LIST OF SUBSIDIARIES EXHIBIT 21
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| Name | Country |
| Shire Albania Sh.p.k. | Albania |
| Baxalta Argentina S.A.U. | Argentina |
| Shire Human Genetic Therapies S.A. | Argentina |
| Baxalta Australia Pty. Ltd. | Australia |
| Farboud Pty Ltd | Australia |
| Fibrotech Therapeutics Pty Ltd | Australia |
| Shire Australia Pty Limited | Australia |
| Viropharma Pty Ltd | Australia |
| Baxalta Innovations GmbH | Austria |
| Baxter AG | Austria |
| Shire Austria GmbH | Austria |
| Shire Intellectual Property 2 SRL | Barbados |
| Shire Intellectual Property SRL | Barbados |
| Baxalta Belgium Manufacturing S.A. | Belgium |
| Baxalta Belgium SPRL | Belgium |
| Baxalta Services Europe SPRL | Belgium |
| Shire Belgium BVBA | Belgium |
| Shire Services BVBA | Belgium |
| Shire Holdings Limited | Bermuda |
| Viropharma Holdings Limited | Bermuda |
| Shire Farmacêutica Brasil Ltda | Brazil |
| Baxalta Bulgaria EOOD | Bulgaria |
| Shire Bulgaria EOOD | Bulgaria |
| Baxalta Canada Corporation | Canada |
| NPS Holdings Company | Canada |
| NPS Pharma Canada Inc. | Canada |
| Shire IP Services Corporation | Canada |
| Shire Pharma Canada ULC | Canada |
| Shire 2005 Investments Limited | Cayman Islands |
| Shire Finance Limited | Cayman Islands |
| Shire Chile SpA | Chile |
| Shire BioScience (Shanghai) Co. Ltd. | China |
| Shire Hong Kong Limited | China |
| Shire (Shanghai) Pharmaceuticals Consultancy Co., Ltd. | China |
| Baxalta Colombia S.A.S. | Colombia |
| Shire Biotech Costa Rica, S.R.L. | Costa Rica |
| Shire društvo s ogranièenom odgovornošæu za trgovinu i usluge | Croatia |
| SG Biotech Limited***** | Cyprus |
| Shire Czech s.r.o. | Czech Republic |
| Shire Denmark A/S | Denmark |
| Shire Biotech Denmark ApS | Denmark |
| Baxalta-Ecuador S.A. | Ecuador |
| Baxalta Estonia OU | Republic of Estonia |
| Shire Finland Oy | Finland |
| Shire Biotech Finland Oy | Finland |
| Shire France S.A.S | France |
| Baxalta Deutschland GmbH | Germany |
| Jerini Ophthalmic Holding GmbH | Germany |
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| Shire Central & Eastern Europe GmbH | Germany |
| Shire Deutschland GmbH | Germany |
| Shire Deutschland Investments GmbH | Germany |
| Shire Orphan Therapies GmbH | Germany |
| SuppreMol GmbH | Germany |
| Baxalta BioScience Greece Single Member LLC | Greece |
| Shire Hellas Pharmaceuticals Import Export and Marketing S.A. | Greece |
| Shire Guatemala, Sociedad Anónima | Guatemala |
| Baxalta Hungary Limited Liability Company | Hungary |
| Shire Hungary Kft | Hungary |
| Baxalta BioScience India Private Limited | India |
| Shire Biotech India Private Limited | India |
| Baxalta Ireland Financing Limited | Ireland |
| Navillus Insurance Company Designated Activity Company | Ireland |
| NPS Pharma Holdings Limited | Ireland |
| NPS Pharma International Limited | Ireland |
| Pharma International Insurance Designated Activity Company | Ireland |
| Shire Acquisitions Investments Ireland Designated Activity Company | Ireland |
| Shire Biopharmaceuticals Ireland Limited | Ireland |
| Shire Holdings Ireland Unlimited Company | Ireland |
| Shire Holdings Ireland No.2 Limited | Ireland |
| Shire Holdings Ireland No.3 Limited | Ireland |
| Shire Intellectual Property Ireland Limited | Ireland |
| Shire Ireland Finance Limited | Ireland |
| Shire Ireland Finance Trading Limited | Ireland |
| Shire Ireland Investment Limited | Ireland |
| Shire Ireland Plasma Limited | Ireland |
| Shire Ireland Premacure Investment Unlimited Company | Ireland |
| Shire Pharmaceutical Holdings Ireland Limited* | Ireland |
| Shire Pharmaceutical Investment Trading Ireland Unlimited Company | Ireland |
| Shire Pharmaceutical Investments 2008 Unlimited Company | Ireland |
| Shire Pharmaceutical Services Ireland Limited | Ireland |
| Shire Pharmaceuticals Finance Ireland Unlimited Company | Ireland |
| Shire Pharmaceuticals International Unlimited Company | Ireland |
| Shire Pharmaceuticals Investments 2007 Unlimited Company | Ireland |
| Shire Pharmaceuticals Ireland Limited | Ireland |
| Shire Pharmaceutical Israel Ltd | Israel |
