60 patents
Page 3 of 3
Utility
Antibodies Binding to Vista at Acidic pH
21 Jan 21
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment.
Robert J. Johnston, Arvind Rajpal, Paul O. Sheppard, Luis Borges, Andrew Rankin, Keith Sadoon Bahjat, Alan J. Korman, Xiaodi Deng, Lin Hui Su, Ginger Rakestraw, Jason R. Pinckney, David A. Critton, Guodong Chen, Richard Y. Huang, Ekaterina G. Deyanova
Filed: 19 Mar 19
Utility
Combination Anti-CSF1R and Anti-PD-1 Antibody Combination Therapy for Pancreatic Cancer
14 Jan 21
The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).
Katherine E. Lewis, Serena Kimi Perna, Michael Carleton, Ke Xu, Penny Phillips, Dimple Pandya, Brian Wong, Julie Hambleton, Robert Sikorski, Emma Masteller, Kevin Hestir, David Bellovin, Janine Powers, Ernestine Lee
Filed: 12 Sep 18
Utility
Anti-CSF1R Antibodies for Treating PVNS
14 Jan 21
Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
Robert Sikorski, Julie Hambleton, Nilacantan Sankar
Filed: 25 Jun 20
Utility
Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)
2 Nov 20
Methods of reducing cytokine levels and methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
Brian Wong, Emma Masteller, Kris Reedquist
Filed: 23 Jan 19
Utility
NOPE for treatment of pathological muscle loss and weakness
12 Oct 20
Methods of treating muscle wasting and other disorders with NOPE extracellular domain (ECD) polypeptides and NOPE ECD fusion molecules are provided.
Aaron Curtis Hinken, Amy W. Hsu, Janine Powers, Warren James Rocque, Alan James Russell
Filed: 23 Apr 17
Utility
Anti-CSF1R Antibody and Anti-PD-1 Antibody Combination Therapy for Cancer
23 Sep 20
Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
Brian Wong, Julie Hambleton, Robert Sikorski, Emma Masteller, Kevin Hestir, David Bellovin, Katherine E. Lewis
Filed: 3 Mar 20
Utility
B7-H4 Antibodies and Methods of Use Thereof
12 Aug 20
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof.
Charles KAPLAN, Derrick HOUSER, Luis BORGES, Gloria BRATTICH, David BELLOVIN, Felicia KEMP, Majid GHODDUSI, Nels P. NIELSON, Kathy MILLER, Maike SCHMIDT
Filed: 9 Mar 20
Utility
Method of treating PVNS with anti-CSF1R antibodies
3 Aug 20
Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
Robert Sikorski, Julie Hambleton, Nilacantan Sankar
Filed: 21 Jun 18
Utility
Combination Therapy for Cancer
29 Jul 20
Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with one or more immune stimulating agents are provided.
Emma Masteller, Thomas Brennan, David Bellovin, Kevin Baker, Brian Wong
Filed: 9 Feb 20
Utility
Antibodies that Bind Colony Stimulating Factor 1 Receptor (CSF1R)
15 Jul 20
Antibodies that bind CSF1R are provided.
Justin Wong, Maximiliano Vasquez
Filed: 7 Jan 20
Utility
Methods of Treatment with CD80 Extracellular Domain Polypeptides
10 Jun 20
This application relates to use of CD80 (B7-1) extracellular domain (ECD) polypeptides and CD80-ECD fusion molecules and their use in methods of increasing the number of central memory T cells or for treatment for cancer or for use in cancer vaccine compositions.
Thomas BRENNAN, Barbara SENNINO, Susannah D. BARBEE, Ursula JEFFRY
Filed: 26 Apr 18
Utility
Anti-CSF1R antibody and anti PD-1 antibody combination therapy for cancer
13 Apr 20
Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
Brian Wong, Julie Hambleton, Robert Sikorski, Emma Masteller, Kevin Hestir, David Bellovin, Katherine E. Lewis
Filed: 8 Jan 19
Utility
Antibodies Binding to ILT4
11 Mar 20
The present application relates to antibodies specifically binding to immunoglobulin-like transcript 4 (ILT4), which is also known as LILRB2, LIR2, MIR10, and CD85d, and corresponding nucleic acids, host cells, compositions, and uses.
Xiao Min Schebye, Diana Yuhui Chen, Andrew Rankin, Xiaodi Deng, Joseph Toth, Linda Liang, Michelle Minhua Han, Christine Bee, Hong-An Truong, Mark J. Selby, Nils Lonberg, Guodong Chen, Richard Y. Huang, Ekaterina G. Deyanova, Alan J. Korman
Filed: 8 Jul 19
Utility
Anti-FGFR2 Antibodies in Combination with Chemotherapy Agents in Cancer Treatment
11 Mar 20
This application relates to uses of antibodies against fibroblast growth factor receptor 2 (FGFR2), including antibodies against the FGFR2 isoform FGFR2-IIIb (also known as FGFR2b), in treatment of certain cancers in combinations with mFOLFOX6 chemotherapy.
Helen L. Collins, James Hnatyszyn, Hong Xiang, Xiang Zhang
Filed: 14 May 18
Utility
Antibodies Binding to VISTA at Acidic pH
19 Feb 20
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment.
Robert J. Johnston, Arvind Rajpal, Paul O. Sheppard, Luis Borges, Andrew Rankin, Keith Sadoon Bahjat, Alan J. Korman, Andy X. Deng, Lin Hui Su, Ginger Rakestraw
Filed: 12 Mar 18
Utility
Antibodies that bind colony stimulating factor 1 receptor (CSF1R)
17 Feb 20
Antibodies that bind CSF1R are provided.
Justin Wong, Maximiliano Vasquez
Filed: 25 Mar 18
Utility
Combination Therapy for Cancer Using Anti-gitr Antibodies
29 Jan 20
Provided herein are methods of treating cancer with a combination of an anti glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related protein (GITR)-antibody and an antibody that binds colony stimulating factor 1 receptor (CSF1R) or with a combination of an anti-GITR antibody and an antibody that binds programmed cell death protein 1 (PD-1).
Susannah D. Barbee, David Bellovin, Luis Borges
Filed: 28 Mar 18
Utility
Methods of treating lung cancer
20 Jan 20
Methods of treating cancers comprising FGFR1 gene amplification are provided.
Thomas Harding, Servando Palencia, Li Long, Kevin Hestir
Filed: 7 Jun 18
Utility
Medical Use of Interferon-lambda for the Treatment of Fibrosis
11 Dec 19
The present invention relates to methods for the treatment of fibrosis.
Timothy Scott Johnson, Breda Twomey, Janine Powers
Filed: 19 Dec 17
Utility
PSGL-1 Antagonists and Uses Thereof
30 Oct 19
Methods of identifying and using PSGL-1 antagonists are provided.
Robert J. Johnston, Andrew Rankin, Arathi Krishnakumar, Paul O. Sheppard, Arvind Rajpal
Filed: 9 Jan 18