Exhibit 12.1
Nuvelo, Inc.
Computation of Ratios of Earnings to Fixed Charges
(in thousands, except ratio)
Years Ended December 31, | Nine Months Ended Sep. 30, 2007 | |||||||||||||||||||||||
2002 | 2003 | 2004 | 2005 | 2006 | ||||||||||||||||||||
Earnings: | ||||||||||||||||||||||||
Loss from continuing operations | $ | (39,512 | ) | $ | (46,229 | ) | $ | (48,942 | ) | $ | (71,611 | ) | $ | (132,777 | ) | $ | (665 | ) | ||||||
Add: Fixed charges | 4,529 | 4,067 | 3,800 | 3,511 | 2,702 | 234 | ||||||||||||||||||
$ | (34,983 | ) | $ | (42,162 | ) | $ | (45,142 | ) | $ | (68,100 | ) | $ | (130,075 | ) | $ | (431 | ) | |||||||
Fixed charges: | ||||||||||||||||||||||||
Estimated interest component of rent | $ | 3,287 | $ | 2,664 | $ | 2,439 | $ | 2,507 | $ | 2,114 | $ | 133 | ||||||||||||
Interest expense | 1,242 | 1,403 | 1,361 | 1,004 | 588 | 101 | ||||||||||||||||||
$ | 4,529 | $ | 4,067 | $ | 3,800 | $ | 3,511 | $ | 2,702 | $ | 234 | |||||||||||||
Ratio of earnings to fixed charges | — | — | — | — | — | — | ||||||||||||||||||
Deficiency | $ | (39,512 | ) | $ | (46,229 | ) | $ | (48,942 | ) | $ | (71,611 | ) | $ | (132,777 | ) | $ | (665 | ) | ||||||