Gilder Gagnon Howe & Co 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	46,367	519,168	SH		DFND		0	0	519,168
1LIFE HEALTHCARE INC	COM	68269G107	88,132	2,426,548	SH		DFND		0	0	2,426,548
2U INC	COM	90214J101	2,147	56,564	SH		DFND		0	0	56,564
ABIOMED INC	COM	003654100	31,425	130,093	SH		DFND		0	0	130,093
ACCEL ENTERTAINMENT INC	COM CL A1	00436Q106	23	2,400	SH		DFND		0	0	2,400
ACTIVISION BLIZZARD INC	COM	00507V109	1,563	20,598	SH		DFND		0	0	20,598
ADAPTIVE BIOTECHNOLOGIES COR	COM	00650F109	118,786	2,455,269	SH		DFND		0	0	2,455,269
ADOBE INC	COM	00724F101	54,449	125,082	SH		DFND		0	0	125,082
ADYEN NV 144A	COM	N3501V104	48,658	33,441	SH		DFND		0	0	33,441
AFYA LTD	CL A COM	G01125106	6,101	260,294	SH		DFND		0	0	260,294
AGORA INC	ADS	00851L103	441	9,991	SH		DFND		0	0	9,991
ALAMOS GOLD INC NEW	COM CL A	011532108	4,933	525,922	SH		DFND		0	0	525,922
ALASKA COMMUNICATIONS SYS GR	COM	01167P101	2,639	946,041	SH		DFND		0	0	946,041
ALECTOR INC	COM	014442107	62,504	2,557,462	SH		DFND		0	0	2,557,462
ALIBABA GROUP HLDG LTD	SPONSORED ADS	01609W102	83,015	384,862	SH		DFND		0	0	384,862
ALLAKOS INC	COM	01671P100	3,218	44,781	SH		DFND		0	0	44,781
ALLOGENE THERAPEUTICS INC	COM	019770106	6,873	160,520	SH		DFND		0	0	160,520
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	130,895	883,768	SH		DFND		0	0	883,768
ALPHABET INC	CAP STK CL A	02079K305	58,197	41,040	SH		DFND		0	0	41,040
ALPHABET INC	CAP STK CL C	02079K107	66,557	47,083	SH		DFND		0	0	47,083
ALTERYX INC	COM CL A	02156B103	14,303	87,065	SH		DFND		0	0	87,065
ALTUS MIDSTREAM CO	CL A	02215L100	755	1,191,925	SH		DFND		0	0	1,191,925
AMAZON COM INC	COM	023135106	452,024	163,847	SH		DFND		0	0	163,847
AMERICAN TOWER CORP NEW	COM	03027X100	19,979	77,276	SH		DFND		0	0	77,276
AMICUS THERAPEUTICS INC	COM	03152W109	32,068	2,126,511	SH		DFND		0	0	2,126,511
AMYRIS INC	COM NEW	03236M200	217	50,718	SH		DFND		0	0	50,718
ANAPLAN INC	COM	03272L108	8,668	191,315	SH		DFND		0	0	191,315
ANTERIX INC	COM	03676C100	2,745	60,532	SH		DFND		0	0	60,532
APACHE CORP	COM	037411105	3,180	235,533	SH		DFND		0	0	235,533
APPFOLIO INC	COM CL A	03783C100	74,555	458,205	SH		DFND		0	0	458,205
APPIAN CORP	CL A	03782L101	1,275	24,873	SH		DFND		0	0	24,873
APPLE INC	COM	037833100	8,726	23,919	SH		DFND		0	0	23,919
APPLIED OPTOELECTRONICS INC	COM	03823U102	77	7,050	SH		DFND		0	0	7,050
APTOSE BIOSCIENCES INC	COM NEW	03835T200	1	125	SH		DFND		0	0	125
ARCO PLATFORM LTD	COM CL A	G04553106	12	286	SH		DFND		0	0	286
ARCUS BIOSCIENCES INC	COM	03969F109	19,918	805,074	SH		DFND		0	0	805,074
ARENA PHARMACEUTICALS INC	COM NEW	040047607	19,829	314,998	SH		DFND		0	0	314,998
ARGENX SE	SPONSORED ADR	04016X101	31,602	140,308	SH		DFND		0	0	140,308
ARISTA NETWORKS INC	COM	040413106	81,200	386,612	SH		DFND		0	0	386,612
ARITZIA INC SUB VTG SHS ISIN CA04045U1021 SEDOL BDCG2C2	COM	04045U102	9,291	665,699	SH		DFND		0	0	665,699
