Guided Therapeutics (GTHP) 10-Q 16 May 22 2022 Q1 Quarterly report Financial data

Cover

Cover - shares	3 Months Ended
	Mar. 31, 2022	May 10, 2022
Cover [Abstract]
Entity Registrant Name	GUIDED THERAPEUTICS, INC.
Entity Central Index Key	0000924515
Document Type	10-Q
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Small Business	true
Entity Shell Company	false
Entity Emerging Growth Company	false
Entity Current Reporting Status	Yes
Document Period End Date	Mar. 31, 2022
Entity Filer Category	Non-accelerated Filer
Document Fiscal Period Focus	Q1
Document Fiscal Year Focus	2022
Entity Common Stock Shares Outstanding		27,568,698
Document Quarterly Report	true
Document Transition Report	false
Entity File Number	0-22179
Entity Incorporation State Country Code	DE
Entity Tax Identification Number	58-2029543
Entity Address Address Line 1	5835 Peachtree Corners East
Entity Address Address Line 2	Suite B
Entity Address City Or Town	Norcross
Entity Address State Or Province	GA
Entity Address Postal Zip Code	30092
City Area Code	770
Local Phone Number	242-8723
Entity Interactive Data Current	Yes

CONSOLIDATED BALANCE SHEETS

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current Assets:
Cash and cash equivalents	$ 725	$ 643
Accounts receivable, net of allowance for doubtful accounts of $126 at December 31, 2021 and 2020	39	46
Inventory, net of reserves of $785 and $758 at December 31, 2021 and 2020, respectively	570	571
Other current assets	453	377
Total current assets	1,787	1,637
Non-Current Assets:
Property and equipment, net	28	14
Operating lease right-of-use asset, net of amortization	355	372
Other assets	17	17
Total non-current assets	400	403
TOTAL ASSETS	2,187	2,040
Current Liabilities:
Accounts payable	2,476	2,362
Accounts payable, related parties	80	87
Accrued liabilities	1,228	1,768
Deferred revenue	514	337
Current portion of lease liability	70	67
Current portion of long-term debt	67	88
Current portion of long-term debt, related parties	27	0
Short-term notes payable	12	48
Short-term notes payable, related parties	31	40
Convertible notes payable in default	161	161
Short-term convertible notes payable	745	736
Derivatives Liability	38	0
Total current liabilities	5,449	5,694
Long-Term Liabilities
Long-term lease liability	307	325
Derivative liability	0	32
Long-term convertible debt	852	820
Long-term debt	0	22
Long-term debt, related parties	568	592
Total long-term liabilities	1,727	1,791
Total liabilities	7,176	7,485
STOCKHOLDERS' DEFICIT:
Common stock, $.001 par value; 500,000 shares authorized, 13,673 and 13,138 shares issued and outstanding as of December 31, 2021 and 2020, respectively.	3,410	3,403
Additional Paid In Capital	129,042	126,800
Treasury stock at cost	(132)	(132)
Accumulated deficit	(143,442)	(142,387)
Total stockholders deficit	(4,989)	(5,445)
TOTAL LIABILITIES AND STOCKHOLDERS DEFICIT	2,187	2,040
Series C Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	105	105
Series C1 Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	170	170
Series C2 Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	531	531
Series D Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	276	276
Series E Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	914	1,639
Series F Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	1,174	1,187
Series F-2 Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	2,963	2,963
Series G Convertible Preferred Shares
STOCKHOLDERS' DEFICIT:
Preferred Stock Value	$ 0	$ 0

CONSOLIDATED BALANCE SHEETS (Pa

CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Accounts receivable, net of allowance	$ 126,000	$ 126,000
Inventory, net of reserves	$ 785,000	$ 785,000
Common stock, par value	$ 0.001	$ 0.001
Common stock, authorized	500,000,000	500,000,000
Common stock, issued	22,316,000	13,673,000
Common stock, outstanding	22,316,000	13,673,000
Series D Convertible Preferred Shares
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	6,000	6,000
Preferred stock, issued	800	800
Preferred stock, outstanding	800	800
Preferred stock, liquidation preference	$ 763,000	$ 763,000
Series E Convertible Preferred Shares
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	5,000	5,000
Preferred stock, issued	1,000	1,700
Preferred stock, outstanding	1,000	1,700
Preferred stock, liquidation preference	$ 968,000	$ 1,736,000
Series F Convertible Preferred Shares
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	1,500	1,500
Preferred stock, issued	1,400	1,400
Preferred stock, outstanding	1,400	1,400
Preferred stock, liquidation preference	$ 1,411,000	$ 1,426,000
Series F-2 Convertible Preferred Shares
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	5,000	5,000
Preferred stock, issued	3,200	3,200
Preferred stock, outstanding	3,200	3,200
Preferred stock, liquidation preference	$ 3,237,000	$ 3,237,000
Series C Convertible Preferred Shares [Member]
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	9,000	9,000
Preferred stock, liquidation preference	286,000	286,000
Preferred stock, issued	300	300
Preferred stock, outstanding	300	300
Series C-1 Convertible Preferred Shares
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	20,300	20,300
Preferred stock, issued	1,000	1,000
Preferred stock, outstanding	1,000	1,000
Preferred stock, liquidation preference	$ 1,049,000	$ 1,049,000
Series C-2 Convertible Preferred Shares
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	5,000,000	5,000,000
Preferred stock, issued	3,300	3,300
Preferred stock, outstanding	3,300	3,300
Preferred stock, liquidation preference	$ 3,263,000	$ 3,263,000
Series G Convertible Preferred Shares
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	1,000,000	1,000,000
Preferred stock, issued	0	0
Preferred stock, outstanding	0	0
Preferred stock, liquidation preference	$ 0	$ 0

CONSOLIDATED STATEMENTS OF OPER

CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
CONSOLIDATED STATEMENTS OF OPERATIONS
Sales - devices and disposables	$ 5	$ 0
Cost of goods sold	1	0
Gross profit	4	0
Operating expenses:
Research and development	21	16
Sales and marketing	40	36
General and administrative	386	771
Total operating expenses	447	823
Loss from operations	(443)	(823)
Other income (expenses):
Interest expense	(101)	(141)
Change in fair value of derivative liability	(6)	(88)
Gain from extinguishment of debt	41	87
Change in fair value of warrants	0	448
Other expenses	2	0
Total other income (expense)	(64)	306
Loss before income taxes	(507)	(517)
Provision for income taxes	0	0
Net loss	(507)	(517)
Preferred stock dividends	(548)	(55)
NET LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS	$ (1,055)	$ (572)
NET LOSS PER SHARE ATTRIBUTABLE TO COMMON STOCKHOLDERS
Basic	$ (0.05)	$ (0.04)
Diluted	$ (0.05)	$ (0.04)
Weighted average shares outstanding
Basic	20,683	13,172
Diluted	20,683	13,172

CONSOLIDATED STATEMENTS OF STOC

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' DEFICIT - USD ($)	Total	Preferred Stock Series C [Member]	Preferred Stock Series C1 [Member]	Preferred Stock Series C2 [Member]	Preferred Stock Series D [Member]	Preferred Stock Series E [Member]	Preferred Stock Series F [Member]	Preferred Stock Series G [Member]	Common Stock [Member]	Additional Paid-In Capital	Treasury Stock [Member]	Accumulated Deficit [Member]	Preferred Stock Series F-2 [Member]
Balance, shares at Dec. 31, 2020			1,000	3,000	1,000	2,000			13,138,000
Balance, amount at Dec. 31, 2020	$ (10,855,000)	$ 105,000	$ 170,000	$ 531,000	$ 276,000	$ 1,639,000			$ 3,403,000	$ 123,109,000	$ (132,000)	$ (139,956,000)
Series F preferred offering, shares							2,000
Series F preferred offering									0	0	0	0
Series F preferred offering, amount	1,667,000						$ 0	$ 1,667,000	0
Issuance of common stock for payment of Series D preferred dividends, amount									0	14,000	0	0
Issuance of warrants to consultants			0	0		0		0	0	398,000	0	0
Issuance of warrants to finders		0	0		0	2,559,000	0		0	151,000
Net loss	(517,000)	0				0		$ 0		0	0	(517,000)
Conversion of debt and expenses for Series F preferred stock		0		0	0				$ 0	0	0
Issuance of common stock for payment of Series D preferred dividends, shares									42,000
Series G preferred offering		0	0	0					$ 0	0	0	0
Conversions of warrants from liability to equity				0		0	0		0	1,755,000	0	0
Series G preferred offering, shares								153,000
Issuance of common stock for payment of Series D preferred dividends		0	$ 0	0	0		0	$ 0
Stock-based compensation	62,000				$ 0	0	0	0	0	62,000	0	0
Accrued preferred dividends		0		$ 0			0	0	$ 0	0	0	(55,000)
Conversion of debt and expenses for Series F preferred stock, amount						0		0
Series G preferred offering, amount						$ 0	$ 0	$ 0
Expense for warrants issued to consultants	398,000
Balance, shares at Mar. 31, 2021			1,000	3,000	1,000	2,000	4,000	153,000	13,180,000
Balance, amount at Mar. 31, 2021		105,000	$ 0	$ 531,000		$ 1,639,000		$ 0	$ 3,403,000	125,489,000	(132,000)	(140,528,000)
Balance, shares at Dec. 31, 2021			1,000	3,000	1,000	2,000	1,000		13,673,000				3,000
Balance, amount at Dec. 31, 2021	(5,445,000)	105,000	$ 170,000	$ 531,000	$ 276,000	$ 1,639,000	$ 1,187,000		$ 3,403,000	126,800,000	(132,000)	(142,387,000)	$ 2,963,000
Issuance of common stock for payment of Series D preferred dividends, amount	15,000					0	0		0	15,000	0	0
Net loss	(507,000)	0	0	0	0	0	0		$ 0	0	0	(507,000)	0
Issuance of common stock for payment of Series D preferred dividends, shares									23,000
Stock-based compensation	44,000
Accrued preferred dividends	(548,000)	0	0	0	0	0	0		$ 0	0	0	(548,000)	0
Common stock warrants exercised, shares									4,478,000
Common stock warrants exercised, amount	716,000					0	0		$ 4,000	712,000	0	0	0
Issuance of common stock for payment of Series E preferred dividends, amount	$ 8,000	0	0	0	0	0	0		$ 13,000	$ 8,000	0	0	0
Issuance of common stock for payment of Series F preferred dividends, shares	105,000								158,000	105,000
Issuance of common stock for payment of Series F preferred dividends, amount	$ 81,000								$ 96,000	$ 81,000	0	0
Issuance of common stock for payment of interest		0	0	0	0	0	0						0
Issuance of common stock for payment of Series F-2 preferred dividends, amount							$ 0		$ 0
Issuance of common stock for Series F and Series F-2 one-time 15% dividends	$ 399,000	0	0	0	0	(1,000)				$ 399,000
Conversion of Series E preferred stock to common stock, shares	64,000						(13,000)			64,000
Conversion of Series F preferred stock to common stock		0	0	0	0	0	$ 0						0
Issuance of common stock for payment of Series F preferred dividends		0	0	0	0	0	0						0
Conversion of Series E preferred stock to common stock, shares									624,000	722,000
Issuance of common stock for Series F and Series F-2 one-time 15% dividends						0							0
Issuance of common stock for payment of Series F-2 preferred dividends		0	0	0	0	0	0						0
Conversion of Series F preferred stock to common stock, shares									3,070,000	13,000
Issuance of common stock for payment of interest, shares									3,000
Conversion of Series E preferred stock to common stock, amount						0							0
Conversion of Series E preferred stock to common stock		0	0	0	0								0
Issuance of common stock for payment of interest, amount									$ 121,000
Issuance of common stock for Series F and Series F-2 one-time 15% dividends, amount									0				0
Expense for warrants issued to consultants	$ 79,000	0	$ 0	$ 0	$ 0	$ 0	0		0	$ 79,000	0	0	$ 0
Expense for warrants issued to consultants amount							$ 0		$ 0
expense for warrants issued to con									60,000
Balance, shares at Mar. 31, 2022			1,000	3,000	1,000	1,000	1,000		22,316,000				3,000
Balance, amount at Mar. 31, 2022	$ (4,989,000)	$ 105,000	$ 170,000	$ 531,000	$ 276,000	$ 0	$ 1,174,000		$ 3,410,000	$ 129,042,000	$ (132,000)	$ (143,442,000)	$ 0

CONSOLIDATED STATEMENTS OF CASH

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (507)	$ (517)
Adjustments to reconcile net loss to net cash used in operating activities:
Amortization of debt issuance costs and discounts	41	64
Amortization of beneficial conversion feature	0	8
Stock based compensation	44	62
Change in fair value of warrants	0	(448)
Change in fair value of derivatives	6	88
Amortization of lease right-of-use-asset	16	0
Expense for warrants issued to consultants	79	398
Gain from forgiveness of debt	(41)	(87)
Other non-cash expenses (income)	6	0
Change in operating assets and liabilities:
Accounts receivable	6	0
Inventory	1	(1)
Other current assets	(76)	46
Other non-current assets	0	(18)
Accounts payable and accrued liabilities	84	65
Lease liabilities	(15)	0
Deferred revenue	177	20
NET CASH USED IN OPERATING ACTIVITIES	(179)	(320)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchase of property and equipment	(14)	(1)
NET CASH USED FOR INVESTING ACTIVITIES	(14)	(1)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from warrant exercises	365	0
Payments made on notes payable	(90)	(557)
Proceeds from Series F offering, net of costs	0	1,818
Proceeds from Series G offering, net of costs	0	125
NET CASH PROVIDED BY FINANCING ACTIVITIES	275	1,386
NET CHANGE IN CASH	82	1,065
Cash at beginning of period	643	182
CASH AT END OF PERIOD	725	1,247
SUPPLEMENTAL DISCLOSURE FOR OPERATING ACTIVITIES:
Cash paid for interest	6	405
SUPPLEMENTAL DISCLOSURE FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Dividends on preferred stock	548	55
Common stock issued for payment of interest	81
Issuance of series F-2 preferred stock	0	2,559
Issuance of warrants to finders in connection with Series F and Series F-2 preferred stock	0	151
Common stock issued for payment of dividends	592	14
Conversion of Series E Preferred Shares into Common Stock	725	1,755
Conversion of Series F Preferred Shares into Common Stock	$ 13	$ 0

