68 patents
Utility
Methods of Treating Conditions Related to the S1P1 Receptor
28 Dec 23
Described herein are methods for treating atopic dermatitis that allows for the effective treatment of the disease with an interruption period if certain adverse events are observed.
Gurpreet AHLUWALIA, Maple M FUNG, Andrew Christopher Wesley SELFRIDGE
Filed: 8 Nov 21
Utility
Modulators of the Prostacyclin (PGI2) Receptor Useful for the Treatment of Disorders Related Thereto
21 Dec 23
Thuy-Anh TRAN, Weichao CHEN, Bryan A. KRAMER, Abu J.M. SADEQUE, Anna SHIFRINA, Young-Jun SHIN, Pureza VALLAR, Ning ZOU
Filed: 28 Apr 23
Utility
Methods of Treating Conditions Related to the S1P1 Receptor
14 Dec 23
Amit D. MUNSHI
Filed: 8 Nov 21
Utility
Methods of Treating Conditions Related to the S1P1 Receptor
26 Oct 23
Provided are methods of treatment of alopecia areata comprising prescribing and/or administering to an individual in need thereof a standard dose of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt thereof.
Catherine M Crosby, Gurpreet Ahluwalia, Andrew Christopher Wesley Selfridge
Filed: 6 Jan 21
Utility
Methods of Treatment
21 Sep 23
Provided is a method of treatment of a 5-hydroxytryptamine (HT)2C receptor-associated disorder comprising: prescribing and/or administering to an individual in need thereof, (R)-N-(2,2-difluoroethyl)-7-methyl-1,2,3,4,6,7-hexahydro-[1,4]diazepino[6,7,1-hi]indole-8-carboxamide (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
Dolly PARASRAMPURIA, Chadwick J. OREVILLO, Philip PERERA
Filed: 9 Mar 23
Utility
Diaryl and Arylheteroaryl Urea Derivatives As Modulators of the 5-HT2A Serotonin Receptor Useful for the Prophylaxis and Treatment of Disorders Related Thereto
7 Sep 23
Bradley Teegarden, Honnappa Jayakumar, Hongmei Li, Sonja Strah-Pleynet, Peter I. Dosa
Filed: 13 Dec 22
Utility
SUBSTITUTED (1,2,3,4-TETRAHYDROCYCLOPENTA[b]INDOL-3-YL)ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
17 Aug 23
Robert M. Jones, Daniel J. Buzard, Sangdon Han, Sun Hee Kim, Juerg Lehmann, Brett Ullman, Jeanne V. Moody, Xiuwen Zhu, Scott Stirn
Filed: 11 Aug 22
Utility
Compounds and Methods for Treatment of Primary Biliary Cholangitis
18 May 23
The present invention relates to, inter alia, methods of treatment and combinations of (R)-2-(7-(4- cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1) useful for the treatment of primary biliary cholangitis (PBC).
Cheryl Geraldine Lassen, Robert M. Jones, Que Liu, Ronald J. Christopher
Filed: 18 Nov 22
Utility
3-PHENOXYAZETIDIN-1-YL-HETEROARYL Pyrrolidine Derivatives and the Use Thereof As Medicament
27 Apr 23
Kai Gerlach, Daniela Gavina Berta, Marco Ferrara, Kirsten Gutsche, Ursula Mueller-Vieira, Scott Hobson, Frank Runge, Graeme Semple, Viktor Vintonyak, Yifeng Xiong
Filed: 9 Sep 22
Utility
Modulators of the Prostacyclin (PGI2) Receptor Useful for the Treatment of Disorders Related Thereto
20 Apr 23
Thuy-Anh TRAN, Weichao CHEN, Bryan A. KRAMER, Abu J.M. SADEQUE, Anna SHIFRINA, Young-Jun SHIN, Pureza VALLAR, Ning ZOU
Filed: 7 Jun 22
Utility
Compounds and Methods for Treatment of Inflammatory Bowel Disease with Extra-intestinal Manifestations
23 Mar 23
The present invention relates to, inter alia, methods of treatment and combinations of (R)-2-(7-(4-cyclopentyl-3-(triflu-oromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1) useful for the treatment of extra-intestinal manifestations (EIM) in an individual with inflammatory bowel disease (BBD) and for the treatment of pyoderma gangrenosum (PG).