ARVINAS INC	COM	04335A105	48,184	1,436,604	SH		DFND		0	0	1,436,604
ASHTEAD GROUP ORD GBP010 ISIN GB0000536739 SEDOL 0053673	COM	G05320109	88,231	2,626,245	SH		DFND		0	0	2,626,245
ATLASSIAN CORP PLC	CL A	G06242104	34,342	190,505	SH		DFND		0	0	190,505
ATRICURE INC	COM	04963C209	46,449	1,033,350	SH		DFND		0	0	1,033,350
AUTO TRADER GROUP PLC ORD GBP001 ISIN GB00BVYVFW23 SEDOL BVYV	COM	G06708104	2,045	314,377	SH		DFND		0	0	314,377
AUTODESK INC	COM	052769106	136,927	572,462	SH		DFND		0	0	572,462
AVIDITY BIOSCIENCES INC	COM	05370A108	283	10,000	SH		DFND		0	0	10,000
AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN US05462W1099 SEDOL	COM	05462W109	1,792	66,979	SH		DFND		0	0	66,979
AXOGEN INC	COM	05463X106	249	26,940	SH		DFND		0	0	26,940
AZEK CO INC	CL A	05478C105	8,430	264,601	SH		DFND		0	0	264,601
AZUL S A	SPONSR ADR PFD	05501U106	32,065	2,868,072	SH		DFND		0	0	2,868,072
BARCLAYS BK PLC	IPTH SR B S&P	06746P621	9,301	273,958	SH		DFND		0	0	273,958
BASICFIT NV 144A REG S ISIN NL0011872650 SEDOL BD9Y9B7	COM	N10058100	12	457	SH		DFND		0	0	457
BEAM THERAPEUTICS INC	COM	07373V105	2,551	91,105	SH		DFND		0	0	91,105
BENEFYTT TECHNOLOGIES INC	COM CL A	08182C106	266	13,010	SH		DFND		0	0	13,010
BERKLEY W R CORP	COM	084423102	4,620	80,646	SH		DFND		0	0	80,646
BERKSHIRE HATHAWAY INC DEL	CL B NEW	084670702	569	3,190	SH		DFND		0	0	3,190
BEYOND MEAT INC	COM	08862E109	54,560	407,228	SH		DFND		0	0	407,228
BIOHAVEN PHARMACTL HLDG CO L	COM	G11196105	7,483	102,352	SH		DFND		0	0	102,352
BK OF AMERICA CORP	COM	060505104	1	35	SH		DFND		0	0	35
BLUEBIRD BIO INC	COM	09609G100	37,385	612,464	SH		DFND		0	0	612,464
BOSTON SCIENTIFIC CORP	COM	101137107	778	22,173	SH		DFND		0	0	22,173
BRP GROUP INC	COM CL A	05589G102	7,329	424,384	SH		DFND		0	0	424,384
BURNING ROCK BIOTECH LTD	SPONSORED ADS	12233L107	58	2,132	SH		DFND		0	0	2,132
CALIX INC	COM	13100M509	33,176	2,226,569	SH		DFND		0	0	2,226,569
CARL ZEISS MEDITEC AG NPV ISIN DE0005313704 SEDOL 5922961	COM	D14895102	1,135	11,647	SH		DFND		0	0	11,647
CARVANA CO	CL A	146869102	178,616	1,485,987	SH		DFND		0	0	1,485,987
CASPER SLEEP INC	COM	147626105	102	11,357	SH		DFND		0	0	11,357
CATAPULT GROUP INTERNATIONAL ISIN AU000000CAT9 SEDOL BTL0Y76	COM	Q2159P101	145	186,684	SH		DFND		0	0	186,684
CELLNEX TELECOM SAU EUR025 144A REG S ISIN ES0105066007 SEDOL	COM	E2R41M104	10,264	168,483	SH		DFND		0	0	168,483
CHARLES RIV LABS INTL INC	COM	159864107	4,399	25,232	SH		DFND		0	0	25,232
CHART INDS INC	COM PAR $0.01	16115Q308	29	607	SH		DFND		0	0	607
CHEGG INC	COM	163092109	103,258	1,535,205	SH		DFND		0	0	1,535,205
CHEWY INC	CL A	16679L109	12,433	278,205	SH		DFND		0	0	278,205
CHIPOTLE MEXICAN GRILL INC	COM	169656105	1	1	SH		DFND		0	0	1
CHUBB LIMITED	COM	H1467J104	11,285	89,124	SH		DFND		0	0	89,124
CITIGROUP INC	COM NEW	172967424	2	35	SH		DFND		0	0	35
CLOUDFLARE INC	CL A COM	18915M107	183,365	5,100,558	SH		DFND		0	0	5,100,558
CODEXIS INC	COM	192005106	29,054	2,548,574	SH		DFND		0	0	2,548,574