ORGANIZATION BACKGROUND AND BAS

ORGANIZATION BACKGROUND AND BASIS OF PRESENTATION	3 Months Ended
	Mar. 31, 2022
ORGANIZATION BACKGROUND AND BASIS OF PRESENTATION
ORGANIZATION, BACKGROUND, AND BASIS OF PRESENTATION	1. ORGANIZATION, BACKGROUND, AND BASIS OF PRESENTATION Guided Therapeutics, Inc. (formerly SpectRx, Inc.), together with its wholly owned subsidiary, InterScan, Inc. (formerly Guided Therapeutics, Inc.), collectively referred to herein as the “Company”, is a medical technology company focused on developing innovative medical devices that have the potential to improve healthcare. The Company’s primary focus is the continued commercialization of its LuViva non-invasive cervical cancer detection device and extension of its cancer detection technology into other cancers, including esophageal. The Company’s technology, including products in research and development, primarily relates to biophotonics technology for the non-invasive detection of cancers. During the year ended December 31, 2021, the Board simultaneously approved a 1-for-20 reverse stock split of our common stock and decreased the total number of authorized common shares to 500,000,000. On November 18, 2021, the Company submitted an Issuer Company Related Action Notification regarding the reverse stock split to the Financial Industry Regulatory Authority (“FINRA”). FINRA has not yet declared an effective date for the reverse stock split. The Company will adjust the number of shares available for future grant under its equity incentive plan and employee stock purchase plans and will also adjust the number of outstanding awards issued to reflect the effects of its reverse split. All historical share and per share amounts reflected throughout this report will be adjusted to reflect stock split at the time it becomes effective. Basis of Presentation The accompanying unaudited consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Therefore, these financial statements should be read in conjunction with our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed with the Securities and Exchange Commission (“SEC”) pursuant to Section 13 or 15(d) under the Securities Exchange Act of 1934. The December 31, 2021 balances reported herein are derived from the audited consolidated financial statements for the year ended December 31, 2021. The results of operations for the interim periods are not necessarily indicative of the results of operations to be expected for the full year. All intercompany transactions and balances have been eliminated in consolidation. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation of the Company as of March 31, 2022 and December 31, 2021, and the consolidated results of operations and cash flows for the three-month periods ended March 31, 2022 and 2021 have been included. The Company’s prospects must be considered in light of the substantial risks, expenses and difficulties encountered by entrants into the medical device industry. This industry is characterized by an increasing number of participants, intense competition and a high failure rate. The Company has experienced net losses since its inception and, as of March 31, 2022, it had an accumulated deficit of approximately $143.4 million. To date, the Company has engaged primarily in research and development efforts and the early stages of marketing its products. The Company may not be successful in growing sales for its products. Moreover, required regulatory clearances or approvals may not be obtained in a timely manner, or at all. The Company’s products may not ever gain market acceptance and the Company may not ever generate significant revenues or achieve profitability. The development and commercialization of the Company’s products requires substantial development, regulatory, sales and marketing, manufacturing and other expenditures. The Company expects operating losses to continue for the foreseeable future as it continues to expend substantial resources to complete development of its products, obtain regulatory clearances or approvals, build its marketing, sales, manufacturing and finance capabilities, and conduct further research and development. The Company is not organized by multiple operating segments for the purpose of making operating decisions or assessing performance. Accordingly, the Company operates in one reportable operating segment. The Company’s principal decision makers are the Chief Executive Officer and its Chief Financial Officer. Management believes that its business operates as one reportable segment because: a) the Company measures profit and loss as a whole; b) the principal decision makers do not review information based on any operating segment; c) the Company does not maintain discrete financial information on any specific segment; d) the Company has not chosen to organize its business around different products and services, and e) the Company has not chosen to organize its business around geographic areas. Going Concern The Company’s consolidated financial statements have been prepared and presented on a basis assuming it will continue as a going concern. The factors below raise substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might be necessary from the outcome of this uncertainty. At March 31, 2022, the Company had a negative working capital of approximately $3.7 million, accumulated deficit of $143.4 million, and incurred a net loss including preferred dividends of $1.1 million for the three months then ended. Stockholders’ deficit totaled approximately $5.0 million at March 31, 2022, primarily due to recurring net losses from operations. During the three-month period ended March 31, 2022, the Company raised $0.4 million of proceeds from warrant exercises. The Company will need to continue to raise capital in order to provide funding for its operations and FDA approval process. If sufficient capital cannot be raised, the Company will continue its plans of curtailing operations by reducing discretionary spending and staffing levels and attempting to operate by only pursuing activities for which it has external financial support. However, there can be no assurance that such external financial support will be sufficient to maintain even limited operations or that the Company will be able to raise additional funds on acceptable terms, or at all. In such a case, the Company might be required to enter into unfavorable agreements or, if that is not possible, be unable to continue operations, and to the extent practicable, liquidate and/or file for bankruptcy protection. The Company had warrants exercisable for approximately 25.4 million shares of its common stock outstanding at March 31, 2022, with exercise prices ranging between $0.15 and $0.80 per share. Exercises of in-the-money warrants would generate a total of approximately $4.7 million in cash, assuming full exercise, although the Company cannot be assured that holders will exercise any warrants. Management may obtain additional funds through the public or private sale of debt or equity, and grants, if available.

SIGNIFICANT ACCOUNTING POLICIES

SIGNIFICANT ACCOUNTING POLICIES	3 Months Ended
	Mar. 31, 2022
SIGNIFICANT ACCOUNTING POLICIES
SIGNIFICANT ACCOUNTING POLICIES	2. SIGNIFICANT ACCOUNTING POLICIES Use of Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. Significant areas where estimates are used include the allowance for doubtful accounts, inventory valuation and input variables for Black-Scholes, Monte Carlo simulations and binomial calculations. The Company uses the Monte Carlo simulations and binomial calculations in the calculation of the fair value of the warrant liabilities and the valuation of embedded conversion options and freestanding warrants. Accounting Standard Updates A variety of proposed or otherwise potential accounting standards are currently under consideration by standard-setting organizations and certain regulatory agencies. Because of the tentative and preliminary nature of such proposed standards, management has not yet determined the effect, if any that the implementation of such proposed standards would have on the Company’s consolidated financial statements. Cash Equivalents The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be a cash equivalent. Accounts Receivable The Company performs periodic credit evaluations of its distributors’ financial conditions and generally does not require collateral. The Company reviews all outstanding accounts receivable for collectability on a quarterly basis. An allowance for doubtful accounts is recorded for any amounts deemed uncollectable. Uncollectibility is determined based on the determination that a distributor will not be able to make payment and the time frame has exceeded one year. The Company does not accrue interest receivables on past due accounts receivable. Concentrations of Credit Risk The Company, from time to time during the years covered by these consolidated financial statements, may have bank balances in excess of its insured limits. Management has deemed this a normal business risk. Inventory Valuation All inventories are stated at lower of cost or net realizable value, with cost determined substantially on a “first-in, first-out” basis. Selling, general, and administrative expenses are not inventoried, but are charged to expense when incurred. As of March 31, 2022 and December 31, 2021, our inventories were as follows: (in thousands) March 31, 2022 December 31, 2021 Raw materials $ 1,254 $ 1,255 Work-in-progress 69 69 Finished goods 32 32 Inventory reserve (785 ) (785 ) Total inventory $ 570 $ 571 The company periodically reviews the value of items in inventory and provides write-downs or write-offs of inventory based on its assessment of market conditions. Write-downs and write-offs are charged to cost of goods sold. Property and Equipment Property and equipment are recorded at cost. Depreciation is computed using the straight-line method over estimated useful lives of three to seven years. Leasehold improvements are amortized at the shorter of the useful life of the asset or the remaining lease term. Depreciation and amortization expense are included in general and administrative expense on the statement of operations. Expenditures for repairs and maintenance are expensed as incurred. Property and equipment are summarized as follows at March 31, 2022 and December 31, 2021: (in thousands) March 31, 2022 December 31, 2021 Equipment $ 1,049 $ 1,048 Software 652 652 Furniture and fixtures 41 41 Leasehold improvements 12 12 Construction in progress 21 8 Subtotal 1,775 1,761 Less accumulated depreciation (1,747 ) (1,747 ) Property, equipment and leasehold improvements, net $ 28 $ 14 Depreciation expense related to property and equipment for the three months ended March 31, 2022 and 2021 was not material. Debt Issuance Costs Debt issuance costs are capitalized and amortized over the term of the associated debt. Debt issuance costs are presented in the balance sheet as a direct deduction from the carrying amount of the debt liability consistent with the debt discount. Patent Costs (Principally Legal Fees) Costs incurred in filing, prosecuting, and maintaining patents are recurring, and expensed as incurred. Maintaining patents are expensed as incurred as the Company has not yet received U.S. FDA approval and recovery of these costs is uncertain. Such costs were not material for the three months ended March 31, 2022 and 2021. Leases A lease provides the lessee the right to control the use of an identified asset for a period of time in exchange for consideration. Right-of-use assets represent the Company’s right to use an underlying asset for the lease term and operating lease liabilities represent the Company’s obligation to make lease payments arising from the lease. The Company determines if an arrangement is a lease at inception. Right-of-use assets and lease liabilities are recognized at the lease commencement date based on the present value of lease payments over the lease term. Where an operating lease contains extension options that the Company is reasonably certain to exercise, the extension period is included in the calculation of the right-of-use assets and lease liabilities. The discount rate used to determine the commencement date present value of lease payments is the interest rate implicit in the lease, or when that is not readily determinable, the Company utilizes its secured borrowing rate. Right-of-use assets include any lease payments required to be made prior to commencement and exclude lease incentives. Both right-of-use assets and lease liabilities exclude variable payments not based on an index or rate, which are treated as period costs. The Company’s lease agreements do not contain significant residual value guarantees, restrictions or covenants. See Note 7 – Commitments and Contingencies. Accrued Liabilities Accrued liabilities as of March 31, 2022 and December 31, 2021 are summarized as follows: (in thousands) March 31, 2022 December 31, 2021 Compensation $ 573 $ 621 Professional fees 41 98 Stock Subscription Payable - 351 Interest 232 261 Vacation 42 39 Preferred dividends 299 349 Other accrued expenses 41 49 Total $ 1,228 $ 1,768 Stock Subscription Payable Cash received from investors for common stock shares that have not yet been issued is recorded as a liability, which is presented within Accrued Liabilities on the consolidated balance sheet. Revenue Recognition ASC 606, Revenue from Contracts with Customers, establishes a single and comprehensive framework which sets out how much revenue is to be recognized, and when. The core principle is that a vendor should recognize revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the vendor expects to be entitled in exchange for those goods or services. Revenue will now be recognized by a vendor when control over the goods or services is transferred to the customer. In contrast, revenue-based revenue recognition around an analysis of the transfer of risks and rewards; this now forms one of a number of criteria that are assessed in determining whether control has been transferred. The application of the core principle in ASC 606 is carried out in five steps: · Step 1 – Identify the contract with a customer: a contract is defined as an agreement (including oral and implied), between two or more parties, that creates enforceable rights and obligations and sets out the criteria for each of those rights and obligations. The contract needs to have commercial substance and it is probable that the entity will collect the consideration to which it will be entitled. · Step 2 – Identify the performance obligations in the contract: a performance obligation in a contract is a promise (including implicit) to transfer a good or service to the customer. Each performance obligation should be capable of being distinct and is separately identifiable in the contract. · Step 3 – Determine the transaction price: transaction price is the amount of consideration that the entity can be entitled to, in exchange for transferring the promised goods and services to a customer, excluding amounts collected on behalf of third parties. · Step 4 – Allocate the transaction price to the performance obligations in the contract: for a contract that has more than one performance obligation, the entity will allocate the transaction price to each performance obligation separately, in exchange for satisfying each performance obligation. The acceptable methods of allocating the transaction price include adjusted market assessment approach, expected cost plus a margin approach, and the residual approach in limited circumstances. Discounts given should be allocated proportionately to all performance obligations unless certain criteria are met and reallocation of changes in standalone selling prices after inception is not permitted. · Step 5 – Recognize revenue as and when the entity satisfies a performance obligation: the entity should recognize revenue at a point in time, except if it meets any of the three criteria, which will require recognition of revenue over time: the entity’s performance creates or enhances an asset controlled by the customer, the customer simultaneously receives and consumes the benefit of the entity’s performance as the entity performs, and the entity does not create an asset that has an alternative use to the entity and the entity has the right to be paid for performance to date. The Company did not recognize material revenues during the three-month periods ended March 31, 2022 or 2021. The Company’s revenues do not require significant estimates or judgments. The Company is not party to contracts that include multiple performance obligations or material variable consideration. Contract Balances The Company defers payments received as revenue until earned based on the related contracts and applying ASC 606 as required. As of March 31, 2022 and December 31, 2021, the Company had $514,000 and $337,000 in deferred revenue, respectively. Significant Distributors As of March 31, 2022, accounts receivable outstanding was $165,000, the outstanding amount was netted against a $126,000 allowance, leaving a balance of $39,000 which was from two distributors. As of December 31, 2021, accounts receivable outstanding was $172,000; the outstanding amount was netted against a $126,000 allowance, leaving a balance of $46,000, which was from two distributors. Research and Development Research and development expenses consist of expenditures for research conducted by the Company and payments made under contracts with consultants or other outside parties and costs associated with internal and contracted clinical trials. All research and development costs are expensed as incurred. Income Taxes The provision for income taxes is determined in accordance with ASC 740, “ Income Taxes The Company has filed its 2021 federal and state corporate tax returns. The Company has entered into an agreed upon payment plan with the IRS for delinquent payroll taxes. The Company has an established payment arrangement for its delinquent state income taxes with the State of Georgia. Although the Company has been experiencing recurring losses, it is obligated to file tax returns for compliance with IRS regulations and that of applicable state jurisdictions. At March 31, 2022, the Company had approximately $61.6 million of net operating losses carryforward available. This net operating loss will be eligible to be carried forward for tax purposes at federal and applicable states level. A full valuation allowance has been recorded related the deferred tax assets generated from the net operating losses. The Company recognizes uncertain tax positions based on a benefit recognition model. Provided that the tax position is deemed more likely than not of being sustained, the Company recognizes the largest amount of tax benefit that is greater than 50.0% likely of being ultimately realized upon settlement. The tax position is derecognized when it is no longer more likely than not of being sustained. The Company classifies income tax related interest and penalties as interest expense and selling, general and administrative expense, respectively, on the consolidated statements of operations. Warrants The Company has issued warrants, which allow the warrant holder to purchase one share of stock at a specified price for a specified period of time. The Company records equity instruments including warrants based on the fair value at the date of issue. The fair value of warrants classified as equity instruments at the date of issuance is estimated using the Black-Scholes Model. The fair value of warrants classified as liabilities at the date of issuance is estimated using the Monte Carlo Simulation or Binomial model. Stock Based Compensation The Company accounts for its stock-based awards in accordance with ASC Subtopic 718, “ Compensation – Stock Compensation The Black-Scholes option pricing model requires the input of certain assumptions that require the Company’s judgment, including the expected term and the expected stock price volatility of the underlying stock. The assumptions used in calculating the fair value of stock-based compensation represent management’s best estimates, but these estimates involve inherent uncertainties and the application of judgment. As a result, if factors change resulting in the use of different assumptions, stock-based compensation expense could be materially different in the future. Derivatives The Company reviews the terms of convertible debt issued to determine whether there are embedded derivative instruments, including embedded conversion options, which are required to be bifurcated and accounted for separately as derivative financial instruments. In circumstances where the host instrument contains more than one embedded derivative instrument, including the conversion option, that is required to be bifurcated, the bifurcated derivative instruments are accounted for as a single, compound derivative instrument. Bifurcated embedded derivatives are initially recorded at fair value and are then revalued at each reporting date with changes in the fair value reported as non-operating income or expense. When the equity or convertible debt instruments contain embedded derivative instruments that are to be bifurcated and accounted for as liabilities, the total proceeds received are first allocated to the fair value of all the bifurcated derivative instruments. The remaining proceeds, if any, are then allocated to the host instruments themselves, usually resulting in those instruments being recorded at a discount from their face value. The discount from the face value of the convertible debt, together with the stated interest on the instrument, is amortized over the life of the instrument through periodic charges to interest expense.

FAIR VALUE OF FINANCIAL INSTRUM

FAIR VALUE OF FINANCIAL INSTRUMENTS	3 Months Ended
	Mar. 31, 2022
FAIR VALUE OF FINANCIAL INSTRUMENTS
FAIR VALUE OF FINANCIAL INSTRUMENTS	3. FAIR VALUE OF FINANCIAL INSTRUMENTS The guidance for fair value measurements, ASC 820, Fair Value Measurements and Disclosures · Level 1–Quoted market prices in active markets for identical assets and liabilities; · Level 2–Inputs, other than level 1 inputs, either directly or indirectly observable; and · Level 3–Unobservable inputs developed using internal estimates and assumptions (there is little or no market date) which reflect those that market participants would use. The Company records its derivative activities at fair value. As of March 31, 2022 we had one instrument that we valued for the derivative liability associated with the bifurcated conversion option of the Auctus loan for $400,000. There was no movement of instruments between fair value hierarchy tiers during the three months ended March 31, 2022. The following tables present the fair value of those liabilities measured on a recurring basis as of March 31, 2022 and December 31, 2021: Fair Value at March 31, 2022 (in thousands) Level 1 Level 2 Level 3 Total Derivative liability/bifurcated conversion option in connection with Auctus $400,000 loan on December 17, 2019 $ - $ - $ (38 ) $ (38 ) Total short-term liabilities at fair value $ - $ - $ (38 ) $ (38 ) Fair Value at December 31, 2021 (in thousands) Level 1 Level 2 Level 3 Total Derivative liability/bifurcated conversion option in connection with Auctus $400,000 loan on December 17, 2019 - - (32 ) (32 ) Total long-term liabilities at fair value $ - $ - $ (32 ) $ (32 ) The following is a summary of changes to Level 3 instruments during the three months ended March 31, 2022: (in thousands) Senior Secured Debt Derivative Total Balance, December 31, 2021 $ - $ (32 ) $ (32 ) Change in fair value during the period - (6 ) (6 ) Balance, March 31, 2022 $ - $ (38 ) $ (38 )

