Exhibit 99.01
| Shire Pharmaceuticals Group plc | |
| Shire Pharmaceuticals Group plc Hampshire International Business Park, Chineham, Basingstoke RG24 8EP UK Tel +44 1256 894000 Fax +44 1256 894708 http://www.shire.com |  |
SHIRE PHARMACEUTICALS GROUP PLC
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | ROBERTS PHARMACEUTICALS OPTION SCHEME |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 25,048,841 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | 10,548 | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 25,038,293 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 134,788,867 | |
| AND THE DATE OF ADMISSION: | 22 DECEMBER 1999 | |
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | STOCK PURCHASE PLAN |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 954,622 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | 148,299 | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 806,323 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 1,011,958 | |
| AND THE DATE OF ADMISSION: | 2 APRIL 1996 | |
| (A FURTHER LISTING OF 513,488 SHARES WAS GRANTED ON 19 APRIL 2002) | ||
| (A FURTHER LISTING OF 100,000 SHARES WAS GRANTED ON 12 JUNE 2002) | ||
| (A FURTHER LISTING OF 100,000,000 SHARES WAS GRANTED ON 8 JULY 2004) | ||
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | "B" EXECUTIVE SHARE OPTION SCHEME |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 1,307,448 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | 1,049,018 | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 258,430 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 1,750,000 | |
| AND THE DATE OF ADMISSION: | 12 MARCH 1999 | |
| (A FURTHER LISTING OF 3,250,000 SHARES WAS GRANTED IN AUGUST 2001) | ||
| (A FURTHER LISTING OF 250,000 SHARES WAS GRANTED IN 12 SEPTEMBER 2003) | ||
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | "A" EXECUTIVE SHARE OPTION SCHEME |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 147,907 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | 12,480 | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 135,427 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 250,000 | |
| AND THE DATE OF ADMISSION: | 12 MARCH 1999 | |
| (A FURTHER LISTING OF 200,000 SHARES WAS GRANTED ON 19 APRIL 2002) | ||
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | SHIRE PHARMACEUTICALS SHARESAVE SCHEME |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 47,852 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | 408 | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 47,444 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 247,500 | |
| AND THE DATE OF ADMISSION: | 21 AUGUST 1999 | |
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | SHIRE RICHWOOD INC SHARE OPTION SCHEME |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 388,852 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | NIL | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 388,852 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 1,597,816 | |
| AND THE DATE OF ADMISSION: | 31 MARCH 1999 | |
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | SHIRE LABORATORIES INC SHARE OPTION SCHEME |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 9,112 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | 1,269 | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 7,843 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 1,741,654 | |
| AND THE DATE OF ADMISSION: | 18 MARCH 1998 | |
| (A FURTHER LISTING OF 390,226 SHARES WAS GRANTED ON 31 MARCH 1999) | ||
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | SHIRE HOLDINGS LTD SHARE OPTION SCHEME |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 3,040 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | NIL | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 3,040 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 1,011,958 | |
| AND THE DATE OF ADMISSION: | 31 MARCH 1999 | |
| (A FURTHER LISTING OF 318,912 SHARES WAS GRANTED ON 19 APRIL 2002) | ||
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | SHIRE BIOCHEM STOCK OPTION PLAN |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 5,349,843 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | 56,892 | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 5,292,951 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 14,822,713 | |
| AND THE DATE OF ADMISSION: | AUGUST 2001 | |
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
BLOCK LISTING SIX MONTHLY REVIEW
| 1. | NAME OF COMPANY: | SHIRE PHARMACEUTICALS GROUP PLC |
| 2. | NAME OF SCHEME: | TPC WARRANTS |
| 3. | PERIOD OF RETURN: | FROM: 10 JULY 2004 TO: 31 DECEMBER 2004 |
| 4. | NUMBER AND CLASS OF SHARES(S) | |
| (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME | ||
| AT END OF THE LAST PERIOD: | 1,346,407 | |
| 5. | NUMBER OF SHARES ISSUED/ ALLOTTED UNDER SCHEME DURING | |
| PERIOD: | NIL | |
| 6. | BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED | |
| AT END OF PERIOD: | 1,346,407 | |
| 7. | NUMBER AND CLASS OF SHARE(S) | |
| (AMOUNT OF STOCK/DEBT SECURITIES) | ||
| ORIGINALLY LISTED: | 741,812 | |
| AND THE DATE OF ADMISSION: | 29 APRIL 2002 | |
| (A FURTHER LISTING OF 604,595 SHARES WAS GRANTED ON 27 NOVEMBER 2002) | ||
| PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS. | ||
| 484,916,034 | ||
For further information please contact:
Vivienne Hemming – Deputy Company Secretary +44 1256 894 276
Notes to editors
Shire Pharmaceuticals Group plc
Shire Pharmaceuticals Group plc (Shire) is a global specialty pharmaceutical company with a strategic focus on meeting the needs of the specialist physician and currently focuses on developing projects and marketing products in the areas of central nervous system (CNS), gastrointestinal (GI), and renal diseases. Shire has operations in the world’s key pharmaceutical markets (US, Canada, UK, France, Italy, Spain and Germany) as well as a specialist drug delivery unit in the US.
For further information on Shire, please visit the Company’s website:www.shire.com