | COM | 83416T100 | 1,049 | 43,840 | SH | | DFND | | 24,151 | 0 | 19,689 |
| SPARK THERAPEUTICS INC COM | COM | 84652J103 | 588 | 11,498 | SH | | DFND | | 4,759 | 0 | 6,739 |
| SPIRIT AIRLS INC COM | COM | 848577102 | 79,280 | 1,766,874 | SH | | DFND | | 439,091 | 0 | 1,327,783 |
| SPLUNK INC COM USD0.001 | COM | 848637104 | 12,628 | 233,079 | SH | | DFND | | 42,971 | 0 | 190,108 |
| SPROUTS FMRS MKT INC COM | COM | 85208M102 | 574 | 25,063 | SH | | DFND | | 9,774 | 0 | 15,289 |
| SPS COMM INC COM | COM | 78463M107 | 3,387 | 55,899 | SH | | DFND | | 9,344 | 0 | 46,555 |
| SQUARE INC CL A | COM | 852234103 | 809 | 89,402 | SH | | DFND | | 21,222 | 0 | 68,180 |
| SS&C TECHNOLOGIES HLDGS INC COM | COM | 78467J100 | 21,209 | 755,322 | SH | | DFND | | 109,434 | 0 | 645,888 |
| STARBUCKS CORP | COM | 855244109 | 59,701 | 1,045,193 | SH | | DFND | | 403,849 | 0 | 641,344 |
| STRAIGHT PATH COMMUNICATIONS INC COM USD0.01 CL B | COM | 862578101 | 15,934 | 575,866 | SH | | DFND | | 104,993 | 0 | 470,873 |
| SUMMIT MATLS INC CL A | COM | 86614U100 | 6,686 | 326,793 | SH | | DFND | | 8,149 | 0 | 318,644 |
| SUNRUN INC COM | COM | 86771W105 | 411 | 69,237 | SH | | DFND | | 6,332 | 0 | 62,905 |
| SURGERY PARTNERS INC COM | COM | 86881A100 | 1,988 | 111,077 | SH | | DFND | | 486 | 0 | 110,591 |
| SVB FINL GROUP | COM | 78486Q101 | 1,794 | 18,850 | SH | | DFND | | 2,840 | 0 | 16,010 |
| T MOBILE US INC COM | COM | 872590104 | 133 | 3,079 | SH | | DFND | | 474 | 0 | 2,605 |
| T2 BIOSYSTEMS INC COM USD0.001 | COM | 89853L104 | 3,252 | 412,150 | SH | | DFND | | 195,151 | 0 | 216,999 |
| TELADOC INC COM | COM | 87918A105 | 1,092 | 68,190 | SH | | DFND | | 16,904 | 0 | 51,286 |
| TENCENT HOLDINGS LIMITED HKD0.00002 ISIN #KYG875721634 SEDOL #BM | COM | G87572163 | 32,162 | 1,416,880 | SH | | DFND | | 408,800 | 0 | 1,008,080 |
| TESLA MOTORS INC COM USD0.001 | COM | 88160R101 | 171,663 | 808,661 | SH | | DFND | | 245,337 | 0 | 563,324 |
| THERAPEUTICSMD INC COM | COM | 88338N107 | 42,169 | 4,961,043 | SH | | DFND | | 1,177,835 | 0 | 3,783,208 |
| TIME INC NEW COM | COM | 887228104 | 36 | 2,201 | SH | | DFND | | 0 | 0 | 2,201 |
| TRACTOR SUPPLY CO | COM | 892356106 | 2,659 | 29,163 | SH | | DFND | | 7,035 | 0 | 22,128 |
| TRANSDIGM GROUP INC COM | COM | 893641100 | 14,649 | 55,553 | SH | | DFND | | 3,597 | 0 | 51,956 |
| TREVENA INC COM | COM | 89532E109 | 40 | 6,292 | SH | | DFND | | 4,176 | 0 | 2,116 |
| TRIPADVISOR INC COM | COM | 896945201 | 86,842 | 1,350,583 | SH | | DFND | | 294,868 | 0 | 1,055,715 |
| TSO3 INC COM ISIN #CA8730151013 SEDOL #2798518 | COM | 873015101 | 8,290 | 4,806,425 | SH | | DFND | | 417,997 | 0 | 4,388,428 |
| TWILIO INC CL A | COM | 90138F102 | 47 | 1,291 | SH | | DFND | | 0 | 0 | 1,291 |
