225 patents
Utility
Scaffolded Nucleic Acid Polymer Particles and Methods of Making and Using
29 Jul 20
The invention provides particle compositions having applications in nucleic acid analysis.
Wolfgang HINZ, John LEAMON, David LIGHT, Jonathan M. ROTHBERG
Filed: 5 Apr 20
Utility
Compositions, Methods, Systems and Kits for Target Nucleic Acid Enrichment
29 Jul 20
The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample.
Mark ANDERSEN, Steven ROMAN
Filed: 12 Apr 20
Utility
Biological Analysis System and Methods
29 Jul 20
A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier.
Kuan Moon BOO, Wei Fuh TEO, Zeqi TAN, Soo Yong LAU, Ming Tiong SIA, Woon Liang SOH, Ching Yee LAM, Shan Hua DONG, Marc HABERSTROH, Michael C. PALLAS, Hardeep Sangha
Filed: 29 Jan 20
Utility
Surface stabilization of biosensors
27 Jul 20
A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure.
Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
Filed: 3 Mar 16
Utility
Conjugated polymeric particle and method of making same
27 Jul 20
A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
Filed: 3 Apr 18
Utility
Visualization tools for digital PCR data
27 Jul 20
A method for generating a data visualization is provided.
Harrison Leong, Nivedita Sumi Majumdar, Jeffrey A. Marks, Theodore E. Straub, Ryan J. Talbot, Kevin S. Bodner, David Hoard
Filed: 6 Nov 13
Utility
Nucleotide Transient Binding for Sequencing Methods
22 Jul 20
Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods.
Peter VANDER HORN, Cheng-Yao CHEN, Guobin LUO, Michael PREVITE, Jamshid TEMIROV, Theo NIKIFOROV, Zhaohui ZHOU, Hongye SUN, Yufang WANG, Stefanie Yukiko NISHIMURA, Hongyi WANG, Marian PERIS, Barnett ROSENBLUM, Michael PHELAN
Filed: 19 Mar 20
Utility
Methods and Apparatus for Gas Stream Mass Transfer with a Liquid
22 Jul 20
A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween.
Christopher D. Brau, Nephi D. Jones, Benjamin R. Madsen, Michael E. Goodwin
Filed: 15 Dec 19
Utility
Capillary Electrophoresis Systems, Related Devices, and Related Methods
22 Jul 20
A biological analysis device (100) for performing capillary electrophoresis includes a voltage section (124) configured to generate a voltage differential across a cathode (106) connector and an anode (116) connector, an optical detector system (112) configured to detect light emission from a sample, a temperature regulation section (126), and a cartridge holding portion configured to receive at least a portion of a removable cartridge (102) comprising one or more capillaries (104) and a separation medium container (118).
Gary LIM, David LIU, Peng LI, Bin CAO, Kirk HIRANO, Alexander DUKHOVNY, John DIXON
Filed: 22 Feb 18
Utility
Methods and apparatus for measuring analytes
20 Jul 20
Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions.
Mark Milgrew, Jonathan Rothberg, James Bustillo
Filed: 30 Jun 19
Utility
System and Method for Determining Copies-per-unit-volume Using PCR and Flow Control of Droplets
15 Jul 20
Methods and systems for quantification of a target nucleic acid in a sample are provided.
Gordon A. JANAWAY, Mark ANDERSEN, Kornelija ZGONC, Michael C. PALLAS, Marcin SIKORA, Casey R. McFARLAND, Ferrier N. LE, Haopeng Wang, Jian GONG, Gothami Padmabandu
Filed: 12 Jan 20
Utility
RNA Quality Assay
15 Jul 20
Disclosed is a method for determining the quality, expressed in terms of a quality value, of an RNA sample based on a multiplex fluorescent ratiometric method, wherein the ratio of small RNA to large and/or structured RNA in a sample is determined, thereby obtaining the quality value.
Chris VONNEGUT, Scott CLARKE
Filed: 3 Oct 18
Design
Lid of an electrophoresis tank
13 Jul 20
Paul Nelson, Syrus Jaffe, Shimon Spector
Filed: 23 Sep 18
Design
Illumination and imaging instrument
13 Jul 20
Xin Mathers
Filed: 12 Nov 18
Utility
Integrated system for nucleic acid amplification and detection
13 Jul 20
Devices, systems, methods, and kits are disclosed for amplifying small quantities of nucleic acid and identifying the nucleic acid sequences of the amplified nucleic acid products.
Jason Yingjie Liu
Filed: 15 Mar 15
Utility
Heat exchanger system with flexible bag
13 Jul 20
A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment.
Clinton C. Staheli, Nephi D. Jones, Michael E. Goodwin
Filed: 8 Dec 16
Utility
Combinatorial Barcode Sequences, and Related Systems and Methods
8 Jul 20
A kit for use with a nucleic acid sequencing instrument can include a plurality of combinatorial barcodes sequences meeting the following criteria: each of the combinatorial barcode sequences comprise a plurality of iterations of a sequence motif, where the sequence motif comprises a first nucleotide base from a first group of nucleotide bases followed by a second nucleotide base from a second group of nucleotide bases, the first group and the second group differing from each other; and the plurality of combinatorial barcode sequences is at least 1,000,000 different barcode sequences.
Earl HUBBELL
Filed: 17 Mar 20
Utility
Surface Stabilization of Biosensors
8 Jul 20
A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure.
Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
Filed: 19 Mar 20
Utility
Labeling and Detection of Post Translationally Modified Proteins
8 Jul 20
Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support.
Brian AGNEW, Kyle GEE, Tamara NYBERG
Filed: 8 Jan 20
Utility
Methods, systems, computer readable media, and kits for sample identification
6 Jul 20
A method for sequencing a polynucleotide sample having a barcode sequence, includes: introducing a series of nucleotides to the polynucleotide sample according to a predetermined flow ordering; obtaining a series of signals resulting from the introducing of nucleotides to the polynucleotide sample; and resolving the series of signals over the barcode sequence to render a flowspace string, wherein the flowspace string is a codeword of an error-tolerant code capable of distinguishing the barcode sequence from other barcode sequences in the presence of one or more errors.
Earl Hubbell
Filed: 29 Aug 12