CONTROLADORA VUELA COMP DE A	SPON ADR RP 10	21240E105	14,011	2,653,543	SH		DFND		0	0	2,653,543
CORECIVIC INC	COM	21871N101	76	8,079	SH		DFND		0	0	8,079
COUPA SOFTWARE INC	COM	22266L106	116,850	421,780	SH		DFND		0	0	421,780
COVETRUS INC	COM	22304C100	0	8	SH		DFND		0	0	8
CREE INC	COM	225447101	897	15,158	SH		DFND		0	0	15,158
CRIMSON WINE GROUP COM USD001	COM	22662X100	370	68,496	SH		DFND		0	0	68,496
CROWDSTRIKE HLDGS INC	CL A	22788C105	62,864	626,824	SH		DFND		0	0	626,824
D R HORTON INC	COM	23331A109	3,312	59,728	SH		DFND		0	0	59,728
DATADOG INC	CL A COM	23804L103	32,663	375,647	SH		DFND		0	0	375,647
DELTA AIR LINES INC DEL	COM NEW	247361702	231	8,247	SH		DFND		0	0	8,247
DENALI THERAPEUTICS INC	COM	24823R105	81,855	3,385,233	SH		DFND		0	0	3,385,233
DEXCOM INC	COM	252131107	204,268	503,868	SH		DFND		0	0	503,868
DIAMONDBACK ENERGY INC	COM	25278X109	2,011	48,096	SH		DFND		0	0	48,096
DINE BRANDS GLOBAL INC	COM	254423106	982	23,329	SH		DFND		0	0	23,329
DISH NETWORK CORPORATION	CL A	25470M109	40,635	1,177,497	SH		DFND		0	0	1,177,497
DISNEY WALT CO	COM DISNEY	254687106	3,965	35,553	SH		DFND		0	0	35,553
DOCUSIGN INC	COM	256163106	257,997	1,498,153	SH		DFND		0	0	1,498,153
DOWNEY FINL CORP	COM	261018105	0	200	SH		DFND		0	0	200
DRAFTKINGS INC	COM CL A	26142R104	801	24,070	SH		DFND		0	0	24,070
EHEALTH INC	COM	28238P109	24,614	250,549	SH		DFND		0	0	250,549
EIDOS THERAPEUTICS INC	COM	28249H104	16,398	343,989	SH		DFND		0	0	343,989
ELASTIC N V	ORD SHS	N14506104	4,077	44,214	SH		DFND		0	0	44,214
ENPHASE ENERGY INC	COM	29355A107	118,548	2,492,066	SH		DFND		0	0	2,492,066
ENTERCOM COMMUNICATIONS CORP	CL A	293639100	36	26,326	SH		DFND		0	0	26,326
EPAM SYS INC	COM	29414B104	94,527	375,094	SH		DFND		0	0	375,094
EQUATOR EXPLORATION COM STK NPV	COM	G3084F128	0	215,000	SH		DFND		0	0	215,000
EROS INTL PLC	SHS NEW	G3788M114	82	25,828	SH		DFND		0	0	25,828
ESPERION THERAPEUTICS INC NE	COM	29664W105	58	1,128	SH		DFND		0	0	1,128
ETSY INC	COM	29786A106	40,620	382,378	SH		DFND		0	0	382,378
EVEREST RE GROUP LTD	COM	G3223R108	3,702	17,955	SH		DFND		0	0	17,955
EXACT SCIENCES CORP	COM	30063P105	122,153	1,405,026	SH		DFND		0	0	1,405,026
FACEBOOK INC	CL A	30303M102	81,849	360,458	SH		DFND		0	0	360,458
FASTLY INC	CL A	31188V100	48,095	564,954	SH		DFND		0	0	564,954
FERGUSON PLC ORD GBP010 ISIN JE00BJVNSS43 SEDOL BJVNSS4	COM	G3421J106	9,427	115,391	SH		DFND		0	0	115,391
FLEX LNG LTD BM USD010 ISIN BMG359472021 SEDOL BJJMGB2	COM	ZZCKKNHC2	365	79,541	SH		DFND		0	0	79,541
FLOOR & DECOR HLDGS INC	CL A	339750101	8,804	152,717	SH		DFND		0	0	152,717
FOUR SEAS MERCANTILE HLDGS HKD010 ISIN KYG365451049 SEDOL 634	COM	G36545104	79	270,000	SH		DFND		0	0	270,000
FRANCO NEV CORP	COM	351858105	10,264	73,501	SH		DFND		0	0	73,501
FRESHPET INC	COM	358039105	178,337	2,131,693	SH		DFND		0	0	2,131,693
FRIENDLY ENERGY EXPLORATION COM NPV	COM	35846A200	0	690	SH		DFND		0	0	690
