43 patents
Utility
Modified Bovine G-CSF Polypeptides and Their Uses
2 Nov 23
Modified bovine G-CSF polypeptides and uses thereof are provided.
Anna-Maria A. HAYS PUTNAM, Nick KNUDSEN, Thea NORMAN, Alan KODER, Vadim KRAYNOV, Lillian SKIDMORE, Peter C. CANNING
Filed: 22 Dec 22
Utility
Porcine G-CSF Variants and Their Uses
26 Oct 23
The present invention relates to variants of porcine granulocyte colony stimulating factor (pG-CSF).
Peter Connor CANNING, Nickolas KNUDSEN, Md Harunur RASHID
Filed: 30 Jan 23
Utility
Modified relaxin polypeptides and their uses
17 Oct 23
Modified relaxin polypeptides and their uses thereof are provided.
Vadim Kraynov, Nick Knudsen, Amha Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
Filed: 3 Mar 22
Utility
Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
3 Oct 23
Described are antibody peptide conjugates (APCs) comprising an antibody conjugated to a peptide analog of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have agonist activity at the glucagon (GCG) receptor and the glucagon-like peptide 1 (GLP-1) receptor and the use of such APCs for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
Paul E. Carrington, Grigori Ermakov, Robert M. Garbaccio, Wolfgang Seghezzi, Elisabetta Bianchi, Federica Orvieto, Dennis Gately, Nick Knudsen, Anthony Manibusan
Filed: 27 Aug 20
Utility
Antibody-tlr Agonist Conjugates, Methods and Uses Thereof
28 Sep 23
Disclosed herein are TLR-agonists compounds, antibody-TLR agonist conjugates, pharmaceutical composition, and methods of use of such compounds or conjugates as therapeutics for treating a disease or condition such as cancer.
Sung Ju Moon, Brian Leon, Mingchao Kang, Nickolas Knudsen, Sukumar Sakamuri, Feng Tian
Filed: 20 Aug 21
Utility
Anti-CD70 Antibody Drug Conjugates
21 Sep 23
This invention relates to anti-CD70 antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid.
Richard S Barnett, Nickolas Knudsen, Ying Sun, Sandra Biroc, Timothy Buss, Tsotne Javahishvili, Damien Bresson, Shailaja Srinagesh, Amha Hewet, Jason Pinkstaff
Filed: 29 Aug 22
Utility
INTERLEUKIN-2 Polypeptide Conjugates and Methods of Use Thereof
20 Jul 23
The present invention provides compositions and methods comprising interleukin-2 (TL-2) polypeptide conjugates.
Sigeng CHEN, Yingchun LU, Md Harunur RASHID, Nickolas KNUDSEN, Feng TIAN
Filed: 7 Sep 22
Utility
Antibody Drug Conjugate for Anti-inflammatory Applications
30 Mar 23
Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
Philip E. Brandish, Robert M. Garbaccio, Jeffrey Kern, Linda Liang, Sanjiv Shah, Dennis Zaller, Andrew Beck, Dennis Gately, Nick Knudsen, Anthony Manibusan, Jianing Wang, Ying Sun
Filed: 26 Oct 22
Utility
Porcine G-CSF variants and their uses
14 Feb 23
The present invention relates to variants of porcine granulocyte colony stimulating factor (pG-CSF).
Peter Connor Canning, Nickolas Knudsen, Md Harunur Rashid
Filed: 10 Oct 18
Utility
Modified Relaxin Polypeptides and Their Uses
26 Jan 23
Modified relaxin polypeptides and their uses thereof are provided
Vadim KRAYNOV, Nick Knudsen, Amha Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
Filed: 25 Jul 22
Utility
Modified bovine G-CSF polypeptides and their uses
3 Jan 23
Modified bovine G-CSF polypeptides and uses thereof are provided.
Anna-Maria A. Hays Putnam, Nick Knudsen, Thea Norman, Alan Koder, Vadim Kraynov, Lillian Skidmore, Peter C. Canning
Filed: 19 Oct 18
Utility
Compositions Containing, Methods Involving, and Uses of Non-natural Amino Acid Linked Dolastatin Derivatives
29 Dec 22
Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides.
Zhenwei MIAO, Kyle ATKINSON, Sandra BIROC, Timothy BUSS, Melissa NEAL, Vadim KRAYNOV, Robin MARSDEN, Jason PINKSTAFF, Lillian SKIDMORE, Ying SUN, Agnieszka SZYDLIK, Delia Ianina LOPEZ DE VALENTA
Filed: 28 Apr 22
Utility
Antibody drug conjugate for anti-inflammatory applications
29 Nov 22
Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
Philip E. Brandish, Robert M. Garbaccio, Jeffrey Kern, Linda Liang, Sanjiv Shah, Dennis Zaller, Andrew Beck, Dennis Gately, Nick Knudsen, Anthony Manibusan, Jianing Wang, Ying Sun
Filed: 30 Sep 16
Utility
Anti-CD70 antibody drug conjugates
4 Oct 22
This invention relates to anti-CD70 antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid.
Richard S Barnett, Nick Knudsen, Ying Sun, Sandra Biroc, Timothy Buss, Tsotne Javahishvili, Damien Bresson, Shailaja Srinagesh, Amha Hewet, Jason Pinkstaff
Filed: 18 Dec 18
Utility
Nucleic acids encoding modified relaxin polypeptides
13 Sep 22
Modified relaxin polypeptides and their uses thereof are provided.
Vadim Kraynov, Nick Knudsen, Amha Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
Filed: 28 May 20
Utility
Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
23 Aug 22
Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides.
Zhenwei Miao, Kyle Atkinson, Sandra Biroc, Timothy Buss, Melissa Neal, Vadim Kraynov, Robin Marsden, Jason Pinkstaff, Lillian Skidmore, Ying Sun, Agnieszka Szydlik, Delia Ianina Lopez De Valenta
Filed: 5 Jan 21
Utility
Modified Relaxin Polypeptides and Their Uses
18 Aug 22
Modified relaxin polypeptides and their uses thereof are provided.
Vadim KRAYNOV, Nick KNUDSEN, Amha HEWET, Kristine DE DIOS, Jason PINKSTAFF, Lorraine SULLIVAN
Filed: 3 Mar 22
Utility
Compositions Containing, Methods and Uses of Antibody-tlr Agonist Conjugates
21 Jul 22
Disclosed herein are Trastuzumab-linked TLR-agonist derivative analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides.
Sung-Ju MOON, Brian LEON, Mingchao KANG, Nickolas KNUDSEN, Jianing WANG, Sukumar SAKAMURI, Feng TIAN
Filed: 12 Feb 20
Utility
Methods of treating heart failure and fibrotic disorders using modified relaxin polypeptides
26 Apr 22
Modified relaxin polypeptides and their uses thereof are provided.
Vadim Kraynov, Nick Knudsen, Amha Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
Filed: 27 May 20
Utility
INTERLEUKIN-2 Polypeptide Conjugates and Their Uses
24 Feb 22
The present invention provides methods for targeting interleukin-2 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using an interleukin-2 (IL-2) variant conjugated to a biologically active molecule that will affect cells expressing the interleukin-2 receptor.
Sigeng CHEN, Yingchun Lu, MD Harunur Rashid, Nickolas Knudsen, Feng Tian
Filed: 11 Sep 19