LIST OF SUBSIDIARIES EXHIBIT 21
Name | Country |
AesRX, LLC | United States |
Amsterdam Newco, Inc | United States |
Armagen Technologies, inc*** | United States |
Auralis Limited | United Kingdom |
Baxalta (Thailand) Limited | Thailand |
Baxalta Argentina S.A.U. | Argentina |
Baxalta Australia Pty. Ltd. | Australia |
Baxalta Belgium Manufacturing S.A. | Belgium |
Baxalta Belgium SPRL | Belgium |
Baxalta Biofarmacevtska druzba d.o.o | Slovenia |
Baxalta Biopharmaceutical Ltd. | Taiwan |
Baxalta BioScience (Shanghai) Co. Ltd. | China |
Baxalta BioScience Costa Rica S.R.L. | Costa Rica |
Baxalta BioScience Greece Single Member LLC | Greece |
Baxalta BioScience India Private Limited | India |
Baxalta Brasil Biociência Ltda. | Brazil |
Baxalta Bulgaria EOOD | Bulgaria |
Baxalta Canada Corporation | Canada |
Baxalta Chile SpA | Chile |
Baxalta Colombia S.A.S. | Colombia |
Baxalta Czech spol. S.r.o. | Czech Republic |
Baxalta Denmark A/S | Denmark |
Baxalta Deutschland GmbH | Germany |
Baxalta Estonia OU | Estonia |
Baxalta Export Corporation | United States |
Baxalta Export Services GmbH | Switzerland |
Baxalta Finland Oy | Finland |
Baxalta France S.A.S. | France |
Baxalta GmbH | Switzerland |
Baxalta Guatemala, Sociedad Anónima | Guatemala |
Baxalta Holding B.V. | Netherlands |
Baxalta Holdings LLC | United States |
Baxalta Hong Kong Limited | China |
Baxalta Hungary Limited Liability Company | Hungary |
Baxalta Incorporated | United States |
Baxalta Innovations GmbH | Austria |
Baxalta Investments B.V. | Netherlands |
Baxalta Ireland Financing Limited | Ireland |
Baxalta Italy Holding S.r.l. | Italy |
Baxalta Italy S.r.l. | Italy |
Baxalta Japan Limited | Japan |
Baxalta Kazakhstan LLP | Kazakhstan |
Baxalta Korea Ltd. | Korea, Republic of |
Baxalta Lithuania UAB | Lithuania |
Baxalta Malaysia SDN. BHD. | Malaysia |
Baxalta Manufacturing S.à r.l. | Switzerland |
Baxalta Mexico Holding LLC | United States |
Baxalta Mexico S. de R.L. de C.V. | Mexico |
Baxalta Netherlands B.V. | Netherlands |
Baxalta Netherlands Holding B.V. | Netherlands |
Baxalta Netherlands Investment B.V. | Netherlands |
Baxalta New Zealand Limited | New Zealand |
Baxalta Norway AS | Norway |
Baxalta Osterreich GmbH | Austria |
Baxalta Panama S.A. | Panama |
Baxalta Poland sp. Z o.o | Poland |
Baxalta Portugal, Unipessoal, Ltda. | Portugal |
Baxalta Recombinant S.à r.l. | Switzerland |
Baxalta S. de R.L. de C.V. | Mexico |
Baxalta S.R.L. | Romania |
Baxalta Schweiz AG | Switzerland |
Baxalta Services Europe SPRL | Belgium |
Baxalta Singapore Holding LLC | United States |
Baxalta Singapore Pte. Ltd. | Singapore |
Baxalta Slovakia s.r.o. | Slovakia |
Baxalta Spain S.L. | Spain |
Baxalta Sweden AB | Sweden |
Baxalta Tunisia SARL | Tunisia |
Baxalta UK Holdco Limited | United Kingdom |
Baxalta UK Investments Ltd. | United Kingdom |
Baxalta UK Limited | United Kingdom |
Baxalta Ukraine LLC | Ukraine |
Baxalta US Inc. | United States |
Baxalta World Trade LLC | United States |
Baxalta Worldwide LLC | United States |
Baxalta-Ecuador S.A. | Ecuador |
Baxter AG | Austria |
Baxter Manufacturing S.p.A. | Italy |
BearTracks, Inc. | United States |
Bikam Pharmaceuticals, Inc. | United States |
BioLife Plasma LLC | United States |
BioLife Plasma Services LP | United States |
Cinacalcet Royalty Sub LLC | United States |
DuoCort Pharma AB | Sweden |
Dyax Corp. | United States |
Dyax Limited | United Kingdom |
Eczacibasi Baxalta Hastane Urunleri Sanayi ve Ticaret A.S.**** | Turkey |
Farboud Pty Ltd | Australia |
FerroKin BioSciences, Inc. | United States |
Fibrotech Therapeutics Pty Ltd | Australia |
Foresight Biotherapeutics, Inc. | United States |
Jerini Ophthalmic Holding GmbH | Germany |
JPT Peptide Technologies Inc | United States |
Knight Newco 1, Inc. | United States |
Laboratorios Baxalta S.A. | United States |
Lotus Tissue Repair Inc | United States |
Lumena Pharma UK Limited | United Kingdom |
Lumena Pharmaceuticals LLC | United States |