GALAPAGOS NV NPV ISIN BE0003818359 SEDOL B07Q2V5	COM	B44170106	56,333	286,526	SH		DFND		0	0	286,526
GENERATION BIO CO	COM	37148K100	1,486	70,741	SH		DFND		0	0	70,741
GEOPARK LTD	USD SHS	G38327105	3,696	377,556	SH		DFND		0	0	377,556
GILEAD SCIENCES INC	COM	375558103	1,323	17,199	SH		DFND		0	0	17,199
GLAUKOS CORP	COM	377322102	34,505	898,094	SH		DFND		0	0	898,094
GLOBAL BLOOD THERAPEUTICS IN	COM	37890U108	445	7,050	SH		DFND		0	0	7,050
GLOBANT S A	COM	L44385109	94,891	633,241	SH		DFND		0	0	633,241
GOLDEN MINERALS CO	COM	381119106	20	47,017	SH		DFND		0	0	47,017
GOLDMAN SACHS GROUP INC	COM	38141G104	78,632	397,897	SH		DFND		0	0	397,897
GRID DYNAMICS HLDGS INC	CL A	39813G109	174	25,234	SH		DFND		0	0	25,234
GROCERY OUTLET HLDG CORP	COM	39874R101	4,066	99,661	SH		DFND		0	0	99,661
GTT COMMUNICATIONS INC	COM	362393100	9,491	1,163,131	SH		DFND		0	0	1,163,131
GUARDANT HEALTH INC	COM	40131M109	729	8,988	SH		DFND		0	0	8,988
H & E EQUIPMENT SERVICES INC	COM	404030108	2,500	135,303	SH		DFND		0	0	135,303
HDFC BANK LTD	SPONSORED ADS	40415F101	6,600	145,186	SH		DFND		0	0	145,186
HEALTHEQUITY INC	COM	42226A107	3,824	65,180	SH		DFND		0	0	65,180
HEARUSA INC NEW	COM	422360305	0	375	SH		DFND		0	0	375
HEICO CORP NEW	CL A	422806208	4,459	54,885	SH		DFND		0	0	54,885
HEICO CORP NEW	COM	422806109	2,764	27,735	SH		DFND		0	0	27,735
HELLOFRESH SE SHS ISIN DE000A161408 SEDOL BYWH8S0	COM	D3R2MA100	86,078	1,616,870	SH		DFND		0	0	1,616,870
HUBSPOT INC	COM	443573100	144,059	642,115	SH		DFND		0	0	642,115
ICICI BANK LIMITED	ADR	45104G104	2,980	320,773	SH		DFND		0	0	320,773
IDEXX LABS INC	COM	45168D104	3,248	9,838	SH		DFND		0	0	9,838
ILLUMINA INC	COM	452327109	6,490	17,524	SH		DFND		0	0	17,524
IMPINJ INC	COM	453204109	1,610	58,607	SH		DFND		0	0	58,607
INARI MED INC	COM	45332Y109	9,839	203,123	SH		DFND		0	0	203,123
INPHI CORP	COM	45772F107	9,436	80,306	SH		DFND		0	0	80,306
INSPIRE MED SYS INC	COM	457730109	96,013	1,103,349	SH		DFND		0	0	1,103,349
INSULET CORP	COM	45784P101	3,499	18,014	SH		DFND		0	0	18,014
INTERBREW PLC GDREACH REPR 1 A SH REG S	COM	45845T308	0	200	SH		DFND		0	0	200
INTL GNRL INSURANCE HLDNGS L	SHS	G4809J106	13,899	2,014,315	SH		DFND		0	0	2,014,315
INTUITIVE SURGICAL INC	COM NEW	46120E602	101,288	177,752	SH		DFND		0	0	177,752
INVITAE CORP	COM	46185L103	220,795	7,289,360	SH		DFND		0	0	7,289,360
IRHYTHM TECHNOLOGIES INC	COM	450056106	39,865	343,990	SH		DFND		0	0	343,990
JPMORGAN CHASE & CO	COM	46625H100	1,594	16,951	SH		DFND		0	0	16,951
KAMBI GROUP PLC EUR0003 ISIN MT0000780107 SEDOL BMNQDC1	COM	X4170A107	25	1,118	SH		DFND		0	0	1,118
KB HOME	COM	48666K109	263	8,563	SH		DFND		0	0	8,563
KIRKLAND LAKE GOLD LTD	COM	49741E100	14,593	353,857	SH		DFND		0	0	353,857
KORNIT DIGITAL LTD	SHS	M6372Q113	52,218	978,238	SH		DFND		0	0	978,238
KRYSTAL BIOTECH INC	COM	501147102	307	7,421	SH		DFND		0	0	7,421
KURA SUSHI USA INC	CL A COM	501270102	408	28,562	SH		DFND		0	0	28,562