STOCKHOLDERS DEFICIT

STOCKHOLDERS DEFICIT	3 Months Ended
	Mar. 31, 2022
STOCKHOLDERS' DEFICIT:
STOCKHOLDERS' DEFICIT	4. STOCKHOLDERS’ DEFICIT Common Stock The Company has authorized 500,000,000 shares of common stock with $0.001 par value. As of March 31, 2022 and December 31, 2021, 22,316,412 and 13,673,583 shares were issued and outstanding, respectively. During the three months ended March 31, 2022, the Company issued 8,642,829 shares of common stock: Number of Shares Common stock warrants exercised 4,477,923 Issuance of common stock for payment of Series D preferred dividends 23,109 Issuance of common stock for payment of Series E preferred dividends 12,432 Issuance of common stock for payment of Series F preferred dividends 158,662 Issuance of common stock for payment of Series F-2 preferred dividends 95,535 Issuance of common stock for payment of interest 121,262 Issuance of common stock for Series F one-time 15% dividend 255,401 Issuance of common stock for Series F-2 one-time 15% dividend 368,505 Conversion of Series E preferred stock to common stock 3,070,000 Conversion of Series F preferred stock to common stock 60,000 Issued during the three months ended March 31, 2022 8,642,829 Summary table of common stock share transactions: Balance at December 31, 2021 13,673,583 Issued in 2022 8,642,829 Balance at March 31, 2022 22,316,412 Preferred Stock The Company has authorized 5,000,000 shares of preferred stock with a $0.001 par value. The board of directors has the authority to issue these shares and to set dividends, voting and conversion rights, redemption provisions, liquidation preferences, and other rights and restrictions. Series C Convertible Preferred Stock The board designated 9,000 shares of preferred stock as Series C Convertible Preferred Stock, (the “Series C Preferred Stock”). Pursuant to the Series C certificate of designations, shares of Series C preferred stock are convertible into common stock by their holder at any time and may be mandatorily convertible upon the achievement of specified average trading prices for the Company’s common stock. At March 31, 2022 and December 31, 2021, there were 286 shares outstanding with a conversion price of $0.50 per share, such that each share of Series C preferred stock would convert into approximately 2,000 shares of the Company’s common stock; for a total convertible of 572,000 common stock shares, subject to customary adjustments, including for any accrued but unpaid dividends and pursuant to certain anti-dilution provisions, as set forth in the Series C certificate of designations. The conversion price will automatically adjust downward to 80% of the then-current market price of the Company’s common stock 15 trading days after any reverse stock split of the Company’s common stock, and 5 trading days after any conversions of the Company’s outstanding convertible debt. Holders of the Series C preferred stock are entitled to quarterly cumulative dividends at an annual rate of 12.0% until 42 months after the original issuance date (the “Dividend End Date”), payable in cash or, subject to certain conditions, the Company’s common stock. Unpaid accrued dividends were $120,120 as of March 31, 2022. Upon conversion of the Series C preferred stock prior to the Dividend End Date, the Company will also pay to the converting holder a “make-whole payment” equal to the number of unpaid dividends through the Dividend End Date on the converted shares. At March 31, 2022 and December 31, 2021, the “make-whole payment” for a converted share of Series C preferred stock would convert to 200 shares of the Company’s common stock. The Series C preferred stock generally has no voting rights except as required by Delaware law. Upon the Company’s liquidation or sale to or merger with another corporation, each share will be entitled to a liquidation preference of $1,000, plus any accrued but unpaid dividends. In addition, the purchasers of the Series C preferred stock received, on a pro rata basis, warrants exercisable to purchase an aggregate of approximately 1 share of Company’s common stock. The warrants contain anti-dilution adjustments in the event that the Company issues shares of common stock, or securities exercisable or convertible into shares of common stock, at prices below the exercise price of such warrants. As a result of the anti-dilution protection, the Company is required to account for the warrants as a liability recorded at fair value each reporting period. As of March 31, 2022, these warrants had expired. Series C1 Convertible Preferred Stock The board designated 20,250 shares of preferred stock as Series C1 Preferred Stock, of which 1,049 shares were issued and outstanding at March 31, 2022 and December 31, 2021. In addition, some holders separately agreed to exchange each share of the Series C1 Preferred Stock held for one (1) share of the Company’s newly created Series C2 Preferred Stock. In total, for 3,262.25 shares of Series C1 Preferred Stock to be surrendered, the Company issued 3,262.25 shares of Series C2 Preferred Stock. At March 31, 2022 and December 31, 2021, shares of Series C2 had a conversion price of $0.50 per share, such that each share of Series C preferred stock would convert into approximately 2,000 shares of the Company’s common stock. At March 31, 2022 and December 31, 2021, there were 1,049.25 shares outstanding with a conversion price of $0.50 per share, such that each share of Series C1 preferred stock would convert into approximately 2,000 shares of the Company’s common stock, for a total convertible of 2,098,500 common stock shares. The Series C1 preferred stock has terms that are substantially the same as the Series C preferred stock, except that the Series C1 preferred stock does not pay dividends (unless and to the extent declared on the common stock) or at-the-market “make-whole payments” and, while it has the same anti-dilution protections afforded the Series C preferred stock, it does not automatically reset in connection with a reverse stock split or conversion of our outstanding convertible debt. Series C2 Convertible Preferred Stock On August 31, 2018, the Company entered into agreements with certain holders of the Company’s Series C1 Preferred Stock, including the chairman of the Company’s board of directors, and the Chief Operating Officer and a director of the Company pursuant to which those holders separately agreed to exchange each share of the Series C1 Preferred Stock held for one (1) share of the Company’s newly created Series C2 Preferred Stock. In total, for 3,262.25 shares of Series C1 Preferred Stock to be surrendered, the Company issued 3,262.25 shares of Series C2 Preferred Stock. At March 31, 2022 and December 31, 2021, shares of Series C2 had a conversion price of $0.50 per share, such that each share of Series C preferred stock would convert into approximately 2,000 shares of the Company’s common stock, for a total convertible of 6,524,500 common stock shares. The terms of the Series C2 Preferred Stock are substantially the same as the Series C1 Preferred Stock, except that (i) shares of Series C1 Preferred Stock may not be convertible into the Company’s common stock by their holder for a period of 180 days following the date of the filing of the Certificate of Designation (the “Lock-Up Period”); (ii) the Series C2 Preferred Stock has the right to vote as a single class with the Company’s common stock on an as-converted basis, notwithstanding the Lock-Up Period; and (iii) the Series C2 Preferred Stock will automatically convert into that number of securities sold in the next Qualified Financing (as defined in the Exchange Agreement) determined by dividing the stated value ($1,000 per share) of such share of Series C2 Preferred Stock by the purchase price of the securities sold in the Qualified Financing. Series D Convertible Preferred Stock The Board designated 6,000 shares of preferred stock as Series D Preferred Stock, 763 of which remained outstanding as of March 31, 2022 and December 31, 2021. On January 8, 2021, the Company entered into a Stock Purchase Agreement with certain accredited investors (“the Series D Investors”) pursuant to all obligations under the Series D Certificate of Designation. The Series D Investors included the Chief Executive Officer, Chief Operating Officer and a director of the Company. In total, for $763,000 the Company issued 763 shares of Series D Preferred Stock, 1,526,000 common stock shares, 1,526,000 common stock warrants, exercisable at $0.25, and 1,526,000 common stock warrants, exercisable at $0.75. Each Series D Preferred Stock is convertible into 3,000 common stock shares. The Series D Preferred Stock will have cumulative dividends at the rate per share of 10% per annum. The stated value and liquidation preference on the Series D Preferred Stock is $763. The 763 Series D Preferred Shares are convertible into debt at the option of the holder during a prescribed time period. If the Series D Preferred Shares are converted, the Series D preferences are surrendered and the debt is then secured by the Company’s assets. As of March 31, 2022, none of the 763 Series D Preferred Shares have been converted to secured debt. Each share of Series D Preferred is convertible, at any time for a period of 5 years after issuance, into that number of shares of Common Stock, determined by dividing the Stated Value by $0.25, subject to certain adjustments set forth in the Series D Certificate of Designation (the “Series D Conversion Price”). The conversion of Series D Preferred is subject to a 4.99% beneficial ownership limitation, which may be increased to 9.99% at the election of the holder of the Series D Preferred. If the average of the VWAPs (as defined in the Series D Certificate of Designation) for any consecutive 5 trading day period (“Measurement Period”) exceeds 200% of the then Series D Conversion Price and the average daily trading volume of the Common Stock on the primary trading market exceeds 1,000 shares per trading day during the Measurement Period (subject to adjustments), the Company may redeem the then outstanding Series D Preferred, for cash in an amount equal to aggregate Stated Value then outstanding plus accrued but unpaid dividends. During the three months ended March 31, 2022, the Company issued 23,109 common stock shares for the payment of accrued Series D Preferred Stock dividends. As of March 31, 2022, the Company had accrued dividends of $14,306. Series E Convertible Preferred Stock The Board designated 5,000 shares of preferred stock as Series E Preferred Stock, 968 and 1,736 of which remained outstanding as of March 31, 2022 and December 31, 2021, respectively. Each share of Series E Preferred is convertible, at any time for a period of 5 years after issuance, into that number of shares of Common Stock, determined by dividing the Stated Value by $0.25, subject to certain adjustments set forth in the Series E Certificate of Designation (the “Series E Conversion Price”). The conversion of Series E Preferred is subject to a 4.99% beneficial ownership limitation, which may be increased to 9.99% at the election of the holder of the Series E Preferred. If the average of the VWAPs (as defined in the Series E Certificate of Designation) for any consecutive 5 trading day period (“Measurement Period”) exceeds 200% of the then Series E Conversion Price and the average daily trading volume of the Common Stock on the primary trading market exceeds 1,000 shares per trading day during the Measurement Period (subject to adjustments), the Company may redeem the then outstanding Series E Preferred, for cash in an amount equal to aggregate Stated Value then outstanding plus accrued but unpaid dividends. Each share of Series E Preferred Stock has a par value of 0.001 per share and a Stated Value equal to $1,000, subject to increase set forth in its Certificate of Designation. Each holder of Series E Preferred Stock is entitled to receive cumulative dividends of 8% per annum, payable annually in cash or, following the listing of the Company’s common stock on certain Canadian trading markets and at the option of the Company, shares of common stock. During the three months ended March 31, 2022, the Company issued 3,070,000 common stock shares for the conversion of 768 shares of Series E Convertible Preferred Stock. During the three months ended March 31, 2022, the Company issued 12,432 common stock shares for the payment of Series E Preferred Stock dividends accrued. As of March 31, 2022, the Company had accrued dividends of $71,099. Series F Convertible Preferred Stock The Board designated 1,500 shares of preferred stock as Series F Preferred Stock, 1,411 and 1,426 of which were issued and outstanding as of March 31, 2022 and December 31, 2021, respectively. During 2021, the Company entered into a Stock Purchase Agreement with certain accredited investors (“the Series F Investors”). In total, for $1,436,000 the Company issued 1,436 shares of Series F Preferred Stock. Each Series F Preferred Stock is convertible into 4,000 common stock shares. The Series F Preferred Stock is entitled to cumulative dividends at the rate per share of 6% per annum. The stated value on the Series F Preferred Stock is $1,411. Each share of Series F Preferred is convertible, at any time for a period of 5 years after issuance, into that number of shares of Common Stock, determined by dividing the Stated Value by $0.25, subject to certain adjustments set forth in the Series F Certificate of Designation (the “Series F Conversion Price”). The conversion of Series F Preferred is subject to a 4.99% beneficial ownership limitation, which may be increased to 9.99% at the election of the holder of the Series F Preferred. If the average of the VWAPs (as defined in the Series F Certificate of Designation) for any consecutive 5 trading day period (“Measurement Period”) exceeds 200% of the then Series F Conversion Price and the average daily trading volume of the Common Stock on the primary trading market exceeds 1,000 shares per trading day during the Measurement Period (subject to adjustments), the Company may redeem the then outstanding Series F Preferred, for cash in an amount equal to aggregate Stated Value then outstanding plus accrued but unpaid dividends. During the three months ended March 31, 2022, the Company issued 60,000 common stock shares for the conversion of 15 shares of Series F Convertible Preferred Stock. During the three months ended March 31, 2022, the Company issued 158,662 common stock shares for the payment of annual Series F Preferred Stock dividends. Additionally, During the three months ended March 31, 2022, the Company issued 255,401 common stock shares for the payment of a one-time, non-recurring 15% dividend to the Series F Preferred shareholders (as required by the Series F Certificate of Designation in the event the Company did not uplist to the NASDAQ stock exchange or file its clinical data intended for FDA approval of LuViva by December 31, 2021). As of March 31, 2022, accrued dividends totaled $1,998. Series F-2 Convertible Preferred Stock The Company was oversubscribed for its Series F Convertible Preferred Stock, resulting in the requirement to file an additional Certificate of Designation for Series F-2 Convertible Preferred Stock with substantially the same terms as the Series F Convertible Preferred Stock. The Board designated 3,500 shares of preferred stock as Series F-2 Preferred Stock, 3,237 of which were issued and outstanding as of March 31, 2022 and December 31, 2021. During 2021, the Company entered into a Stock Purchase Agreement with certain accredited investors (“the Series F-2 Investors”). In total, for $678,000 the Company issued 678 shares of Series F-2 Preferred Stock. In addition, the Company exchanged outstanding debt of $2,559,000 for 2,559 shares of Series F-2 Preferred Stock. Each Series F-2 Preferred Stock is convertible into 4,000 common stock shares. The Series F-2 Preferred Stock will have cumulative dividends at the rate per share of 6% per annum. The stated value on the Series F-2 Preferred Stock is 3,237. Each share of Series F-2 Preferred is convertible, at any time for a period of 5 years after issuance, into that number of shares of Common Stock, determined by dividing the Stated Value by 0.25, subject to certain adjustments set forth in the Series F-2 Certificate of Designation (the “Series F-2 Conversion Price”). The conversion of Series F-2 Preferred is subject to a 4.99% beneficial ownership limitation, which may be increased to 9.99% at the election of the holders of the Series F-2 Preferred. If the average of the VWAPs (as defined in the Series F-2 Certificate of Designation) for any consecutive 5 trading day period (“Measurement Period”) exceeds 200% of the then Series F-2 Conversion Price and the average daily trading volume of the Common Stock on the primary trading market exceeds 1,000 shares per trading day during the Measurement Period (subject to adjustments), the Company may redeem the then outstanding Series F-2 Preferred, for cash in an amount equal to aggregate Stated Value then outstanding plus accrued but unpaid dividends. During the three months ended March 31, 2022, the Company issued 95,535 common stock shares for the payment of annual Series F-2 Preferred Stock dividends. Additionally, During the three months ended March 31, 2022, the Company issued 368,505 common stock shares for the payment of a one-time, non-recurring 15% dividend to the Series F-2 Preferred shareholders (as required by the Series F-2 Certificate of Designation in the event the Company did not uplist to the NASDAQ stock exchange or file its clinical data intended for FDA approval of LuViva by December 31, 2021). As of March 31, 2022, accrued dividends totaled $91,592. Powerup (Series G Convertible Preferred Stock) During January 2021, the Company finalized an investment by Power Up Lending Group Ltd. Power Up invested $78,500, net to the Company is $75,000, for 91,000 shares of Series G preferred stock with additional tranches of financing up to $925,000 in the aggregate over the terms of the Series G preferred stock. Series G will be non-voting on any matters requiring shareholder vote. The Series G Preferred Stock will have cumulative dividends at the rate per share of 8% per annum. At any time during the period indicated below, after the date of the issuance of shares of Series G preferred stock, the Company will have the right, at the Company’s option, to redeem all of the shares of Series G preferred stock by paying an amount equal to: (i) the number of shares of Series G preferred stock multiplied by then stated value (including accrued dividends); (ii) multiplied by the corresponding percentage as follows: Day 1-60, 105%; Day 61-90, 110%; Day 91-120, 115%; and Day 121-180, 122%. After the expiration of the 180 days following the issuance date, except for mandatory redemption, the Company shall have no right to redeem the Series G preferred stock. Mandatory redemption occurs within 24 months. In addition, if the Company does not redeem the Series G preferred stock, then Power Up will have the option to convert to common stock shares. The variable conversion price will be the value equal to a discount of 19% off of the trading price; which is calculated as the average of the three lowest closing bid prices over the last fifteen trading days. The conversion of Series G Preferred is subject to a 4.99% beneficial ownership limitation, which may be increased to 9.99% at the election of the holder of the Series G Preferred. The Company has redeemed all of the Series G preferred stock and the balance is paid. During February 2021, the Company finalized an investment by Power Up Lending Group Ltd. Power Up invested $53,500, net to the Company is $50,000, for 62,000 shares of Series G preferred stock with additional tranches of financing up to $925,000 in the aggregate over the terms of the Series G preferred stock. Series G will be non-voting on any matters requiring shareholder vote. The Series G Preferred Stock will have cumulative dividends at the rate per share of 8% per annum. At any time during the period indicated below, after the date of the issuance of shares of Series G preferred stock, the Company will have the right, at the Company’s option, to redeem all of the shares of Series G preferred stock by paying an amount equal to: (i) the number of shares of Series G preferred stock multiplied by then stated value (including accrued dividends); (ii) multiplied by the corresponding percentage as follows: Day 1-60, 105%; Day 61-90, 110%; Day 91-120, 115%; and Day 121-180, 122%. After the expiration of the 180 days following the issuance date, except for mandatory redemption, the Company shall have no right to redeem the Series G preferred stock. Mandatory redemption occurs within 24 months. In addition, if the Company does not redeem the Series G preferred stock then Power Up will have the option to convert to common stock shares. The variable conversion price will be the value equal to a discount of 19% off of the trading price; which is calculated as the average of the three lowest closing bid prices over the last fifteen trading days. The conversion of Series G Preferred is subject to a 4.99% beneficial ownership limitation, which may be increased to 9.99% at the election of the holder of the Series G Preferred. Due to the mandatory redemption feature of the Series G preferred stock, the total amount of 125,000 was recorded as a liability. On June 4, 2021, the Company redeemed the January 2021 investment of $75,000 for $114,597, this $39,597 difference was recorded as interest expense. On July 8, 2021, the Company redeemed the February 2021 investment of $50,000 for $78,094. The difference of 28,094 was recorded as interest expense. As of March 31, 2022 and December 31, 2021, the amount outstanding was nil. Warrants The following table summarizes transactions involving the Company’s outstanding warrants to purchase common stock for the three months ended March 31, 2022: Warrants (Underlying Shares) Weighted-Average Exercise Price Per Share Outstanding, December 31, 2021 27,669,634 $ 0.29 Warrants exercised (2,284,324 ) $ 0.16 Outstanding, March 31, 2022 25,385,310 $ 0.30

