Shire plc Corporate Headquarters: 5 Riverwalk Citywest Business Campus Dublin 24 Ireland |  |
www.shire.com
| To: | Barclays Bank Plc (as Agent) |
| From: | Shire plc (as Parent Company) |
| Dated: | 18 February 2014 |
Shire PLC - US$ 2,600,000,000 Term Facilities Agreement
dated 11 November 2013 (the “Agreement”)
| 1. | We refer to the Agreement. Terms defined in the Agreement have the same meaning in this letter unless given a different meaning in this letter. |
| 2. | We refer to Clause 7.2 (Voluntary cancellation). |
| (a) | The Parent company requests the voluntary cancellation of US$350,000,000.00 (Three hundred and fifty million US dollars) of Available Facility under Facility A. |
| (b) | The effective date of such cancellation is 21 February 2014. |
| 3. | This letter may be executed in any number of counterparts and this has the same effect as if the signatures on the counterparts were on a single copy of this letter. |
| 4. | This letter and any non-contractual obligations arising out of or in connection with it are governed by English law. |
| 5. | This letter has been entered into on the date stated at the beginning of this letter. |
| 6. | This letter is irrevocable. |
/s/ Thomas Greene
Shire plc
By: Tom Greene
/s/ Simon Deaves
Barclays Bank Plc
By: Simon Deaves
Incorporated and registered In Jersey No. 99854
Registered Office: Shire plc, 22 Grenville Street, St Heller, Jersey JE-4 8PX