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	848	19,927	SH		DFND		0	0	19,927
LGI HOMES INC	COM	50187T106	98,695	1,121,153	SH		DFND		0	0	1,121,153
LI NING CO LTD HKD01 ISIN KYG5496K1242 SEDOL B01JCK9	COM	G5496K124	15	4,621	SH		DFND		0	0	4,621
LIBERTY MEDIA CORP DEL	COM A BRAVES GRP	531229706	2,632	131,054	SH		DFND		0	0	131,054
LIBERTY MEDIA CORP DEL	COM C BRAVES GRP	531229888	7,107	360,018	SH		DFND		0	0	360,018
LIBERTY MEDIA CORP DEL	COM SER C FRMLA	531229854	1,915	60,394	SH		DFND		0	0	60,394
LIVE NATION ENTERTAINMENT IN	COM	538034109	12	278	SH		DFND		0	0	278
LIVEPERSON INC	COM	538146101	5,310	128,168	SH		DFND		0	0	128,168
LIVONGO HEALTH INC	COM	539183103	126,071	1,676,694	SH		DFND		0	0	1,676,694
LOVESAC COMPANY	COM	54738L109	746	28,423	SH	��	DFND		0	0	28,423
LULULEMON ATHLETICA INC	COM	550021109	32,648	104,638	SH		DFND		0	0	104,638
LUMENTUM HLDGS INC	COM	55024U109	813	9,986	SH		DFND		0	0	9,986
LYFT INC	CL A COM	55087P104	1,958	59,321	SH		DFND		0	0	59,321
MAG SILVER CORP	COM	55903Q104	20,105	1,425,868	SH		DFND		0	0	1,425,868
MAGENTA THERAPEUTICS INC	COM	55910K108	32,546	4,333,703	SH		DFND		0	0	4,333,703
MAGNOLIA OIL & GAS CORP	CL A	559663109	3,417	563,884	SH		DFND		0	0	563,884
MARINEMAX INC	COM	567908108	2,011	89,824	SH		DFND		0	0	89,824
MARTIN MARIETTA MATLS INC	COM	573284106	23,568	114,091	SH		DFND		0	0	114,091
MASTERCARD INCORPORATED	CL A	57636Q104	23,803	80,496	SH		DFND		0	0	80,496
MATCH GROUP INC	COM	57665R106	94,906	886,562	SH		DFND		0	0	886,562
MAXAR TECHNOLOGIES INC	COM	57778K105	18,541	1,032,342	SH		DFND		0	0	1,032,342
MAYVILLE ENGINEERING CO INC	COM	578605107	973	123,214	SH		DFND		0	0	123,214
MERCADOLIBRE INC	COM	58733R102	146,207	148,318	SH		DFND		0	0	148,318
MGP INGREDIENTS INC NEW	COM	55303J106	772	21,030	SH		DFND		0	0	21,030
MICROSOFT CORP	COM	594918104	52,210	256,547	SH		DFND		0	0	256,547
MOLECULAR TEMPLATES INC	COM	608550109	7,146	518,174	SH		DFND		0	0	518,174
MONGODB INC	CL A	60937P106	178,199	787,306	SH		DFND		0	0	787,306
MONOLITHIC PWR SYS INC	COM	609839105	10,593	44,695	SH		DFND		0	0	44,695
MYOKARDIA INC	COM	62857M105	731	7,562	SH		DFND		0	0	7,562
MYOVANT SCIENCES LTD	COM	G637AM102	3,786	183,597	SH		DFND		0	0	183,597
NATERA INC	COM	632307104	59,248	1,188,281	SH		DFND		0	0	1,188,281
NATIONAL VISION HLDGS INC	COM	63845R107	18	603	SH		DFND		0	0	603
NEOPHOTONICS CORP	COM	64051T100	604	67,979	SH		DFND		0	0	67,979
NETCOMPANY GROUP AS DKK1 144A ISIN DK0060952919 SEDOL BFYDWS1	COM	K7020C102	1,254	19,124	SH		DFND		0	0	19,124
NETFLIX INC	COM	64110L106	525,736	1,155,363	SH		DFND		0	0	1,155,363
NEW PACIFIC METALS CORP COM NPV ISIN CA6478241012 SEDOL BF4CP8	COM	647824101	8,747	2,154,287	SH		DFND		0	0	2,154,287
NEW YORK TIMES CO	CL A	650111107	121,818	2,898,349	SH		DFND		0	0	2,898,349
NIKE INC	CL B	654106103	13,593	138,634	SH		DFND		0	0	138,634
NINTENDO CO LTD ADR8 CNV INTO 1 ORDNPV	COM	654445303	262	4,713	SH		DFND		0	0	4,713
