| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2U INC COM USD0.001 | COM | 90214J101 | 149,750 | 3,191,599 | SH | | DFND | | 779,929 | 0 | 2,411,670 |
| ABIOMED INC | COM | 003654100 | 2,199 | 15,347 | SH | | DFND | | 3,586 | 0 | 11,761 |
| ABRAXAS PETE CORP | COM | 003830106 | 658 | 406,279 | SH | | DFND | | 48,408 | 0 | 357,871 |
| ACACIA COMMUNICATIONS INC COM | COM | 00401C108 | 53,382 | 1,287,255 | SH | | DFND | | 231,943 | 0 | 1,055,312 |
| ACADIA HEALTHCARE COMPANY INC COM | COM | 00404A109 | 6,574 | 133,138 | SH | | DFND | | 1,303 | 0 | 131,835 |
| ACADIA PHARMACEUTICALS INC COM | COM | 004225108 | 312 | 11,189 | SH | | DFND | | 2,112 | 0 | 9,077 |
| ACTIVISION BLIZZARD INC COM | COM | 00507V109 | 101,586 | 1,764,561 | SH | | DFND | | 344,610 | 0 | 1,419,951 |
| ADESTO TECHNOLOGIES CORP COM | COM | 00687D101 | 7,567 | 1,663,117 | SH | | DFND | | 97,291 | 0 | 1,565,826 |
| ADOBE SYS INC | COM | 00724F101 | 71,336 | 504,356 | SH | | DFND | | 172,272 | 0 | 332,084 |
| ADVERUM BIOTECHNOLOGIES INC COM | COM | 00773U108 | 111 | 44,556 | SH | | DFND | | 20,510 | 0 | 24,046 |
| ALIBABA GROUP HLDG LTD SPONSORED ADS | COM | 01609W102 | 51,999 | 369,047 | SH | | DFND | | 132,393 | 0 | 236,654 |
| ALIGN TECHNOLOGY INC COM | COM | 016255101 | 105,574 | 703,264 | SH | | DFND | | 86,284 | 0 | 616,980 |
| ALLEGIANT TRAVEL CO COM | COM | 01748X102 | 15,040 | 110,915 | SH | | DFND | | 8,119 | 0 | 102,796 |
| ALLERGAN PLC. COM USD0.0001 | COM | G0177J108 | 405 | 1,666 | SH | | DFND | | 46 | 0 | 1,620 |
| ALMOST FAMILY INC | COM | 020409108 | 23,019 | 373,382 | SH | | DFND | | 55,660 | 0 | 317,722 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 94,546 | 1,185,380 | SH | | DFND | | 292,823 | 0 | 892,557 |
| ALPHABET INC CAP STK CL A | COM | 02079K305 | 44,975 | 48,377 | SH | | DFND | | 4,799 | 0 | 43,578 |
| ALPHABET INC CAP STK CL C | COM | 02079K107 | 59,947 | 65,968 | SH | | DFND | | 8,223 | 0 | 57,745 |
| AMAZON.COM INC | COM | 023135106 | 475,411 | 491,127 | SH | | DFND | | 185,619 | 0 | 305,508 |
| AMBER ROAD INC COM USD0.001 | COM | 02318Y108 | 627 | 73,153 | SH | | DFND | | 7,099 | 0 | 66,054 |
| AMEDISYS INC COM | COM | 023436108 | 51,469 | 819,433 | SH | | DFND | | 405,281 | 0 | 414,152 |
| AMERICAN INTL GROUP INC COM NEW | COM | 026874784 | 207 | 3,303 | SH | | DFND | | 91 | 0 | 3,212 |
| AMERICAN TOWER CORPORATION | COM | 03027X100 | 11,871 | 89,716 | SH | | DFND | | 8,593 | 0 | 81,123 |
| AMS AG NPV (BR) ISIN #AT0000A18XM4 SEDOL #BPF0548 | COM | A0400Q115 | 142 | 2,187 | SH | | DFND | | 192 | 0 | 1,995 |
| APACHE CORP | COM | 037411105 | 25,141 | 524,535 | SH | | DFND | | 85,329 | 0 | 439,206 |
| APPIAN CORP CL A | COM | 03782L101 | 5,282 | 291,023 | SH | | DFND | | 33,236 | 0 | 257,787 |
| APPLE INC | COM | 037833100 | 3,768 | 26,162 | SH | | DFND | | 6,177 | 0 | 19,985 |
| APPLIED OPTOELECTRONICS INC COM | COM | 03823U102 | 16,633 | 269,185 | SH | | DFND | | 28,883 | 0 | 240,302 |
| ARISTA NETWORKS INC COM USD0.0001 | COM | 040413106 | 87,694 | 585,445 | SH | | DFND | | 29,102 | 0 | 556,343 |
| ASV HLDGS INC COM | COM | 00215L104 | 7,494 | 919,498 | SH | | DFND | | 32,729 | 0 | 886,769 |
| AT HOME GROUP INC COM | COM | 04650Y100 | 1,957 | 84,012 | SH | | DFND | | 7,172 | 0 | 76,840 |
| ATHENAHEALTH INC DELAWARE | COM | 04685W103 | 396 | 2,817 | SH | | DFND | | 363 | 0 | 2,454 |
| ATKORE INTL GROUP INC COM | COM | 047649108 | 2,243 | 99,485 | SH | | DFND | | 40,734 | 0 | 58,751 |
| ATLASSIAN CORPORATION PLC COM USD0.1 CL A | COM | G06242104 | 19,633 | 558,069 | SH | | DFND | | 65,608 | 0 | 492,461 |
| AUTO TRADER GROUP PLC ORD GBP0.01 ISIN #GB00BVYVFW23 SEDOL #BVYV | COM | G06708104 | 5,891 | 1,193,494 | SH | | DFND | | 234,204 | 0 | 959,290 |
| AUTODESK INC COM | COM | 052769106 | 81,458 | 807,953 | SH | | DFND | | 133,941 | 0 | 674,012 |
| AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN #US05462W1099 SEDOL # | COM | 05462W109 | 671 | 16,871 | SH | | DFND | | 16,275 | 0 | 596 |
| AXOGEN INC COM | COM | 05463X106 | 9,516 | 568,124 | SH | | DFND | | 120,867 | 0 | 447,257 |
| AZUL SA SPON ADR EACH REP 3 PFD SHS | COM | 05501U106 | 102,420 | 4,858,619 | SH | | DFND | | 919,665 | 0 | 3,938,954 |
| BAIDU INC SPONS ADR REPR 0.10 ORD CLS A | COM | 056752108 | 8,785 | 49,116 | SH | | DFND | | 10,910 | 0 | 38,206 |
| BANCO MACRO S.A. ADR REP 10 CLS B SHS ARS1 | COM | 05961W105 | 74 | 799 | SH | | DFND | | 151 | 0 | 648 |
| BELLATRIX EXPLORATION LTD COM ISIN #CA0783141017 SEDOL #B580BW5 | COM | 078314101 | 366 | 630,589 | SH | | DFND | | 108,869 | 0 | 521,720 |
| BERKLEY W R CORP | COM | 084423102 | 4,643 | 67,125 | SH | | DFND | | 17,947 | 0 | 49,178 |
| BERKSHIRE HATHAWAY INC DEL CL B NEW | COM | 084670702 | 34 | 200 | SH | | DFND | | 0 | 0 | 200 |
| BIOHAVEN PHARMACEUTICAL HLDG CO LTD COM NPV | COM | G11196105 | 1,929 | 77,169 | SH | | DFND | | 19,388 | 0 | 57,781 |
| BIOSCRIP INC | COM | 09069N108 | 41,298 | 15,211,136 | SH | | DFND | | 3,389,083 | 0 | 11,822,053 |
| BLACKLINE INC COM | COM | 09239B109 | 6,105 | 170,816 | SH | | DFND | | 32,526 | 0 | 138,290 |
| BMC STK HLDGS INC COM | COM | 05591B109 | 21,827 | 998,943 | SH | | DFND | | 118,735 | 0 | 880,208 |
| BOINGO WIRELESS INC COM USD0.0001 | COM | 09739C102 | 14,410 | 963,223 | SH | | DFND | | 157,411 | 0 | 805,812 |
| BOOHOO.COM PLC ORD GBP0.01 ISIN #JE00BG6L7297 SEDOL #BG6L729 | COM | G6153P109 | 578 | 191,713 | SH | | DFND | | 75,422 | 0 | 116,291 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 | 1,279 | 46,126 | SH | | DFND | | 20,722 | 0 | 25,404 |
| BOX INC CL A | COM | 10316T104 | 5,254 | 288,051 | SH | | DFND | | 51,148 | 0 | 236,903 |
| BRIGHTCOVE INC COM USD0.001 | COM | 10921T101 | 189 | 30,421 | SH | | DFND | | 3,656 | 0 | 26,765 |
| C S X CORP | COM | 126408103 | 2,291 | 41,991 | SH | | DFND | | 10,421 | 0 | 31,570 |
| C&J ENERGY SVCS INC NEW COM | COM | 12674R100 | 242 | 7,058 | SH | | DFND | | 2,555 | 0 | 4,503 |
| CAESARS ENTMT CORP COM | COM | 127686103 | 1,792 | 149,305 | SH | | DFND | | 40,105 | 0 | 109,200 |
| CANADA GOOSE HOLDINGS INC COM NPV SUB VTNG SHS ISIN #CA135086106 | COM | 135086106 | 500 | 25,328 | SH | | DFND | | 0 | 0 | 25,328 |
| CARDIOVASCULAR SYS INC DEL COM | COM | 141619106 | 2,051 | 63,651 | SH | | DFND | | 13,801 | 0 | 49,850 |
| CARL ZEISS MEDITEC AG NPV ISIN #DE0005313704 SEDOL #5922961 | COM | D14895102 | 868 | 16,660 | SH | | DFND | | 6,380 | 0 | 10,280 |
| CARROLS RESTAURANT GROUP INC COM | COM | 14574X104 | 10,231 | 835,158 | SH | | DFND | | 80,358 | 0 | 754,800 |
| CATAPULT GROUP INTL LTD ISIN #AU000000CAT9 SEDOL #BTL0Y76 | COM | Q2159P101 | 12,090 | 6,764,629 | SH | | DFND | | 2,278,384 | 0 | 4,486,245 |
| CAVIUM INC COM | COM | 14964U108 | 36,134 | 581,590 | SH | | DFND | | 75,599 | 0 | 505,991 |
| CBS CORP NEW CL B | COM | 124857202 | 1,741 | 27,292 | SH | | DFND | | 5,616 | 0 | 21,676 |
| CHARTER COMMUNICATIONS INC NEW CL A | COM | 16119P108 | 201 | 596 | SH | | DFND | | 26 | 0 | 570 |
| CHEGG INC COM USD0.001 | COM | 163092109 | 55,365 | 4,504,885 | SH | | DFND | | 325,995 | 0 | 4,178,890 |
| CHIPOTLE MEXICAN GRILL INC COM | COM | 169656105 | 16 | 39 | SH | | DFND | | 11 | 0 | 28 |
| CITIGROUP INC COM NEW | COM | 172967424 | 4,406 | 65,881 | SH | | DFND | | 11,071 | 0 | 54,810 |
| CLOUDERA INC COM | COM | 18914U100 | 745 | 46,512 | SH | | DFND | | 2,770 | 0 | 43,742 |
| COGENT COMMUNICATION HLDGS INC COM NEW | COM | 19239V302 | 288 | 7,186 | SH | | DFND | | 667 | 0 | 6,519 |
| COGNEX CORP COM | COM | 192422103 | 28,435 | 334,927 | SH | | DFND | | 113,362 | 0 | 221,565 |
| CONSTELLATION BRANDS INC CL A | COM | 21036P108 | 9,910 | 51,152 | SH | | DFND | | 4,650 | 0 | 46,502 |
| CONYERS PK ACQUISITION CL A COM | COM | 212894109 | 138 | 11,720 | SH | | DFND | | 295 | 0 | 11,425 |