| Baxalta Italy Holding S.r.l. | Italy |
| Baxalta Italy S.r.l. | Italy |
| Baxter Manufacturing S.p.A. | Italy |
| Shire Italia S.p.A. | Italy |
| Baxalta Japan Limited | Japan |
| Shire Japan KK | Japan |
| Shire Biopharmaceuticals Holdings Ireland Limited | Jersey |
| Shire Jersey Limited | Jersey |
| Baxalta Kazakhstan LLP | Republic of Kazakhstan |
| Shire Pharma Korea Yuhan Hoesa | Republic of Korea |
| Baxalta Lithuania UAB | Lithuania |
| Shire Holdings Europe No.2 S.à r.l. | Luxembourg |
| Shire Holdings Luxembourg S.à r.l. | Luxembourg |
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| Shire Luxembourg Finance S.à r.l. | Luxembourg |
| Shire Luxembourg Intellectual Property No.2 S.à r.l. | Luxembourg |
| Shire Luxembourg Intellectual Property S.à r.l. | Luxembourg |
| Shire Luxembourg S.à r.l. | Luxembourg |
| Shire Pharmaceuticals International Finance S.à r.l. | Luxembourg |
| Shire Sweden Holdings S.à r.l. | Luxembourg |
| Baxalta Malaysia SDN. BHD. | Malaysia |
| Shire Pharmaceuticals Mexico S.A. de C.V. | Mexico |
| Baxalta Holding B.V. | Netherlands |
| Baxalta Investments B.V. | Netherlands |
| Baxalta Netherlands B.V. | Netherlands |
| Baxalta Netherlands Holding B.V. | Netherlands |
| Baxalta Netherlands Investment B.V. | Netherlands |
| Shire Holdings Europe B.V. | Netherlands |
| Shire International Licensing BV | Netherlands |
| Shire Licensing V.O.F. | Netherlands |
| Tanaud International BV | Netherlands |
| Baxalta New Zealand Limited | New Zealand |
| Shire New Zealand Limited | New Zealand |
| Shire Norway AS | Norway |
| Shire Biotech Norway AS | Norway |
| Shire Panama, S.A. | Panama |
| Shire Peru S.A.C. | Peru |
| Shire Polska Sp. z o. o. | Poland |
| Shire Pharmaceuticals Portugal, Lda | Portugal |
| Baxalta S.R.L. | Romania |
| Shire Romania SRL | Romania |
| SG Biotech Joint Stock Company******* | Russian Federation |
| Shire Biotech Rus Limited Liability Company | Russian Federation |
| Shire Rus Limited Liability Company | Russian Federation |
| Shire doo Beograd | Serbia |
| Shire Singapore Pte. Ltd. | Singapore |
| Baxalta Slovakia s.r.o. | Slovak Republic |
| Shire Slovakia s.r.o. | Slovak Republic |
| Baxalta Biofarmacevtska druzba d.o.o | Slovenia |
| Shire Pharmaceuticals South Africa (Pty) Ltd | South Africa |
| Shire Pharmaceuticals Iberica S.L.U. | Spain |
| DuoCort Pharma AB | Sweden |
| Premacure AB | Sweden |
| Premacure Uppsala AB | Sweden |
| Shire Human Genetic Therapies AB | Sweden |
| Shire Sweden AB | Sweden |
| ViroPharma AB | Sweden |
| SG Biotech Sàrl*** | Switzerland |
| Shire Export Services GmbH | Switzerland |
| Baxalta GmbH | Switzerland |
| Baxalta Manufacturing S.à r.l. | Switzerland |
| Baxalta Recombinant S.à r.l. | Switzerland |
| Baxalta Schweiz AG | Switzerland |
| Shire International Finance GmbH | Switzerland |
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| Shire International GmbH | Switzerland |
| Shire Switzerland GmbH | Switzerland |
| Shire Biotech Taiwan Limited | Taiwan |
| Taiwan Shire Limited Company | Taiwan |
| Shire (Thailand) Limited | Thailand |
| Baxalta Tunisia SARL | Tunisia |
| Eczacýbaþý Shire Saðlýk Ürünleri Sanayi ve Ticaret A.Þ.**** | Turkey |
| Shire Ilac Ticaret Limited Sirketi | Turkey |
| Baxalta Ukraine LLC | Ukraine |
| Shire Ukraine LLC | Ukraine |
| Auralis Limited | United Kingdom |
| Baxalta UK Holdco Limited | United Kingdom |
| Baxalta UK Investments Ltd. | United Kingdom |
| Baxalta UK Limited | United Kingdom |
| Dyax Limited | United Kingdom |
| Lumena Pharma UK Limited | United Kingdom |
| Monmouth Pharmaceuticals Limited | United Kingdom |
| NPS Pharma UK Limited | United Kingdom |
| Rybar Laboratories Limited | United Kingdom |
| Shire Biopharmaceuticals Holdings | United Kingdom |
| Shire Biotech UK Holdings Limited | United Kingdom |
| Shire Corporate Services Limited | United Kingdom |
| Shire Europe Finance | United Kingdom |
| Shire Europe Limited | United Kingdom |
| Shire Global Finance | United Kingdom |
| Shire Holdings Europe Limited | United Kingdom |
| Shire Holdings UK Canada Limited | United Kingdom |
| Shire Holdings UK Limited | United Kingdom |