NOBLE MIDSTREAM PARTNERS LP	COM UNIT REPST	65506L105	8	945	SH		DFND		0	0	945
NORDSTROM INC	COM	655664100	19,256	1,243,139	SH		DFND		0	0	1,243,139
NV5 GLOBAL INC	COM	62945V109	33	644	SH		DFND		0	0	644
NVIDIA CORPORATION	COM	67066G104	67,929	178,804	SH		DFND		0	0	178,804
OCADO GROUP PLC ORD GBP002 ISIN GB00B3MBS747 SEDOL B3MBS74	COM	G6718L106	275,000	10,974,557	SH		DFND		0	0	10,974,557
OKTA INC	CL A	679295105	323,266	1,614,474	SH		DFND		0	0	1,614,474
ONEWATER MARINE INC	CL A COM	68280L101	17,000	700,148	SH		DFND		0	0	700,148
OPTION CARE HEALTH INC	COM NEW	68404L201	46,772	3,369,762	SH		DFND		0	0	3,369,762
PAGERDUTY INC	COM	69553P100	2,443	85,343	SH		DFND		0	0	85,343
PALOMAR HLDGS INC	COM	69753M105	12,566	146,528	SH		DFND		0	0	146,528
PARAMOUNT RESOURCES LIMITED COM NPV CLASS A ISIN CA6993202069 S	COM	699320206	118	101,091	SH		DFND		0	0	101,091
PASSAGE BIO INC	COM	702712100	1,134	41,487	SH		DFND		0	0	41,487
PAYPAL HLDGS INC	COM	70450Y103	29,274	168,017	SH		DFND		0	0	168,017
PDF SOLUTIONS INC	COM	693282105	538	27,528	SH		DFND		0	0	27,528
PELOTON INTERACTIVE INC	CL A COM	70614W100	213,113	3,688,984	SH		DFND		0	0	3,688,984
PENN NATL GAMING INC	COM	707569109	13,694	448,410	SH		DFND		0	0	448,410
PENN TREATY AMERN CORP COM NEW	COM	707874400	0	125	SH		DFND		0	0	125
PENSKE AUTOMOTIVE GRP INC	COM	70959W103	2,423	62,590	SH		DFND		0	0	62,590
PENUMBRA INC	COM	70975L107	344	1,923	SH		DFND		0	0	1,923
PINDUODUO INC	SPONSORED ADS	722304102	13,494	157,205	SH		DFND		0	0	157,205
PINTEREST INC	CL A	72352L106	302	13,618	SH		DFND		0	0	13,618
POOL CORPORATION	COM	73278L105	91,279	335,745	SH		DFND		0	0	335,745
PREVAIL THERAPEUTICS INC	COM	74140Y101	0	5	SH		DFND		0	0	5
PROOFPOINT INC	COM	743424103	5,145	46,299	SH		DFND		0	0	46,299
PROVENTION BIO INC	COM	74374N102	17,655	1,251,260	SH		DFND		0	0	1,251,260
PURPLE INNOVATION INC	COM	74640Y106	17,371	965,043	SH		DFND		0	0	965,043
Q2 HLDGS INC	COM	74736L109	55,685	649,088	SH		DFND		0	0	649,088
QUANTERIX CORP	COM	74766Q101	74,847	2,732,633	SH		DFND		0	0	2,732,633
QUIDEL CORP	COM	74838J101	8,527	38,113	SH		DFND		0	0	38,113
QUOTIENT LTD	SHS	G73268107	3,052	412,415	SH		DFND		0	0	412,415
REDFIN CORP	COM	75737F108	3,358	80,117	SH		DFND		0	0	80,117
REECE LIMITED NPV ISIN AU000000REH4 SEDOL 6728801	COM	Q80528138	3,253	514,098	SH		DFND		0	0	514,098
REGENERON PHARMACEUTICALS	COM	75886F107	4,356	6,985	SH		DFND		0	0	6,985
RENAISSANCERE HOLDINGS LTD	COM	G7496G103	3,446	20,147	SH		DFND		0	0	20,147
RENALYTIX AI PLC ORD GBP00025 ISIN GB00BYWL4Y04 SEDOL BYWL4Y0	COM	G7489R108	1,615	246,582	SH		DFND		0	0	246,582
REPARE THERAPEUTICS INC	COM	760273102	115	3,711	SH		DFND		0	0	3,711
REPLIGEN CORP	COM	759916109	61,181	494,952	SH		DFND		0	0	494,952
RIGHTMOVE ORD GBP0001 ISIN GB00BGDT3G23 SEDOL BGDT3G2	COM	G7565D106	5,871	870,172	SH		DFND		0	0	870,172
RINGCENTRAL INC	CL A	76680R206	299,126	1,049,529	SH		DFND		0	0	1,049,529
