4 patents
Utility
Peptide Epoxyketone Proteasome Inhibitors In Combination with Pim Kinase Inhibitors for Treatment of Cancers
25 Aug 22
This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.
Shirin Kapur, Alana Lerner, Christopher J. Kirk, Eric Lowe, Tracey Lin
Filed: 23 Sep 21
Utility
Compounds for Proteasome Enzyme Inhibition
25 Aug 22
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Nn) hydrolases.
Mark S. Smyth, Guy J. Laidig
Filed: 29 Apr 22
Utility
Methods of Treating Multiple Myeloma
4 Nov 21
Provided herein are methods of treating a subject suffering from multiple myeloma by administering a triplet therapy of carfilzomib, dexamethasone, and an antibody that specifically recognizes CD38.
Zandra Klippel
Filed: 29 Apr 21
Utility
Compounds for proteasome enzyme inhibition
14 Oct 20
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases.
Mark S. Smyth, Guy J. Laidig
Filed: 25 Jun 20
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