Exhibit 99.01
| Press Release |  |
| www.shire.com |
Notification of major interests in shares
November 6, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG)
1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: | Shire plc |
| 2. Reason for the notification | State Yes/No |
| An acquisition or disposal of voting rights | Yes |
| An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached | No |
| An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments | Yes |
| An event changing the breakdown of voting rights | No |
| Other (please specify): | No |
| 3. Full name of person(s) subject to the notification obligation: | BlackRock Inc |
| 4. Full name of shareholder(s) (if different from 3.): | N/A |
| 5. Date of the transaction (and date on which the threshold is crossed or reached if different): | 2 November 2012 |
| 6. Date on which issuer notified: | 6 November 2012 |
| 7. Threshold(s) that is/are crossed or reached: | Above 10% |
| 8. Notified details: | |||||||
A: Voting rights attached to shares | |||||||
Class/type of shares if possible using the ISIN CODE | Situation previous to the Triggering transaction | Resulting situation after the triggering transaction | |||||
Number of Shares | Number of Voting Rights | Number of shares | Number of voting rights | % of voting rights | |||
| Direct | Indirect | Direct | Indirect | ||||
| JE00B2QKY057 | 33,336,203 | 33,336,203 | N/A | N/A | 54,260,621 | N/A | 9.66% |
B: Qualifying Financial Instruments | ||||
Resulting situation after the triggering transaction | ||||
Type of financial instrument | Expiration date | Exercise/Conversion Period/ Date | Number of voting rights that may be acquired if the instrument is exercised/converted | % of voting rights |
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX
C: Financial Instruments with similar economic effect to Qualifying Financial Instruments | ||||||
Resulting situation after the triggering transaction | ||||||
Type of financial instrument | Exercise price | Expiration date | Exercise/ Conversion period | Number of voting rights instrument refers to | % of voting rights | |
| CFD | 2,272,938 | Nominal | Delta | |||
| 0.40% | 0.40% | |||||
| Total (A+B+C) | |
| Number of voting rights | % of voting rights |
| 56,533,559 | 10.06 |
| 9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: |
BlackRock Investment Management (UK) Limited – 56,533,559 (10.06%) |
Proxy Voting: 10. Name of the proxy holder: | N/A |
| 11. Number of voting rights proxy holder will cease to hold: | N/A |
| 12. Date on which proxy holder will cease to hold voting rights: | N/A |
| 13. Additional information: | BlackRock Regulatory Threshold Reporting Team |
| 14. Contact name: | Wayne Powell |
| 15. Contact telephone number: | 020 7743 2216; wayne.powell@blackrock.com |
Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746
For further information please contact:
| Investor Relations | ||
| Eric Rojas | erojas@shire.com | +1 781 482 0999 |
| Sarah Elton-Farr | seltonfarr@shire.com | +44 1256 894157 |
Notes to editors
Shire enables people with life-altering conditions to lead better lives.
Through our deep understanding of patients’ needs, we develop and provide healthcare in the areas of:
| · | Behavioral Health and Gastro Intestinal conditions |
| · | Rare Diseases |
| · | Regenerative Medicine |
as well as other symptomatic conditions treated by specialist physicians.
We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.