ROKU INC	COM CL A	77543R102	283,087	2,429,306	SH		DFND		0	0	2,429,306
ROYALTY PHARMA PLC	SHS CL A	G7709Q104	1,460	30,069	SH		DFND		0	0	30,069
SAFARICOM PLC KES005 ISIN KE1000001402 SEDOL B2QN3J6	COM	V74587102	25,803	95,960,324	SH		DFND		0	0	95,960,324
SAFETY INS GROUP INC	COM	78648T100	354	4,645	SH		DFND		0	0	4,645
SALESFORCE COM INC	COM	79466L302	40,179	214,481	SH		DFND		0	0	214,481
SAREPTA THERAPEUTICS INC	COM	803607100	144,253	899,671	SH		DFND		0	0	899,671
SCOTTS MIRACLE GRO CO	CL A	810186106	46,955	349,188	SH		DFND		0	0	349,188
SELECTQUOTE INC	COM	816307300	21,226	837,976	SH		DFND		0	0	837,976
SEMLER SCIENTIFIC INC COM USD0001	COM	81684M104	2,546	55,346	SH		DFND		0	0	55,346
SENESTECH INC	COM NEW	81720R208	77	38,294	SH		DFND		0	0	38,294
SENSEONICS HLDGS INC	COM	81727U105	5,804	14,881,590	SH		DFND		0	0	14,881,590
SERES THERAPEUTICS INC	COM	81750R102	493	103,553	SH		DFND		0	0	103,553
SERVICENOW INC	COM	81762P102	43,257	106,792	SH		DFND		0	0	106,792
SHAKE SHACK INC	CL A	819047101	158,414	2,990,065	SH		DFND		0	0	2,990,065
SHERWIN WILLIAMS CO	COM	824348106	875	1,515	SH		DFND		0	0	1,515
SHOCKWAVE MED INC	COM	82489T104	90,678	1,914,242	SH		DFND		0	0	1,914,242
SHOPIFY INC	CL A	82509L107	432,680	455,836	SH		DFND		0	0	455,836
SHOTSPOTTER INC	COM	82536T107	51,141	2,029,405	SH		DFND		0	0	2,029,405
SI BONE INC	COM	825704109	21,443	1,345,207	SH		DFND		0	0	1,345,207
SILK RD MED INC	COM	82710M100	5,070	121,027	SH		DFND		0	0	121,027
SILVERCREST METALS INC	COM	828363101	79,377	8,665,558	SH		DFND		0	0	8,665,558
SINTX TECHNOLOGIES INC	COM NEW	829392307	0	71	SH		DFND		0	0	71
SITEONE LANDSCAPE SUPPLY INC	COM	82982L103	29,558	259,352	SH		DFND		0	0	259,352
SITIME CORP	COM	82982T106	9,925	209,341	SH		DFND		0	0	209,341
SLACK TECHNOLOGIES INC	COM CL A	83088V102	113,338	3,645,485	SH		DFND		0	0	3,645,485
SMARTSHEET INC	COM CL A	83200N103	289	5,676	SH		DFND		0	0	5,676
SNAP INC	CL A	83304A106	66,735	2,840,990	SH		DFND		0	0	2,840,990
SONOS INC	COM	83570H108	764	52,247	SH		DFND		0	0	52,247
SPDR GOLD TR	GOLD SHS	78463V107	13,991	83,596	SH		DFND		0	0	83,596
SPLUNK INC	COM	848637104	20,704	104,199	SH		DFND		0	0	104,199
SPORTSMANS WHSE HLDGS INC	COM	84920Y106	11,778	826,535	SH		DFND		0	0	826,535
SPOTIFY TECHNOLOGY S A	SHS	L8681T102	151,203	585,628	SH		DFND		0	0	585,628
SQUARE INC	CL A	852234103	108,001	1,029,168	SH		DFND		0	0	1,029,168
SS&C TECHNOLOGIES HLDGS INC	COM	78467J100	36,343	643,475	SH		DFND		0	0	643,475
STAAR SURGICAL CO	COM PAR $0.01	852312305	13	212	SH		DFND		0	0	212
STAMPS COM INC	COM NEW	852857200	344	1,871	SH		DFND		0	0	1,871
STAR BULK CARRIERS CORP.	SHS PAR	Y8162K204	66	10,000	SH		DFND		0	0	10,000
STARBUCKS CORP	COM	855244109	870	11,823	SH		DFND		0	0	11,823
STITCH FIX INC	COM CL A	860897107	92	3,680	SH		DFND		0	0	3,680
STOKE THERAPEUTICS INC	COM	86150R107	37,403	1,569,564	SH		DFND		0	0	1,569,564