| COSTCO WHOLESALE CORP | COM | 22160K105 | 158 | 985 | SH | | DFND | | 26 | 0 | 959 |
| CRIMSON WINE GROUP COM USD0.01 | COM | 22662X100 | 219 | 20,452 | SH | | DFND | | 525 | 0 | 19,927 |
| CTRIP.COM INTERNATIONAL LTD ADS EACH REP 0.125 ORD USD0.01 | COM | 22943F100 | 27,257 | 506,079 | SH | | DFND | | 141,889 | 0 | 364,190 |
| DEERE & COMPANY | COM | 244199105 | 12 | 100 | SH | | DFND | | 0 | 0 | 100 |
| DELTA AIR LINES INC DEL COM NEW | COM | 247361702 | 8,172 | 152,070 | SH | | DFND | | 4,553 | 0 | 147,517 |
| DEXCOM INC | COM | 252131107 | 3,176 | 43,423 | SH | | DFND | | 35 | 0 | 43,388 |
| DIRTT ENVIRONMENTAL SOLUT LTD COM ISIN #CA25490H1064 SEDOL #BH13 | COM | 25490H106 | 52,360 | 9,926,997 | SH | | DFND | | 603,471 | 0 | 9,323,526 |
| DOMINOS PIZZA ENTERPRISES LIMITED NPV ISIN #AU000000DMP0 SEDOL # | COM | Q32503106 | 32,645 | 817,197 | SH | | DFND | | 246,114 | 0 | 571,083 |
| ECO STIM ENERGY SOLUTIONS INC COM | COM | 27888D101 | 985 | 787,940 | SH | | DFND | | 70,475 | 0 | 717,465 |
| ECOSYNTHETIX INC COM ISIN #CA27923D1087 SEDOL #B4XBZ35 | COM | 27923D108 | 144 | 63,320 | SH | | DFND | | 4,804 | 0 | 58,516 |
| ELBIT SYSTEMS LTD ISIN #IL0010811243 SEDOL #6308913 | COM | M3760D101 | 34,148 | 275,947 | SH | | DFND | | 120,364 | 0 | 155,583 |
| ELECTRONIC ARTS | COM | 285512109 | 34,165 | 323,169 | SH | | DFND | | 61,249 | 0 | 261,920 |
| ENPHASE ENERGY INC COM USD0.00001 | COM | 29355A107 | 660 | 763,126 | SH | | DFND | | 41,929 | 0 | 721,197 |
| ENZO BIOCHEM INC | COM | 294100102 | 11,040 | 999,961 | SH | | DFND | | 224,177 | 0 | 775,784 |
| EPAM SYS INC COM USD0.001 | COM | 29414B104 | 51,852 | 616,625 | SH | | DFND | | 35,153 | 0 | 581,472 |
| EROS INTERNATIONAL COM GBP0.30 | COM | G3788M114 | 28,711 | 2,507,529 | SH | | DFND | | 709,944 | 0 | 1,797,585 |
| ESPERION THERAPEUTICS INC COM USD0.001 | COM | 29664W105 | 78 | 1,689 | SH | | DFND | | 204 | 0 | 1,485 |
| ETSY INC COM | COM | 29786A106 | 239 | 15,918 | SH | | DFND | | 4,210 | 0 | 11,708 |
| EVERBRIDGE INC COM | COM | 29978A104 | 17,414 | 714,858 | SH | | DFND | | 116,914 | 0 | 597,944 |
| EVOLENT HEALTH INC CL A | COM | 30050B101 | 1,869 | 73,735 | SH | | DFND | | 22,125 | 0 | 51,610 |
| EXACT SCIENCES CORP | COM | 30063P105 | 110,659 | 3,128,615 | SH | | DFND | | 629,927 | 0 | 2,498,688 |
| EXTRACTION OIL AND GAS INC COM | COM | 30227M105 | 7,246 | 538,713 | SH | | DFND | | 79,533 | 0 | 459,180 |
| FACEBOOK INC COM USD0.000006 CL A | COM | 30303M102 | 315,389 | 2,088,948 | SH | | DFND | | 578,246 | 0 | 1,510,702 |
| FAIRFAX INDIA HOLDINGS CORPORATION COM SUB VTG SHS ISIN #CA30389 | COM | 303897102 | 320 | 20,000 | SH | | DFND | | 20,000 | 0 | 0 |
| FARMER BROS CO COM | COM | 307675108 | 2,778 | 91,822 | SH | | DFND | | 21,645 | 0 | 70,177 |
| FB FINL CORP COM | COM | 30257X104 | 358 | 9,902 | SH | | DFND | | 4,239 | 0 | 5,663 |
| FEVERTREE DRINKS PLC ORD GBP0.0025 ISIN #GB00BRJ9BJ26 SEDOL #BRJ | COM | G33929103 | 1,201 | 54,222 | SH | | DFND | | 29,742 | 0 | 24,480 |
| FIRST REP BK SAN FRANCISCO CAL COM | COM | 33616C100 | 34,587 | 345,529 | SH | | DFND | | 45,892 | 0 | 299,637 |
| FLEXION THERAPEUTICS INC COM | COM | 33938J106 | 86,282 | 4,267,164 | SH | | DFND | | 787,937 | 0 | 3,479,227 |
| FLOOR &DECOR HLDGS INC CL A | COM | 339750101 | 79,390 | 2,022,163 | SH | | DFND | | 292,097 | 0 | 1,730,066 |
| FOUNDATION MEDICINE INC USD0.0001 | COM | 350465100 | 62,895 | 1,582,265 | SH | | DFND | | 495,428 | 0 | 1,086,837 |
| FRANCO NEVADA CORP COM ISIN #CA3518581051 SEDOL #B29NF31 | COM | 351858105 | 6,460 | 89,527 | SH | | DFND | | 2,715 | 0 | 86,812 |
| FRESHPET INC COM | COM | 358039105 | 12,863 | 774,866 | SH | | DFND | | 58,260 | 0 | 716,606 |
| GALAPAGOS NV NPV ISIN #BE0003818359 SEDOL #B07Q2V5 | COM | B44170106 | 22,001 | 288,516 | SH | | DFND | | 101,714 | 0 | 186,802 |
| GASLOG LTD COM USD0.01 | COM | G37585109 | 3,370 | 220,961 | SH | | DFND | | 52,795 | 0 | 168,166 |
