28 patents
Utility
Multi-Functional Hemocompatible Porous Bead Sorbent For Removing Protein Based Toxins And Potassium From Biological Fluids
18 Jan 24
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Filed: 30 Jun 23
Utility
The Use of a Hemocompatible Porous Polymer Bread Sorbent for Removal of Pamps and Damps
30 Nov 23
The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules.
Maryann GRUDA, Pamela O'SULLIVAN, Tamaz GULIASHVILI, Andrew SCHEIRER, Thomas GOLOBISH, Vincent CAPPONI, Philip CHAN
Filed: 16 Feb 23
Utility
Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules
28 Nov 23
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.
Tamaz Guliashvili, Thomas Golobish, Maryann Gruda, Pamela O'Sullivan, Andrew Scheirer, Vincent Capponi, Phillip Chan, Wei-Tai Young
Filed: 12 Jul 21
Utility
Reduction of Advanced Glycation Endproducts from Bodily Fluids
5 Oct 23
The invention concerns removing advanced glycation end products from a bodily fluid by contacting the bodily fluid with a sorbent.
Andreas Viktor SIMM, Jorg SCHEIER, Christian STEINER, Vincent CAPPONI, Phillip P. CHAN
Filed: 19 May 23
Utility
Therapeutic And Cosmetic Wound Treatment
5 Oct 23
The invention concerns methods for the selective, topical or trans dermal delivery or removal of one or more substances to, or from, respectively, the skin or surface of a human or animal subject, via the topical or transdermal application of a porous, polymeric composition capable of releasing or sorbing (adsorbing and/or absorbing) said substances, wherein said porous polymer is a particulate material, with particles having an average diameter in the range of approximately 0.1 microns to approximately 0.5 centimeters, and having a plurality of pores with an average pore diameter in a range of approximately 50 Angstroms to approximately 40,000 Angstroms.
Phillip P. CHAN, Ophir ORTIZ, Thomas D. Golobish, Vincent J. CAPPONI, Wei-Tai Young
Filed: 19 Aug 21
Utility
Hemocompatibility modifiers for cross-linked polymeric material
12 Sep 23
The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.
Thomas D. Golobish, Vincent J. Capponi, David R. Clay
Filed: 31 Mar 14
Utility
Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids
15 Aug 23
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Filed: 8 Jun 21
Utility
Methods for reducing contamination in a biological substance
14 Mar 23
Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin.
Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 26 Apr 17
Utility
Use Of A Hemocompatible Porous Polymer Bead Sorbent For Removal Of Endotoxemia-Inducing Molecules
3 Feb 22
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.
Tamaz Guliashvili, Thomas Golobish, Maryann Gruda, Pamela O'Sullivan, Andrew Scheirer, Vincent Capponi, Phillip Chan, Wei-Tai Young
Filed: 12 Jul 21
Utility
Crosslinked Polysaccharide Based Absorbents for Removal of Anti-a And/or Anti-b Antibodies from Human Plasma and Whole Blood
3 Feb 22
The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.
Tamaz GULIASHVILI, Maryann GRUDA, Thomas GOLOBISH, David JAMES, Karl-Gustav RUGGEBERG, Pamela O'SULLIVAN, Sarah PATTERSON
Filed: 2 Dec 19
Utility
Hemocompatibility Modifiers For Cross-Linked Polymeric Material
30 Dec 21
The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.
Thomas D. Golobish, Vincent J. Capponi, David R. Clay
Filed: 6 May 21
Utility
Multi-Functional Hemocompatible Porous Polymer Bead Sorbent For Removing Protein Based Toxins And Potassium From Biological Fluids
30 Dec 21
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Filed: 8 Jun 21
Utility
Methods for removal of toxins from blood using an extracorporeal circuit comprised of a hollow-fiber filter module and polymer sorbent in combination
21 Dec 21
This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
Wei-Tai Young, Tamaz Guliashvili, Andrew Scheirer, Josh Vichare, Timothy Kovacs, Maryann Gruda, Thomas Golobish, Vincent Capponi, Phillip Chan
Filed: 22 Mar 18
Utility
Method Of Treating Inflammation
28 Oct 21
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient.
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 13 Apr 21
Utility
Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules
20 Jul 21
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.
Tamaz Guliashvili, Thomas Golobish, Maryann Gruda, Pamela O'Sullivan, Andrew Scheirer, Vincent Capponi, Phillip Chan, Wei-Tai Young
Filed: 18 May 17
Utility
Method of treating inflammation
13 Jul 21
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient.
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 3 Jun 16
Utility
Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids
22 Jun 21
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Filed: 21 Oct 16
Utility
Hemocompatibility modifiers for cross-linked polymeric material
1 Jun 21
The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.
Thomas D. Golobish, Vincent J. Capponi, David R. Clay
Filed: 17 Apr 20
Utility
Method of treating inflammation
6 Apr 21
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient.
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 26 Jun 18
Utility
Method of treating inflammation
16 Mar 21
The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 29 May 19