Exhibit 12.1
Nuvelo, Inc.
Computation of Ratios of Earnings to Fixed Charges
(in thousands, except ratio)
Years Ended December 31, | Nine Months Ended September 30, 2004 | |||||||||||||||||||||||
1999 | 2000 | 2001 | 2002 | 2003 | ||||||||||||||||||||
Net Loss | $ | (18,547 | ) | $ | (22,253 | ) | $ | (36,472 | ) | $ | (44,978 | ) | $ | (50,187 | ) | $ | (39,507 | ) | ||||||
Add: Fixed charges | 1,141 | 1,580 | 3,580 | 4,529 | 4,356 | 4,307 | ||||||||||||||||||
Earnings as defined | (17,406 | ) | (20,673 | ) | (32,892 | ) | (40,449 | ) | (45,831 | ) | (35,200 | ) | ||||||||||||
Estimated interest component of rent | 451 | 709 | 2,689 | 3,287 | 2,664 | 1,781 | ||||||||||||||||||
Interest expense(1) | 690 | 871 | 891 | 1,242 | 1,692 | 2,526 | ||||||||||||||||||
Total fixed charges | $ | 1,141 | $ | 1,580 | $ | 3,580 | $ | 4,529 | $ | 4,356 | $ | 4,307 | ||||||||||||
Ratio(2)(3) | — | — | — | — | — | — | ||||||||||||||||||
(1) | Includes amortization of debt issuance costs |
(2) | We have not included a ratio of earnings to combined fixed charges and preferred stock dividends because we do not have preferred stock outstanding |
(3) | Earnings (as defined) for the period were insufficient to cover fixed charges |