Mesenchymal stem cells for the treatment of CNS diseases
30 Nov 21
An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell.
Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
Filed: 27 Jul 18
Methods of Generating Mesenchymal Stem Cells Which Secrete Neurotrophic Factors
4 Nov 21
A method of generating MSCs which secrete neurotrophic factors (NTFs) comprising incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP.
Yael GOTHELF, Yosef LEVY, Alex BURSHTEIN
Filed: 14 Jul 21
Methods for Treating Amyotrophic Lateral Sclerosis (Als)
6 May 21
Described herein are mesenchymal stem cells and populations thereof, which can be used for treating neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) disease.
Revital ARICHA, Yael GOTHELF, Natalie ABRAMOV, Haggai KASPI
Filed: 13 Jul 17
Cell-type Specific Exosomes and Use Thereof
4 Feb 21
Provided herein are highly-characterized isolated exosomes, methods to produce such exosomes, and methods for the use of such exosomes in treating diseases such as neurodegenerative diseases.
Revital ARICHA, Haggai KASPI, Jonathan SEMO, Yael GOTHELF
Filed: 10 Apr 19
Populations of mesenchymal stem cells that secrete neurotrophic factors
17 Feb 20
Yael Gothelf, Yosef Levy
Filed: 10 Feb 15
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