| GEOPARK LIMITED COM USD0.001 | COM | G38327105 | 1,962 | 259,893 | SH | | DFND | | 6,403 | 0 | 253,490 |
| GIGAMON INC COM USD0.0001 | COM | 37518B102 | 36,714 | 933,011 | SH | | DFND | | 85,188 | 0 | 847,823 |
| GILDAN ACTIVEWEAR INC COM ISIN #CA3759161035 SEDOL #2254645 | COM | 375916103 | 10,403 | 338,514 | SH | | DFND | | 38,181 | 0 | 300,333 |
| GLAUKOS CORP COM | COM | 377322102 | 61,408 | 1,480,772 | SH | | DFND | | 339,712 | 0 | 1,141,060 |
| GLOBAL BLOOD THERAPEUTICS INC COM | COM | 37890U108 | 251 | 9,170 | SH | | DFND | | 3,527 | 0 | 5,643 |
| GODADDY INC CL A | COM | 380237107 | 65 | 1,525 | SH | | DFND | | 0 | 0 | 1,525 |
| GOLAR LNG LIMITED COM STK USD1.00 | COM | G9456A100 | 5,891 | 264,759 | SH | | DFND | | 51,038 | 0 | 213,721 |
| GOLD STD VENTURES CORP COM ISIN #CA3807381049 SEDOL #B05J9S2 | COM | 380738104 | 1,813 | 1,060,220 | SH | | DFND | | 104,900 | 0 | 955,320 |
| GOLDEN MINERALS CO COM ISIN #US3811191069 SEDOL #B3K4M51 | COM | 381119106 | 28 | 49,704 | SH | | DFND | | 5,744 | 0 | 43,960 |
| GRACE W R & CO DEL NEW | COM | 38388F108 | 14,797 | 205,484 | SH | | DFND | | 38,968 | 0 | 166,516 |
| GREEN BRICK PARTNERS INC | COM | 392709101 | 183 | 15,975 | SH | | DFND | | 500 | 0 | 15,475 |
| GRUPO FINANCIERO GALICIA SA ADR EACH REPR 10 CLASS B ARS1 LVL11 | COM | 399909100 | 121 | 2,836 | SH | | DFND | | 540 | 0 | 2,296 |
| GRUPO SUPERVIELLE S A SPONSORED ADR | COM | 40054A108 | 73 | 4,031 | SH | | DFND | | 770 | 0 | 3,261 |
| GTT COMMUNICATIONS INC COM USD0.0001 | COM | 362393100 | 60,660 | 1,916,594 | SH | | DFND | | 351,096 | 0 | 1,565,498 |
| GUIDEWIRE SOFTWARE INC COM USD0.0001 | COM | 40171V100 | 2,446 | 35,596 | SH | | DFND | | 8,071 | 0 | 27,525 |
| H &E EQUIPMENT SERVICES INC COM | COM | 404030108 | 1,820 | 89,177 | SH | | DFND | | 13,483 | 0 | 75,694 |
| HDFC BANK LTD ADS EACH REPR 3 INR10(MGT) | COM | 40415F101 | 49,598 | 570,294 | SH | | DFND | | 167,801 | 0 | 402,493 |
| HEALTHEQUITY INC COM | COM | 42226A107 | 4,205 | 84,387 | SH | | DFND | | 6,665 | 0 | 77,722 |
| HERC HLDGS INC COM | COM | 42704L104 | 223 | 5,672 | SH | | DFND | | 3,213 | 0 | 2,459 |
| HUBSPOT INC COM | COM | 443573100 | 90,985 | 1,383,795 | SH | | DFND | | 229,049 | 0 | 1,154,746 |
| ICICI BANK LIMITED ADR EACH REPR 2 ORD INR10(SPON) | COM | 45104G104 | 161 | 17,955 | SH | | DFND | | 11,919 | 0 | 6,036 |
| IDORSIA LTD ISIN #CH0363463438 SEDOL #BF0YK62 | COM | H3879B109 | 3,777 | 199,839 | SH | | DFND | | 36,104 | 0 | 163,735 |
| ILLUMINA INC COM | COM | 452327109 | 301 | 1,734 | SH | | DFND | | 441 | 0 | 1,293 |
| IMPERVA INC COM | COM | 45321L100 | 5,330 | 111,390 | SH | | DFND | | 19,672 | 0 | 91,718 |
| IMPINJ INC COM | COM | 453204109 | 102,500 | 2,106,879 | SH | | DFND | | 399,865 | 0 | 1,707,014 |
| INCYTE CORP COM | COM | 45337C102 | 68,750 | 546,023 | SH | | DFND | | 229,098 | 0 | 316,925 |
| INPHI CORPORATION COM USD0.001 | COM | 45772F107 | 3,839 | 111,910 | SH | | DFND | | 18,265 | 0 | 93,645 |
| INSULET CORP COM | COM | 45784P101 | 752 | 14,664 | SH | | DFND | | 6,046 | 0 | 8,618 |
| INTUITIVE SURGICAL INC COM NEW | COM | 46120E602 | 68,204 | 72,917 | SH | | DFND | | 5,335 | 0 | 67,582 |
| IQE PLC ORD GBP0.01 ISIN #GB0009619924 SEDOL #0961992 | COM | G49356119 | 189 | 173,519 | SH | | DFND | | 15,217 | 0 | 158,302 |
| IRHYTHM TECHNOLOGIES INC COM | COM | 450056106 | 4,912 | 115,592 | SH | | DFND | | 13,856 | 0 | 101,736 |
| ITAU UNIBANCO HOLDINGS S.A. ADR EACH REPR 1 PRF NPV | COM | 465562106 | 2,818 | 254,989 | SH | | DFND | | 36,128 | 0 | 218,861 |
| JD COM INC SPONSORED ADR REPSTG COM CL A | COM | 47215P106 | 12,003 | 306,037 | SH | | DFND | | 203,620 | 0 | 102,417 |
| JELD-WEN HLDG INC COM | COM | 47580P103 | 2,102 | 64,764 | SH | | DFND | | 4,220 | 0 | 60,544 |
| KANSAS CITY SOUTHERN COM | COM | 485170302 | 8,175 | 78,119 | SH | | DFND | | 7,688 | 0 | 70,431 |