STOCK OPTIONS

STOCK OPTIONS	3 Months Ended
	Mar. 31, 2022
STOCK OPTIONS
STOCK OPTIONS	5. STOCK OPTIONS The new Stock Plan (the “Plan”) allows for the issuance of incentive stock options, nonqualified stock options, and stock purchase rights. The exercise price of options was determined by the Company’s board of directors, but incentive stock options were granted at an exercise price equal to the fair market value of the Company’s common stock as of the grant date. Options historically granted have generally become exercisable over four years and expire ten years from the date of grant. The plan provides for stock options to be granted up to 10% of the outstanding common stock shares. There was no stock option activity during the three months ended March 31, 2022. The following table summarizes the Company’s outstanding and exercisable stock options as of March 31, 2022: Number of Shares Weighted-Average Exercise Price Per Share Weighted-Average Remaining Contractual Life Aggregate Intrinsic Value of In-the-Money Options (in thousands) Options outstanding as of March 31, 2022 1,500,000 $ 0.49 8.3 years $ 240 Options exercisable as of March 31, 2022 1,045,227 $ 0.49 8.3 years $ 167 The aggregate intrinsic value is calculated as the difference between the Company’s closing stock price as of March 31, 2022 and the exercise price, multiplied by the number of options. As of March 31, 2022, there was $219,558 of unrecognized stock-based compensation expense. Such costs are expected to be recognized over a weighted average period of approximately 1.25 years. The weighted-average fair value of awards granted was nil and $0.47 during the three months ended March 31, 2022 and 2021, respectively. The Company recognizes compensation expense for stock option awards on a straight-line basis over the applicable service period of the award. The service period is generally the vesting period. The Black-Scholes option pricing model and the following weighted-average assumptions were used to estimate the fair value of awards granted during the three months ended March 31, 2021: March 31, 2021 Expected term (years) 10 years Volatility 153.12 % Risk-free interest rate 0.98 % Dividend yield 0.00 %

LITIGATION AND CLAIMS

LITIGATION AND CLAIMS	3 Months Ended
	Mar. 31, 2022
LITIGATION AND CLAIMS
LITIGATION AND CLAIMS	6. LITIGATION AND CLAIMS From time to time, the Company may be involved in various legal proceedings and claims arising in the ordinary course of business. Management believes that the dispositions of these matters, individually or in the aggregate, are not expected to have a material adverse effect on the Company’s financial condition. However, depending on the amount and timing of such disposition, an unfavorable resolution of some or all of these matters could materially affect the future results of operations or cash flows in a particular year. As of March 31, 2022, and December 31, 2021, there was no accrual recorded for any potential losses related to pending litigation.

COMMITMENTS AND CONTINGENCIES

COMMITMENTS AND CONTINGENCIES	3 Months Ended
	Mar. 31, 2022
COMMITMENTS AND CONTINGENCIES
COMMITMENTS AND CONTINGENCIES	7. COMMITMENTS AND CONTINGENCIES Operating Leases The below table presents total operating lease right-of-use assets and lease liabilities as of March 31, 2022: (in thousands) Three Months Ended March 31, 2022 Operating lease right-of-use assets $ 355 Operating lease liabilities $ 377 The table below presents the maturities of operating lease liabilities as of March 31, 2022: (in thousands) Operating Leases 2022 (remaining) $ 82 2023 112 2024 115 2025 118 2026 50 Total future lease payments 477 Less: discount (100 ) Total lease liabilities $ 377 The table below presents the weighted-average remaining lease term and discount rate used in the calculation of operating lease right-of-use assets and lease liabilities: Three Months Ended March 31, 2022 Weighted average remaining lease term (years) 4.2 Weighted average discount rate 11.4 % Related Party Contracts On June 5, 2016, the Company entered into a license agreement with Shenghuo Medical, LLC pursuant to which the Company granted Shenghuo an exclusive license to manufacture, sell and distribute LuViva in Taiwan, Brunei Darussalam, Cambodia, Laos, Myanmar, Philippines, Singapore, Thailand, and Vietnam. Shenghuo was already the Company’s exclusive distributor in China, Macau and Hong Kong, and the license extended to manufacturing in those countries as well. Under the terms of the license agreement, once Shenghuo was capable of manufacturing LuViva in accordance with ISO 13485 for medical devices, Shenghuo would pay the Company a royalty equal to $2.00 or 20% of the distributor price (subject to a discount under certain circumstances), whichever is higher, per disposable distributed within Shenghuo’s exclusive territories. In connection with the license grant, Shenghuo was to underwrite the cost of securing approval of LuViva with Chinese Food and Drug Administration. At its option, Shenghuo also would provide up to $1.0 million in furtherance of the Company’s efforts to secure regulatory approval for LuViva from the U.S. Food and Drug Administration, in exchange for the right to receive payments equal to 2% of the Company’s future sales in the United States, up to an aggregate of $4.0 million. Pursuant to the license agreement, Shenghuo had the option to have a designee appointed to the Company’s board of directors (current director Richard Blumberg is the designee). On September 6, 2016, the Company entered into a royalty agreement with one of its directors, John Imhoff, and another stockholder, Dolores Maloof, pursuant to which the Company sold to them a royalty of future sales of single-use cervical guides for LuViva. Under the terms of the royalty agreement, and for consideration of $50,000, the Company will pay them an aggregate perpetual royalty initially equal to $0.10, and from and after October 2, 2016, equal to $0.20, for each disposable that the Company sells (or that is sold by a third party pursuant to a licensing arrangement with the Company). On January 22, 2020, the Company entered into a promotional agreement with a related party, which is partially owned by Mr. Blumberg, to provide investor and public relations services for a period of two years. As compensation for these services, the Company will issue a total of 5,000,000 warrants, broken into four tranches of 1,250,000. The warrants have a strike price of $0.25 and are subject to vesting based upon the close of the Series D offering and a minimum share price based on the 30-day VWAP. If the minimum share price per the terms of the agreement is not achieved, the warrants will expire three years after the issuance date. The warrants were valued using the Black Scholes model on the grant date of January 22, 2020, which resulted in a total fair value of $715,000. The Company did not appropriately expense the services received in connection with this agreement in 2020. During the three months ended March 31, 2022, the Company recognized $79,444 of consulting expenses as a result of this agreement. Unrecognized consulting expense to be recognized under this agreement is nil as of March 31, 2022. On March 10, 2021, the Company entered into a consulting agreement with Richard Blumberg. As a result of the consulting agreement Mr. Blumberg provided $350,000, which was recorded to subscription receivable, to the Company in exchange for the following: (1) on September 26, 2021, 900,000 3-year warrants with an exercise price of $0.30 and 400,000 common stock shares; (2) on March 26, 2022, 900,000 3-year warrants with an exercise price of $0.40 and 400,000 common stock shares; (3) on September 26, 2022, 900,000 3-year warrants with an exercise price of $0.50 and 400,000 common stock shares; and (4) on March 26, 2023, 900,000 3-year warrants with an exercise price of $0.60 and 400,000 common stock shares. During the year ended December 31, 2021, the consulting agreement was amended to clarify that $350,000 is not intended to be debt and will not be required to be repaid in cash. Additionally, issuance of the warrants is now predicated on the Company receiving funding receipts of $1,000,000, whether from a financing, series of financing, or gross sales. The amended agreement clarified that the warrants issued to Mr. Blumberg are compensation for services, which involve obtaining financing. The Company will recognize expense for the services equal to the fair value of the warrants issued to Mr. Blumberg as the services are provided, which will coincide with the successful execution of a financing agreement over $1,000,000. Other Commitments On July 24, 2019, Shandong Yaohua Medical Instrument Corporation (“SMI”), agreed to modify its existing agreement. Under the terms of this modification, the Company agreed to grant (1) exclusive manufacturing rights, excepting the disposable cervical guides for the Republic of Turkey, and the final assembly rights for Hungary, and (2) exclusive distribution and sales for LuViva in jurisdictions, subject to the following terms and conditions. First, SMI shall complete the payment for parts, per the purchase order, for five additional LuViva devices. Second, in consideration for the $885,144 that the Company received, SMI will receive 12,147 common stock shares. Third, SMI shall honor all existing purchase orders it has executed to date with the Company, in order to maintain jurisdiction sales and distribution rights. If SMI needs to purchase cervical guides, then it will do so at a cost including labor, plus ten percent markup. The Company will provide 200 cervical guides at no cost for the clinical trials. Fourth, the Company and SMI will make best efforts to sell devices after CFDA approval. With an initial estimate of year one sales of 200 LuViva devices; year two sales of 500 LuViva devices; year three sales of 1,000 LuViva devices; and year four sales of 1,250 LuViva devices. Fifth, SMI shall pay for entire costs of securing approval of LuViva with the Chinese FDA. Sixth, SMI shall arrange, at its sole cost, for a manufacturer in China to build tooling to support manufacturing. In addition, SMI retains the right to manufacture for China, Hong Kong, Macau and Taiwan, where SMI has distribution and sales rights. For each single-use cervical guide sold by SMI in the jurisdictions, SMI shall transfer funds to escrow agent at a rate of $1.90 per device chip. If within 18 months of the license’s effective date, SMI fails to achieve commercialization of LuViva in China, SMI shall no longer have any rights to manufacture, distribute or sell LuViva. Commercialization is defined as: filing an application with the Chinese FDA for the approval of LuViva; any assembly or manufacture of the devices or disposables that begins in China; and purchase of at least 10 devices and disposables for clinical evaluations and regulatory use and or sales in the jurisdictions. On August 12, 2021, the Company executed an amendment to its agreement with SMI, which established a payment schedule for the balance owed by SMI to the Company for outstanding purchase orders. The remaining balance owed for outstanding purchase orders was $23,445 as of March 31, 2022. Under the terms of the amended agreement, the parties agreed that if by October 30, 2022, SMI fails to achieve commercialization of LuViva in China, SMI shall no longer have any rights to manufacture, distribute or sell LuViva. Contingencies The current outbreak of the Coronavirus SARS-CoV-2, the pathogen responsible for COVID-19, which has already had an impact on financial markets, could result in additional repercussions to the Company’s operating business, including but not limited to, the sourcing of materials for product candidates, manufacture of supplies for preclinical and/or clinical studies, delays in clinical operations, which may include the availability or the continued availability of patients for trials due to such things as quarantines, conduct of patient monitoring and clinical trial data retrieval at investigational study sites. The future impact of the outbreak is highly uncertain and cannot be predicted, and the Company cannot provide any assurance that the outbreak will not have a material adverse impact on the Company’s operations or future results or filings with regulatory health authorities. The extent of the impact to the Company, if any, will depend on future developments, including actions taken to contain the coronavirus. The Russia-Ukraine conflict and the sanctions imposed in response to this crisis could result in repercussions to our operating business, including delays in obtaining regulatory approval to market our products in Russia. The future impact of the conflict is highly uncertain and cannot be predicted, and we cannot provide any assurance that the conflict will not have a material adverse impact on our operations or future results or filings with regulatory health authorities.

NOTES PAYABLE

NOTES PAYABLE	3 Months Ended
	Mar. 31, 2022
NOTES PAYABLE
NOTES PAYABLE	8. NOTES PAYABLE Short Term Notes Payable At March 31, 2022 and December 31, 2021, the Company maintained short term notes payable to related and non-related parties totaling approximately $43,253 and $87,615, respectively. These notes are short term, straight-line amortizing notes. The notes carry annual interest rates between 4.3% and 16%, or 18% in the event of default. On July 4, 2021, the Company entered into a premium finance agreement to finance its insurance policies totaling $117,560. The note requires monthly payments of $11,968, including interest at 4.3% and matured in April 2022. As of March 31, 2022, the balance on that note was $11,968. During 2019, the Company issued promissory notes to Mr. Cartwright totaling $45,829. The note was initially issued with 0% interest, however interest increased to 6.0% interest 90 days after the Company received $1,000,000 in financing proceeds. As of March 31, 2022, the balance on the notes was $31,285. On December 21, 2016 and January 19, 2017, the Company issued promissory notes to Mr. Fowler, in the amounts of approximately $12,500 and $13,900. The notes were initially issued with 0% interest and then went into default with an interest rate of 18%. As part of the March 22, 2021 exchange agreement these notes were combined into one short term note payable of $26,400 and $18,718 in principal and interest of the two previous notes, respectively, for the total balance of $45,118. The aforementioned agreement brought the note current and will accrue interest at a rate of 6.0%. The note carries a monthly payment of $3,850. As of March 31, 2022, the note was paid in full. The following table summarizes short-term notes payable, including related parties: Short-term notes payable, including related parties March 31, 2022 December 31, 2021 Dr. Cartwright $ 31 $ 34 Mr. Fowler - 6 Premium Finance (insurance) 12 48 Short-term notes payable $ 43 $ 88 The short-term notes payable due to related parties was $31,285 at March 31, 2022 and $40,000 of the $88,000 balance at December 31, 2021.

