| Subsidiary/Undertaking | Jurisdiction of Incorporation |
| 3829359 Canada Inc. | Canada |
| BioChem Vaccines BV | Netherlands |
| GeneChem Enterprise Inc. | Canada |
| GeneChem Financial Corporation | Canada |
| GeneChem Management Inc. | Canada |
| GeneChem Therapeutics Inc. | Canada |
| Monmouth Pharmaceuticals Limited | England and Wales |
| Orpharm SA | Argentina |
| Pharma International Insurance Limited | Ireland |
| Rybar Laboratories Limited | England and Wales |
| Shire 2005 Investments Limited | Cayman Islands |
| Shire Acquisition Inc. | Canada |
| Shire Australia Pty Limited | Australia |
| Shire Belgium BVBA | Belgium |
| Shire Canada Inc. | Canada |
| Shire Deutschland GmbH | Germany |
| Shire Development Inc. | State of Delaware, USA |
| Shire Europe Limited | England and Wales |
| Shire Europe Finance | England and Wales |
| Shire Executive Services LLC | State of Delaware, USA |
| Shire Finance Limited | Cayman Islands |
| Shire France S.A. | France |
| Shire Jersey Limited | Jersey |
| Shire Global Finance Limited | England and Wales |
| Shire Holdings AG | Switzerland |
| Shire Holdings Europe Limited | England and Wales |
| Shire Holdings Europe SA | Luxembourg |
| Shire Holdings Europe No.2 S.a.r.l | Luxembourg |
| Shire Holdings Ireland Limited | Ireland |
| Shire Holdings Ireland No.2 Limited | Ireland |
| Shire Holdings Limited | Bermuda |
| Shire Holdings UK Canada Limited | England and Wales |
| Shire Holdings UK Limited | England and Wales |
| Shire Holdings US AG | State of Delaware, USA |
| Shire Human Genetic Therapies AB | Sweden |
| Shire Human Genetic Therapies Inc | State of Delaware, USA |
| Shire Human Genetic Therapies (Canada) Inc. | Canada |
| Shire Human Genetic Therapies Securities Corporation | Commonwealth of Massachusetts, USA |
| Shire Human Genetic Therapies Limited | England and Wales |
| Shire Human Genetic Therapies Ltda | Brazil |
| Shire Human Genetic Therapies Srl | Italy |
| Shire Human Genetic Therapies UK Limited | England and Wales |
| Shire Human Genetics Therapies, S.L. | Spain |
| Shire Incorporated | State of Delaware, USA |
| Shire Intellectual Property 2 SRL | Barbados |
| Shire Intellectual Property SRL | Barbados |
| Shire International Licensing BV | Netherlands |
| Shire Investments & Finance (U.K.) Company | England and Wales |
| Shire IP Services Corporation | Canada |