| KB HOME COM | COM | 48666K109 | 14,769 | 616,163 | SH | | DFND | | 63,725 | 0 | 552,438 |
| KITE PHARMA INC COM | COM | 49803L109 | 918 | 8,851 | SH | | DFND | | 3,498 | 0 | 5,353 |
| KORNIT DIGITAL LTD ORD ILS0.01 | COM | M6372Q113 | 36,963 | 1,910,209 | SH | | DFND | | 577,042 | 0 | 1,333,167 |
| LGI HOMES INC COM | COM | 50187T106 | 82,120 | 2,043,799 | SH | | DFND | | 379,616 | 0 | 1,664,183 |
| LHC GROUP INC COM | COM | 50187A107 | 1,964 | 28,928 | SH | | DFND | | 8,625 | 0 | 20,303 |
| LIBERTY MEDIA CORP DELAWARE COM A BRAVES GRP | COM | 531229706 | 4,626 | 193,646 | SH | | DFND | | 5,543 | 0 | 188,103 |
| LIBERTY MEDIA CORP DELAWARE COM C BRAVES GRP | COM | 531229888 | 6,432 | 268,319 | SH | | DFND | | 7,181 | 0 | 261,138 |
| LIBERTY MEDIA CORP DELAWARE COM C SIRIUSXM | COM | 531229607 | 300 | 7,192 | SH | | DFND | | 183 | 0 | 7,009 |
| LIBERTY MEDIA CORP DELAWARE COM SER C FRMLA | COM | 531229854 | 623 | 17,003 | SH | | DFND | | 452 | 0 | 16,551 |
| LILIS ENERGY INC COM NEW | COM | 532403201 | 3,384 | 690,522 | SH | | DFND | | 135,132 | 0 | 555,390 |
| LIVEPERSON INC | COM | 538146101 | 20,608 | 1,873,455 | SH | | DFND | | 37,284 | 0 | 1,836,171 |
| LUMBER LIQUIDATORS HLDGS INC COM | COM | 55003T107 | 46,029 | 1,836,754 | SH | | DFND | | 659,980 | 0 | 1,176,774 |
| LUMENTUM HLDGS INC COM | COM | 55024U109 | 119,791 | 2,099,760 | SH | | DFND | | 368,788 | 0 | 1,730,972 |
| MADISON SQUARE GARDEN CO NEW CL A | COM | 55825T103 | 6,026 | 30,603 | SH | | DFND | | 5,534 | 0 | 25,069 |
| MAKEMYTRIP LTD USD0.0005 | COM | V5633W109 | 4,060 | 121,022 | SH | | DFND | | 25,469 | 0 | 95,553 |
| MARTIN MARIETTA MATLS INC | COM | 573284106 | 67,930 | 305,195 | SH | | DFND | | 35,367 | 0 | 269,828 |
| MASONITE INTERNATIONAL CORP COM NPV | COM | 575385109 | 8,683 | 115,009 | SH | | DFND | | 28,941 | 0 | 86,068 |
| MASTERCARD INCORPORATED CL A | COM | 57636Q104 | 13,274 | 109,297 | SH | | DFND | | 21,147 | 0 | 88,150 |
| MATERIALISE NV SPON ADS EA REPSTG 1 ORD | COM | 57667T100 | 223 | 18,814 | SH | | DFND | | 2,000 | 0 | 16,814 |
| MAZOR ROBOTICS LTD SPON ADS EA REPR 2 ORD ILS0.00 | COM | 57886P103 | 8,014 | 231,742 | SH | | DFND | | 33,087 | 0 | 198,655 |
| MCDONALDS CORP | COM | 580135101 | 56,568 | 369,339 | SH | | DFND | | 25,939 | 0 | 343,400 |
| MEG ENERGY CORP COM ISIN #CA5527041084 SEDOL #B4XF9J1 | COM | 552704108 | 41 | 13,935 | SH | | DFND | | 3,600 | 0 | 10,335 |
| MERCADOLIBRE INC | COM | 58733R102 | 21,793 | 86,867 | SH | | DFND | | 25,743 | 0 | 61,124 |
| MERCURY SYS INC COM | COM | 589378108 | 45,511 | 1,081,276 | SH | | DFND | | 298,179 | 0 | 783,097 |
| MERSANA THERAPEUTICS INC COM | COM | 59045L106 | 70 | 5,000 | SH | | DFND | | 0 | 0 | 5,000 |
| METRO BANK PLC ORD GBP0.000001 ISIN #GB00BZ6STL67 SEDOL #BZ6STL6 | COM | G60640102 | 169,380 | 3,634,274 | SH | | DFND | | 804,543 | 0 | 2,829,731 |
| MICRON TECHNOLOGY | COM | 595112103 | 1,172 | 39,261 | SH | | DFND | | 14,795 | 0 | 24,466 |
| MICROSOFT CORP | COM | 594918104 | 35,707 | 518,023 | SH | | DFND | | 140,624 | 0 | 377,399 |
| MIMECAST LIMITED COM USD0.012 | COM | G14838109 | 5,266 | 196,653 | SH | | DFND | | 8,730 | 0 | 187,923 |
| MOLSON COORS BREWING CO CL B | COM | 60871R209 | 217 | 2,509 | SH | | DFND | | 62 | 0 | 2,447 |
| MOMO INC ADR EACH REPR 2 CL A ORD | COM | 60879B107 | 116 | 3,131 | SH | | DFND | | 608 | 0 | 2,523 |
| MONOLITHIC PWR SYS INC COM | COM | 609839105 | 10,489 | 108,802 | SH | | DFND | | 10,599 | 0 | 98,203 |
| MORRISON(WM.)SUPERMA KETS ORD GBP0.10 ISIN #GB0006043169 SEDOL # | COM | G62748119 | 304 | 96,993 | SH | | DFND | | 23,334 | 0 | 73,659 |
| MULESOFT INC CL A | COM | 625207105 | 32,331 | 1,296,332 | SH | | DFND | | 351,011 | 0 | 945,321 |
| NEOPHOTONICS CORP COM | COM | 64051T100 | 816 | 105,741 | SH | | DFND | | 10,898 | 0 | 94,843 |
| NETFLIX COM INC COM | COM | 64110L106 | 379,710 | 2,541,393 | SH | | DFND | | 588,519 | 0 | 1,952,874 |
