10 patents
Utility
Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
1 Feb 22
The invention relates to treatment of heart failure in a mammal.
Anthony O. Caggiano, Anindita Ganguly, Jennifer Iaci, Tom Parry
Filed: 9 Sep 19
Utility
Methods of reducing extravasation of inflammatory cells
12 Oct 21
A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided.
Elliott A. Gruskin, Jack L. Tseng, Anthony O. Caggiano
Filed: 17 Jul 17
Utility
Carbonate prodrugs and methods of using the same
5 Oct 21
The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety.
Naweed Muhammad, Keith R. Bley
Filed: 1 Jul 19
Utility
Methods for detecting cardiac damage
27 Jul 21
The present invention relates to a method for detecting heart damage in a patient.
Xinhua Yan, Anthony O. Caggiano
Filed: 20 Mar 19
Utility
Water-soluble acetaminophen analogs
1 Jun 21
The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration.
Naweed Muhammad, Keith R. Bley
Filed: 9 Sep 19
Utility
Compositions and methods for treating Alzheimer's disease and Parkinson's disease
13 Apr 21
The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose.
Christopher G. Salentine, Thomas R. Malefyt
Filed: 16 Jan 19
Utility
Methods for cardiomyocyte survival, proliferation or differentiation by NRG-2
20 Jul 20
The invention features methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules, and antibodies.
Mark Marchionni
Filed: 28 Aug 18
Utility
Method for achieving desired glial growth factor 2 plasma levels
8 Jun 20
The present invention relates to administering glial growth factor 2 (GGF2) to a patient in need thereof, to achieve serum levels of GGF2 within a desired therapeutic window determined based on the disease or disorder afflicting the patient.
Haesun Kim, Anthony O. Caggiano
Filed: 24 Jul 17
Utility
Compositions and methods for treatment during non-acute periods following CNS neurological injury
1 Jun 20
This invention relates to treatment of neuroinjury in a post-acute window or in a chronic period following neuroinjury.
Anthony Caggiano, Jennifer Iaci
Filed: 20 Nov 16
Utility
Water-soluble acetaminophen analogs
14 Oct 19
The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration.
Naweed Muhammad, Keith R. Bley
Filed: 24 Apr 18
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