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New words:
abbreviated, ABIO, abnormally, absorption, abuse, acid, Adj, adjourn, adjourned, Adjudicated, aforementioned, aldosterone, alleviate, alliance, analytical, analyze, analyzed, ANDA, angiotensin, Annex, API, ARB, ARCA, Arista, arrhythmia, aspect, atrial, attendant, attestation, Attorney, Aurora, bankruptcy, barred, baseline, beat, beta, billion, bioavailability, blockade, blocker, BMS, book, bordering, Boulder, brand, branded, breadth, brewer, bring, bringing, bristow, Broomfield, brought, bucindolol, burden, burdensome, Bystolic, capacity, cardiac, CardioDx, cardiomyopathic, carrier, Carvedilol, cast, certify, characteristic, cheek, chemical, chemistry, Christopher, clarification, cleared, cohort, College, Colorado, companion, competitor, compromise, compromised, conceived, conceptually, concomitant, confirmatory, conserve, consummated, consummation, contraindication, Cooperative, Coreg, correction, corrective, counteract, CPEC, CR, credibility, CRF, criterion, cure, curve, customary, daily, damage, database, david, Dawn, deepened, DEL, deletion, denial, destroy, destructive, detain, detrimentally, developmental, Diagram, die, disadvantage, disproportionate, disputed, downstream, downturn, drafted, dysfunction, earliest, economy, educate, educational, ejection, encompassed, enduring, Engineering, enjoy, episode, equipoise, exaggerated, expenditure, expert, exploring, export, fact, falberg, familiar, fatigue, feel, fibrillation, floating, Forest, formally, formulation, Foundation, franchise, fraudulent, frequency, freytag, frustrating, fulfilling, fundamental, Gencaro, GencaroTM, genotype, gradually, Guide, guided, Hakko, headcount, hearing, hereto, HF, hierarchy, history, housing, hydrochloride, hypertension, hypothesized, Ib, IDE, identical, illegally, illustrated, impossible, imprisonment, incorrectly, incurrence, indeterminate, indirect, influential, ingredient, inotropic, insert, insolvency, Intercardia, InterWest, introduced, introducing, introduction, invention, inventory, involuntary, IRC, ISO, IX, Japan, jeopardize, john, junction, jurisdiction, Justice, justify, kathryn, kidney, Kyowa, LabCorp, language, larger, Laurent, leader, learning, leave, left, licensee, Liggett, light, malfunction, malfunctioned, managerial, mandatory, Medicaid, Metoprolol, Mexico, mid, mild, mission, mode, moiety, monetary, mortality, myocyte, narrow, NCE, NE, nerve, network, neurotransmitter, newly, noncompetitive, nonexclusive, Nonqualified, norepinephrine, North, notification, Novasep, nucleic, NYHA, oral, Orange, orderly, outsourced, outweigh, Ozeroff, Pacific, paragraph, parallel, partnership, Patheon, pathophysiology, PDUFA, permission, pharmacogenetic, pharmacogenetically, pharmacologic, pharmacologically, pharmacology, pioneer, PMA, poorly, postmarketing, predicate, Premarket, prepayment, presence, prevalence, printing, problem, procedure, prone, proven, proximity, punishable, QSR, qualitatively, Randall, rationale, reaction, recession, recordkeeping, redeployment, refinance, refinancing, regional, registry, reinterpreted, remuneration, reorganization, reputation, residing, resistant, rest, restitution, retail, richard, rigorously, robust, route, safer, sample, sampling, scrutiny, secrecy, seize, serve, shape, shortly, simply, situation, Skyline, solid, sought, sponsorship, Squibb, St, stagnant, Stephen, stimulatory, store, straightforward, strain, stratify, strength, strike, subgroup, sublet, sublicense, sublicensed, subpopulation, substudy, Succinate, susceptible, swab, switch, sympathetic, systolic, tablet, tableting, tabulation, tampering, tangible, terrorist, tool, transplant, transplantation, TTE, turnaround, umbrella, unadjusted, unannounced, unanticipated, unapproved, unaware, unethical, unevenly, unfeasible, unknown, unpredictable, untitled, unusual, usable, User, variant, vasodilator, ventricular, Veteran, VII, violated, visibility, visit, war, warehouse, Wednesday, wholesale, william, worse, worsening, zabriskie