| NETSHOES CAYMAN LTD COM USD0.0033 | COM | G6455X107 | 24,404 | 1,282,406 | SH | | DFND | | 354,613 | 0 | 927,793 |
| NEVRO CORP COM USD0.001 | COM | 64157F103 | 90 | 1,207 | SH | | DFND | | 228 | 0 | 979 |
| NEW HOME CO INC COM | COM | 645370107 | 360 | 31,372 | SH | | DFND | | 2,500 | 0 | 28,872 |
| NEW RELIC INC COM | COM | 64829B100 | 6,159 | 143,206 | SH | | DFND | | 24,732 | 0 | 118,474 |
| NINTENDO CO LTD ADR(8 CNV INTO 1 ORD)NPV | COM | 654445303 | 1,035 | 24,699 | SH | | DFND | | 11,841 | 0 | 12,858 |
| NINTENDO CO LTD NPV ISIN #JP3756600007 SEDOL #6639550 | COM | J51699106 | 544 | 1,623 | SH | | DFND | | 415 | 0 | 1,208 |
| NOBLE MIDSTREAM PARTNERS LP COM UNIT REPST | COM | 65506L105 | 59 | 1,289 | SH | | DFND | | 0 | 0 | 1,289 |
| NORTHERN DYNASTY MINS COM NPV ISIN #CA66510M2040 SEDOL #2637848 | COM | 66510M204 | 702 | 504,955 | SH | | DFND | | 25,612 | 0 | 479,343 |
| NORWEGIAN CRUISE LINE HLDGS LTD COM | COM | G66721104 | 710 | 13,079 | SH | | DFND | | 1,256 | 0 | 11,823 |
| NOVELION THERAPEUTICS INC COM NPV(POST REV SPLT) ISIN #CA67001K2 | COM | 67001K202 | 202 | 21,833 | SH | | DFND | | 18,817 | 0 | 3,016 |
| NUTANIX INC CL A | COM | 67059N108 | 81 | 4,036 | SH | | DFND | | 343 | 0 | 3,693 |
| NUTRI SYS INC NEW COM | COM | 67069D108 | 13,488 | 259,132 | SH | | DFND | | 45,611 | 0 | 213,521 |
| NUVASIVE INC COM | COM | 670704105 | 2,157 | 28,043 | SH | | DFND | | 5,436 | 0 | 22,607 |
| NUVECTRA CORP COM | COM | 67075N108 | 12,662 | 953,431 | SH | | DFND | | 176,618 | 0 | 776,813 |
| NV5 GLOBAL INC COM | COM | 62945V109 | 7,704 | 181,260 | SH | | DFND | | 8,060 | 0 | 173,200 |
| NVIDIA CORP | COM | 67066G104 | 34,669 | 239,822 | SH | | DFND | | 93,166 | 0 | 146,656 |
| NXSTAGE MED INC COM | COM | 67072V103 | 55,159 | 2,200,219 | SH | | DFND | | 650,885 | 0 | 1,549,334 |
| OCADO GROUP PLC ORD GBP0.02 ISIN #GB00B3MBS747 SEDOL #B3MBS74 | COM | G6718L106 | 70,057 | 18,636,368 | SH | | DFND | | 3,509,295 | 0 | 15,127,073 |
| OCEANAGOLD CORPORATION COM ISIN #CA6752221037 SEDOL #B1Z7L21 | COM | 675222103 | 2,731 | 907,100 | SH | | DFND | | 27,045 | 0 | 880,055 |
| OKTA INC CL A | COM | 679295105 | 23,054 | 1,011,140 | SH | | DFND | | 157,771 | 0 | 853,369 |
| ORBITAL ATK INC COM | COM | 68557N103 | 100 | 1,013 | SH | | DFND | | 204 | 0 | 809 |
| PACIFIC BIOSCIENCES CALIFORNIA INC COM USD0.0001 | COM | 69404D108 | 4,057 | 1,139,583 | SH | | DFND | | 866,224 | 0 | 273,359 |
| PACIFIC ETHANOL INC COM PAR $.001 | COM | 69423U305 | 14 | 2,215 | SH | | DFND | | 646 | 0 | 1,569 |
| PACIRA PHARMACEUTICALS INC COM USD0.001 | COM | 695127100 | 49,747 | 1,042,912 | SH | | DFND | | 421,031 | 0 | 621,881 |
| PANDORA MEDIA INC COM | COM | 698354107 | 121 | 13,525 | SH | | DFND | | 1,219 | 0 | 12,306 |
| PAYPAL HLDGS INC COM | COM | 70450Y103 | 28,115 | 523,853 | SH | | DFND | | 189,553 | 0 | 334,300 |
| PDF SOLUTIONS INC | COM | 693282105 | 26,520 | 1,612,154 | SH | | DFND | | 159,929 | 0 | 1,452,225 |
| PENSKE AUTOMOTIVE GROUP INC | COM | 70959W103 | 3,603 | 82,061 | SH | | DFND | | 18,724 | 0 | 63,337 |
| POOL CORP COM | COM | 73278L105 | 50,578 | 430,194 | SH | | DFND | | 65,235 | 0 | 364,959 |
| PROOFPOINT INC COM USD0.0001 | COM | 743424103 | 7,173 | 82,613 | SH | | DFND | | 4,324 | 0 | 78,289 |
| PURPLEBRICKS GROUP PLC ORD GBP0.01 ISIN #GB00BYV2MV74 SEDOL #BYV | COM | G7S98A108 | 125 | 22,110 | SH | | DFND | | 16,196 | 0 | 5,914 |
| Q2 HLDGS INC COM | COM | 74736L109 | 52,104 | 1,410,134 | SH | | DFND | | 333,305 | 0 | 1,076,829 |
| RENAISSANCERE HOLDINGS LTD COM STK USD1 | COM | G7496G103 | 23 | 167 | SH | | DFND | | 0 | 0 | 167 |
| REPUBLIC FIRST BANCORP INC COM | COM | 760416107 | 16,683 | 1,803,614 | SH | | DFND | | 721,807 | 0 | 1,081,807 |
| RIGHTMOVE PLC WINTERHILL SHS ISIN #GB00B2987V85 SEDOL #B2987V8 | COM | G75657109 | 20,397 | 369,484 | SH | | DFND | | 51,620 | 0 | 317,864 |
