EXHIBIT 21
LIST OF SUBSIDIARIES
Subsidiary/Undertaking | Jurisdiction of Incorporation |
3829359 Canada Inc. | Canada |
BioChem Vaccines BV | Netherlands |
GeneChem Enterprise Inc. | Canada |
GeneChem Financial Corporation | Canada |
GeneChem Management Inc. | Canada |
GeneChem Therapeutics Inc. | Canada |
Monmouth Pharmaceuticals Limited | England and Wales |
Orpharm SA | Argentina |
Pharma International Insurance Limited | Ireland |
Rybar Laboratories Limited | England and Wales |
Shire 2005 Investments Limited | Cayman Islands |
Shire Acquisition Inc. | Canada |
Shire Australia Pty Limited | Australia |
Shire Belgium BVBA | Belgium |
Shire Canada Inc. | Canada |
Shire Deutschland GmbH | Germany |
Shire Development Inc. | State of Delaware, USA |
Shire Europe Limited | England and Wales |
Shire Europe Finance | England and Wales |
Shire Executive Services LLC | State of Delaware, USA |
Shire Finance Limited | Cayman Islands |
Shire France S.A. | France |
Shire Jersey Limited | Jersey |
Shire Global Finance Limited | England and Wales |
Shire Holdings AG | Switzerland |
Shire Holdings Europe Limited | England and Wales |
Shire Holdings Europe SA | Luxembourg |
Shire Holdings Europe No.2 S.a.r.l | Luxembourg |
Shire Holdings Ireland Limited | Ireland |
Shire Holdings Ireland No.2 Limited | Ireland |
Shire Holdings Limited | Bermuda |
Shire Holdings UK Canada Limited | England and Wales |
Shire Holdings UK Limited | England and Wales |
Shire Holdings US AG | State of Delaware, USA |
Shire Human Genetic Therapies AB | Sweden |
Shire Human Genetic Therapies Inc | State of Delaware, USA |
Shire Human Genetic Therapies (Canada) Inc. | Canada |
Shire Human Genetic Therapies Securities Corporation | Commonwealth of Massachusetts, USA |
Shire Human Genetic Therapies Limited | England and Wales |
Shire Human Genetic Therapies Ltda | Brazil |
Shire Human Genetic Therapies Srl | Italy |
Shire Human Genetic Therapies UK Limited | England and Wales |
Shire Human Genetics Therapies, S.L. | Spain |
Shire Incorporated | State of Delaware, USA |
Shire Intellectual Property 2 SRL | Barbados |
Shire Intellectual Property SRL | Barbados |
Shire International Licensing BV | Netherlands |
Shire Investments & Finance (U.K.) Company | England and Wales |
Shire IP Services Corporation | Canada |
Shire Italia S.p.A. | Italy |
Shire Limited | England and Wales |
Shire LLC | Commonwealth of Kentucky, USA |
Shire Pharmaceutical Contracts Limited | England and Wales |
Shire Pharmaceutical Development Inc | State of Maryland, USA |
Shire Pharmaceutical Development Limited | England and Wales |
Shire Pharmaceutical Investment Holdings Limited | Malta |
Shire Pharmaceutical Investment Trading Ireland Limited | Ireland |
Shire Pharmaceutical Investment Limited | Malta |
Shire Pharmaceuticals Group Limited | England and Wales |
Shire Pharmaceuticals Investments 2007 Limited | Ireland |
Shire Pharmaceuticals Ireland Limited | Ireland |
Shire Pharmaceuticals Iberica S.L. | Spain |
Shire Pharmaceuticals Inc | State of Delaware, USA |
Shire Pharmaceuticals Investments (British Virgin Islands) Limited | British Virgin Islands |
Shire Pharmaceuticals Limited | England and Wales |
Shire Pharmaceuticals Mexico SA de CV | Mexico |
Shire Pharmaceutical Holdings Ireland Limited | Ireland |
Shire Pharmaceutical Investments 2008 Limited | Ireland |
Shire Pharmaceuticals Services Limited | England and Wales |
Shire Properties US | State of Delaware, USA |
Shire Regulatory Inc | State of Delaware, USA |
Shire Supplies U.S. LLC | State of Delaware, USA |
Shire UK Investments Limited | England and Wales |
Shire US Holdings Inc. | State of Delaware, USA |
Shire US Inc | State of New Jersey, USA |
Shire US Investments | England and Wales |
Shire US Manufacturing Inc | State of Maryland, USA |
Sparkleflame Limited | England and Wales |
SPG Insurance Company Limited | Guernsey |
Tanaud International BV | Netherlands |
Tanaud Ireland Inc | Ireland |
The Endocrine Centre Limited | England and Wales |
TKT Argentina srl | Argentina |
All subsidiary undertakings of Shire Limited are beneficially owned (directly or indirectly) as to 100% and are all consolidated in the consolidated financial statements of Shire Limited.
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