Removed:
accentuated, adequacy, advancement, advantage, affecting, affiliated, affirming, agree, Almanor, alteplase, announce, APB, approximate, arbitration, attain, Attracting, augment, Avecia, Avenue, avoidance, aware, back, banking, bid, bioequivalence, Biologic, biotech, BLA, blackout, bleeding, block, breaching, British, broadening, Cambridge, capture, CEFF, cellular, chance, chemotherapy, chosen, claiming, collateral, commencing, committed, comparability, comparing, competency, complement, computing, continually, convenience, conveyance, copyright, currency, dedicated, deducting, deliver, Deltagen, demonstration, denominated, depth, designate, designated, desirable, desire, detail, detection, devote, devoted, Diego, diminish, discount, disrupt, dissolver, diversifying, diversity, divest, dominant, drawn, earthquake, ease, EMEA, enabling, enforceable, enforced, Enterprise, environment, epithelial, executing, expressed, extreme, factor, fall, fever, fibrin, filling, finalize, fire, forecasted, forma, gastrointestinal, gather, Genentech, george, GLP, half, heavily, heavy, hedge, hedged, hedging, hemorrhagic, honored, hypothetical, improbability, improving, ineffective, informed, inhibition, institution, insured, intense, intention, interim, interruption, issuing, Kingsbridge, KPMG, lending, listing, location, magnitude, manageable, mark, maturing, media, merge, message, mg, move, NAPA, naturally, necessitate, nondisclosure, Notwithstanding, occluded, offered, opening, opposing, opting, oxidizing, pace, PAO, partnering, path, PDL, percent, performing, perry, personal, pertain, plant, point, political, potent, pound, pre, predictability, prefer, prevented, proceeding, profit, prohibited, properly, radiation, rathmann, raw, recruitment, reevaluation, reform, reincorporation, relation, reliance, relocated, render, repaid, repaying, replicated, residual, revolving, safeguard, sector, seizure, sending, setback, sharing, simultaneously, solicitation, speed, Speedy, strategically, stringently, subjected, Suite, supplement, sustain, sustainable, team, tiered, tissue, toxic, toxicology, traditional, transferred, tumor, turnover, twelve, unaudited, unauthorized, unavailability, unavailable, uneconomical, uninsured, unpatented, unproven, unqualified, unreliable, validated, valuable, viable, Virtually, VWAP, waste, withdrawn
Filing tables
Filing exhibits
- 10-K Annual report
- 3.1 Amended and Restated Certificate of Incorporation of the Registrant, As Amended
- 3.2 Amended and Restated Bylaws of the Registrant, As Amended
- 4.3 Warrant to Purchase Stock Agreement, Dated July 17, 2007
- 4.4 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 4.5 Warrant to Purchase Stock Agreement, Dated August 19, 2008
- 4.6 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 4.7 Warrant to Purchase Stock Agreement, Dated October 10, 2008
- 4.8 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 4.9 Warrant to Purchase Stock Agreement, Dated October 10, 2008
- 4.10 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 4.11 Warrant to Purchase Stock Agreement, Dated October 10, 2008
- 4.12 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 4.13 Warrant to Purchase Stock Agreement, Dated October 10, 2008
- 4.14 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 4.15 Warrant to Purchase Stock Agreement, Dated October 10, 2008
- 4.16 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 4.17 Warrant to Purchase Stock Agreement, Dated October 10, 2008
- 4.18 Amendment No. 1 to Warrant to Purchase Stock Agreement, Dated February 19, 2009
- 10.9 Lease, Dated February 8, 2008
- 10.10 Loan and Security Agreement, Dated July 17, 2007
- 10.11 First Amendment to Loan and Security Agreement, Dated January 21, 2009