SHORT-TERM CONVERTIBLE DEBT

SHORT-TERM CONVERTIBLE DEBT	3 Months Ended
	Mar. 31, 2022
SHORT-TERM CONVERTIBLE DEBT
SHORT-TERM CONVERTIBLE DEBT	9. SHORT-TERM CONVERTIBLE DEBT Short-term Convertible Notes Payable Auctus On December 17, 2019, the Company entered into a securities purchase agreement and convertible note with Auctus. The convertible note issued to Auctus will be for a total of $2.4 million. The first tranche of $700,000 was received in December 2019 and matured December 17, 2021 and accrued interest at a rate of ten percent (10%). The note may not have been prepaid in whole or in part except as otherwise explicitly allowed. Any amount of principal or interest on the note which was not paid when due shall bore interest at the rate of the lessor of 24% or the maximum permitted by law (the “default interest”). The variable conversion prices equaled the lesser of: (i) the lowest trading price on the issue date, and (ii) the variable conversion price. The variable conversion price was 95% multiplied by the market price (the market price means the average of the five lowest trading prices during the period beginning on the issue date and ending on the maturity date), minus $0.04 per share, provided however that in no event could the variable conversion price be less than $0.15. If an event of default under this note occurred and/or the note was not extinguished in its entirety prior to December 17, 2020 the $0.15 price floor no longer applied. In connection with the first tranche of $700,000, the Company issued 7,500,000 warrants to purchase common stock at an exercise price of $0.20. The fair value of the warrants at the date of issuance was $745,972; $635,000 was allocated to the warrant liability and a loss of $110,972 was recorded at the date of issuance for the amount of the fair value in excess of the net proceeds received of $635,000. The $700,000 proceeds were received net of debt issuance costs of $65,000 (net proceeds of $635,000, after administrative and legal expenses Company received $570,000). The Company used $65,000 of the proceeds to make a partial payment of the $89,250 convertible promissory note issued on July 3, 2018 to Auctus. The Company made a $700,000 payment on June 1, 2021, which resulted in a prepayment penalty of $350,000 being assessed to the Company, which remained outstanding as of March 31, 2022. The Company recorded this prepayment penalty as interest expense. Interest will not be assessed on the prepayment penalty. As of March 31, 2022 and December 31, 2021, the outstanding amount of the note was nil. On May 27, 2020, the Company received the second tranche in the amount of $400,000, from the December 17, 2019 securities purchase agreement and convertible note with Auctus. The net amount paid to the Company was $313,000 This second tranche is part of the convertible note issued to Auctus for a total of $2.4 million of which $700,000 has already been provided by Auctus. The note maturity date is May 27, 2022 and the note accrues interest at a rate of ten percent (10%). The note may not be prepaid in whole or in part except as otherwise explicitly allowed. Any amount of principal or interest on the note which is not paid when due shall bear interest at the rate of the lessor of 24% or the maximum permitted by law (the “default interest”). The variable conversion prices shall equal the lesser of: (i) the lowest trading price on the issue date, and (ii) the variable conversion price. The variable conversion price shall mean 95% multiplied by the market price (the market price means the average of the five lowest trading prices during the period beginning on the issue date and ending on the maturity date), minus $0.04 per share, provided however that in no event shall the variable conversion price be less than $0.15. If an event of default under this note occurs and/or the note is not extinguished in its entirety prior to December 17, 2020 the $0.15 price shall no longer apply. The last tranche of $1.3 million will be received within 60 days of the S-1 registration statement becoming effective. The conversion price of the notes will be at market value with a minimum conversion amount of $0.15. In addition, as part of this transaction the Company was required to pay a 2.0% fee to a registered broker-dealer. As of March 31, 2022 and December 31, 2021, $400,000 of principal remained outstanding and accrued interest totaled $74,778 and $64,778, respectively. Further, as of March 31, 2022 and December 31, 2020, the Company had unamortized debt issuance costs of $5,211 and $13,586. As of March 31, 2022 and December 31, 2021, the estimated fair value of the derivative liability for the bifurcated conversion option was $38,129 and $31,889, respectively. Convertible Notes in Default On March 31, 2020, we entered into a securities purchase agreement with Auctus Fund, LLC for the issuance and sale to Auctus of $112,750 in aggregate principal amount of a 12% convertible promissory note. On June 30, 2020, we issued the note to Auctus and issued 250,000 five-year common stock warrants at an exercise price of $0.16. On April 3, 2020, we received net proceeds of $100,000. The note matured on January 26, 2021 and accrues interest at a rate of 12% per year. We may not prepay the note, in whole or in part. After the 90 th The following table summarizes the Short-term Convertible Notes Payable, including debt in default (in thousands): March 31, 2022 December 31, 2021 Auctus Tranche 2 $ 400 $ 400 Auctus prepayment penalty 350 350 Auctus (March 31, 2020 Note) 161 161 Debt discount and issuance costs to be amortizaed (5 ) (14 ) Convertible notes payable - short-term $ 906 $ 897 On June 2, 2021, we entered into an exchange agreement with Auctus, which was amended on February 1, 2022. Pursuant to this agreement, Auctus agreed to exchange an aggregate of $668,290 of outstanding notes (the “Notes”), including accrued interest, and the associated warrants issued in connection with the Notes (the warrants, for the purpose of the exchange, are valued at, in the aggregate, $1,681,707) into unregistered units of our common stock, warrants and prefunded warrants otherwise in the form and ratios issued in a proposed underwritten public offering on the Nasdaq Capital Markets (the “Nasdaq Offering”). The exchange price will be on a $1 for $1 basis such that Auctus will receive $2,349,997 of units consisting of common stock, warrants and prefunded warrants. The units being issued in the exchange with Auctus are unregistered and are being issued pursuant to Section 4(a)(2) under the Securities Act of 1933, as amended. Additionally, the units and the common stock underlying the units will be subject to a lock up agreement with the underwriters until the earlier of 120 days after the Nasdaq Offering and the date that the daily volume weighted average price of the common stock exceeds 200% of the Nasdaq Offering price for at least five consecutive trading days. Further, the termination date of the June 2, 2021 agreement was extended to April 15, 2022. The $350,000 related to default penalties will be exchanged into $350,000 of securities offered in the Nasdaq Offering.

LONG TERM DEBT

LONG TERM DEBT	3 Months Ended
	Mar. 31, 2022
LONG TERM DEBT
LONG-TERM DEBT	10. LONG-TERM DEBT Long-term Debt – Related Parties On July 14, 2018, the Company entered into an exchange agreement with Dr. Faupel, whereby Dr. Faupel agreed to exchange outstanding amounts due to him for loans, interest, bonus, salary and vacation pay in the amount of $660,895 for a $207,111 promissory note dated September 4, 2018. On July 20, 2018, the Company entered into an exchange agreement with Dr. Cartwright, whereby Dr. Cartwright agreed to exchange outstanding amounts due to him for loans, interest, bonus, salary and vacation pay in the amount of $1,621,499 for a $319,000 promissory note dated September 4, 2018 that incurs interest at a rate of 6% per annum. On July 24, 2019, Dr. Faupel and Mr. Cartwright agreed to an addendum to the debt restructuring exchange agreement and to modify the terms of the original exchange agreement. Under this modification Dr. Faupel and Mr. Cartwright agreed to extend the note to be due in full on the third anniversary of that agreement. On February 19, 2021, the Company entered into new promissory notes replacing the original notes from September 4, 2018, with Mark Faupel and Gene Cartwright. For Dr. Cartwright the principal amount on the new note was $267,085, matures on February 18, 2023, and will accrue interest at a rate of 6.0%. For Dr. Faupel the principal amount on the new note was $153,178, matures on February 18, 2023, and will accrue interest at a rate of 6.0%. The modifications extended the maturity date on both of the notes. On February 19, 2021, the Company exchanged $100,000 and $85,000 of long-term debt for Dr. Cartwright and Dr. Faupel in exchange for 100 and 85 shares of Series F2 Preferred Stock, respectively. The table below summarizes the detail of the exchange agreement: For Dr. Faupel: Salary $ 134 Bonus 20 Vacation 95 Interest on compensation 67 Loans to Company 196 Interest on loans 149 Total outstanding prior to exchange 661 Amount forgiven in prior years (454 ) Amount exchanged for Series F-2 Preferred Stock (85 ) Total interest accrued through December 31, 2021 39 Balance outstanding at December 31, 2021 $ 161 Interest accrued through March 31, 2022 2 Balance outstanding at March 31, 2022 $ 163 For Dr.Cartwright Salary $ 337 Bonus 675 Loans to Company 528 Interest on loans 81 Total outstanding prior to exchange 1,621 Amount forgiven in prior years (1,302 ) Amount exchanged for Series F-2 Preferred Stock (100 ) Total interest accrued through December 31, 2021 62 Balance outstanding at December 31, 2021 $ 281 Interest accrued through March 31, 2022 4 Balance outstanding at March 31, 2022 $ 285 On March 22, 2021, the Company entered into an exchange agreement with Richard Fowler. As of December 31, 2020, the Company owed Mr. Fowler $546,214 ($412,624 in deferred salary and $133,590 in accrued interest). The Company exchanged $50,000 of the amount owed of $546,214 for 50 share of Series F-2 Preferred Shares (convertible into 200,000 common stock shares), and a $150,000 unsecured note. The note accrues interest at the rate of 6% (18% in the event of default) beginning on March 22, 2022 and is payable in monthly installments of $3,580 for four years, with the first payment due on March 15, 2022. The effective interest rate of the note is 6.18%. During the three months ended March 31, 2022, Mr. Fowler forgave $6,232 of the outstanding balance and may forgive up to $253,429 of the remaining principal and accrued interest if the Company complies with the repayment plan described above. The reduction in the outstanding balance met the criteria for troubled debt. The basic criteria are that the borrower is troubled, i.e., they are having financial difficulties, and a concession is granted by the creditor. The outstanding principal amount owed on the note was $146,400 as of March 31, 2022, of which $26,586 is included in “Current portion of long-term debt, related parties” and the remainder of which is included in “Long-term debt, related parties” on the consolidated balance sheets. Future debt obligations as shown below include: $284,867, $163,376, and $146,400 for a total of $594,643 for Dr. Cartwright, Dr. Faupel, and Mr. Fowler, respectively. Future debt obligations as of March 31, 2022 for debt owed to related parties is as follows (in thousands): Year Amount 2022 $ 27 2023 485 2024 39 2025 41 2026 3 Thereafter - Total $ 595 Small Business Administration Loan On May 4, 2020, the Company received a loan from the Small Business Administration (SBA) pursuant to the Paycheck Protection Program (PPP) as part of the Coronavirus Aid, Relief, and Economic Security Act (CARES Act) in the amount of $50,184. The loan bears interest at a rate of 1.00%, and matures in 24 months, with the principal and interest payments being deferred until the date of forgiveness with interest accruing, then converting to monthly principal and interest payments, at the interest rate provided herein, for the remaining eighteen (18) months. Lender will apply each payment first to pay interest accrued to the day Lender received the payment, then to bring principal current, and will apply any remaining balance to reduce principal. Payments must be made on the same day as the date of this Note in the months they are due. Lender shall adjust payments at least annually as needed to amortize principal over the remaining term of the Note. Under the provisions of the PPP, the loan amounts will be forgiven as long as: the loan proceeds are used to cover payroll costs, and most mortgage interest, rent, and utility costs over a 24-week period after the loan is made; and employee and compensation levels are maintained. In addition, payroll costs are capped at $100,000 on an annualized basis for each employee. Not more than 40% of the forgiven amount may be for non-payroll costs. As of March 31, 2022 and December 31, 2021, the outstanding balance was $4,491 (this amount is presented in current portion of long-term debt) and $11,181, including $407 and $385 in accrued interest, respectively. 10% Senior Unsecured Convertible Debenture On May 17, 2021, the Company issued 10% Senior Unsecured convertible debentures to investors, which mature on May 17, 2024 (the “Maturity Date”). The Company subscribed $1,130,000 of the $1,000 convertible debentures. The terms of the debentures are as follows: 1) the principal amount of some or all of the convertible debentures and accrued interest are convertible into common stock shares at the holder’s option, at a price of $0.50 per common stock share (the “conversion price”), subject to adjustment in certain events, at any time prior to maturity date; 2) upon successful uplist to a U.S. National Exchange, the note will automatically convert into the uplisting financing; 3) each debenture unit will have a right to 1,000 warrants for common stock shares, warrants have an exercise price of $0.80 and an expiration date of May 17, 2023; 4) if a Change of Control (as defined in the Convertible Debenture Certificate) occurs prior to the Maturity Date, unless the holder elects in writing to convert the Convertible Debentures into common shares, the Company will repay in cash upon the closing of such Change of Control all outstanding principal and accrued interest under each Convertible Debenture plus a Change of Control premium equal to an additional 3% of the outstanding principal sum under such Convertible Debenture. Prior to the closing of an Change of Control, in lieu of repayment as set forth in the preceding sentence, the holder has the right to elect in writing to convert, effective immediately prior to the effective date of such Change of Control, all outstanding principal and accrued Interest under the Convertible Debentures into common shares at the Conversion Price; 5) Subject to a holder’s option of electing conversion prior to the Redemption Date (as such term is defined below), on or after the date that is 24 months from the Closing Date if the daily volume weighted average trading price of the common shares is $1.50 per common share or more for each trading day over a 30 consecutive trading day period, the Company may, at any time (the “Redemption Date”), at its option, redeem all, or any portion of the Convertible Debentures for either: (i) a cash payment (in the form of a certified cheque or bank draft) that is equal to all outstanding principal and accrued interest under each Convertible Debenture up to the Redemption Date; or (ii) by issuing and delivering common shares to the holders of Convertible Debentures at a deemed price of US$0.50 per common share that is equal to all outstanding principal and accrued interest under each Convertible Debenture up to the Redemption Date, or any combination of (i) or (ii), upon not less than 30 days and not more than 60 days prior written notice in the manner provided in the Debenture Certificate, to the holder of Convertible Debentures. At March 31, 2022 and December 31, 2021, the balance due on the 10% Senior Secured Convertible Debenture was $1,130,000 and total accrued interest was $28,250 and $73,326, respectively. The bond payable discount and unamortized debt issuance costs as of March 31, 2022 and December 31, 2021 are presented below (in thousands): March 31, 2022 December 31, 2021 10% Senior Unsecured Convertible Debentures $ 1,130 $ 1,130 Debt Issuance costs to be amortized (62 ) (69 ) Debt Discount (216 ) (241 ) Long-term convertible debt $ 852 $ 820 6% Unsecured Promissory Note On July 9, 2020, we entered into an exchange agreement with Mr. Bill Wells (a former employee). In lieu of agreeing to dismiss approximately half of what was owed to him, or $220,000, Mr. Wells received the following: (i) cash payments of $ 20,000; (ii) an unsecured promissory note in the amount of $90,000 to be executed within 30 days of completing new financing(s) totaling at least $3.0 million, (iii) 66,000 common share stock options that vest at a rate of 3,667 per month and have a $0.49 exercise price (if two consecutive payments in (ii) are not made the stock options will be canceled and a cash payment will be required; and (iv) the total amount of forgiveness by creditor of approximately $110,000 shall be prorated according to amount paid. During the year ended December 31, 2021, the Company closed a financing round that exceeded the $3.0 million threshold and issued an unsecured promissory note in the amount of $97,052 to Mr. Wells. The note, for which monthly installment payments of $5,000 are due, matures 18 months after the issuance date and incurs interest at a rate of 6.0% per annum. During the three months ended March 31, 2022, the Company made payments of $35,000 to Mr. Wells, which resulted in forgiveness of $35,000 of the remaining balance of accrued compensation. The reduction in the outstanding balance met the criteria for troubled debt. The basic criteria are that the borrower is troubled, i.e., they are having financial difficulties, and a concession is granted by the creditor. As of March 31, 2022, the total amount owed to Mr. Wells (principal and accrued interest), was $65,299, which is included in “Current portion of long-term debt” on the consolidated balance sheet.

INCOME (LOSS) PER COMMON SHARE

INCOME (LOSS) PER COMMON SHARE	3 Months Ended
	Mar. 31, 2022
INCOME (LOSS) PER COMMON SHARE
INCOME (LOSS) PER COMMON SHARE	11. INCOME (LOSS) PER COMMON SHARE Basic net income (loss) per share attributable to common stockholders, amounts are computed by dividing the net income (loss) plus preferred stock dividends and deemed dividends on preferred stock by the weighted average number of shares outstanding during the year. Diluted net income (loss) per share attributable to common stockholders amounts are computed by dividing the net income (loss) plus preferred stock dividends, deemed dividends on preferred stock, after-tax interest on convertible debt and convertible dividends by the weighted average number of shares outstanding during the year, plus Series C, Series D, Series E, Series F and Series F-2 convertible preferred stock, Series G preferred stock, convertible debt, convertible preferred dividends and warrants convertible into common stock shares. The following table sets forth pertinent data relating to the computation of basic and diluted net loss per share attributable to common shareholders (in thousands, except for per-share data): March 31, 2022 2021 Net loss (1,055 ) (572 ) Basic weighted average number of shares outstanding 20,683 13,172 Net loss per share (basic) (0.05 ) (0.04 ) Diluted weighted average number of shares outstanding 20,683 13,172 Net loss per share (diluted) (0.05 ) (0.04 ) Dilutive equity instruments (number of equivalent units): Stock options 917 - Preferred stock 15,572 17,994 Convertible debt 2,018 315 Warrants 13,609 17,400 Total Dilutive instruments 32,116 35,709 For period of net loss, basic and diluted earnings per share are the same as the assumed exercise of warrants and the conversion of convertible debt are anti-dilutive. Troubled Debt Restructurings - 2022 During the three months ended March 31, 2022, two of the Company’s creditors forgave $41,232 of debt. The reductions in the outstanding balances met the criteria for troubled debt. The basic criteria are that the borrower is troubled, i.e., they are having financial difficulties, and a concession is granted by the creditor. As of March 31, 2022, the troubled debt restructurings in total would have decreased the net loss by $41,232, with no impact to net loss per share. Troubled Debt Restructurings - 2021 During the three months ended March 31, 2021, the Company restructured several debt agreements that met the criteria for troubled debt. The basic criteria are that the borrower is troubled, i.e., they are having financial difficulties, and a concession is granted by the creditor. As of March 31, 2022, the troubled debt restructurings in total would have decreased the net loss by $972,000, causing the per share calculation to change from .04 to .11 net loss per share.

SUBSEQUENT EVENTS

SUBSEQUENT EVENTS	3 Months Ended
	Mar. 31, 2022
SUBSEQUENT EVENTS
SUBSEQUENT EVENTS	12. SUBSEQUENT EVENTS Auctus Exchange Agreement On April 14, 2022, we entered into an agreement with Auctus that extended the April 15, 2022 deadline to May 15, 2022. See Footnote 9 – “ Short-Term Convertible Debt” Series D Exchange Agreements Subsequent to March 31, 2022, the Company entered into various agreements with Series D Preferred shareholders, pursuant to which each holder separately agreed to exchange their Series D Preferred shares into the Company’s common shares (in accordance with their existing Series D Preferred Share Agreements). In addition, the holders agreed to exchange 650,000 common stock warrants with a strike price of $0.25 for 650,000 warrants with a strike price of $0.20, which were required to be immediately exercised. The Company received $130,000 from the holders for exercises of the aforementioned warrants. Common Stock Issuances Subsequent to March 31, 2022, we issued 1,864,000 shares of common stock for the conversion of Series F-2 Preferred shares. Subsequent to March 31, 2022, we issued 1,360,000 shares of common stock for the conversion of Series F Preferred shares. Subsequent to March 31, 2022, we issued 320,000 shares of common stock for the conversion of Series E Preferred shares. Subsequent to March 31, 2022, we issued 650,000 shares of common stock for warrant exercises. Subsequent to March 31, 2022, we issued 975,000 shares of common stock for the conversion of Series D Preferred shares. Subsequent to March 31, 2022, we 22,829 shares of common stock for Series D Preferred dividends. Subsequent to March 31, 2022, we issued 43,470 shares of common stock for Series E Preferred dividends. Subsequent to March 31, 2022, we issued 16,987 shares of common stock for Series F Preferred dividends.

