| Exhibit 99.01 | ||
| Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com |  | |
| Press Release | ||
BLOCK LISTING SIX MONTHLY RETURN
Basingstoke, UK and Philadelphia, US – May 26, 2006– Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ)
| Name of applicant: | SHIRE PLC | |||
| Name of scheme: | STOCK PURCHASE PLAN | |||
| Period of return: | From: | 26 November 2005 | To: | 25 May 2006 |
| Balance under scheme from previous return: | Nil | |||
| The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: | Nil | |||
| Number of securities issued/allotted under scheme during period: | 223,621 | |||
| Balance under scheme not yet issued/allotted at end of period | 1,776,379 | |||
| Number and class of securities originally listed and the date of admission | 2,000,000 on 25 November 2005 | |||
| Total number of securities in issue at the end of the period | 498,833,835 | |||
| Name of applicant: | SHIRE PLC |
| Name of scheme: | 1996 EXECUTIVE SHARE OPTION SCHEME |
Registered in England 2883758 Registered Office as above
Period of return: | From: | 26 November 2005 | To: | 25 May 2006 |
Balance under scheme from previous return: | Nil | |||
| The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: | Nil | |||
| Number of securities issued/allotted under scheme during period: | 198,826 | |||
| Balance under scheme not yet issued/allotted at end of period | 1,001,174 | |||
| Number andclassofsecurities originally listed and the date of admission | 1,200,000 on 25 November 2005 | |||
| Total number ofsecurities in issue at the end of the period | 498,833,835 | |||
| Name of applicant: | SHIRE PLC | |||
| Name of scheme: | 2000 EXECUTIVE SHARE OPTION SCHEME | |||
| Period of return: | From: | 26 November 2005 | To: | 25 May 2006 |
| Balance under scheme from previous return: | Nil | |||
| The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: | Nil | |||
| Number of securities issued/allotted under scheme during period: | 2,116,076 | |||
| Balance under scheme not yet issued/allotted at end of period | 7,883,924 | |||
| Number and class of securities originally listed and the date of admission | 10,000,000 on 25 November 2005 | |||
| Total number of securities in issue at the end of the period | 498,833,835 | |||
| Name of applicant: | SHIRE PLC | |||
| Name of scheme: | SHIRE PLC SHARESAVE SCHEME | |||
| Period of return: | From: | 26 November 2005 | To: | 25 May 2006 |
| Balance under scheme from previous return: | Nil | |||
| The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: | Nil | |||
| Number of securities issued/allotted under scheme during period: | 47,662 | |||
| Balance under scheme not yet issued/allotted at end of period | 952,388 | |||
| Number and class of securities originally listed and the date of admission | 1,000,000 on 25 November 2005 | |||
| Total number of securities in issue at the end of the period | 498,833,835 | |||
| Name of applicant: | SHIRE PLC | |||
| Name of scheme: | BIOCHEM PHARMA STOCK OPTION PLAN | |||
| Period of return: | From: | 26 November 2005 | To: | 25 May 2006 |
| Balance under scheme from previous return: | Nil | |||
| The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: | Nil | |||
| Number of securities issued/allotted under scheme during period: | 10,930 | |||
| Balance under scheme not yet issued/allotted at end of period | 3,589,070 | |||
| Number and class of securities originally listed and the date of admission | 3,600,000 on 25 November 2005 | |||
| Total number ofsecurities in issue at the end of the period | 498,833,835 |
| Name of applicant: | SHIRE PLC | |||
| Name of scheme: | EXCHANGEABLE SHARES IN SHIRE ACQUISITION INC | |||
| Period of return: | From: | 2 February2006 | To: | 25 May 2006 |
| Balance under scheme from previous return: | Nil | |||
| The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: | Nil | |||
| Number of securities issued/allotted under scheme during period: | 195,900 | |||
| Balance under scheme not yet issued/allotted at end of period | 2,804,100 | |||
| Number and class of securities originally listed and the date of admission | 3,000,000 on 2 February 2006 | |||
| Total number of securities in issue at the end of the period | 498,833,835 | |||
| Name of contact: | Vivienne Hemming – Deputy Company Secretary |
| Address of contact: | Shire plc, Lime Tree Way, Hampshire International Business Park, Chinham, Basingstoke, RG24 8EP |
| Telephone number of contact: | +44 1256 894 276 |
For further information please contact:
| Investor Relations | Cléa Rosenfeld (Rest of the World) | +44 1256 894 160 |
| Brian Piper (North America) | +1 484 595 8252 |
Notes to editors
SHIRE PLC
Shire’s strategic goal is to become the leading specialty pharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on central nervous system, gastrointestinal, general products and human genetic therapies. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire believes that a carefully selected portfolio of products with a strategically aligned and relatively small-scale sales force will deliver strong results.
Shire’s focused strategy is to develop and market products for specialty physicians. Shire’s in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe.
For further information on Shire, please visit the Company’s website:www.shire.com.