Meritage Pharma, Inc. | United States |
Monmouth Pharmaceuticals Limited | United Kingdom |
NPS Holdings Company | Canada |
NPS Pharma Canada Inc. | Canada |
NPS Pharma Holdings Limited | Ireland |
NPS Pharma Holdings U.S., Inc. | United States |
NPS Pharma International Limited | Ireland |
NPS Pharma UK Limited | United Kingdom |
NPS Services, L.C. | United States |
Pharma International Insurance Designated Activity Company (DAC) | Ireland |
Premacure AB | Sweden |
Premacure Uppsala AB | Sweden |
Rare Disease Charitable Foundation | United States |
Rybar Laboratories Limited | United Kingdom |
SARcode Bioscience Inc. | United States |
SG Biotech Joint Stock Company******* | Russian Federation |
SG Biotech Limited****** | Cyprus |
SG Biotech Sàrl***** | Switzerland |
Shire (Shanghai) Pharmaceuticals Consultancy Co., Ltd. | China |
Shire 2005 Investments Limited | Cayman Islands |
Shire Acquisitions Investments Ireland Designated Activity Company (DAC) | Ireland |
Shire Albania Sh.p.k. | Albania |
Shire Australia Pty Limited | Australia |
Shire Austria GmbH | Austria |
Shire Belgium BVBA | Belgium |
Shire Biopharmaceuticals Holdings | United Kingdom |
Shire Biopharmaceuticals Holdings Ireland Limited | Jersey |
Shire Biopharmaceuticals Ireland Limited | Ireland |
Shire Brandywine LLC | United States |
Shire Bulgaria EOOD | Bulgaria |
Shire Central & Eastern Europe GmbH | Germany |
Shire Chile SpA | Chile |
Shire Colombia S.A.S | Colombia |
Shire Czech S.R.O. | Czech Republic |
Shire Denmark ApS | Denmark |
Shire Deutschland GmbH | Germany |
Shire Deutschland Investments GmbH | Germany |
Shire Development LLC | United States |
Shire doo Beograd | Serbia |
Shire društvo s ogranièenom odgovornošæu za trgovinu i usluge | Croatia |
Shire Europe Finance | United Kingdom |
Shire Europe Limited | United Kingdom |
Shire Executive Services LLC | United States |
Shire Farmacêutica Brasil Ltda | Brazil |
Shire Finance Limited | Cayman Islands |
Shire Finland Oy | Finland |
Shire France S.A.S | France |
Shire Global Finance | United Kingdom |
Shire Hellas Pharmaceuticals Import Export and Marketing S.A. | Greece |
Shire Holdings Europe B.V. | Netherlands |
Shire Holdings Europe Limited | United Kingdom |
Shire Holdings Europe No.2 S.à r.l. | Luxembourg |
Shire Holdings Ireland No.2 Limited | Ireland |
Shire Holdings Ireland No.3 Limited | Ireland |
Shire Holdings Ireland UC | Ireland |
Shire Holdings Limited | Bermuda |
Shire Holdings Luxembourg S.à r.l. | Luxembourg |
Shire Holdings UK Canada Limited | United Kingdom |
Shire Holdings UK Limited | United Kingdom |
Shire Holdings US AG | United States |
Shire Human Genetic Therapies AB | Sweden |
Shire Human Genetic Therapies Limited | United Kingdom |
Shire Human Genetic Therapies S.A. | Argentina |
Shire Human Genetic Therapies Securities Corporation | United States |
Shire Human Genetic Therapies UK Limited | United Kingdom |
Shire Human Genetic Therapies, Inc. | United States |
Shire Hungary Kft | Hungary |
Shire Ilac Ticaret Limited Sirketi | Turkey |
Shire Incorporated | United States |
Shire Intellectual Property 2 SRL | Barbados |
Shire Intellectual Property Ireland Limited | Ireland |
Shire Intellectual Property SRL | Barbados |
Shire International Finance GmbH | Switzerland |
Shire International GmbH | Switzerland |
Shire International Licensing BV | Netherlands |
Shire Investments & Finance (U.K.) Company | United Kingdom |
Shire Invicta US Inc | United States |
Shire IP Services Corporation | Canada |
Shire Ireland Finance Limited | Ireland |
Shire Ireland Finance Trading Limited | Ireland |
Shire Ireland Investment Limited | Ireland |
Shire Ireland Premacure Investment UC | Ireland |
Shire Italia S.p.A. | Italy |
Shire Japan KK | Japan |
Shire Jersey Limited | Jersey |
Shire Licensing V.O.F. | Netherlands |
Shire LLC | United States |
Shire Luxembourg Finance S.à r.l. | Luxembourg |