| Shire Human Genetic Therapies Limited | United Kingdom |
| Shire Human Genetic Therapies UK Limited | United Kingdom |
| Shire Investments & Finance (U.K.) Company | United Kingdom |
| Shire Pharmaceutical Contracts Limited | United Kingdom |
| Shire Pharmaceutical Development Limited | United Kingdom |
| Shire Pharmaceuticals Group | United Kingdom |
| Shire Pharmaceuticals Limited | United Kingdom |
| Shire Pharmaceuticals Services Limited | United Kingdom |
| Shire UK Investments Limited | United Kingdom |
| Shire US Investments | United Kingdom |
| Sigma-Tau Pharma Limited | United Kingdom |
| Sparkleflame Limited | United Kingdom |
| The Endocrine Centre Limited | United Kingdom |
| Viropharma Limited | United Kingdom |
| AesRX, LLC | United States |
| Amsterdam Newco, Inc | United States |
| Armagen Technologies, Inc****** | United States |
| Baxalta Export Corporation | United States |
| Baxalta Holdings LLC | United States |
| Baxalta Incorporated | United States |
| Baxalta Mexico Holding LLC | United States |
| Baxalta Singapore Holding LLC | United States |
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| Baxalta US Inc. | United States |
| Baxalta World Trade LLC | United States |
| Baxalta Worldwide LLC | United States |
| BearTracks, Inc. | United States |
| Bikam Pharmaceuticals, Inc. | United States |
| BioLife Plasma LLC | United States |
| BioLife Plasma Services LP | United States |
| Cinacalcet Royalty Sub LLC | United States |
| Dyax Corp. | United States |
| FerroKin BioSciences, Inc. | United States |
| Foresight Biotherapeutics, Inc. | United States |
| Jerini Ophthalmic, Inc** | United States |
| JPT Peptide Technologies Inc | United States |
| Knight Newco 1, Inc. | United States |
| Laboratorios Baxalta S.A. | United States |
| Lotus Tissue Repair Inc | United States |
| Lumena Pharmaceuticals LLC | United States |
| Meritage Pharma, Inc. | United States |
| NPS Pharma Holdings U.S., Inc. | United States |
| NPS Services, L.C. | United States |
| Rare Disease Charitable Foundation | United States |
| SARcode Bioscience Inc. | United States |
| Shire Brandywine LLC | United States |
| Shire Development LLC | United States |
| Shire Executive Services LLC | United States |
| Shire Holdings US AG | United States |
| Shire Human Genetic Therapies Securities Corporation | United States |
| Shire Human Genetic Therapies, Inc. | United States |
| Shire Incorporated | United States |
| Shire Invicta US Inc | United States |
| Shire LLC | United States |
| Shire North American Group Inc. | United States |
| Shire Orphan Therapies LLC | United States |
| Shire Pharmaceutical Development Inc | United States |
| Shire Pharmaceuticals LLC | United States |
| Shire Properties US | United States |
| Shire Regenerative Medicine LLC* | United States |
| Shire Regulatory Inc | United States |
| Shire Supplies U.S. LLC | United States |
| Shire US Holdings LLC | United States |
| Shire US Inc | United States |
| Shire US Investment Inc | United States |
| Shire US Manufacturing Inc | United States |
| Shire ViroPharma Incorporated | United States |
| Shire-NPS Pharmaceuticals, Inc. | United States |
| VCO Incorporated | United States |
| Viropharma Biologics Inc | United States |
| Viropharma Holdings LLC | United States |
| VPDE Incorporated | United States |
| VPINT Incorporated | United States |
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| Shire Pharmaceuticals Investments (British Virgin Islands) Limited | British Virgin Islands |
With the exception of those entities indicated, all subsidiary undertakings of Shire plc are 100% indirectly beneficially owned.
All subsidiary undertakings are consolidated in the consolidated financial statements of Shire plc.
*these entities are 100% directly beneficially owned
**this entity is 96% indirectly beneficially owned
***this entity is 51% indirectly beneficially owned
****this entity is 50.00% indirectly beneficially owned
*****this entity is 26.01% indirectly beneficially owned
******this entity is 22.13% indirectly beneficially owned
*******this entity is 13.26% indirectly beneficially owned