| RINGCENTRAL INC-CLASS A | COM | 76680R206 | 126,360 | 3,457,172 | SH | | DFND | | 602,583 | 0 | 2,854,589 |
| SAFETY INS GROUP INC | COM | 78648T100 | 422 | 6,173 | SH | | DFND | | 1,170 | 0 | 5,003 |
| SALESFORCE COM INC | COM | 79466L302 | 40,571 | 468,489 | SH | | DFND | | 118,804 | 0 | 349,685 |
| SALLY BEAUTY HLDGS INC COM | COM | 79546E104 | 27 | 1,342 | SH | | DFND | | 565 | 0 | 777 |
| SANGAMO THERAPEUTICS INC COM | COM | 800677106 | 514 | 58,378 | SH | | DFND | | 14,382 | 0 | 43,996 |
| SAREPTA THERAPEUTICS INC COM | COM | 803607100 | 487 | 14,437 | SH | | DFND | | 5,840 | 0 | 8,597 |
| SCHNEIDER NATIONAL INC CL B | COM | 80689H102 | 2,024 | 90,474 | SH | | DFND | | 18,797 | 0 | 71,677 |
| SCIENTIFIC GAMES CRP CL A | COM | 80874P109 | 1,719 | 65,864 | SH | | DFND | | 15,345 | 0 | 50,519 |
| SECTOR SPDR TR SHS BEN INT TECHNOLOGY | COM | 81369Y803 | 1,495 | 27,324 | SH | | DFND | | 5,492 | 0 | 21,832 |
| SENESTECH INC COM | COM | 81720R109 | 5,969 | 1,047,169 | SH | | DFND | | 111,818 | 0 | 935,351 |
| SEQUANS COMMUNICATIONS SPON ADR EA REPR 1 ORD SHS | COM | 817323108 | 2,565 | 774,850 | SH | | DFND | | 125,984 | 0 | 648,866 |
| SERVICENOW INC COM USD0.001 | COM | 81762P102 | 17,544 | 165,505 | SH | | DFND | | 29,596 | 0 | 135,909 |
| SHAKE SHACK INC CL A | COM | 819047101 | 80,883 | 2,318,882 | SH | | DFND | | 507,393 | 0 | 1,811,489 |
| SHERWIN WILLIAMS CO | COM | 824348106 | 941 | 2,680 | SH | | DFND | | 75 | 0 | 2,605 |
| SHOPIFY INC COM NPV CL A ISIN #CA82509L1076 SEDOL #BX865C7 | COM | 82509L107 | 15,329 | 176,400 | SH | | DFND | | 33,247 | 0 | 143,153 |
| SHOTSPOTTER INC COM | COM | 82536T107 | 9,539 | 745,826 | SH | | DFND | | 173,155 | 0 | 572,671 |
| SIENTRA INC COM USD0.01 | COM | 82621J105 | 10,833 | 1,114,511 | SH | | DFND | | 154,392 | 0 | 960,119 |
| SIGNATURE BK NEW YORK N Y COM | COM | 82669G104 | 3,509 | 24,448 | SH | | DFND | | 4,050 | 0 | 20,398 |
| SILVERCREST METALS INC COM NPV ISIN #CA8283631015 SEDOL #BYVY3D2 | COM | 828363101 | 977 | 682,021 | SH | | DFND | | 105,575 | 0 | 576,446 |
| SIRIUS XM HLDGS INC COM | COM | 82968B103 | 98 | 17,844 | SH | | DFND | | 3,564 | 0 | 14,280 |
| SITEONE LANDSCAPE SUPPLY INC COM | COM | 82982L103 | 19,444 | 373,498 | SH | | DFND | | 49,198 | 0 | 324,300 |
| SIX FLAGS ENTMT CORP NEW COM | COM | 83001A102 | 9,382 | 157,386 | SH | | DFND | | 51,370 | 0 | 106,016 |
| SMART SAND INC COM | COM | 83191H107 | 3,589 | 402,823 | SH | | DFND | | 70,381 | 0 | 332,442 |
| SNAP INC CL A | COM | 83304A106 | 47,819 | 2,690,978 | SH | | DFND | | 467,391 | 0 | 2,223,587 |
| SOLARIS OILFIELD INFRSTR INC COM CL A | COM | 83418M103 | 17,799 | 1,543,743 | SH | | DFND | | 189,164 | 0 | 1,354,579 |
| SPIRIT AIRLS INC COM | COM | 848577102 | 19,111 | 370,012 | SH | | DFND | | 36,859 | 0 | 333,153 |
| SPLUNK INC COM USD0.001 | COM | 848637104 | 4,785 | 84,102 | SH | | DFND | | 13,469 | 0 | 70,633 |
| SQUARE INC CL A | COM | 852234103 | 11,382 | 485,145 | SH | | DFND | | 71,779 | 0 | 413,366 |
| SS&C TECHNOLOGIES HLDGS INC COM | COM | 78467J100 | 30,375 | 790,811 | SH | | DFND | | 130,433 | 0 | 660,378 |
| STAMPS COM INC COM NEW | COM | 852857200 | 42 | 268 | SH | | DFND | | 198 | 0 | 70 |
| STEADYMED LTD ILS0.01 | COM | M84920103 | 73 | 11,570 | SH | | DFND | | 2,203 | 0 | 9,367 |
| STRAIGHT PATH COMMUNICATIONS INC COM USD0.01 CL B | COM | 862578101 | 21,276 | 118,432 | SH | | DFND | | 24,754 | 0 | 93,678 |
| SUMMIT MATLS INC CL A | COM | 86614U100 | 13,209 | 457,533 | SH | | DFND | | 30,335 | 0 | 427,198 |
| SUNOPTA INC COM ISIN #CA8676EP1086 SEDOL #2817510 | COM | 8676EP108 | 6,028 | 590,940 | SH | | DFND | | 91,796 | 0 | 499,144 |
| SUNRUN INC COM | COM | 86771W105 | 433 | 60,870 | SH | | DFND | | 6,332 | 0 | 54,538 |
| SVB FINL GROUP | COM | 78486Q101 | 4,707 | 26,774 | SH | | DFND | | 4,388 | 0 | 22,386 |
| T MOBILE US INC COM | COM | 872590104 | 307 | 5,061 | SH | | DFND | | 474 | 0 | 4,587 |