| TWITTER INC COM USD0.000005 | COM | 90184L102 | 439 | 25,964 | SH | | DFND | | 9,815 | 0 | 16,149 |
| ULTA SALON COSMETCS &FRAG INC COM | COM | 90384S303 | 60,923 | 250,054 | SH | | DFND | | 18,130 | 0 | 231,924 |
| ULTIMATE SOFTWARE GROUP INC | COM | 90385D107 | 4,909 | 23,342 | SH | | DFND | | 4,013 | 0 | 19,329 |
| ULTRAGENYX PHARMACEUTICAL INC | COM | 90400D108 | 335 | 6,842 | SH | | DFND | | 2,747 | 0 | 4,095 |
| UNDER ARMOUR INC CL A | COM | 904311107 | 50,092 | 1,248,247 | SH | | DFND | | 293,949 | 0 | 954,298 |
| UNDER ARMOUR INC CL C | COM | 904311206 | 44,957 | 1,235,089 | SH | | DFND | | 290,073 | 0 | 945,016 |
| UNITED STATES LIME &MINERALS COM | COM | 911922102 | 1,640 | 27,800 | SH | | DFND | | 1,230 | 0 | 26,570 |
| UNIVERSAL DISPLAY CORP | COM | 91347P105 | 235 | 3,466 | SH | | DFND | | 2,126 | 0 | 1,340 |
| UPLAND SOFTWARE INC COM | COM | 91544A109 | 13 | 1,650 | SH | | DFND | | 502 | 0 | 1,148 |
| VALIDUS HOLDING LTD COM STK USD0.175 | COM | G9319H102 | 5,750 | 118,336 | SH | | DFND | | 27,452 | 0 | 90,884 |
| VANECK VECTORS ETF TR GOLD MINERS ETF | COM | 92189F106 | 15,474 | 558,410 | SH | | DFND | | 17,308 | 0 | 541,102 |
| VEEVA SYS INC CL A COM | COM | 922475108 | 5,249 | 153,852 | SH | | DFND | | 30,590 | 0 | 123,262 |
| VULCAN MATERIALS CO | COM | 929160109 | 149 | 1,238 | SH | | DFND | | 43 | 0 | 1,195 |
| WALGREENS BOOTS ALLIANCE INC COM | COM | 931427108 | 401 | 4,810 | SH | | DFND | | 684 | 0 | 4,126 |
| WELLS FARGO & CO NEW | COM | 949746101 | 1,275 | 26,943 | SH | | DFND | | 4,147 | 0 | 22,796 |
| WINDELN.DE AG NPV ISIN #DE000WNDL110 SEDOL #BWZMZJ8 | COM | D9695L100 | 17 | 3,913 | SH | | DFND | | 787 | 0 | 3,126 |
| WORKDAY INC CL A | COM | 98138H101 | 6,208 | 83,141 | SH | | DFND | | 14,053 | 0 | 69,088 |
| XERO LIMITED NPV ISIN #NZXROE0001S2 SEDOL #B1Y43C7 | COM | Q98665104 | 20,318 | 1,567,535 | SH | | DFND | | 461,921 | 0 | 1,105,614 |
| XTREME DRILLING &COIL SVCS CO COM ISIN #CA98419V1004 SEDOL #B7J8 | COM | 98419V100 | 1,591 | 791,488 | SH | | DFND | | 21,931 | 0 | 769,557 |
| YOOX NET-A-PORTER GROUP NPV ISIN #IT0003540470 SEDOL #B4YC9W4 | COM | T9846S106 | 26,869 | 1,163,345 | SH | | DFND | | 78,080 | 0 | 1,085,265 |
| ZELTIQ AESTHETICS INC COM | COM | 98933Q108 | 1,172 | 42,882 | SH | | DFND | | 13,400 | 0 | 29,482 |
| ZENDESK INC COM USD0.01 | COM | 98936J101 | 11,443 | 433,772 | SH | | DFND | | 82,327 | 0 | 351,445 |
| ZILLOW GROUP INC CL A | COM | 98954M101 | 20,015 | 546,111 | SH | | DFND | | 22,171 | 0 | 523,940 |
| ZILLOW GROUP INC CL C CAP STK | COM | 98954M200 | 41,519 | 1,144,400 | SH | | DFND | | 83,446 | 0 | 1,060,954 |
| ZOES KITCHEN INC COM | COM | 98979J109 | 195 | 5,390 | SH | | DFND | | 1,057 | 0 | 4,333 |
| ZOETIS INC COM USD0.01 CL A | COM | 98978V103 | 319 | 6,730 | SH | | DFND | | 237 | 0 | 6,493 |