SIGNIFICANT ACCOUNTING POLICI_2

SIGNIFICANT ACCOUNTING POLICIES (Policies)	3 Months Ended
	Mar. 31, 2022
SIGNIFICANT ACCOUNTING POLICIES
Use of Estimates	The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. Significant areas where estimates are used include the allowance for doubtful accounts, inventory valuation and input variables for Black-Scholes, Monte Carlo simulations and binomial calculations. The Company uses the Monte Carlo simulations and binomial calculations in the calculation of the fair value of the warrant liabilities and the valuation of embedded conversion options and freestanding warrants.
Accounting Standards Update	A variety of proposed or otherwise potential accounting standards are currently under consideration by standard-setting organizations and certain regulatory agencies. Because of the tentative and preliminary nature of such proposed standards, management has not yet determined the effect, if any that the implementation of such proposed standards would have on the Company’s consolidated financial statements.
Cash Equivalents	The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be a cash equivalent.
Accounts Receivable	The Company performs periodic credit evaluations of its distributors’ financial conditions and generally does not require collateral. The Company reviews all outstanding accounts receivable for collectability on a quarterly basis. An allowance for doubtful accounts is recorded for any amounts deemed uncollectable. Uncollectibility is determined based on the determination that a distributor will not be able to make payment and the time frame has exceeded one year. The Company does not accrue interest receivables on past due accounts receivable.
Concentrations of Credit Risk	The Company, from time to time during the years covered by these consolidated financial statements, may have bank balances in excess of its insured limits. Management has deemed this a normal business risk.
Inventory Valuation	All inventories are stated at lower of cost or net realizable value, with cost determined substantially on a “first-in, first-out” basis. Selling, general, and administrative expenses are not inventoried, but are charged to expense when incurred. As of March 31, 2022 and December 31, 2021, our inventories were as follows: (in thousands) March 31, 2022 December 31, 2021 Raw materials $ 1,254 $ 1,255 Work-in-progress 69 69 Finished goods 32 32 Inventory reserve (785 ) (785 ) Total inventory $ 570 $ 571 The company periodically reviews the value of items in inventory and provides write-downs or write-offs of inventory based on its assessment of market conditions. Write-downs and write-offs are charged to cost of goods sold.
Property and Equipment	Property and equipment are recorded at cost. Depreciation is computed using the straight-line method over estimated useful lives of three to seven years. Leasehold improvements are amortized at the shorter of the useful life of the asset or the remaining lease term. Depreciation and amortization expense are included in general and administrative expense on the statement of operations. Expenditures for repairs and maintenance are expensed as incurred. Property and equipment are summarized as follows at March 31, 2022 and December 31, 2021: (in thousands) March 31, 2022 December 31, 2021 Equipment $ 1,049 $ 1,048 Software 652 652 Furniture and fixtures 41 41 Leasehold improvements 12 12 Construction in progress 21 8 Subtotal 1,775 1,761 Less accumulated depreciation (1,747 ) (1,747 ) Property, equipment and leasehold improvements, net $ 28 $ 14 Depreciation expense related to property and equipment for the three months ended March 31, 2022 and 2021 was not material.
Debt Issuance Costs	Debt issuance costs are capitalized and amortized over the term of the associated debt. Debt issuance costs are presented in the balance sheet as a direct deduction from the carrying amount of the debt liability consistent with the debt discount.
Patent Costs (Principally Legal Fees)	Costs incurred in filing, prosecuting, and maintaining patents are recurring, and expensed as incurred. Maintaining patents are expensed as incurred as the Company has not yet received U.S. FDA approval and recovery of these costs is uncertain. Such costs were not material for the three months ended March 31, 2022 and 2021.
Leases	A lease provides the lessee the right to control the use of an identified asset for a period of time in exchange for consideration. Right-of-use assets represent the Company’s right to use an underlying asset for the lease term and operating lease liabilities represent the Company’s obligation to make lease payments arising from the lease. The Company determines if an arrangement is a lease at inception. Right-of-use assets and lease liabilities are recognized at the lease commencement date based on the present value of lease payments over the lease term. Where an operating lease contains extension options that the Company is reasonably certain to exercise, the extension period is included in the calculation of the right-of-use assets and lease liabilities. The discount rate used to determine the commencement date present value of lease payments is the interest rate implicit in the lease, or when that is not readily determinable, the Company utilizes its secured borrowing rate. Right-of-use assets include any lease payments required to be made prior to commencement and exclude lease incentives. Both right-of-use assets and lease liabilities exclude variable payments not based on an index or rate, which are treated as period costs. The Company’s lease agreements do not contain significant residual value guarantees, restrictions or covenants. See Note 7 – Commitments and Contingencies.
Accrued Liabilities	Accrued liabilities as of March 31, 2022 and December 31, 2021 are summarized as follows: (in thousands) March 31, 2022 December 31, 2021 Compensation $ 573 $ 621 Professional fees 41 98 Stock Subscription Payable - 351 Interest 232 261 Vacation 42 39 Preferred dividends 299 349 Other accrued expenses 41 49 Total $ 1,228 $ 1,768
Stock Subscription Payable	Cash received from investors for common stock shares that have not yet been issued is recorded as a liability, which is presented within Accrued Liabilities on the consolidated balance sheet.
Revenue Recognition	ASC 606, Revenue from Contracts with Customers, establishes a single and comprehensive framework which sets out how much revenue is to be recognized, and when. The core principle is that a vendor should recognize revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the vendor expects to be entitled in exchange for those goods or services. Revenue will now be recognized by a vendor when control over the goods or services is transferred to the customer. In contrast, revenue-based revenue recognition around an analysis of the transfer of risks and rewards; this now forms one of a number of criteria that are assessed in determining whether control has been transferred. The application of the core principle in ASC 606 is carried out in five steps: · Step 1 – Identify the contract with a customer: a contract is defined as an agreement (including oral and implied), between two or more parties, that creates enforceable rights and obligations and sets out the criteria for each of those rights and obligations. The contract needs to have commercial substance and it is probable that the entity will collect the consideration to which it will be entitled. · Step 2 – Identify the performance obligations in the contract: a performance obligation in a contract is a promise (including implicit) to transfer a good or service to the customer. Each performance obligation should be capable of being distinct and is separately identifiable in the contract. · Step 3 – Determine the transaction price: transaction price is the amount of consideration that the entity can be entitled to, in exchange for transferring the promised goods and services to a customer, excluding amounts collected on behalf of third parties. · Step 4 – Allocate the transaction price to the performance obligations in the contract: for a contract that has more than one performance obligation, the entity will allocate the transaction price to each performance obligation separately, in exchange for satisfying each performance obligation. The acceptable methods of allocating the transaction price include adjusted market assessment approach, expected cost plus a margin approach, and the residual approach in limited circumstances. Discounts given should be allocated proportionately to all performance obligations unless certain criteria are met and reallocation of changes in standalone selling prices after inception is not permitted. · Step 5 – Recognize revenue as and when the entity satisfies a performance obligation: the entity should recognize revenue at a point in time, except if it meets any of the three criteria, which will require recognition of revenue over time: the entity’s performance creates or enhances an asset controlled by the customer, the customer simultaneously receives and consumes the benefit of the entity’s performance as the entity performs, and the entity does not create an asset that has an alternative use to the entity and the entity has the right to be paid for performance to date. The Company did not recognize material revenues during the three-month periods ended March 31, 2022 or 2021. The Company’s revenues do not require significant estimates or judgments. The Company is not party to contracts that include multiple performance obligations or material variable consideration. Contract Balances The Company defers payments received as revenue until earned based on the related contracts and applying ASC 606 as required. As of March 31, 2022 and December 31, 2021, the Company had $514,000 and $337,000 in deferred revenue, respectively.
Significant Distributors	As of March 31, 2022, accounts receivable outstanding was $165,000, the outstanding amount was netted against a $126,000 allowance, leaving a balance of $39,000 which was from two distributors. As of December 31, 2021, accounts receivable outstanding was $172,000; the outstanding amount was netted against a $126,000 allowance, leaving a balance of $46,000, which was from two distributors.
Research and Development	Research and development expenses consist of expenditures for research conducted by the Company and payments made under contracts with consultants or other outside parties and costs associated with internal and contracted clinical trials. All research and development costs are expensed as incurred.
Income Taxes	The provision for income taxes is determined in accordance with ASC 740, “ Income Taxes The Company has filed its 2021 federal and state corporate tax returns. The Company has entered into an agreed upon payment plan with the IRS for delinquent payroll taxes. The Company has an established payment arrangement for its delinquent state income taxes with the State of Georgia. Although the Company has been experiencing recurring losses, it is obligated to file tax returns for compliance with IRS regulations and that of applicable state jurisdictions. At March 31, 2022, the Company had approximately $61.6 million of net operating losses carryforward available. This net operating loss will be eligible to be carried forward for tax purposes at federal and applicable states level. A full valuation allowance has been recorded related the deferred tax assets generated from the net operating losses. The Company recognizes uncertain tax positions based on a benefit recognition model. Provided that the tax position is deemed more likely than not of being sustained, the Company recognizes the largest amount of tax benefit that is greater than 50.0% likely of being ultimately realized upon settlement. The tax position is derecognized when it is no longer more likely than not of being sustained. The Company classifies income tax related interest and penalties as interest expense and selling, general and administrative expense, respectively, on the consolidated statements of operations.
Warrants	The Company has issued warrants, which allow the warrant holder to purchase one share of stock at a specified price for a specified period of time. The Company records equity instruments including warrants based on the fair value at the date of issue. The fair value of warrants classified as equity instruments at the date of issuance is estimated using the Black-Scholes Model. The fair value of warrants classified as liabilities at the date of issuance is estimated using the Monte Carlo Simulation or Binomial model.
Stock Based Compensation	The Company accounts for its stock-based awards in accordance with ASC Subtopic 718, “ Compensation – Stock Compensation The Black-Scholes option pricing model requires the input of certain assumptions that require the Company’s judgment, including the expected term and the expected stock price volatility of the underlying stock. The assumptions used in calculating the fair value of stock-based compensation represent management’s best estimates, but these estimates involve inherent uncertainties and the application of judgment. As a result, if factors change resulting in the use of different assumptions, stock-based compensation expense could be materially different in the future.
Derivatives	The Company reviews the terms of convertible debt issued to determine whether there are embedded derivative instruments, including embedded conversion options, which are required to be bifurcated and accounted for separately as derivative financial instruments. In circumstances where the host instrument contains more than one embedded derivative instrument, including the conversion option, that is required to be bifurcated, the bifurcated derivative instruments are accounted for as a single, compound derivative instrument. Bifurcated embedded derivatives are initially recorded at fair value and are then revalued at each reporting date with changes in the fair value reported as non-operating income or expense. When the equity or convertible debt instruments contain embedded derivative instruments that are to be bifurcated and accounted for as liabilities, the total proceeds received are first allocated to the fair value of all the bifurcated derivative instruments. The remaining proceeds, if any, are then allocated to the host instruments themselves, usually resulting in those instruments being recorded at a discount from their face value. The discount from the face value of the convertible debt, together with the stated interest on the instrument, is amortized over the life of the instrument through periodic charges to interest expense.

SIGNIFICANT ACCOUNTING POLICI_3

SIGNIFICANT ACCOUNTING POLICIES (Tables)	3 Months Ended
	Mar. 31, 2022
SIGNIFICANT ACCOUNTING POLICIES
Inventory valuation	(in thousands) March 31, 2022 December 31, 2021 Raw materials $ 1,254 $ 1,255 Work-in-progress 69 69 Finished goods 32 32 Inventory reserve (785 ) (785 ) Total inventory $ 570 $ 571
Property and equipment	(in thousands) March 31, 2022 December 31, 2021 Equipment $ 1,049 $ 1,048 Software 652 652 Furniture and fixtures 41 41 Leasehold improvements 12 12 Construction in progress 21 8 Subtotal 1,775 1,761 Less accumulated depreciation (1,747 ) (1,747 ) Property, equipment and leasehold improvements, net $ 28 $ 14
Accrued liabilities	(in thousands) March 31, 2022 December 31, 2021 Compensation $ 573 $ 621 Professional fees 41 98 Stock Subscription Payable - 351 Interest 232 261 Vacation 42 39 Preferred dividends 299 349 Other accrued expenses 41 49 Total $ 1,228 $ 1,768

FAIR VALUE OF FINANCIAL INSTR_2

FAIR VALUE OF FINANCIAL INSTRUMENTS (Tables)	3 Months Ended
	Mar. 31, 2022
FAIR VALUE OF FINANCIAL INSTRUMENTS
Schedule of fair value for liabilities measured on a recurring basis	Fair Value at March 31, 2022 (in thousands) Level 1 Level 2 Level 3 Total Derivative liability/bifurcated conversion option in connection with Auctus $400,000 loan on December 17, 2019 $ - $ - $ (38 ) $ (38 ) Total short-term liabilities at fair value $ - $ - $ (38 ) $ (38 ) Fair Value at December 31, 2021 (in thousands) Level 1 Level 2 Level 3 Total Derivative liability/bifurcated conversion option in connection with Auctus $400,000 loan on December 17, 2019 - - (32 ) (32 ) Total long-term liabilities at fair value $ - $ - $ (32 ) $ (32 )
Summary of changes to Level 3 instruments	(in thousands) Senior Secured Debt Derivative Total Balance, December 31, 2021 $ - $ (32 ) $ (32 ) Change in fair value during the period - (6 ) (6 ) Balance, March 31, 2022 $ - $ (38 ) $ (38 )

STOCKHOLDERS DEFICIT (Tables)

STOCKHOLDERS DEFICIT (Tables)	3 Months Ended
	Mar. 31, 2022
STOCKHOLDERS' DEFICIT:
Common stock issued	Number of Shares Common stock warrants exercised 4,477,923 Issuance of common stock for payment of Series D preferred dividends 23,109 Issuance of common stock for payment of Series E preferred dividends 12,432 Issuance of common stock for payment of Series F preferred dividends 158,662 Issuance of common stock for payment of Series F-2 preferred dividends 95,535 Issuance of common stock for payment of interest 121,262 Issuance of common stock for Series F one-time 15% dividend 255,401 Issuance of common stock for Series F-2 one-time 15% dividend 368,505 Conversion of Series E preferred stock to common stock 3,070,000 Conversion of Series F preferred stock to common stock 60,000 Issued during the three months ended March 31, 2022 8,642,829 Summary table of common stock share transactions: Balance at December 31, 2021 13,673,583 Issued in 2022 8,642,829 Balance at March 31, 2022 22,316,412
Outstanding warrants to purchase common stock	Warrants (Underlying Shares) Weighted-Average Exercise Price Per Share Outstanding, December 31, 2021 27,669,634 $ 0.29 Warrants exercised (2,284,324 ) $ 0.16 Outstanding, March 31, 2022 25,385,310 $ 0.30

COMMITMENTS AND CONTINGENCIES (

COMMITMENTS AND CONTINGENCIES (Tables)	3 Months Ended
	Mar. 31, 2022
COMMITMENTS AND CONTINGENCIES
Operating lease right-of-use assets and lease liabilities	(in thousands) Three Months Ended March 31, 2022 Operating lease right-of-use assets $ 355 Operating lease liabilities $ 377 (in thousands) Operating Leases 2022 (remaining) $ 82 2023 112 2024 115 2025 118 2026 50 Total future lease payments 477 Less: discount (100 ) Total lease liabilities $ 377
Weighted-average remaining lease term and discount rate used in the calculation of operating lease right-of-use assets and lease liabilities	Three Months Ended March 31, 2022 Weighted average remaining lease term (years) 4.2 Weighted average discount rate 11.4 %

STOCK OPTIONS (Tables)

STOCK OPTIONS (Tables)	3 Months Ended
	Mar. 31, 2022
STOCK OPTIONS
Stock option activity	Number of Shares Weighted-Average Exercise Price Per Share Weighted-Average Remaining Contractual Life Aggregate Intrinsic Value of In-the-Money Options (in thousands) Options outstanding as of March 31, 2022 1,500,000 $ 0.49 8.3 years $ 240 Options exercisable as of March 31, 2022 1,045,227 $ 0.49 8.3 years $ 167
Stock options vested, unvested and granted	March 31, 2021 Expected term (years) 10 years Volatility 153.12 % Risk-free interest rate 0.98 % Dividend yield 0.00 %