| TACTILE SYS TECHNOLOGY INC COM | COM | 87357P100 | 12,489 | 436,991 | SH | | DFND | | 77,358 | 0 | 359,633 |
| TAKE-TWO INTERACTIVE SOFTWARE COM | COM | 874054109 | 36,762 | 500,986 | SH | | DFND | | 147,332 | 0 | 353,654 |
| TAL EDUCATION GROUP ADS EA REPR 2 CL A ORD SHS | COM | 874080104 | 25,867 | 211,487 | SH | | DFND | | 17,196 | 0 | 194,291 |
| TALEND SA ADR EACH REP 1 ORD SHS | COM | 874224207 | 1,409 | 40,511 | SH | | DFND | | 7,387 | 0 | 33,124 |
| TELADOC INC COM | COM | 87918A105 | 4,627 | 133,338 | SH | | DFND | | 25,245 | 0 | 108,093 |
| TELESITES SAB DE CV COM NPV SER B-1 ISIN #MX01SI080038 SEDOL #BD | COM | P90355135 | 144 | 195,763 | SH | | DFND | | 13,077 | 0 | 182,686 |
| TENCENT HOLDINGS LIMITED HKD0.00002 ISIN #KYG875721634 SEDOL #BM | COM | G87572163 | 62,093 | 1,736,137 | SH | | DFND | | 506,139 | 0 | 1,229,998 |
| TESLA INC COM | COM | 88160R101 | 250,521 | 692,792 | SH | | DFND | | 242,071 | 0 | 450,721 |
| THERAPEUTICSMD INC COM | COM | 88338N107 | 15,987 | 3,033,680 | SH | | DFND | | 1,083,355 | 0 | 1,950,325 |
| TIME INC NEW COM | COM | 887228104 | 28 | 1,927 | SH | | DFND | | 0 | 0 | 1,927 |
| TRANSDIGM GROUP INC COM | COM | 893641100 | 12,253 | 45,571 | SH | | DFND | | 932 | 0 | 44,639 |
| TSO3 INC COM ISIN #CA8730151013 SEDOL #2798518 | COM | 873015101 | 12,867 | 5,407,912 | SH | | DFND | | 480,985 | 0 | 4,926,927 |
| TWITTER INC COM USD0.000005 | COM | 90184L102 | 157 | 8,781 | SH | | DFND | | 8,781 | 0 | 0 |
| ULTA BEAUTY INC COM | COM | 90384S303 | 82,316 | 286,477 | SH | | DFND | | 40,030 | 0 | 246,447 |
| ULTIMATE SOFTWARE GROUP INC | COM | 90385D107 | 3,719 | 17,705 | SH | | DFND | | 2,733 | 0 | 14,972 |
| UNIVERSAL DISPLAY CORP | COM | 91347P105 | 515 | 4,713 | SH | | DFND | | 3,344 | 0 | 1,369 |
| VALIDUS HOLDING LTD COM STK USD0.175 | COM | G9319H102 | 5,550 | 106,786 | SH | | DFND | | 27,428 | 0 | 79,358 |
| VANECK VECTORS ETF TR GOLD MINERS ETF | COM | 92189F106 | 11,288 | 511,241 | SH | | DFND | | 17,175 | 0 | 494,066 |
| VEEVA SYS INC CL A COM | COM | 922475108 | 52,124 | 850,166 | SH | | DFND | | 286,399 | 0 | 563,767 |
| VIVENDI SA EUR5.50 ISIN #FR0000127771 SEDOL #4834777 | COM | F97982106 | 94,194 | 4,237,360 | SH | | DFND | | 754,161 | 0 | 3,483,199 |
| VOCERA COMMUNICATIONS INC COM | COM | 92857F107 | 6,564 | 248,460 | SH | | DFND | | 43,998 | 0 | 204,462 |
| WAGEWORKS INC COM USD0.001 | COM | 930427109 | 67 | 991 | SH | | DFND | | 191 | 0 | 800 |
| WARRIOR MET COAL INC COM | COM | 93627C101 | 4,256 | 248,442 | SH | | DFND | | 30,382 | 0 | 218,060 |
| WEIBO CORP SPONSORED ADR | COM | 948596101 | 2,128 | 32,016 | SH | | DFND | | 4,961 | 0 | 27,055 |
| WELLS FARGO CO NEW COM | COM | 949746101 | 1,363 | 24,590 | SH | | DFND | | 2,697 | 0 | 21,893 |
| WHEATON PRECIOUS METALS CORP COM NPV ISIN #CA9628791027 SEDOL #B | COM | 962879102 | 1,818 | 91,418 | SH | | DFND | | 635 | 0 | 90,783 |
| WORKDAY INC CL A | COM | 98138H101 | 10,583 | 109,099 | SH | | DFND | | 21,236 | 0 | 87,863 |
| XILINX INC | COM | 983919101 | 45,766 | 711,536 | SH | | DFND | | 51,481 | 0 | 660,055 |
| XTREME DRILLING CORP ISIN #CA98419V1004 SEDOL #B7J8QB6 | COM | 98419V100 | 944 | 594,872 | SH | | DFND | | 67,593 | 0 | 527,279 |
| YEXT INC COM | COM | 98585N106 | 82 | 6,164 | SH | | DFND | | 0 | 0 | 6,164 |
| YUM CHINA HLDGS INC COM | COM | 98850P109 | 1,137 | 28,836 | SH | | DFND | | 3,977 | 0 | 24,859 |
| ZAYO GROUP HLDGS INC COM | COM | 98919V105 | 230 | 7,434 | SH | | DFND | | 617 | 0 | 6,817 |
| ZENDESK INC COM USD0.01 | COM | 98936J101 | 9,451 | 340,209 | SH | | DFND | | 59,201 | 0 | 281,008 |
| ZILLOW GROUP INC CL A | COM | 98954M101 | 32,597 | 667,428 | SH | | DFND | | 50,968 | 0 | 616,460 |
| ZILLOW GROUP INC CL C CAP STK | COM | 98954M200 | 56,466 | 1,152,126 | SH | | DFND | | 93,720 | 0 | 1,058,406 |
| ZOETIS INC COM USD0.01 CL A | COM | 98978V103 | 486 | 7,795 | SH | | DFND | | 237 | 0 | 7,558 |