- 10.12 Second Amendment to Loan and Security Agreement, Dated March 23, 2009
- 10.13 Note and Warrant Purchase Agreement, Dated September 24, 2008
- 10.14 Amendment to Note and Warrant Purchase Agreement, Dated October 10, 2008
- 10.34 Arca Biopharma, Inc. 2004 Equity Incentive Plan
- 10.35 Arca Biopharma, Inc. 2004 Equity Incentive Plan
- 10.36 Arca Biopharma, Inc. 2004 Equity Incentive Plan
- 10.37 Arca Biopharma, Inc. 2004 Equity Incentive Plan
- 10.38 Arca Biopharma, Inc. 2004 Equity Incentive Plan
- 10.43 Amended and Restated Employment and Retention Agreement, Dated June 4, 2008
- 10.44 Amended and Restated Employment and Retention Agreement, Dated July 7, 2008
- 10.45 Amended and Restated Employment Agreement, Dated June 12, 2008
- 10.46 Assignment and Assumption Agreement, Dated January 26, 2009
- 10.47 Assignment and Assumption Agreement, Dated January 26, 2009
- 10.48 Assignment and Assumption Agreement, Dated January 26, 2009
- 10.50 Employment Agreement, Dated February 24, 2009
- 10.51 Employment Agreement, Dated February 23, 2009
- 10.52 Indemnity Agreement
- 21.1 Subsidiaries of Arca Biopharma, Inc. As of March 24, 2009
- 23.1 Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm
- 31.1 Certification of Chief Executive Officer
- 31.2 Certification of Chief Financial Officer
- 32.1 Certification of Chief Executive Officer and Chief Financial Officer
ORKA similar filings
Filing view
External links
Exhibit 4.18
AMENDMENT NO. 1 TO WARRANT
TO
PURCHASE COMMON STOCK
THIS AMENDMENT NO. 1 TO WARRANT TO PURCHASE COMMON STOCK (this “Amendment”) is entered into as of the 19th day of February 2009, by and between ARCA biopharma, Inc., a Delaware corporation (f/k/a Nuvelo, Inc.) and Skyline Venture Partners Qualified Purchaser Fund IV, L.P.
Recitals
A. The Holder was previously issued a Warrant to Purchase Common Stock dated as of October 10, 2008 (the “Warrant”). Capitalized terms used in this Amendment, but not otherwise defined in this Amendment, shall have the meanings assigned to them in the Warrant.
B. The Holder and ARCA biopharma, Inc., a Delaware corporation (f/k/a Nuvelo, Inc.) desire to amend the Warrant to reflect the closing of the Merger and the exchange of the common stock of the Corporation (as defined below) for the common stock of ARCA biopharma Colorado, Inc., a Delaware corporation (f/k/a ARCA biopharma, Inc.) in connection with such closing.
Amendments
1. The definition of the term “Exercise Price” in Section 1(b) of the Warrant shall be deleted in its entirety and replaced with the following:
“(b)“Exercise Price” shall mean $9.7406, subject to adjustment pursuant to the terms of the Warrant, including Section 5 of the Warrant.”
2. The definition of the term “Exercise Shares” in Section 1(c) of the Warrant shall be deleted in its entirety and replaced with the following:
“(c)“Exercise Shares” shall mean 37,486 shares of common stock of the Corporation (the “Common Stock”) issuable upon the exercise of the Warrant, subject to adjustment pursuant to the terms of the Warrant, including Section 5 of the Warrant.”
3. The following defined term shall be added to Section 1 of the Warrant:
“(e)“Corporation” shall mean ARCA biopharma, Inc. a Delaware corporation (f/k/a Nuvelo, Inc.).”
4. Except for revisions expressly set forth in this Amendment, the parties hereby ratify and confirm the terms of the Warrant in their entirety.
IN WITNESS WHEREOF, the undersigned have executed this Amendment to be effective as of the date first set forth above.
| Corporation: | Holder: | |||||||
| ARCA BIOPHARMA, INC. | Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | |||||||
| By: | Skyline Venture Management IV, LLC | |||||||
| Its General Partner | ||||||||
| By: | /s/ Christopher D. Ozeroff | By: | /s/ John G. Freund | |||||
Christopher D. Ozeroff, Executive Vice of Business Development and General Counsel | John G Freund, Managing Director | |||||||