NOTES PAYABLE (Tables)

NOTES PAYABLE (Tables)	3 Months Ended
	Mar. 31, 2022
NOTES PAYABLE
Short-term notes payable, including related parties	Short-term notes payable, including related parties March 31, 2022 December 31, 2021 Dr. Cartwright $ 31 $ 34 Mr. Fowler - 6 Premium Finance (insurance) 12 48 Short-term notes payable $ 43 $ 88

SHORT-TERM CONVERTIBLE DEBT (Ta

SHORT-TERM CONVERTIBLE DEBT (Tables)	3 Months Ended
	Mar. 31, 2022
SHORT-TERM CONVERTIBLE DEBT
Schedule of short-term convertible notes payable	March 31, 2022 December 31, 2021 Auctus Tranche 2 $ 400 $ 400 Auctus prepayment penalty 350 350 Auctus (March 31, 2020 Note) 161 161 Debt discount and issuance costs to be amortizaed (5 ) (14 ) Convertible notes payable - short-term $ 906 $ 897

LONG TERM DEBT (Tables)

LONG TERM DEBT (Tables)	3 Months Ended
	Mar. 31, 2022
LONG TERM DEBT
Long-term debt, related parties	For Dr. Faupel: Salary $ 134 Bonus 20 Vacation 95 Interest on compensation 67 Loans to Company 196 Interest on loans 149 Total outstanding prior to exchange 661 Amount forgiven in prior years (454 ) Amount exchanged for Series F-2 Preferred Stock (85 ) Total interest accrued through December 31, 2021 39 Balance outstanding at December 31, 2021 $ 161 Interest accrued through March 31, 2022 2 Balance outstanding at March 31, 2022 $ 163 For Dr.Cartwright Salary $ 337 Bonus 675 Loans to Company 528 Interest on loans 81 Total outstanding prior to exchange 1,621 Amount forgiven in prior years (1,302 ) Amount exchanged for Series F-2 Preferred Stock (100 ) Total interest accrued through December 31, 2021 62 Balance outstanding at December 31, 2021 $ 281 Interest accrued through March 31, 2022 4 Balance outstanding at March 31, 2022 $ 285
Long-term debt, related parties debt obligations	Year Amount 2022 $ 27 2023 485 2024 39 2025 41 2026 3 Thereafter - Total $ 595
Bond payable discount and unamortized debt issuance costs	March 31, 2022 December 31, 2021 10% Senior Unsecured Convertible Debentures $ 1,130 $ 1,130 Debt Issuance costs to be amortized (62 ) (69 ) Debt Discount (216 ) (241 ) Long-term convertible debt $ 852 $ 820

INCOME (LOSS) PER COMMON SHARE

INCOME (LOSS) PER COMMON SHARE (Tables)	3 Months Ended
	Mar. 31, 2022
INCOME (LOSS) PER COMMON SHARE
Earnings per share	March 31, 2022 2021 Net loss (1,055 ) (572 ) Basic weighted average number of shares outstanding 20,683 13,172 Net loss per share (basic) (0.05 ) (0.04 ) Diluted weighted average number of shares outstanding 20,683 13,172 Net loss per share (diluted) (0.05 ) (0.04 ) Dilutive equity instruments (number of equivalent units): Stock options 917 - Preferred stock 15,572 17,994 Convertible debt 2,018 315 Warrants 13,609 17,400 Total Dilutive instruments 32,116 35,709

ORGANIZATION BACKGROUND AND B_2

ORGANIZATION BACKGROUND AND BASIS OF PRESENTATION (Details Narrative) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Decrease in authorized common share			500,000,000
Accumulated deficit	$ (143,400)
Total stockholders' deficits	(5,000)
Working capital	(3,700)
Net loss including preferred dividend	1,100
Proceeds from exercise of warrants	400
Proceeds from exercise of warrants	$ 365	$ 0
Warrants [Member] | Minimum
Warrants exercise price per share	$ 0.15
Warrants [Member] | Maximum
Warrants exercise price per share	$ 0.80
Warrants [Member] | Exchange Agreement With GPB [Member]
Warrants exercisable for common stock outstanding	25,400,000
Proceeds from exercise of warrants	$ 4,700

SIGNIFICANT ACCOUNTING POLICI_4

SIGNIFICANT ACCOUNTING POLICIES (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
SIGNIFICANT ACCOUNTING POLICIES
Raw materials	$ 1,254	$ 1,255
Work in process	69	69
Finished goods	32	32
Inventory reserve	(785)	(785)
Total	$ 570	$ 571

SIGNIFICANT ACCOUNTING POLICI_5

SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Property and equipment, gross	$ 1,775	$ 1,761
Less accumulated depreciation and amortization	(1,747)	(1,747)
Property and equipment, net	28	14
Furniture and Fixtures
Property and equipment, gross	41	41
Construction in Progress [Member]
Property and equipment, gross	21	8
Equipment
Property and equipment, gross	1,049	1,048
Software
Property and equipment, gross	652	652
Leasehold Improvement
Property and equipment, gross	$ 12	$ 12

SIGNIFICANT ACCOUNTING POLICI_6

SIGNIFICANT ACCOUNTING POLICIES (Details 2) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
SIGNIFICANT ACCOUNTING POLICIES
Compensation	$ 573,000	$ 621,000
Professional fees	41,000	98,000
Stock Subscription Payable	0	351,000
Interest	232,000	261,000
Vacation	42,000	39,000
Preferred dividends	299,000	349,000
Other accrued expenses	41,000	49,000
Total	$ 1,228,000	$ 1,768,000

SIGNIFICANT ACCOUNTING POLICI_7

SIGNIFICANT ACCOUNTING POLICIES (Details Narrative) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
SIGNIFICANT ACCOUNTING POLICIES
Accounts receivable outstanding	$ 165,000,000	$ 172,000,000
Outstanding amount balance	39,000	46,000
Accounts receivable, net of allowance	126,000,000	126,000,000
Deferred revenue	514,000,000	$ 337,000,000
Net operating loss carry forward	$ 61,600,000

FAIR VALUE OF FINANCIAL INSTR_3

FAIR VALUE OF FINANCIAL INSTRUMENTS (Details) - USD ($) $ in Thousands	Sep. 30, 2021	Dec. 31, 2020
Derivative liability	$ 38	$ 32
Auctus Loan
Derivative liability	38	32
Level 1
Derivative liability	0
Level 1 | Auctus Loan
Derivative liability	0
Level 2
Derivative liability	0
Level 2 | Auctus Loan
Derivative liability	0
Level 3
Derivative liability	38	32
Level 3 | Auctus Loan
Derivative liability	$ 38	$ 32

FAIR VALUE OF FINANCIAL INSTR_4

FAIR VALUE OF FINANCIAL INSTRUMENTS (Details 1) - Level 3 $ in Thousands	3 Months Ended
	Mar. 31, 2022USD ($)
Beginning Balance, Warrants	$ (32)
Change in fair value during the year	(6)
Ending Balance, Warrants	(38)
Senior Secured Debt
Beginning Balance, Warrants	0
Change in fair value during the year	0
Ending Balance, Warrants	0
Derivative
Beginning Balance, Warrants	(32)
Change in fair value during the year	(6)
Ending Balance, Warrants	$ (38)

FAIR VALUE OF FINANCIAL INSTR_5

FAIR VALUE OF FINANCIAL INSTRUMENTS (Details Narrative)	Mar. 31, 2022USD ($)
FAIR VALUE OF FINANCIAL INSTRUMENTS
Derivative liability	$ 400,000

STOCKHOLDERS DEFICIT (Details)

STOCKHOLDERS DEFICIT (Details) - shares	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2020
STOCKHOLDERS' DEFICIT:
Common stock warrants exercised	4,477,923
Issuance of common stock for payment of Series D preferred dividends	23,109
Issuance of common stock for payment of Series E preferred dividends	12,432
Issuance of common stock for payment of Series F-2 preferred dividends	95,535
Issuance of common stock for payment of interest	121,262
Issuance of common stock for Series F one-time 15% dividend	255,401
Issuance of common stock for Series F-2 one-time 15% dividend	368,505
Conversion of Series E preferred stock to common stock	3,070,000
Conversion of Series F Preferred shares into common stock	60,000
Issued during the three months ended March 31, 2022	8,642,829
Share issued	8,642,829
Outstanding	22,316,412	13,673,583

STOCKHOLDERS DEFICIT (Details 1

STOCKHOLDERS DEFICIT (Details 1)	3 Months Ended
	Mar. 31, 2022$ / sharesshares
STOCKHOLDERS' DEFICIT:
Warrants outstanding, beginning | shares	27,669,634
Warrants exercised | shares	(2,284,324)
Warrants outstanding, ending | shares	25,385,310
Weighted Average Exercise Price Per Share, beginning | $ / shares	$ 0.29
Weighted Average Exercise Price Per Share, Warrants exercised | $ / shares	0.16
Weighted Average Exercise Price Per Share, ending | $ / shares	$ 0.30

STOCKHOLDERS DEFICIT (Details N

STOCKHOLDERS DEFICIT (Details Narrative) - USD ($)	Jul. 08, 2021	Aug. 02, 2018	Feb. 28, 2021	Jan. 31, 2021	Mar. 31, 2022	Dec. 31, 2021
Common stock, shares authorized					500,000,000
Common stock shares issued					22,316,412	13,673,583
Common stock shares outstanding					22,316,412	13,673,583
Common stock, par value					$ 0.001	$ 0.001
Common Stock issued					8,642,829
Preferred stock shares surrendered					3,262
Preferred stock shares converts into common stock					60,000
Common stock warrants					650,000
Series C1 Convertible Preferred Shares
Shares exchange					3,262
Conversion price per share					$ 0.50
Preferred stock shares converts into common stock					2,000
Total convertible of common stock shares					2,098,500
Preferred stock shares designated					20,250
Preferred stock shares issued					1,049	1,049
Preferred stock shares outstanding					1,049
Series C2 Convertible Preferred Shares
Preferred stock shares surrendered					3,262
Shares exchange					3,262
Conversion price per share					$ 0.50
Preferred stock shares converts into common stock					2,000
Total convertible of common stock shares					6,524,500
Dividing the stated value					$ 10,000
Series C Convertible Preferred Shares
Conversion price per share					$ 0.50
Preferred stock shares converts into common stock					200
Total convertible of common stock shares		6,524,500			572,000
Preferred stock shares designated					9,000
Liquidation preference						$ 1,000
Series F-2 Convertible Preferred Shares
Conversion price per share					$ 0.25
Preferred stock shares converts into common stock					4,000
Preferred stock shares designated					3,500
Preferred stock shares issued					3,200	3,200
Preferred stock shares outstanding					3,200	3,200
Liquidation preference					$ 3,237
Increased beneficial ownership percentage					9.99
Common Stock primary trading shares exceed					1,000
Exceeds percentage					200.00%
Preferred stock shares par value					$ 0.001	$ 0.001
Conversion beneficial ownership limitation					4.99%
Maturity period					5 years
Accrued dividend amount					$ 91,592
Issuance of common stock for payment pf annual series					95,535
Additional stock issued during period for payment of non recurring dividend					368,505
Preferred stock shares received					678,000
Preferred stock, liquidation preference					$ 3,237,000	$ 3,237,000
Preferred stock shares authorized					5,000	5,000
Series G Convertible Preferred Shares
Preferred stock shares issued					0	0
Preferred stock shares outstanding					0	0
Preferred stock shares par value					$ 0.001	$ 0.001
Preferred stock, liquidation preference					$ 0	$ 0
Investment net					$ 114,597
Preferred stock redeemed					91,000
Preferred stock shares authorized					1,000,000	1,000,000
Series G Convertible Preferred Shares | Power Up Lending Group Ltd [Member]
Total investment amount					$ 75,000
Investment net				$ 78,500	$ 53,500
Preferred stock redeemed					925,000
Additional Series G preferred stock shares, amount				$ 75,000
Additional tranches of financing					$ 925,000
Discount rate					19.00%
Discounted rate			19.00%
Redemption of february 2021 investment, amount	$ 78,094
Difference of interest expense	$ 28,094				$ 39,597
Conversion beneficial ownership limitation			4.99%	4.99%
Increased election holders			9.99%	9.99%
Cumulative dividends rate			8.00%	8.00%
Corresponding percentage Description			Day 1-60, 105%; Day 61-90, 110%; Day 91-120, 115%; and Day 121-180, 122%	Day 1-60, 105%; Day 61-90, 110%; Day 91-120, 115%; and Day 121-180, 122%
Net proceeds					125,000
Outstanding amount					$ 50,000
Series D Preferred Shares
Shares exchange						23,109
Conversion price per share					$ 0.25
Preferred stock shares converts into common stock					763
Preferred stock shares designated					6,000
Preferred stock shares issued					763
Common stock, issued public shares					1,526,000
Liquidation preference					$ 763
Beneficial ownership percentage					4.99
Increased beneficial ownership percentage					9.99
Shares outstanding					763
Common stock warrants 1					1,526,000
Warrant exercise price per share					0.25
Common stock warrants					1,526,000
Common stock warrants exercise price 1					$ 0.75
Conversion of investor shares					763
Preferred stock dividends accrued					$ 14,306
Common Stock primary trading shares exceed					1,000
Exceeds percentage					200.00%
Series E Preferred Shares
Conversion price per share					$ 0.25
Preferred stock shares designated					5,000
Liquidation preference					$ 768	$ 1,736
Common Stock primary trading shares exceed					1,000
Exceeds percentage					200.00%
Preferred stock shares par value					$ 0.001
Conversion beneficial ownership limitation					4.99%
Preferred stock stated value					$ 1,000
Common stock shares issued for preferred stock dividends					12,432
Accrued dividends					$ 71,099
Issuance of common stock for conversion of Series E Convertible Preferred Stock					3,070,000
Increased election holder					9.99%
Maturity period					5 years
Series F Preferred Shares
Conversion price per share					$ 0.25
Preferred stock shares converts into common stock					4,000
Preferred stock shares designated					1,500
Preferred stock shares issued					1,411	1,426
Liquidation preference					$ 1,411
Common Stock primary trading shares exceed					1,000
Exceeds percentage					200.00%
Conversion beneficial ownership limitation					4.99%
Increased election holder					9.99%
Maturity period					5 years
Preferred stock shares outstanding					1,436
Number of shares converted into common stock					15
Shares converted into common stock					60,000
Accrued dividend amount					$ 1,998
Cumulative dividend rate					6.00%
Issuance of common stock for payment pf annual series					158,662
Additional stock issued during period for payment of non recurring dividend					255,401
Accredited investors					$ 1,436,000
Preferred Stock [Member]
Preferred stock shares par value					$ 0.001
Preferred stock shares authorized					500,000,000

STOCK OPTIONS (Details)

STOCK OPTIONS (Details)	3 Months Ended
	Mar. 31, 2022USD ($)$ / sharesshares
STOCK OPTIONS
Outstanding at ending of year | shares	1,500,000
Number of shares exercisable | shares	1,045,227
Options outstanding weighted average exercise price, ending | $ / shares	$ 0.49
Options exercisable weighted average exercise price | $ / shares	$ 0.49
Weighted average remaining contractual life outstanding	8 years 3 months 18 days
Weighted average remaining contractual life exercisable	8 years 3 months 18 days
Agrregate intrensic value outstanding | $	$ 240
Agrregate intrensic value exercisable | $	$ 167

STOCK OPTIONS (Details 1)

STOCK OPTIONS (Details 1)	3 Months Ended
	Mar. 31, 2021
STOCK OPTIONS
Expected term (years)	10 years
Volatility	153.12%
Risk-free interest rate	0.98%
Dividend yield	0.00%

STOCK OPTION (Details Narrative

STOCK OPTION (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
STOCK OPTIONS
Weighted average period	1 year 3 months
Unrecognized stock-based compensation expense	$ 219,558
Weighted-average fair value of awards granted	$ 0	$ 0.47
Stock options granted outstanding common stock shares percentage	10.00%
Options granted expiration term	ten years
Options granted exercisable term	four years

COMMITMENTS AND CONTINGENCIES_2

COMMITMENTS AND CONTINGENCIES (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
COMMITMENTS AND CONTINGENCIES
Operating lease right-of-use assets	$ 355,000	$ 372,000
Total lease liabilities	$ 377