Cheryl Geraldine Lassen
Filed: 18 Oct 22
Utility
5-HT2C Receptor Agonists and Compositions and Methods of Use
23 Feb 23
Juerg Lehmann, Konrad Feichtinger, Albert S. Ren, Graeme Semple
Filed: 10 Jun 22
Utility
Compounds and Methods for Treatment of Visceral Pain
2 Feb 23
The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof and their use in methods for the alleviation and/or treatment of visceral pain, for example abdominal pain; pelvic pain; male pelvic pain; pain from an internal organ; bladder pain; painful bladder syndrome; post-surgical abdominal pain (e.g., GI resection, hysterectomy, oophorectomy, C-section, and the like); or pain arising from or related to: pancreatitis (e.g., chronic pancreatitis), prostatitis (e.g., chronic prostatitis), inflammatory bowel disease (e.g., Crohn's disease), endometriosis, interstitial cystitis, prostatitis (e.g., chronic prostatitis), epididymitis (e.g., chronic epididymitis), or post-surgical abdominal lesions.
Cheryl Geraldine Lassen, Marcelo Fabian Piccirillo
Filed: 21 Jun 22
Utility
Methods of Treating Conditions Related to the S1P1 Receptor
29 Dec 22
Provided are methods of treatment of eosinophilic GI diseases comprising prescribing and/or administering to an individual in need thereof a standard dose of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt thereof.
Heather Kiyomi Komori-Occhicone, Thai Curtis Nguyen-Cleary, Jin Yu
Filed: 20 Nov 20
Utility
Modulators of the BETA-3 Adrenergic Receptor Useful for the Treatment or Prevention of Heart Failure and Disorders Related Thereto
15 Dec 22
Thuy-Anh Tran, Brett Ullman, Bryan Aubrey Kramer, Quyen-Quyen Thuy Do, Young-Jun Shin
Filed: 22 Apr 22
Utility
Substituted 3-PHENOXYAZETIDIN-1-YL-PYRAZINES
10 Nov 22
The invention relates to substituted 3-phenoxyazetidin-1-yl-pyrazines of general formula (I) which are agonists of GPR52, useful in treating central nervous system diseases and other diseases.
Kai Gerlach, Graeme Semple, Yifeng Xiong, Barbara Bertani, Marco Ferrara, Giacomo Fossati, Scott Hobson, Uta Friederike Lessel, Frank Runge, Ursula Mueller-Vieira, Julian Wippich
Filed: 29 Mar 21
Utility
Method of Treating Conditions Related to the PGI2 Receptor
10 Nov 22
Provided in some embodiments are titration packages, kits, and methods of treating pulmonary arterial hypertension comprising prescribing and/or administering to a patient in need thereof 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof, via a titration scheme that comprises the up-titration of Compound 1, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, over a period of no more than about nine weeks until an optimized dose is administered.
Alan GLICKLICH
Filed: 12 Jul 22
Utility
Methods of Treating Conditions Related to the S1P1 Receptor
3 Nov 22
Provided are methods of treatment of Crohn's Disease comprising prescribing and/or administering to an individual in need thereof a standard dose of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)pbenzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
Thai Curtis Nguyen-Cleary, Lisette Marie Acevedo
Filed: 30 Sep 20
Utility
Cannabinoid Receptor Modulators
29 Sep 22
The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor.
Robert M. Jones, Sangdon Han, Lars Thoresen, Jae-Kyu Jung, Sonja Strah-Pleynet, Xiuwen Zhu, Yifeng Xiong, Dawei Yue
Filed: 8 Nov 21
Utility
Processes for the Preparation of (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOL-3-YL)ACETIC Acid and Salts Thereof
18 Aug 22
Antonio Garrido Montalban, Daniel J. Buzard, John A. DeMattei, Tawfik Gharbaoui, Stephen R. Johannsen, Ashwin M. Krishnan, Young Mi Kuhlman, You-An Ma, Michael John Martinelli, Suzanne Michiko Sato, Dipanjan Sengupta
Filed: 14 Sep 21