Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
Audit Committee, Board of Directors and Stockholders
Simmons First National Corporation
Pine Bluff, Arkansas
We consent to the incorporation by reference in Registration Statement Nos. 333-134240, 333-134241, 333-134276, 333-134301, 333-134356 and 333-138629 on Form S-8 and Registration Statement No. 333-161558 on Form S-3 of Simmons First National Corporation (Company) of our report dated December 30, 2010, on our audit of the statement of assets acquired and liabilities assumed by Simmons First National Bank (a wholly owned subsidiary of Simmons First National Corporation) pursuant to the purchase and assumption agreement dated October 15, 2010, and included in this Form 8-K/A.
/s/ BKD, LLP
Pine Bluff, Arkansas
December 30, 2010