COMMITMENTS AND CONTINGENCIES_3

COMMITMENTS AND CONTINGENCIES (Details 1) $ in Thousands	Mar. 31, 2022USD ($)
COMMITMENTS AND CONTINGENCIES
2022 (remaining)	$ 82
2023	112
2024	115
2025	118
2026	50
Total future lease payments	477
Less: discount	(100)
Total lease liabilities	$ 377

COMMITMENTS AND CONTINGENCIES_4

COMMITMENTS AND CONTINGENCIES (Details 2)	3 Months Ended
	Mar. 31, 2022
COMMITMENTS AND CONTINGENCIES
Weighted average remaining lease term (years)	4 years 2 months 12 days
Weighted average discount rate	11.40%

COMMITMENTS AND CONTINGENCIES_5

COMMITMENTS AND CONTINGENCIES (Details Narrative) - USD ($)	Mar. 10, 2021	Sep. 06, 2016	Jun. 05, 2016	Jan. 22, 2022	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2020	Jan. 22, 2020	Jul. 24, 2019
Escrow agent rate per share									$ 1.90
Consideration received									$ 885,144
Financing agreement amount					$ 1,000,000
Royalty percent			20
Licences			$ 1,000,000
Warrants								5,000,000
Warrants broken into four tranches								1,250,000
Strike price								$ 0.25
Sales			$ 4,000,000
Shenghuo Medical, LLC [Member]
Payment receive descriptions			the right to receive payments equal to 2% of the Company’s future sales in the United States, up to an aggregate of $4.0 million
Shandong Yaohua Medical Instrument Corporation [Member]
Balance due for outstanding purchase order					23,445
Shares exchange							12,147		12,147
Consulting Agreement [Member] | Mr. Blumberg
Terms of amendment to agreement	the consulting agreement was amended to clarify that $350,000 is not intended to be debt and will not be required to be repaid in cash. Additionally, issuance of the warrants is now predicated on the Company receiving funding receipts of $1,000,000
Related party liability written off						$ 350,000
Gain on writing off the liability	$ 350,000
Description of exchange of subscription	on September 26, 2021, 900,000 3-year warrants with an exercise price of $0.30 and 400,000 common stock shares; (2) on March 26, 2022, 900,000 3-year warrants with an exercise price of $0.40 and 400,000 common stock shares; (3) on September 26, 2022, 900,000 3-year warrants with an exercise price of $0.50 and 400,000 common stock shares; and (4) on March 26, 2023, 900,000 3-year warrants with an exercise price of $0.60 and 400,000 common stock shares
Subscription receivable	$ 350,000
Promotional Agreement [Member]
Consulting expenses					79,444
Fair vaue of warrants				$ 715,000
Unrecognized consulting expense					$ 0
Royalty Agreement [Member]
Royalty paid description		royalty initially equal to $0.10, and from and after October 2, 2016, equal to $0.20, for each disposable
Royalty consideration		$ 50,000

NOTES PAYABLE (Details)

NOTES PAYABLE (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2020
Notes payable in default, including related parties	$ 43	$ 88
Dr. Cartwright
Notes payable in default, including related parties	31	34
Mr. Fowler
Notes payable in default, including related parties	0	6
Premium Finance insurance
Notes payable in default, including related parties	$ 12	$ 48

NOTES PAYABLE (Details Narrativ

NOTES PAYABLE (Details Narrative) - USD ($)	Jul. 04, 2021	Mar. 31, 2022	Dec. 31, 2021	Dec. 31, 2019	Jan. 19, 2017	Dec. 21, 2016
Short-term notes payable		$ 43,253	$ 87,615
Annual interest rate description		The notes carry annual interest rates between 4.3% and 16%, or 18% in the event of default
Outstanding principal balance		$ 39,000	46,000
Accrued interest		1,228,000	1,768,000
Premium Finance Agreement [Member]
Line of credit, balance		11,968
Monthly payment of insurance	$ 11,968
Line of credit facility, maximum borrowing capacity	$ 117,560
Interest and maturity date description	interest at 4.3% and matured in April 2022
Dr. Cartwright
Annual interest rate description				The note was initially issued with 0% interest, however interest increased to 6.0% interest
Promissory notes issued			100	$ 45,829
Financing proceeds received by company				$ 1,000,000
Line of credit, balance		31,285
Outstanding principal balance			$ 1,621,000
Mr. Fowler
Annual interest rate description				The notes were initially issued with 0% interest and then went into default with an interest rate of 18%
Outstanding principal balance		146,400			$ 13,900	$ 12,500
Mr. Fowler | March 22, 2021 exchange agreement [Member]
Accrued interest		18,718
Monthly payment of insurance		3,850
Short term promissory note		45,118
Short term promissory note, principal		26,400
Mr. Fowler | Long-Term Debt - Related Parties
Outstanding principal balance		$ 26,400

SHORTTERM CONVERTIBLE DEBT (Det

SHORTTERM CONVERTIBLE DEBT (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Convertible notes payable	$ 161,000	$ 161,000
Total Convertible Notes Payable
Convertible notes payable	906,000		$ 897,000
Auctus
Convertible notes payable	161,000		161,000
Debt Discount and Issuance Costs to be Amortized
Convertible notes payable	5		14
Auctus Tranche 2 [Member]
Convertible notes payable	400,000		400,000
Auctus Prepayment Penalty [Member]
Convertible notes payable	$ 350,000		$ 350,000

SHORTTERM CONVERTIBLE DEBT (D_2

SHORTTERM CONVERTIBLE DEBT (Details Narrative) - USD ($)	1 Months Ended				3 Months Ended
	Jun. 30, 2021	May 27, 2020	Mar. 31, 2020	Dec. 17, 2019	Mar. 31, 2022	Dec. 31, 2021	Jan. 22, 2020	Dec. 31, 2019
Accrued interest					$ 74,778	$ 64,778
Outstanding remaining principal amount					400,000	400,000
Fair value of derivative liability					38,129	31,889
Unamortized debt issuance costs					5,211	13,586
Warrants issued							5,000,000
Proceeds from warrant issued					400,000
Troubled Debt Restructuring [Member]
Prepayment penalty					350,000
Second Tranche [Member]
Total Convertible note issued		$ 2,400,000
Convertible note received		400,000
Net payment amount		$ 313,000
Interest rate of lessor		24.00%
Description of variable conversion prices		The variable conversion price shall mean 95% multiplied by the market price (the market price means the average of the five lowest trading prices during the period beginning on the issue date and ending on the maturity date), minus $0.04 per share, provided however that in no event shall the variable conversion price be less than $0.15. If an event of default under this note occurs and/or the note is not extinguished in its entirety prior to December 17, 2020 the $0.15 price shall no longer apply. The last tranche of $1.3 million will be received within 60 days of the S-1 registration statement becoming effective. The conversion price of the notes will be at market value with a minimum conversion amount of $0.15. In addition, as part of this transaction the Company was required to pay a 2.0% fee to a registered broker-dealer
Rate of interest		10.00%
Note maturity date		May 27, 2022
First Tranche [Member]
Convertible note received				$ 700,000
Interest rate of lessor				24.00%
Description of variable conversion prices				The variable conversion price was 95% multiplied by the market price (the market price means the average of the five lowest trading prices during the period beginning on the issue date and ending on the maturity date), minus $0.04 per share, provided however that in no event could the variable conversion price be less than $0.15. If an event of default under this note occurred and/or the note was not extinguished in its entirety prior to December 17, 2020 the $0.15 price floor no longer applied
Rate of interest				10.00%
Fair value of warrants				$ 745,972
Warrants issued								7,500,000
Warrant liability				$ 635,000
Exercise price				$ 0.20
Proceeds from warrant issued				$ 635,000
Debt issuance cost				65,000
Administrative and legal expenses				570,000
Payment to convertible promissory note				89,250
Prepayment penalty	$ 700,000			$ 350,000	350,000			$ 700,000
unamortized debt discount on warrants, balance					350,000
Matured date				Dec. 17, 2021
Auctus Fund, LLC [Member]
Accrued interest					46,099	36,428
Outstanding remaining principal amount					161,184	$ 161,184
Total Convertible note issued				$ 2,400,000
Exchange of aggregate outstanding notes					668,290
Unregistered units of our common stock					1,681,707
Default penalty					$ 48,434
Notes issued	250,000
Net proceeds	$ 100,000
Exercise price	$ 0.16
Accrues interest rate	12.00%
Description of conversion price			the lesser of: (i) the lowest Trading Price during the twenty-five (25) trading day period on the last trading prior to the issue date and (ii) the variable conversion price (55% multiplied by the market price, market price means the lowest trading price for the common stock during the twenty-five (25) trading day period ending on the latest complete trading day prior to the conversion date. Trading price is the lowest trade price on the trading market as reported. The note includes customary events of default provisions and a default interest rate of 24% per year		The exchange price will be on a $1 for $1 basis
Aggregate principal amount			$ 112,750
Convertible promissory note			12.00%

LONG TERM DEBT (Details)

LONG TERM DEBT (Details) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2021	Dec. 31, 2019
Bonus	$ 573,000	$ 621,000
Vacation	42,000	39,000
Total outstanding prior to exchange	39,000	46,000
Amount forgiven in prior years	41,232
Dr. Cartwright
Salary		337,000
Bonus		675,000
Loans to Company		528,000
Interest on loans		81,000
Total outstanding prior to exchange		1,621,000
Amount forgiven in prior years		1,302,000
Amount exchanged for Series F-2 Preferred Stock		100	$ 45,829
Total interest accrued through December 31, 2021		62,000
Interest accrued through March 31, 2022	4
Balance outstanding, end of period	285,000	281,000
Dr. Faupel
Salary		134,000
Bonus		20,000
Vacation		95,000
Interest on compensation		67,000
Loans to Company		196,000
Interest on loans		149,000
Total outstanding prior to exchange		661,000
Amount forgiven in prior years		454,000
Amount exchanged for Series F-2 Preferred Stock		85
Total interest accrued through December 31, 2021		39,000
Interest accrued through March 31, 2022	2
Balance outstanding, end of period	$ 163,000	$ 161,000

LONG TERM DEBT (Details 1)

LONG TERM DEBT (Details 1) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Total	$ 0	$ 22
Long-Term Debt - Related Parties | Mr. Fowler
2022	27
2023	485
2024	39
2025	41
2026	3
Thereafter	0
Total	$ 595

LONG TERM DEBT (Details 2)

LONG TERM DEBT (Details 2) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
LONG TERM DEBT
10% Senior Unsecured Convertible Debentures	$ 1,130	$ 1,130
Debt Issuance costs to be amortized	(62)	(69)
Debt Discount	(216)	(241)
Long-term convertible debt	$ 852	$ 820

LONG TERM DEBT (Details Narrati

LONG TERM DEBT (Details Narrative) - USD ($)	May 04, 2020	May 17, 2021	Mar. 22, 2021	Feb. 19, 2021	Mar. 31, 2022	Dec. 31, 2021	Jul. 09, 2020	Sep. 04, 2018	Jan. 19, 2017	Dec. 21, 2016
Future debt obligations					$ 594,643
Total outstanding prior to exchange					39,000	$ 46,000
Accrued interest					232,000	261,000
Debt forgiveness amount					41,232
Current portion of long-term debt					67,000	88,000
10% Senior Unsecured Convertible Debenture
Accrued interest					28,250	73,326
Convertible debentures right description		each debenture unit will have a right to 1,000 warrants for common stock shares, warrants have an exercise price of $0.80 and an expiration date of May 17, 2023
Change of Control premium percentage		3.00%
Deemed price		$ 0.50
Convertible debentures		$ 1,000				1,130,000
Debt maturity date		May 17, 2024
Proceeds from convertible debenture		$ 1,130,000
Conversion price		$ 0.50
Paycheck Protection Program
Total outstanding prior to exchange					4,491,000
Accrued interest					407	385
Current portion of long-term debt						11,181
Loan maturity term	24 years
Proceeds from loan	$ 50,184
Loan interest rate	1.00%
Payroll costs					100,000
Dr. Cartwright
Future debt obligations					284,867
Total outstanding prior to exchange						1,621,000
Promissory note interest rate				6.00%
Debt instrument converted amount				$ 85,000
Series F-2 Preferred Stock issued upon conversion of debt				100
Debt forgiveness amount						1,302,000
Salary						337,000
Principal amount of promissory note				$ 267,085
Loans, interest, bonus, salary and vacation paid amount								$ 1,621,499
Interest rate per annum								6.00%
Issuance of promissory note in exchange of related party debt								$ 319,000
Promissory note maturity date				Feb. 18, 2023
Mr. Fowler
Future debt obligations					146,400
Total outstanding prior to exchange					146,400				$ 13,900	$ 12,500
Long-term debt-related parties					26,586
Due to related party			$ 546,214		6,232
Promissory note interest rate			6.00%
Debt instrument converted amount			$ 50,000
Series F-2 Preferred Stock issued upon conversion of debt			50
Accrued interest			$ 133,590
Due to related party, amount			$ 546,214
Promissory note interest rate description			The note accrues interest at the rate of 6% (18% in the event of default) beginning on March 22, 2022 and is payable in monthly installments of $3,580 for four years
Accrued interest rate description			The notes accrue at an interest rate of 6% (18% in the event of default).
Promissory note default interest rate			18.00%
Promissory note monthly installment			$ 3,580
Preferred shares converted into common stock			200,000
Effective interest rate			6.18
Deferred salary			$ 412,624
Unsecured note issued upon conversion of debt			$ 150,000
Debt forgiveness amount					253,429,000
Dr. Faupel
Future debt obligations					$ 163,376
Total outstanding prior to exchange						661,000
Due to related party								660,895
Promissory note interest rate				6.00%
Debt instrument converted amount				$ 100,000
Series F-2 Preferred Stock issued upon conversion of debt				85
Debt forgiveness amount						454,000
Salary						134,000
Principal amount of promissory note				$ 153,178
Issuance of promissory note in exchange of related party debt								$ 207,111
Promissory note maturity date				Feb. 18, 2023
Mr. Bill Wells
Total outstanding prior to exchange						97,052	$ 90,000
Promissory note interest rate					6.00%
Debt forgiveness amount					$ 35,000
Current portion of long-term debt					$ 65,299
Loan maturity term					18 years
Common share stock option							66,000
Salary							$ 220,000
Exercise price							$ 0.49
Received cash payment					$ 35,000		$ 20,000
Total amount to be receive						3,000,000	3,000,000
Monthly payment due						$ 5,000	$ 3,667

INCOME (LOSS) PER COMMON SHAR_2

INCOME (LOSS) PER COMMON SHARE (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Net loss	$ (1,055)	$ (572)
Basic weighted average number of shares outstanding	20,683	13,172
Net loss per share (basic)	$ (0.05)	$ (0.04)
Diluted weighted average number of shares outstanding	20,683	13,172
Net loss per share (diluted)	$ (0.05)	$ (0.04)
Dilutive equity instruments (number of equivalent units):
Dilutive equity instruments (number of equivalent units)	32,116	35,709
Warrants [Member]
Dilutive equity instruments (number of equivalent units):
Dilutive equity instruments (number of equivalent units)	13,609	17,400
Convertible Debt [Member]
Dilutive equity instruments (number of equivalent units):
Dilutive equity instruments (number of equivalent units)	2,018	315
Preferred Stock [Member]
Dilutive equity instruments (number of equivalent units):
Dilutive equity instruments (number of equivalent units)	15,572	17,994
Stock Option [Member]
Dilutive equity instruments (number of equivalent units):
Dilutive equity instruments (number of equivalent units)	917

INCOME (LOSS) PER COMMON SHAR_3

INCOME (LOSS) PER COMMON SHARE (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
INCOME (LOSS) PER COMMON SHARE
Decrease in net loss	$ 41,232	$ 972,000
Account payable forgivness amount	$ 41,232
Troubled debt restructuring description		the troubled debt restructurings in total would have decreased the net loss by $972,000, causing the per share calculation to change from .04 to .11 net loss per share

SUBSEQUENT EVENTS (Details Narr

SUBSEQUENT EVENTS (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2022	Dec. 31, 2021
Common stock warrants	650,000
Common stock share issued	22,316,000	13,673,000
Seried D Exchange Agreements
Aggregate outstanding common stock warrants	650,000
Common stock warrants Strike price	$ 0.25
Warrants shares	650,000
Warants strike price	$ 0.20
Amount received of common stock, warrants and prefunded warrants	$ 130,000
10% Senior Unsecured Convertible Debenture
Common stock share issued	16,987
Series D Preferred Shares
Common stock warrants	1,526,000
Common stock share issued	975,000,000
Series F-2 Preferred shares
Common stock share issued	1,864,000
Series F Preferred shares
Common stock share issued	1,360,000
Series F Preferred share dividends
Common stock share issued	16,987
Series D Preferred share dividends
Common stock share issued	22,829
Series E Preferred share dividends
Common stock share issued	43,470
Series E Preferred shares
Common stock share issued	320,000