178 patents
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Biocatalysts for the Preparation of Hydroxy Substituted Carbamates
18 Jan 24
The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.
Fabien Louis Cabirol, Haibin Chen, Anupam Gohel, Steven J. Collier, Derek J. Smith, Birgit Kosjek, Jacob Janey
Filed: 12 Jun 23
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Engineered Leucine Decarboxylases
18 Jan 24
The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase (LDC) polypeptides.
Joyce Liu, Leann Quertinmont Teadt, Nikki Dellas, Stephan Jenne, Faye Loan Du, Kristen Jean Vallieu, Kerryn McCluskie
Filed: 2 Aug 23
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Engineered Glycosyltransferases and Steviol Glycoside Glucosylation Methods
11 Jan 24
The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Stephanie Sue Galanie, Jack Liang, Joyce Liu, Nikki Dellas, Melissa Ann Mayo, David Entwistle
Filed: 2 Aug 23
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Engineered Pantothenate Kinase Variant Enzymes
4 Jan 24
The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jovana Nazor, Mikayla Jianghongxia Krawczyk, Zara Maxine Seibel, Nandhitha Subramanian, Joshua Kolev
Filed: 29 Sep 21
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Engineered Transaminase Polypeptides
4 Jan 24
The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions.
Scott J. Novick, Nikki Dellas
Filed: 1 Sep 23
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Engineered Phosphopentomutase Variant Enzymes
23 Nov 23
The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Santhosh Sivaramakrishnan, Jessica Anna Hurtak
Filed: 5 Oct 21
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Engineered Galactose Oxidase Variant Enzymes
23 Nov 23
The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Margie Tabuga Borra-Garske, Jovana Nazor, Nandhitha Subramanian, Oscar Alvizo, Anna Fryszkowska
Filed: 1 Oct 21
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Recombinant Factor VIII Variants
26 Oct 23
The present disclosure provides recombinant factor VIII polypeptides, polynucleotides encoding the recombinant factor VIII polypeptides, and compositions thereof, wherein the recombinant factor VIII polypeptides have been engineered to provide improved expression, activity/potency, clotting activity/potency, serum/plasma stability, and/or reduced immunogenicity.
Jeremiah Dallas Heredia, Nikki D. Kruse, Aksiniya Lyubenova Petkova, Marcus Rohovie, Adam P. Silverman
Filed: 5 Jan 23
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Engineered Biocatalysts and Methods for Synthesizing Chiral Amines
19 Oct 23
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
Weng Lin Tang, Helen Hsieh, Son Pham, Derek Smith, Steven J. Collier
Filed: 29 Jun 23
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Biocatalysts and Methods for the Synthesis of Substituted Lactams
5 Oct 23
The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.
Fabien Louis Cabirol, Haibin Chen, Anupam Gohel, Paulina Elena Salim, Derek J. Smith, Jacob Janey, Birgit Kosjek, Weng Lin Tang, Helen Hsieh, Son Q. Pham
Filed: 3 Feb 23
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Engineered Phenylalanine Ammonia Lyase Polypeptides
21 Sep 23
The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides.
Chinping Chng, William Casey Hallows, Nicholas J. Agard, Oscar Alvizo, Nikki Dellas, Gjalt W. Huisman, John Joseph Nicols
Filed: 13 Jan 23
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Engineered Imine Reductases and Methods for the Reductive Amination of Ketone and Amine Compounds
21 Sep 23
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
Filed: 17 Feb 23
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Engineered Phenylalanine Ammonia Lyase Polypeptides
21 Sep 23
The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides.
Chinping Chng, William Casey Hallows, Nicholas J. Agard, Oscar Alvizo, Nikki Dellas, Gjalt W. Huisman, John Joseph Nicols
Filed: 13 Jan 23
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Ketoreductase Polypeptides and Polynucleotides
14 Sep 23
The present invention provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme, as well as polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a chiral alcohol.
Jack Liang, Nandhitha Subramanian, Charlene Ching, David William Homan, Katie Whalen, Matthew Blake Jones
Filed: 24 Sep 20
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Engineered Monoamine Oxidases for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds
14 Sep 23
The present invention provides novel biocatalysts and associated methods of use for the oxidative desymmetrization of fused bicyclic proline analogues to produce APIs and intermediates.
Jessica Anna Hurtak, Jonathan Vroom, David Watts
Filed: 10 Mar 23
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Engineered Leucine Decarboxylases
7 Sep 23
The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase polypeptides.
Jonathan Benjamin Asfaha, Subhamoy Das, Faye Loan Du, Stephan Jenne, Nikki D. Kruse, Joyce Liu, Kerryn McCluskie, Roasa Mehmood, Adam P. Silverman, Kristen Jean Vallieu
Filed: 1 Nov 22
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Engineered Oxalate Decarboxylases
7 Sep 23
The present disclosure provides engineered oxalate decarboxylase (ODC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered oxalate decarboxylase polypeptides.
Chinping Chng, Nikki D. Kruse, Joyce Liu, Adam P. Silverman, Rebecca Hong Thibodeau, Tricia Windgassen
Filed: 10 Feb 23
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Biocatalysts and Methods for Hydroxylation of Chemical Compounds
31 Aug 23
The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
Jovana Nazor, Robert Osborne, Jack Liang, Jonathan Vroom, Xiyun Zhang, David Entwistle, Rama Voladri, Ravi David Garcia, Jeffrey C. Moore, Shane Grosser, Birgit Kosjek, Matthew Truppo
Filed: 8 Mar 23
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Penicillin-g Acylases
31 Aug 23
The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
Rama Voladri, Christopher Michael Micklitsch, Oscar Alvizo, Jovana Nazor, Da Duan, Judy Victoria Antonio Viduya, Stephan Jenne, Chihui An, Keith Allen Canada, Paul N. Devine, Iman Farasat, Anna Fryszkowska, Katrina W. Lexa, Robert Kevin Orr
Filed: 23 Mar 23
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Ketoreductase Polypeptides for the Reduction of Acetophenones
17 Aug 23
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme.
Jack Liang, Stephane J. Jenne, Emily Mundorff, Charlene Ching, John M. Gruber, Anke Krebber, Gjalt W. Huisman
Filed: 15 Sep 22