EXHIBIT 21
LIST OF SUBSIDIARIES
Subsidiary/undertaking | Jurisdiction of incorporation |
3829359 Canada Inc. | Canada |
BioChem Vaccines BV | Netherlands |
Monmouth Pharmaceuticals Limited | United Kingdom |
Orpharm SA | Argentina |
Pharma International Insurance Limited | Ireland |
Rybar Laboratories Limited | United Kingdom |
Shire 2005 Investments Limited | Cayman Islands |
Shire Acquisition Inc | Canada |
Shire Australia Pty Limited | Australia |
Shire Belgium BVBA | Belgium |
Shire Biopharmaceuticals Holdings | United Kingdom |
Shire Biopharmaceuticals Ireland Limited | Ireland |
Shire Biopharmaceuticals Ireland No.2 Limited | Ireland |
Shire Canada Inc. | Canada |
Shire Deutschland GmbH | Germany |
Shire Deutschland Investments GmbH | Germany |
Shire Development Inc | United States |
Shire Europe Finance | United Kingdom |
Shire Europe Limited | United Kingdom |
Shire Executive Services LLC | United States |
Shire Finance Limited | Cayman Islands |
Shire France S.A. | France |
Shire Global Finance | United Kingdom |
Shire Holdings AG | Switzerland |
Shire Holdings Europe B.V. | Netherlands |
Shire Holdings Europe Limited | United Kingdom |
Shire Holdings Europe No.2 S.a.r.l. | Luxembourg |
Shire Holdings Ireland Limited | Ireland |
Shire Holdings Ireland No.2 Limited | Ireland |
Shire Holdings Limited | Bermuda |
Shire Holdings UK Canada Limited | United Kingdom |
Shire Holdings UK Limited | United Kingdom |
Shire Holdings US AG | United States |
Shire Human Genetic Therapies (Canada) Inc. | Canada |
Shire Human Genetic Therapies AB | Sweden |
Shire Human Genetic Therapies Inc | United States |
Shire Human Genetic Therapies Limited | United Kingdom |
Shire Human Genetic Therapies Ltda | Brazil |
Shire Human Genetic Therapies Securities Corporation | United States |
Shire Human Genetic Therapies UK Limited | United Kingdom |
Shire Incorporated | United States |
Shire Intellectual Property 2 SRL | Barbados |
Shire Intellectual Property SRL | Barbados |
Shire International Licensing BV | Netherlands |
Shire Investments & Finance (U.K.) Company | United Kingdom |
Shire IP Services Corporation | Canada |
Shire Italia S.p.A. | Italy |
Shire Jersey Limited | Jersey |
Shire LLC | United States |
Shire Luxembourg Sarl | Luxembourg |
Shire Pharmaceutical Contracts Limited | United Kingdom |
Shire Pharmaceutical Development Inc | United States |
Shire Pharmaceutical Development Limited | United Kingdom |
Shire Pharmaceutical Holdings Ireland Limited | Ireland |
Shire Pharmaceutical Investment Holdings Limited | Malta |
Shire Pharmaceutical Investment Limited | Malta |
Shire Pharmaceutical Investment Trading Ireland | Ireland |
Shire Pharmaceutical Investments 2008 | Ireland |
Shire Pharmaceuticals Group | United Kingdom |
Shire Pharmaceuticals Iberica S.L. | Spain |
Shire Pharmaceuticals Inc | United States |
Shire Pharmaceuticals Investments (British Virgin Islands) Limited | Virgin Islands, British |
Shire Pharmaceuticals Investments 2007 Limited | Ireland |
Shire Pharmaceuticals Ireland Limited | Ireland |
Shire Pharmaceuticals Limited | United Kingdom |
Shire Pharmaceuticals Mexico SA de CV | Mexico |
Shire Pharmaceuticals Services Limited | United Kingdom |
Shire plc | Jersey |
Shire Properties US | United States |
Shire Regulatory Inc | United States |
Shire Supplies U.S. LLC | United States |
Shire UK Investments Limited | United Kingdom |
Shire US Holdings Inc. | United States |
Shire US Inc | United States |
Shire US Investments | United Kingdom |
Shire US Manufacturing Inc | United States |
Sparkleflame Limited | United Kingdom |
SPG Insurance Company Limited | Guernsey |
Tanaud International BV | Netherlands |
Tanaud Ireland Inc. | Ireland |
The Endocrine Centre Limited | United Kingdom |
TKT Argentina srl | Argentina |
Jerini AG | Germany |
Jerini US, Inc. | United States |
JPT Peptide Technologies GmbH | Germany |
JPT Peptide Technologies, Inc. | United States |
Jerini Ophthalmic Holding GmbH | Germany |
Jerini Ophthalmic, Inc. | United States |
Jerini Beteiligungen GmbH | Germany |
Jerini Holding Ltd | Malta |
Jerini Trading Ltd | Malta |
All subsidiary undertakings (with the exception of the Jerini subsidiaries which are held at 98.6%) of Shire plc are beneficially owned (directly or indirectly) as to 100% and are all consolidated in the consolidated financial statements of Shire plc.