STONECO LTD	COM CL A	G85158106	44,901	1,158,443	SH		DFND		0	0	1,158,443
SUNTIMES MEDIA GROUP INC CLASS A COM USD001 NO STOCKHOLDER EQU	COM	86688Q100	0	650	SH		DFND		0	0	650
SVB FINANCIAL GROUP	COM	78486Q101	5,292	24,555	SH		DFND		0	0	24,555
SVMK INC	COM	78489X103	4,468	189,793	SH		DFND		0	0	189,793
TACTILE SYS TECHNOLOGY INC	COM	87357P100	185	4,458	SH		DFND		0	0	4,458
TAL EDUCATION GROUP	SPONSORED ADS	874080104	117,901	1,724,210	SH		DFND		0	0	1,724,210
TALON THERAPEUTICS CVR NEW	COM	874CNT108	0	125	SH		DFND		0	0	125
TANDEM DIABETES CARE INC	COM NEW	875372203	140,670	1,422,057	SH		DFND		0	0	1,422,057
TELADOC HEALTH INC	COM	87918A105	180,338	944,968	SH		DFND		0	0	944,968
TENCENT HOLDINGS LIMITED HKD000002 ISIN KYG875721634 SEDOL BM	COM	G87572163	87,030	1,352,839	SH		DFND		0	0	1,352,839
TESLA INC	COM	88160R101	561,335	519,846	SH		DFND		0	0	519,846
THE A2 MILK COMPANY LTD NPV ISIN NZATME0002S8 SEDOL BWSRTS7	COM	ZZCXTSUT2	2,539	197,644	SH		DFND		0	0	197,644
THOR INDS INC	COM	885160101	5,763	54,100	SH		DFND		0	0	54,100
T-MOBILE US INC	COM	872590104	74,756	717,777	SH		DFND		0	0	717,777
TRANSDIGM GROUP INC	COM	893641100	7,126	16,120	SH		DFND		0	0	16,120
TRUPANION INC	COM	898202106	28,144	659,273	SH		DFND		0	0	659,273
TWILIO INC	CL A	90138F102	13,848	63,110	SH		DFND		0	0	63,110
TWIST BIOSCIENCE CORP	COM	90184D100	601	13,274	SH		DFND		0	0	13,274
TWITTER INC	COM	90184L102	2,435	81,739	SH		DFND		0	0	81,739
UBER TECHNOLOGIES INC	COM	90353T100	40,655	1,308,077	SH		DFND		0	0	1,308,077
VANECK VECTORS ETF TR	GOLD MINERS ETF	92189F106	13,771	375,444	SH		DFND		0	0	375,444
VEEVA SYS INC	CL A COM	922475108	14,590	62,240	SH		DFND		0	0	62,240
VERACYTE INC	COM	92337F107	82,040	3,167,579	SH		DFND		0	0	3,167,579
VERIZON COMMUNICATIONS INC	COM	92343V104	12,876	233,558	SH		DFND		0	0	233,558
VICOR CORP	COM	925815102	11,001	152,904	SH		DFND		0	0	152,904
VIRGIN GALACTIC HOLDINGS INC	COM	92766K106	409	25,026	SH		DFND		0	0	25,026
VISA INC	COM CL A	92826C839	347	1,798	SH		DFND		0	0	1,798
VULCAN MATLS CO	COM	929160109	3,575	30,860	SH		DFND		0	0	30,860
WHEATON PRECIOUS METALS CORP	COM	962879102	3,475	78,890	SH		DFND		0	0	78,890
WILLSCOT CORP	COM	971375126	5,054	411,216	SH		DFND		0	0	411,216
WINNEBAGO INDS INC	COM	974637100	2,793	41,930	SH		DFND		0	0	41,930
WORKDAY INC	CL A	98138H101	29,850	159,320	SH		DFND		0	0	159,320
WUXI BIOLOGICS CAYMAN INC USD0000025 144A REG S ISIN KYG9700	COM	G97008109	56,464	3,086,203	SH		DFND		0	0	3,086,203
WYNN RESORTS LTD	COM	983134107	104	1,400	SH		DFND		0	0	1,400
XP INC	CL A	G98239109	26,955	641,626	SH		DFND		0	0	641,626
XYLEM INC	COM	98419M100	24,266	373,548	SH		DFND		0	0	373,548
ZAI LAB LTD	ADR	98887Q104	93,113	1,133,732	SH		DFND		0	0	1,133,732
ZILLOW GROUP INC	CL A	98954M101	246	4,278	SH		DFND		0	0	4,278
ZILLOW GROUP INC	CL C CAP STK	98954M200	15,748	273,348	SH		DFND		0	0	273,348
ZOOM VIDEO COMMUNICATIONS IN	CL A	98980L101	297,206	1,172,227	SH		DFND		0	0	1,172,227