15 patents
Utility
Compositions Comprising BISFLUOROALKYL-1,4-BENZODIAZEPINONE Compounds for Treating Adenoid Cystic Carcinoma
30 Nov 23
The present invention provides methods of treating or suppressing Adenoid Cystic Carcinoma (ACC) or inhibiting ACC tumor growth in subjects by administering compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds, including compounds of Formula (III) or prodrugs thereof.
Dana GELBAUM, Jeffrey KAUFMAN, Joel KAYE
Filed: 17 Sep 21
Utility
Methods of Preparing Chiral Benzodiazepinone Derivatives
6 Apr 23
The present invention provides methods of preparing compound of Formula (I), wherein the compounds are represented by the structure of Formula (I) wherein: R1 each is independently F, Cl, Br, I, OCH3, CN or NO2; R2 each is independently identical or different C1-C5 alkyl; n1 is an integer between 1 and 5; and n2 is an integer between 1 and 4.
Christopher M. CIMARUSTI, Anandkumar Madanlal LAHOTI, Madan Raja Gopal Reddy DARAM
Filed: 16 Feb 21
Utility
Compositions and methods comprising KLK3 or FOLH1 antigen
20 Sep 22
The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant Listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.
Yvonne Paterson, John Rothman, Vafa Shahabi
Filed: 1 Nov 19
Utility
Compositions and Methods for Lyophilization of Bacteria or Listeria Strains
3 Mar 22
Methods and compositions are provided for lyophilization of bacteria or Listeria strains, such as Listeria monocytogenes.
David Fela, Anu Wallecha, Mike Grace, Melissa Gosse
Filed: 18 Oct 21
Utility
Compositions and methods for lyophilization of bacteria or listeria strains
23 Nov 21
Methods and compositions are provided for lyophilization of bacteria or Listeria strains, such as Listeria monocytogenes.
David Fela, Anu Wallecha, Mike Grace, Melissa Gosse
Filed: 29 Aug 18
Utility
Listeria-Based Compositions Comprising a Peptide Minigene Expression System and Methods of Use Thereof
12 Aug 21
This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for inducing an immune response against an antigen-expressing tumor and for treating the same, and vaccinating against the same in subjects bearing the tumors.
Robert Petit, Michael F. Princiotta
Filed: 18 Dec 20
Utility
Compositions and Methods for Evaluating Potency of Listeria-based Immunotherapeutics
5 Aug 21
Methods and compositions are provided for assessing antigen presentation and potency of Listeria-based immunotherapeutics in inducing an immune response.
Anu WALLECHA, Mike GRACE
Filed: 25 Apr 19
Utility
Immunogenic Heteroclitic Peptides from Cancer-associated Proteins and Methods of Use Thereof
17 Jun 21
Provided herein are tumor-associated antigen peptides comprising heteroclitic mutations and fusion polypeptides comprising such heteroclitic peptide.
Robert PETIT, Michael F. PRINCIOTTA, Brandon CODER, David BALLI
Filed: 8 Nov 18
Utility
Listeria-based compositions comprising a peptide minigene expression system and methods of use thereof
26 Jan 21
This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for inducing an immune response against an antigen-expressing tumor and for treating the same, and vaccinating against the same in subjects bearing the tumors.
Robert Petit, Michael F. Princiotta
Filed: 3 Mar 16
Utility
Compositions and Methods for Evaluating Attenuation and Infectivity of Listeria Strains
6 Jan 21
Methods and compositions are provided for assessing attenuation and/or infectivity of bacteria or Listeria strains, such as Listeria monocytogenes.
Poonam MOLLI, Anu WALLECHA
Filed: 7 Mar 19
Utility
Compositions and Methods for Lyophilization of Bacteria or Listeria Strains
19 Aug 20
Methods and compositions are provided for lyophilization of bacteria or Listeria strains, such as Listeria monocytogenes.
David FELA, Anu WALLECHA, Mike GRACE, Melissa GOSSE
Filed: 28 Aug 18
Utility
Compositions and Methods Comprising KLK3 or FOLH1 Antigen
4 Mar 20
The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant Listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.
Yvonne PATERSON, John ROTHMAN, Vafa SHAHABI
Filed: 31 Oct 19
Utility
Combination of Listeria-based Vaccine with ANTI-CTLA-4 or ANTI-CD137 Antibodies
26 Feb 20
The subject matter described herein is directed to methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated tumor or cancer, comprising the step of administering to a subject a recombinant Listeria strain expressing a construct comprising at least one human papillomavirus antigen in combination with one or more other therapeutic agents to treat a tumor or metastatic cancer.
Sandra M. HAYES, Rachelle KOSOFF, Jun ZOU
Filed: 6 Nov 17
Utility
Personalized Delivery Vector-based Immunotherapy and Uses Thereof
18 Dec 19
This invention provides a system of providing and creating personalized immunotherapeutic compositions for a subject having a disease or condition, including therapeutic immunotherapy delivery vectors and methods of making the same comprising gene expression constructs expressing peptides associated with one or more neo-epitopes or peptides containing mutations that are specific to a subject's cancer or unhealthy tissue.
Robert PETIT, Kyle PERRY, Michael F. PRINCIOTTA, Daniel J O'CONNOR
Filed: 25 May 16
Utility
Immunogenic Compositions Targeting Recurrent Cancer Mutations And Methods Of Use Thereof
23 Oct 19
Provided herein are recombinant fusion polypeptides comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins.
Robert Petit, Michael F. Princiotta, Brandon Coder, David Balli
Filed: 29 Nov 17
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