481 patents
Page 3 of 25
Utility
Novel Reverse Transcriptases and Uses Thereof
19 Oct 23
Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
Xiao-Song GONG, Yan WANG
Filed: 23 Mar 23
Utility
Method and System for Sizing a Population of Nucleic Acid Fragments Using a Digital Assay
12 Oct 23
Methods, systems, and computer-readable media for sizing a population of nucleic acid fragments.
Stephen C. BOLARIS, Meiye WU, Mark WHITE, Dawne N. SHELTON
Filed: 24 Mar 23
Utility
Methods and Compositions for Maximum Release of Oligonucleotides
12 Oct 23
The methods allow for provision of a mixture of a plurality of beads, each bead linked to oligonucleotides, wherein the mixture can be treated as a bulk solution (prior to partitioning) to cleave a covalent bond linking the oligonucleotides to the beads while retaining a non-covalent linkage (via hybridization) between the beads and the oligonucleotides, allowing for distribution of the oligonucleotides and beads to partitions or 2D arrays prior to separation of the oligonucleotides from the beads, which occurs for example in the partitions.
Vishal SHARMA, Ronald LEBOFSKY
Filed: 16 Mar 23
Utility
System, method, and device for forming an array of emulsions
10 Oct 23
Systems, methods, and devices for forming an array of emulsions.
Thomas Henry Cauley, III, John Dzenitis, Steve Hobbs, Stefano Schiaffino
Filed: 13 Dec 21
Utility
Cell Barcoding for Single Cell Sequencing
5 Oct 23
Methods and compositions for attaching cell-specific barcodes without formation of partitions is provided.
Ronald LEBOFSKY
Filed: 6 Feb 23
Utility
Cell Capture System and Method of Use
5 Oct 23
A cell capture system including an array, an inlet manifold, and an outlet manifold.
Kalyan Handique
Filed: 9 May 23
Utility
Cell Capture System and Method of Use
5 Oct 23
A cell capture system including an array, an inlet manifold, and an outlet manifold.
Kalyan Handique
Filed: 9 May 23
Utility
Compositions and methods for molecular labeling
26 Sep 23
The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct.
Michael L. Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
Filed: 19 Feb 20
Utility
Modification of surface properties of microfluidic devices
19 Sep 23
Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica.
Joshua Ritchey, Yi Xue, Robert Meltzer
Filed: 20 Jan 21
Utility
Multiple beads per droplet resolution
19 Sep 23
Methods of generating a nucleic acid signature for identifying particles associated in a partition are provided.
Ronald Lebofsky, Nicholas Heredia
Filed: 20 Jul 21
Utility
Analysis of Nucleic Acids
14 Sep 23
Method of haplotype analysis.
John F. REGAN, Serge SAXONOV, Michael Y. LUCERO, Benjamin J. HINDSON, Phillip BELGRADER, Simant DUBE, Austin SO, Jeffrey Clark MELLEN, Nicholas Jack HEREDIA, Kevin D. NESS, Billy W. COLSTON, Jr.
Filed: 14 Nov 22
Utility
Enzyme quantification
12 Sep 23
The invention generally relates to methods for quantifying an amount of enzyme molecules.
Darren Roy Link, Michael L. Samuels
Filed: 3 Feb 20
Utility
Adjustable Digital Microscope Display
7 Sep 23
The present invention relates in general to microscopy systems.
Frank HSIUNG, Kelly KROEGER, Robert ARCHER, Veronika KORTISOVA, Teresa RUBIO, Amber IRAETA
Filed: 13 Feb 23
Utility
Sandwich Assays In Droplets
7 Sep 23
The invention generally relates to performing sandwich assays in droplets.
Michael L. Samuels, Darren Roy Link
Filed: 24 Apr 23
Utility
Compositions and methods for molecular labeling
5 Sep 23
The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct.
Michael L. Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
Filed: 14 Jul 20
Utility
Mixed mode cation exchange chromatography ligands based on 1,3-dioxoisoindolin-2-yl structures
22 Aug 23
The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
Christopher Belisle, Jiali Liao, Edwin Lozano
Filed: 17 Mar 22
Utility
Compositions and Methods for Enhancing Reverse Transcriptase Activity And/or Reducing the Inhibition of Reverse Transcriptase
17 Aug 23
The subject application pertains to compositions and methods for enhancing reverse transcriptase (RT) activity and/or reducing the inhibition of RT by inhibitors, such as formalin, tannic acid and/or heparin.
XIANGDONG MENG, XIAOSONG GONG, CINDY CT WAN
Filed: 1 Mar 23
Utility
System and method for automated single cell processing and analyses
15 Aug 23
A system and method for automated single cell capture and processing is described, where the system includes a deck supporting and positioning a set of sample processing elements (including an integrated imaging subsystem); a gantry for actuating tools for interactions with the set of sample processing elements supported by the deck; and a base supporting various processing subsystems and a control subsystems in communication with the processing subsystems.
Kalyan Handique
Filed: 2 Jun 20
Utility
Second strand direct
15 Aug 23
Methods and compositions are provided herein for preparing high-throughput cDNA sequencing libraries.
Ronald Lebofsky, Jeremy Agresti
Filed: 23 Nov 20
Utility
Digital Affinity Linkage Assay
10 Aug 23
Methods of detecting a target in a sample are provided.
Boaz GILDOR, Dalia SHEZIFI
Filed: 20 Mar 23