Shire Luxembourg Intellectual Property No.2 S.à r.l. | Luxembourg |
Shire Luxembourg Intellectual Property No.3 S.à r.l. | Luxembourg |
Shire Luxembourg Intellectual Property S.à r.l. | Luxembourg |
Shire Luxembourg S.à r.l. | Luxembourg |
Shire New Zealand Limited | New Zealand |
Shire North American Group Inc. | United States |
Shire Norway AS | Norway |
Shire Orphan and Rare Diseases GmbH | Switzerland |
Shire Orphan Therapies GmbH | Germany |
Shire Orphan Therapies LLC | United States |
Shire Pharma Canada ULC | Canada |
Shire Pharma Korea Yuhan Hoesa | Korea, Republic of |
Shire Pharmaceutical Contracts Limited | United Kingdom |
Shire Pharmaceutical Development US Inc | United States |
Shire Pharmaceutical Development Limited | United Kingdom |
Shire Pharmaceutical Holdings Ireland Limited* | Ireland |
Shire Pharmaceutical Investment Trading Ireland UC | Ireland |
Shire Pharmaceutical Investments 2008 UC | Ireland |
Shire Pharmaceutical Israel Ltd | Israel |
Shire Pharmaceutical Services Ireland Limited | Ireland |
Shire Pharmaceuticals Finance Ireland Unlimited Company | Ireland |
Shire Pharmaceuticals Group | United Kingdom |
Shire Pharmaceuticals Iberica S.L. | Spain |
Shire Pharmaceuticals International Finance S.à r.l. | Luxembourg |
Shire Pharmaceuticals International UC | Ireland |
Shire Pharmaceuticals Investments (British Virgin Islands) Limited | Virgin Islands, British |
Shire Pharmaceuticals Investments 2007 UC | Ireland |
Shire Pharmaceuticals Ireland Limited | Ireland |
Shire Pharmaceuticals Limited | United Kingdom |
Shire Pharmaceuticals LLC | United States |
Shire Pharmaceuticals Mexico SA de CV | Mexico |
Shire Pharmaceuticals Portugal, Lda | Portugal |
Shire Pharmaceuticals Services Limited | United Kingdom |
Shire Pharmaceuticals South Africa (Pty) Ltd | South Africa |
Shire Polska Sp. z o. o. | Poland |
Shire Properties US | United States |
Shire Regenerative Medicine LLC* | United States |
Shire Regulatory Inc | United States |
Shire Romania SRL | Romania |
Shire Rus Limited Liability Company | Russian Federation |
Shire Services BVBA | Belgium |
Shire Singapore Pte. Ltd. | Singapore |
Shire Slovakia s.r.o. | Slovakia |
Shire Supplies U.S. LLC | United States |
Shire Sweden AB | Sweden |
Shire Sweden Holdings S.à r.l. | Luxembourg |
Shire Switzerland GmbH | Switzerland |
Shire UK Investments Limited | United Kingdom |
Shire Ukraine LLC | Ukraine |
Shire US Holdings LLC | United States |
Shire US Inc | United States |
Shire US Investment Inc | United States |
Shire US Investments | United Kingdom |
Shire US Manufacturing Inc | United States |
Shire ViroPharma Incorporated | United States |
Shire ViroPharma Incorporated | Puerto Rico |
Shire-NPS Pharmaceuticals, Inc. | United States |
Sigma-Tau Pharma Ltd. | United Kingdom |
Sparkleflame Limited | United Kingdom |
SuppreMol GmbH | Germany |
Taiwan Shire Limited Company | Taiwan |
Tanaud International BV | Netherlands |
The Endocrine Centre Limited | United Kingdom |
VCO Incorporated | United States |
ViroPharma AB | Sweden |
Viropharma Biologics Inc | United States |
Viropharma Holdings Limited | Bermuda |
Viropharma Holdings LLC | United States |
Viropharma Limited | United Kingdom |
Viropharma Pty Ltd | Australia |
VPDE Incorporated | United States |
VPINT Incorporated | United States |
Navillus Insurance Company DAC | Ireland |
With the exception of those entities indicated, all subsidiary undertakings of Shire plc are 100% indirectly beneficially owned.
All subsidiary undertakings are consolidated in the consolidated financial statements of Shire plc.
*these entities are 100% directly beneficially owned
**this entity is 96% indirectly beneficially owned
***this entity is 22.13% indirectly beneficially owned
****this entity is 50.00% indirectly beneficially owned
*****this entity is 51.00% indirectly beneficially owned
******this entity is 26.01% indirectly beneficially owned
*******this entity is 13.26% indirectly beneficially owned