100 patents
Page 5 of 5
Utility
Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
27 Jul 20
Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising modifying the aptamer by uracil-DNA glycosylase enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture.
Igor V. Kutyavin, Sergey G. Lokhov
Filed: 4 Dec 18
Utility
Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands
27 Jul 20
Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising cleaving the aptamer by endonuclease V enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture.
Igor V. Kutyavin, Sergey G. Lokhov
Filed: 4 Dec 18
Design
Loading track
6 Jul 20
Ronald Chang, Steven M. Montgomery, Gregory Mote
Filed: 15 May 18
Utility
Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
22 Jun 20
Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising cleaving the aptamer by endonuclease V enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture.
Igor V. Kutyavin, Sergey G. Lokhov
Filed: 4 Dec 18
Utility
Molecular Diagnostic Assay System
17 Jun 20
Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein.
Douglas B. Dority, Tien Phan, David Fromm, Rick Casler, Dustin Dickens, Stuart Morita, Matthew Piccini
Filed: 8 Jan 20
Utility
Fluid Processing and Control
20 May 20
A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region.
Douglas B. Dority, Ronald Chang
Filed: 4 Dec 19
Utility
Thermal Control Device and Methods of Use
15 Apr 20
Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein.
David Fromm, Tien Phan, Matthew Piccini
Filed: 11 Dec 19
Utility
System, Device and Methods of Sample Processing Using Semiconductor Detection Chips
15 Apr 20
Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein.
DOUGLAS B. DORITY, Jonathan Siegrist, Ronald Chang
Filed: 19 Sep 19
Utility
Methods of Detecting Influenza
1 Apr 20
Compositions and methods for detecting influenza are provided.
Anupama Mokkapati, Bradley Brown, Robert Jones
Filed: 7 Oct 19
Utility
Multi-chambered Lid Apparatus with Reagent Port
4 Mar 20
A lid apparatus for a multi-chambered container.
Paul Jordan, Rohan Kurse
Filed: 26 Sep 19
Utility
Molecular diagnostic assay system
17 Feb 20
Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein.
Doug Dority, Tien Phan, David Fromm, Rick Casler, Dustin Dickens, Stuart Morita, Matthew Piccini
Filed: 21 Jul 16
Utility
Thermal control device and methods of use
27 Jan 20
Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein.
David Fromm, Tien Phan, Matthew Piccini
Filed: 21 Jul 16
Utility
Fluid processing and control
6 Jan 20
A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region.
Douglas B. Dority, Ronald Chang
Filed: 21 May 17
Utility
Methods of Detecting Bladder Cancer
18 Dec 19
Compositions and methods for detecting bladder cancer are provided.
Leena McCann, Stacey Ellen Wallace, Edwin Wei-Lung Lai, Russell Higuchi
Filed: 13 May 19
Utility
Methods of Detecting Bladder Cancer
27 Nov 19
Compositions and methods for detecting bladder cancer are provided.
Russell Higuchi, Stacey Ellen Wallace, Edwin Wei-Lung Lai
Filed: 10 Feb 19
Utility
Methods of detecting influenza
18 Nov 19
Compositions and methods for detecting influenza are provided.
Anupama Mokkapati, Bradley Brown, Robert Jones
Filed: 21 Aug 14
Utility
Compositions and methods for DNA and RNA extraction from tissue samples
4 Nov 19
Methods and reagents are provided for the rapid extraction of nucleic acids from a cell or tissue sample.
Kenneth E. Ho
Filed: 11 Jul 16
Utility
Encoderless Motor with Improved Granularity and Methods of Use
30 Oct 19
A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with permanent magnets distributed radially about the rotor, the permanent magnets extending beyond the magnetic core, and sensors mounted to the substrate adjacent the permanent magnets.
Tien Phan, Doug Dority
Filed: 3 Apr 19
Utility
Multi-chambered Lid Apparatus
16 Oct 19
A lid apparatus for a multi-chambered container.
Paul Jordan
Filed: 17 Mar 19
Utility
Thermostable Polymerase Inhibitor Compositions and Methods
16 Oct 19
The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis.
Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
Filed: 5 Jun 17