Exhibit 12.1
Nuvelo, Inc.
Computation of Ratios of Earnings to Fixed Charges
(in thousands, except ratio)
Years Ended December 31, | Three Months Ended March 31, 2005 | |||||||||||||||||||||||
2000 | 2001 | 2002 | 2003 | 2004 | ||||||||||||||||||||
Net Loss | $ | (22,253 | ) | $ | (36,472 | ) | $ | (44,978 | ) | $ | (50,187 | ) | $ | (52,489 | ) | $ | (14,662 | ) | ||||||
Add: Fixed charges | 1,580 | 3,580 | 4,529 | 4,356 | 5,626 | 884 | ||||||||||||||||||
Adjusted Earnings | (20,673 | ) | (32,892 | ) | (40,449 | ) | (45,831 | ) | (46,863 | ) | (13,778 | ) | ||||||||||||
Estimated interest component of rent | 709 | 2,689 | 3,287 | 2,664 | 2,439 | 569 | ||||||||||||||||||
Interest expense | 871 | 891 | 1,242 | 1,692 | 3,187 | 316 | ||||||||||||||||||
Total fixed charges | $ | 1,580 | $ | 3,580 | $ | 4,529 | $ | 4,356 | $ | 5,626 | $ | 884 | ||||||||||||
Ratio(1) | — | — | — | — | — | — | ||||||||||||||||||
(1) | Adjusted earnings, as shown above, were insufficient to cover fixed charges in each period. We have not included a ratio of earnings to combined fixed charges and preferred stock dividends because we do not have preferred stock outstanding |